New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

Journal of Medicinal Chemistry

Volumn 56, Issue 21, 2013, Pages 8915-8930

  Pautus, Stéphane ^a,b   Sehr, Peter ^c   Lewis, Joe ^c   Fortuné, Antoine ^a   Wolkerstorfer, Andrea ^d   Szolar, Oliver ^d   Guilligay, Delphine ^b   Lunardi, Thomas ^b   Décout, Jean Luc ^a   Cusack, Stephen ^b  

^a Centre National de la Recherche Scientifique   (France)

^b UNIV GRENOBLE ALPES   (France)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d Savira Pharmaceuticals GmbH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLGUANINE; CAP BINDING PROTEIN; MESSENGER RNA PRECURSOR; PEPTIDE NUCLEIC ACID; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; BIOTINYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IN VITRO STUDY; INFLUENZA VIRUS A H5N1; MOLECULAR DOCKING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN SUBUNIT; REACTION OPTIMIZATION; SUBSTITUTION REACTION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANINE; INFLUENZA A VIRUS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 84887926053     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401369y     Document Type: Article

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