Structural basis of an essential interaction between influenza polymerase and Pol II CTD

Nature

Volumn 541, Issue 7635, 2017, Pages 117-121

  Lukarska, Maria ^a   Fournier, Guillaume ^b,c,d   Pflug, Alexander ^a   Resa Infante, Patricia ^a   Reich, Stefan ^a   Naffakh, Nadia ^b,c,d   Cusack, Stephen ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^b Sorbonne Paris Cité   (France)

^c Institut Pasteur   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CAPPED RNA; HETEROTRIMERIC INFLUENZA POLYMERASE; MESSENGER RNA; NUCLEOTIDYLTRANSFERASE; PHOSPHOSERINE; RECOMBINANT ENZYME; RNA POLYMERASE II; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS RNA; ANTIVIRUS AGENT; PEPTIDE FRAGMENT; PROTEIN BINDING; PROTEIN SUBUNIT; RNA DIRECTED RNA POLYMERASE;

BIOASSAY; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; GENETIC ANALYSIS; INFLUENZA; MUTATION; PEPTIDE; POLYMERASE CHAIN REACTION; VIRULENCE; VIRUS;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BAT; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENETIC STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA REPLICATION; RNA SYNTHESIS; RNA TRANSCRIPTION; STRUCTURE ANALYSIS; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS VIRULENCE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; MUTATION; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; PATHOGENICITY; PROTEIN DOMAIN; PROTEIN SUBUNIT; VIROLOGY; VIRULENCE; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CHIROPTERA; CRYSTALLOGRAPHY, X-RAY; INFLUENZA A VIRUS; INFLUENZA B VIRUS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; MUTATION; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; PEPTIDE FRAGMENTS; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN SUBUNITS; RNA POLYMERASE II; RNA REPLICASE; VIRULENCE; VIRUS REPLICATION;

EID: 85016158967     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20594     Document Type: Article

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