Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 13, 2016, Pages 3669-3674

  Song, Min Suk ^a   Kumar, Gyanendra ^a   Shadrick, William R ^a   Zhou, Wei ^b   Jeevan, Trushar ^a   Li, Zhenmei ^a   Slavish, P Jake ^a   Fabrizio, Thomas P ^a   Yoon, Sun Woo ^a   Webb, Thomas R ^a   Webby, Richard J ^c   White, Stephen W ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Chungbuk National University College of Medicine   (South Korea)

^c SRI INTERNATIONAL   (United States)

Author keywords

Diketo acid; Infection; Mutation; Replication; Virus

Indexed keywords

ANTIVIRUS AGENT; ENDONUCLEASE; ENDONUCLEASE INHIBITOR; ESTERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; ENZYME INHIBITOR; HYDROXYBUTYRIC ACID; L-742,001; PIPERIDINE DERIVATIVE; RNA DIRECTED RNA POLYMERASE;

ANIMAL CELL; ANIMAL MODEL; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA; INFLUENZA VIRUS; MDCK CELL LINE; MOUSE; MUTAGENESIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; VIROGENESIS; VIRUS DETECTION; VIRUS IDENTIFICATION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; DOG; DRUG EFFECT; ENZYMOLOGY; GENETIC VARIATION; GENETICS; INFLUENZA A VIRUS; INFLUENZA A VIRUS (H1N1); KINETICS; METABOLISM; MOLECULAR MODEL; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG RESISTANCE, VIRAL; ENDONUCLEASES; ENZYME INHIBITORS; GENETIC VARIATION; HYDROXYBUTYRATES; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; KINETICS; MADIN DARBY CANINE KIDNEY CELLS; MODELS, MOLECULAR; MUTAGENESIS; PIPERIDINES; RNA REPLICASE;

EID: 84962106718     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519772113     Document Type: Article

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