메뉴 건너뛰기




Volumn 97, Issue , 2018, Pages 87-93

Spray- or freeze-drying of casein micelles loaded with Vitamin D2: Studies on storage stability and in vitro digestibility

Author keywords

Dried casein micelle; Encapsulation; In vitro digestion; Nanocarrier; Vitamin D

Indexed keywords

CASEIN; DAIRIES; DRYING; ENCAPSULATION; PROTEOLYSIS;

EID: 85049042993     PISSN: 00236438     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lwt.2018.04.003     Document Type: Article
Times cited : (49)

References (45)
  • 1
    • 84855496627 scopus 로고    scopus 로고
    • Formation and potential uses of milk proteins as nano delivery vehicles for nutraceuticals: A review
    • Abd El-Salam, M.H., El-Shibiny, S., Formation and potential uses of milk proteins as nano delivery vehicles for nutraceuticals: A review. International Journal of Dairy Technology 65:1 (2012), 13–21.
    • (2012) International Journal of Dairy Technology , vol.65 , Issue.1 , pp. 13-21
    • Abd El-Salam, M.H.1    El-Shibiny, S.2
  • 4
    • 85049038577 scopus 로고    scopus 로고
    • Bundesministerien für Ernährung, Landwirtschaft und Verbraucherschutz und für Gesundheit im Einvernehmen mit den Bundesministerien für Wirtschaft und Technologie, für Umwelt, Naturschutz und Reaktorsicherheit, der Finanzen und der Justi. (2007). Verordnung über Anforderungen an die Hygiene beim Herstellen, Behandeln und Inverkehrbringen von bestimmten Lebensmitteln tierischen Ursprungs (Tierische Lebensmittel-Hygieneverordnung -Tier-LMHV). Bundesministeriums der Justiz und für Verbraucherschutz: Retrieved from
    • Bundesministerien für Ernährung, Landwirtschaft und Verbraucherschutz und für Gesundheit im Einvernehmen mit den Bundesministerien für Wirtschaft und Technologie, für Umwelt, Naturschutz und Reaktorsicherheit, der Finanzen und der Justi. (2007). Verordnung über Anforderungen an die Hygiene beim Herstellen, Behandeln und Inverkehrbringen von bestimmten Lebensmitteln tierischen Ursprungs (Tierische Lebensmittel-Hygieneverordnung -Tier-LMHV). Bundesministeriums der Justiz und für Verbraucherschutz: Retrieved from https://www.gesetze-im-internet.de/tier-lmhv/Tier-LMHV.pdf.
  • 5
    • 85021749981 scopus 로고    scopus 로고
    • Re-assembled casein micelles improve in vitro bioavailability of Vitamin D in a Caco-2 cell model
    • Cohen, Y., Levi, M., Lesmes, U., Margier, M., Reboul, E., Livney, Y.D., Re-assembled casein micelles improve in vitro bioavailability of Vitamin D in a Caco-2 cell model. Food & Function 8:6 (2017), 2133–2141.
    • (2017) Food & Function , vol.8 , Issue.6 , pp. 2133-2141
    • Cohen, Y.1    Levi, M.2    Lesmes, U.3    Margier, M.4    Reboul, E.5    Livney, Y.D.6
  • 6
    • 85014274370 scopus 로고    scopus 로고
    • A current look at nutraceuticals - key concepts and future prospects
    • da Costa, J.P., A current look at nutraceuticals - key concepts and future prospects. Trends in Food Science & Technology 62 (2017), 68–78.
    • (2017) Trends in Food Science & Technology , vol.62 , pp. 68-78
    • da Costa, J.P.1
  • 7
    • 0348114294 scopus 로고    scopus 로고
    • Casein micelle structure, functions and interactions
    • P.F.M. Fox P.L.H. McSweeney Kluwer Academic/Plenum Publishers New York
    • De Kruif, C.G., Holt, C., Casein micelle structure, functions and interactions. Fox, P.F.M., McSweeney, P.L.H., (eds.) Advanced dairy chemistry, Vol. 1, 2003, Kluwer Academic/Plenum Publishers, New York, 233–277.
    • (2003) Advanced dairy chemistry , vol.1 , pp. 233-277
    • De Kruif, C.G.1    Holt, C.2
  • 8
    • 84879116540 scopus 로고    scopus 로고
    • Spray-dried casein-based micelles as a vehicle for solubilization and controlled delivery of flutamide: Formulation, characterization, and in vivo pharmacokinetics
    • Elzoghby, A.O., Helmy, M.W., Samy, W.M., Elgindy, N.A., Spray-dried casein-based micelles as a vehicle for solubilization and controlled delivery of flutamide: Formulation, characterization, and in vivo pharmacokinetics. European Journal of Pharmaceutics and Biopharmaceutics 84:3 (2013), 487–496.
    • (2013) European Journal of Pharmaceutics and Biopharmaceutics , vol.84 , Issue.3 , pp. 487-496
    • Elzoghby, A.O.1    Helmy, M.W.2    Samy, W.M.3    Elgindy, N.A.4
  • 9
    • 85104544302 scopus 로고    scopus 로고
    • Select committee on GRAS substances (SCOGS) Opinion: Calcium caseinate; casein; sodium caseinate
    • Retrieved 12.05.2017, 2017, from
    • FDA, Select committee on GRAS substances (SCOGS) Opinion: Calcium caseinate; casein; sodium caseinate. 2015 Retrieved 12.05.2017, 2017, from https://www.fda.gov/food/ingredientspackaginglabeling/gras/scogs/ucm260879.htm.
    • (2015)
    • FDA1
  • 10
    • 27144501029 scopus 로고    scopus 로고
    • Milk proteins: General and historical aspects
    • 3rd ed. P.F.M. Fox P.L.H. McSweeney Kluwer Academix/Plenum Publishers New York
    • Fox, P.F., Milk proteins: General and historical aspects., 3rd ed. Fox, P.F.M., McSweeney, P.L.H., (eds.) Advanced dairy chemistry, Vol 1, 2003, Kluwer Academix/Plenum Publishers, New York, 1–41.
    • (2003) Advanced dairy chemistry , vol.1 , pp. 1-41
    • Fox, P.F.1
  • 12
    • 0030212443 scopus 로고    scopus 로고
    • Influence of freezing rate and the ripeness state of fresh courgette on the quality of freeze-dried products and freeze-drying time
    • Genin, N., Rene, F., Influence of freezing rate and the ripeness state of fresh courgette on the quality of freeze-dried products and freeze-drying time. Journal of Food Engineering 29:2 (1996), 201–209.
    • (1996) Journal of Food Engineering , vol.29 , Issue.2 , pp. 201-209
    • Genin, N.1    Rene, F.2
  • 13
    • 34548696197 scopus 로고    scopus 로고
    • Applications of spray-drying in microencapsulation of food ingredients: An overview
    • Gharsallaoui, A., Roudaut, G., Chambin, O., Voilley, A., Saurel, R., Applications of spray-drying in microencapsulation of food ingredients: An overview. Food Research International 40:9 (2007), 1107–1121.
    • (2007) Food Research International , vol.40 , Issue.9 , pp. 1107-1121
    • Gharsallaoui, A.1    Roudaut, G.2    Chambin, O.3    Voilley, A.4    Saurel, R.5
  • 14
    • 84863671550 scopus 로고    scopus 로고
    • Stability and bioavailability of Vitamin D nanoencapsulated in casein micelles
    • Haham, M., Ish-Shalom, S., Nodelman, M., Duek, I., Segal, E., Kustanovich, M., et al. Stability and bioavailability of Vitamin D nanoencapsulated in casein micelles. Food & Function 3:7 (2012), 737–744.
    • (2012) Food & Function , vol.3 , Issue.7 , pp. 737-744
    • Haham, M.1    Ish-Shalom, S.2    Nodelman, M.3    Duek, I.4    Segal, E.5    Kustanovich, M.6
  • 15
    • 76549088749 scopus 로고    scopus 로고
    • Influence of casein-based microencapsulation on freeze-drying and storage of probiotic cells
    • Heidebach, T., Forst, P., Kulozik, U., Influence of casein-based microencapsulation on freeze-drying and storage of probiotic cells. Journal of Food Engineering 98:3 (2010), 309–316.
    • (2010) Journal of Food Engineering , vol.98 , Issue.3 , pp. 309-316
    • Heidebach, T.1    Forst, P.2    Kulozik, U.3
  • 18
    • 84885147755 scopus 로고    scopus 로고
    • Spray drying of casein aggregates loaded with beta-carotene: Influences of acidic conditions and storage time on surface structure and encapsulation efficiencies
    • Jarunglumlert, T., Nakagawa, K., Spray drying of casein aggregates loaded with beta-carotene: Influences of acidic conditions and storage time on surface structure and encapsulation efficiencies. Drying Technology 31:13–14 (2013), 1459–1465.
    • (2013) Drying Technology , vol.31 , Issue.13-14 , pp. 1459-1465
    • Jarunglumlert, T.1    Nakagawa, K.2
  • 19
    • 84930947252 scopus 로고    scopus 로고
    • Digestibility and structural parameters of spray-dried casein clusters under simulated gastric conditions
    • Jarunglumlert, T., Nakagawa, K., Adachi, S., Digestibility and structural parameters of spray-dried casein clusters under simulated gastric conditions. Food Research International 75 (2015), 166–173.
    • (2015) Food Research International , vol.75 , pp. 166-173
    • Jarunglumlert, T.1    Nakagawa, K.2    Adachi, S.3
  • 20
  • 21
    • 0041386015 scopus 로고    scopus 로고
    • Modelling of the acidification process and rheological properties of milk fermented with a yogurt starter culture using response surface methodology
    • Kristo, E., Biliaderis, C.G., Tzanetakis, N., Modelling of the acidification process and rheological properties of milk fermented with a yogurt starter culture using response surface methodology. Food Chemistry 83:3 (2003), 437–446.
    • (2003) Food Chemistry , vol.83 , Issue.3 , pp. 437-446
    • Kristo, E.1    Biliaderis, C.G.2    Tzanetakis, N.3
  • 23
    • 84912150759 scopus 로고    scopus 로고
    • Soybean beta-Conglycinin Nanoparticles for delivery of hydrophobic nutraceuticals
    • Levinson, Y., Israeli-Lev, G., Livney, Y.D., Soybean beta-Conglycinin Nanoparticles for delivery of hydrophobic nutraceuticals. Food Biophysics 9:4 (2014), 332–340.
    • (2014) Food Biophysics , vol.9 , Issue.4 , pp. 332-340
    • Levinson, Y.1    Israeli-Lev, G.2    Livney, Y.D.3
  • 25
    • 67649939005 scopus 로고    scopus 로고
    • Emulsification alters simulated gastrointestinal proteolysis of β-casein and β-lactoglobulin
    • Macierzanka, A., Sancho, A.I., Mills, E.N.C., Rigbya, N.M., Mackiea, A.R., Emulsification alters simulated gastrointestinal proteolysis of β-casein and β-lactoglobulin. Soft Matter 5:3 (2009), 538–550.
    • (2009) Soft Matter , vol.5 , Issue.3 , pp. 538-550
    • Macierzanka, A.1    Sancho, A.I.2    Mills, E.N.C.3    Rigbya, N.M.4    Mackiea, A.R.5
  • 26
    • 84857820950 scopus 로고    scopus 로고
    • Maillard-conjugate based core-shell co-assemblies for nanoencapsulation of hydrophobic nutraceuticals in clear beverages
    • Markman, G., Livney, Y.D., Maillard-conjugate based core-shell co-assemblies for nanoencapsulation of hydrophobic nutraceuticals in clear beverages. Food & Function 3:3 (2012), 262–270.
    • (2012) Food & Function , vol.3 , Issue.3 , pp. 262-270
    • Markman, G.1    Livney, Y.D.2
  • 27
    • 71649109997 scopus 로고    scopus 로고
    • Effect of manufacture and reconstitution of milk protein concentrate powder on the size and rennet gelation behaviour of casein micelles
    • Martin, G.J.O., Williams, R.P.W., Dunstan, D.E., Effect of manufacture and reconstitution of milk protein concentrate powder on the size and rennet gelation behaviour of casein micelles. International Dairy Journal 20:2 (2010), 128–131.
    • (2010) International Dairy Journal , vol.20 , Issue.2 , pp. 128-131
    • Martin, G.J.O.1    Williams, R.P.W.2    Dunstan, D.E.3
  • 33
    • 84906237011 scopus 로고    scopus 로고
    • pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity
    • Pan, K., Luo, Y.C., Gan, Y.D., Baek, S.J., Zhong, Q.X., pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity. Soft Matter 10:35 (2014), 6820–6830.
    • (2014) Soft Matter , vol.10 , Issue.35 , pp. 6820-6830
    • Pan, K.1    Luo, Y.C.2    Gan, Y.D.3    Baek, S.J.4    Zhong, Q.X.5
  • 34
    • 84879491135 scopus 로고    scopus 로고
    • Enhanced dispersibility and bioactivity of curcumin by encapsulation in casein nanocapsules
    • Pan, K., Zhong, Q.X., Baek, S.J., Enhanced dispersibility and bioactivity of curcumin by encapsulation in casein nanocapsules. Journal of Agricultural and Food Chemistry 61:25 (2013), 6036–6043.
    • (2013) Journal of Agricultural and Food Chemistry , vol.61 , Issue.25 , pp. 6036-6043
    • Pan, K.1    Zhong, Q.X.2    Baek, S.J.3
  • 35
    • 84880578875 scopus 로고    scopus 로고
    • Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-A review of recent evidence
    • Pludowski, P., Holick, M.F., Pilz, S., Wagner, C.L., Hollis, B.W., Grant, W.B., et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-A review of recent evidence. Autoimmunity Reviews 12:10 (2013), 976–989.
    • (2013) Autoimmunity Reviews , vol.12 , Issue.10 , pp. 976-989
    • Pludowski, P.1    Holick, M.F.2    Pilz, S.3    Wagner, C.L.4    Hollis, B.W.5    Grant, W.B.6
  • 36
    • 0035452841 scopus 로고    scopus 로고
    • Hot air and freeze-drying of high-value foods: A review
    • Ratti, C., Hot air and freeze-drying of high-value foods: A review. Journal of Food Engineering 49:4 (2001), 311–319.
    • (2001) Journal of Food Engineering , vol.49 , Issue.4 , pp. 311-319
    • Ratti, C.1
  • 37
    • 2442481757 scopus 로고    scopus 로고
    • Cross-linking by transglutaminase changes neither the in vitro proteolysis nor the in vivo digestibility of caseinate
    • Roos, N., Lorenzen, P.C., Sick, H., Schrezenmeir, J., Schlimme, E., Cross-linking by transglutaminase changes neither the in vitro proteolysis nor the in vivo digestibility of caseinate. Kieler Milchwirtschaftliche Forschungsberichte 55:4 (2003), 261–276.
    • (2003) Kieler Milchwirtschaftliche Forschungsberichte , vol.55 , Issue.4 , pp. 261-276
    • Roos, N.1    Lorenzen, P.C.2    Sick, H.3    Schrezenmeir, J.4    Schlimme, E.5
  • 38
    • 84873710829 scopus 로고    scopus 로고
    • Thermal protection of beta-carotene in re-assembled casein micelles during different processing technologies applied in food industry
    • Saiz-Abajo, M.J., Gonzalez-Ferrero, C., Moreno-Ruiz, A., Romo-Hualde, A., Gonzalez-Navarro, C.J., Thermal protection of beta-carotene in re-assembled casein micelles during different processing technologies applied in food industry. Food Chemistry 138:2–3 (2013), 1581–1587.
    • (2013) Food Chemistry , vol.138 , Issue.2-3 , pp. 1581-1587
    • Saiz-Abajo, M.J.1    Gonzalez-Ferrero, C.2    Moreno-Ruiz, A.3    Romo-Hualde, A.4    Gonzalez-Navarro, C.J.5
  • 39
    • 1842665848 scopus 로고    scopus 로고
    • High pressure effects on the colloidal calcium phosphate and the structural integrity of micellar casein in milk.1. High pressure dissolution of colloidal calcium phosphate in heated milk systems
    • Schrader, K., Buchheim, W., Morr, C.V., High pressure effects on the colloidal calcium phosphate and the structural integrity of micellar casein in milk.1. High pressure dissolution of colloidal calcium phosphate in heated milk systems. Nahrung-food 41:3 (1997), 133–138.
    • (1997) Nahrung-food , vol.41 , Issue.3 , pp. 133-138
    • Schrader, K.1    Buchheim, W.2    Morr, C.V.3
  • 40
    • 33947182943 scopus 로고    scopus 로고
    • Casein micelle as a natural nano-capsular vehicle for nutraceuticals
    • Semo, E., Kesselman, E., Danino, D., Livney, Y.D., Casein micelle as a natural nano-capsular vehicle for nutraceuticals. Food Hydrocolloids 21:5–6 (2007), 936–942.
    • (2007) Food Hydrocolloids , vol.21 , Issue.5-6 , pp. 936-942
    • Semo, E.1    Kesselman, E.2    Danino, D.3    Livney, Y.D.4
  • 41
    • 77952653781 scopus 로고    scopus 로고
    • Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (citrus reticulata blanco cv. Sainampueng) from northern Thailand
    • Stuetz, W., Prapamontol, T., Hongsibsong, S., Biesalski, H.K., Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (citrus reticulata blanco cv. Sainampueng) from northern Thailand. Journal of Agricultural and Food Chemistry 58:10 (2010), 6069–6074.
    • (2010) Journal of Agricultural and Food Chemistry , vol.58 , Issue.10 , pp. 6069-6074
    • Stuetz, W.1    Prapamontol, T.2    Hongsibsong, S.3    Biesalski, H.K.4
  • 42
    • 0043241649 scopus 로고    scopus 로고
    • Casein-whey protein interactions in heated milk: The influence of pH
    • Vasbinder, A.J., de Kruif, C.G., Casein-whey protein interactions in heated milk: The influence of pH. International Dairy Journal 13:8 (2003), 669–677.
    • (2003) International Dairy Journal , vol.13 , Issue.8 , pp. 669-677
    • Vasbinder, A.J.1    de Kruif, C.G.2
  • 44
    • 85049033427 scopus 로고    scopus 로고
    • Handbuch der landwirtschaftlichen Versuchs- und Untersuchungsmethodik (Methodenbuch) Methodenbuch Band IV; Chemische, physikalische und mikrobiologische Untersuchungsverfahren für Milch, Milchprodukte und Molkereihilfsstoffe
    • VDLUFA-Verlag Darmstadt
    • VDLUFA, Handbuch der landwirtschaftlichen Versuchs- und Untersuchungsmethodik (Methodenbuch) Methodenbuch Band IV; Chemische, physikalische und mikrobiologische Untersuchungsverfahren für Milch, Milchprodukte und Molkereihilfsstoffe. 2000, VDLUFA-Verlag, Darmstadt.
    • (2000)
    • VDLUFA1
  • 45
    • 79952539269 scopus 로고    scopus 로고
    • Re-assembled casein micelles and casein nanoparticles as nano-vehicles for omega-3 polyunsaturated fatty acids
    • Zimet, P., Rosenberg, D., Livney, Y.D., Re-assembled casein micelles and casein nanoparticles as nano-vehicles for omega-3 polyunsaturated fatty acids. Food Hydrocolloids 25:5 (2011), 1270–1276.
    • (2011) Food Hydrocolloids , vol.25 , Issue.5 , pp. 1270-1276
    • Zimet, P.1    Rosenberg, D.2    Livney, Y.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.