Second-hand aerosol from tobacco and electronic cigarettes: Evaluation of the smoker emission rates and doses and lung cancer risk of passive smokers and vapers

Science of the Total Environment

Volumn 642, Issue , 2018, Pages 137-147

  Avino, Pasquale ^a,b   Scungio, Mauro ^c   Stabile, Luca ^d   Cortellessa, Gino ^d   Buonanno, Giorgio ^d,e,f   Manigrasso, Maurizio ^g  

^a UNIVERSITY OF MOLISE   (Italy)

^b Institute of Ecotoxicology and Environmental Sciences   (India)

^c UNIVERSITY OF TUSCIA   (Italy)

^d UNIVERSITY OF CASSINO AND SOUTHERN LAZIO   (Italy)

^e QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^f UNIVERSITY OF NAPLES PARTHENOPE   (Italy)

^g DEPARTMENT OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   (Italy)

Author keywords

Cigarettes; Dose; Electronic cigarettes; Risk; Second hand smoke; Ultrafine particles

Indexed keywords

AEROSOLS; BIOLOGICAL ORGANS; DISEASES; HEAVY METALS; INDOOR AIR POLLUTION; PARTICLE SIZE; PARTICULATE EMISSIONS; RESPIRATORY SYSTEM; RISKS; TOBACCO;

CIGARETTES; DOSE; ELECTRONIC CIGARETTES; SECOND HAND SMOKES; ULTRAFINE PARTICLE;

RISK PERCEPTION;

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ARSENIC; BENZO[A]PYRENE; BLACK CARBON; CADMIUM; HEAVY METAL; NICKEL; NITROSAMINE; NITROSONORNICOTINE;

AEROSOL; CANCER; EMISSION; HEALTH RISK; PARTICLE SIZE; RISK ASSESSMENT; SMOKING; TOBACCO;

AEROSOL; AMBIENT AIR; ARTICLE; CANCER RISK; CARCINOGENICITY; CONCENTRATION (PARAMETERS); ELECTRONIC CIGARETTE; HUMAN; HUMAN EXPERIMENT; LUNG CANCER; MICROENVIRONMENT; PARTICLE SIZE; PARTICULATE MATTER; PASSIVE SMOKING; PRIORITY JOURNAL; TOBACCO; ANALYSIS; LUNG TUMOR; SMOKING; STATISTICS AND NUMERICAL DATA;

NICOTIANA TABACUM;

AEROSOLS; ELECTRONIC NICOTINE DELIVERY SYSTEMS; HUMANS; LUNG NEOPLASMS; SMOKERS; TOBACCO; TOBACCO SMOKE POLLUTION;

EID: 85048167803     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2018.06.059     Document Type: Article

References (72)

1. Allen, J.G., Flanigan, S.S., Leblanc, M., Vallarino, J., Macnaughton, P., Stewart, J.H., Christiani, D.C., Flavoring chemicals in e-cigarettes: diacetyl, 2,3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored e-cigarettes. Environ. Health Perspect. 124 (2016), 733–739.
2. Anjilvel, S., Asgharian, B., A multiple-path model of particle deposition in the rat lung. Fundam. Appl. Toxicol. 28 (1995), 41–50.
3. Asgharian, B., Hofmann, W., Bergmann, R., Particle deposition in a multiple-path model of the human lung. Aerosol Sci. Technol. 34 (2001), 332–339.
4. Asgharian, B., Price, O.T., Oldham, M., Chen, L.C., Saunders, E.L., Gordon, T., Mikheev, V.B., Minard, K.R., Teeguarden, J.G., Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract. Inhal. Toxicol. 26 (2014), 829–842.
5. Avino, P., Manigrasso, M., Dynamic of submicrometer particles in urban environment. Environ. Sci. Pollut. Res. Int. 24 (2017), 13908–13920.
6. Avino, P., Lopez, F., Manigrasso, M., Regional deposition of submicrometer aerosol in the human respiratory system determined at 1-s time resolution of particle size distribution measurements. Aerosol Air Qual. Res. 13 (2013), 1702–1711.
7. Avino, P., Manigrasso, M., Pandolfi, P., Tornese, C., Settimi, D., Paolucci, N., Submicron particles during macro- and micro-weldings procedures in industrial indoor environments and health implications for welding operators. Metals 5 (2015), 1045–1060.
8. Avino, P., Protano, C., Vitali, M., Manigrasso, M., Benchmark study on fine-mode aerosol in a big urban area and relevant doses deposited in the human respiratory tract. Environ. Pollut. 216 (2016), 530–537.
9. Azzopardi, D., Patel, K., Jaunky, T., Santopietro, S., Camacho, O.M., Mcaughey, J., Gaca, M., Electronic cigarette aerosol induces significantly less cytotoxicity than tobacco smoke. Toxicol. Mech. Methods 26 (2016), 477–491.
10. Ballbè M., Martínez-Sánchez, J.M., Sureda, X., Fu, M., Pérez-Ortuño, R., Pascual, J.A., Saltó E., Fernández, E., Cigarettes vs. e-cigarettes: passive exposure at home measured by means of airborne marker and biomarkers. Environ. Res. 135 (2014), 76–80.
11. Buonanno, G., Dell'Isola, M., Stabile, L., Viola, A., Uncertainty budget of the SMPS-APS system in the measurement of PM 1, PM 2.5, and PM 10. Aerosol Sci. Technol. 43 (2009), 1130–1141.
12. Buonanno, G., Morawska, L., Stabile, L., Particle emission factors during cooking activities. Atmos. Environ. 43 (2009), 3235–3242.
13. Buonanno, G., Dell'Isola, M., Stabile, L., Viola, A., Critical aspects of the uncertainty budget in the gravimetric PM measurements. Measurement 44 (2010), 139–147.
14. Buonanno, G., Giovinco, G., Morawska, L., Wang, L., Submicrometer particle dose for different population age groups in Brisbane, Australia. Metrology Society of Australia Conference, a Climate for Better Measurement Deakin Management and Convention Centre, Geelong (VIC). 19–21 October 2011, 2011.
15. Buonanno, G., Johnson, G., Morawska, L., Stabile, L., Volatility characterization of cooking-generated aerosol particles. Aerosol Sci. Technol. 45 (2011), 1069–1077.
16. Buonanno, G., Morawska, L., Stabile, L., Exposure to welding particles in automotive plants. J. Aerosol Sci. 42 (2011), 295–304.
17. Buonanno, G., Giovinco, G., Morawska, L., Stabile, L., Lung cancer risk of airborne particles for Italian population. Environ. Res. 142 (2015), 443–451.
18. Buonanno, G., Stabile, L., Morawska, L., Giovinco, G., Querol, X., Do air quality targets really represent safe limits for lung cancer risk?. Sci. Total Environ. 580 (2017), 74–82.
19. d'Ambrosio Alfano, F.R., Dell'Isola, M., Ficco, G., Tassini, F., Experimental analysis of air tightness in Mediterranean buildings using the fan pressurization method. Build. Environ. 53 (2012), 16–25.
20. d'Ambrosio Alfano, F., Dell'Isola, M., Ficco, G., Palella, B., Riccio, G., Experimental air-tightness analysis in Mediterranean buildings after windows retrofit. Sustainability, 8, 2016, 991.
21. Farsalinos, K.E., Tsiapras, D., Kyrzopoulos, S., Savvopoulou, M., Voudris, V., Acute effects of using an electronic nicotine-delivery device (electronic cigarette) on myocardial function: comparison with the effects of regular cigarettes. BMC Cardiovasc. Disord., 14, 2014, 78.
22. Farsalinos, K.E., Gillman, G., Poulas, K., Voudris, V., Tobacco-specific nitrosamines in electronic cigarettes: comparison between liquid and aerosol levels. Int. J. Environ. Res. Public Health 12 (2015), 9046–9053.
23. Farsalinos, K.E., Voudris, V., Poulas, K., Are metals emitted from electronic cigarettes a reason for health concern? A risk-assessment analysis of currently available literature. Int. J. Environ. Res. Public Health 12 (2015), 5215–5232.
24. Flouris, A.D., Poulianiti, K.P., Chorti, M.S., Jamurtas, A.Z., Kouretas, D., Owolabi, E.O., Tzatzarakis, M.N., Tsatsakis, A.M., Koutedakis, Y., Acute effects of electronic and tobacco cigarette smoking on complete blood count. Food Chem. Toxicol. 50 (2012), 3600–3603.
25. Flouris, A.D., Chorti, M.S., Poulianiti, K.P., Jamurtas, A.Z., Kostikas, K., Tzatzarakis, M.N., Wallace Hayes, A., Tsatsakis, A.M., Koutedakis, Y., Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhal. Toxicol. 25 (2013), 91–101.
26. Fuoco, F., Buonanno, G., Stabile, L., Vigo, P., Influence parameters of particle concentration and size distribution in the mainstream of e-cigarettes. Environ. Pollut. 184 (2014), 523–529.
27. Fuoco, F., Stabile, L., Buonanno, G., Scungio, M., Manigrasso, M., Frattolillo, A., Tracheobronchial and alveolar particle surface area doses in smokers. Atmosphere, 8, 2017, 19.
28. Ganapathy, V., Manyanga, J., Brame, L., Mcguire, D., Sadhasivam, B., Floyd, E., Rubenstein, D.A., Ramachandran, I., Wagener, T., Queimado, L., Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage. PLoS One, 12, 2017, e0177780.
29. Gillman, I.G., Kistler, K.A., Stewart, E.W., Paolantonio, A.R., Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols. Regul. Toxicol. Pharmacol. 75 (2016), 58–65.
30. Goniewicz, M.L., Knysak, J., Gawron, M., Kosmider, L., Sobczak, A., Kurek, J., Prokopowicz, A., Jablonska-Czapla, M., Rosik-Dulewska, C., Havel, C., Jacob, P., Benowitz, N., Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob. Control. 23 (2014), 133–139.
31. He, C., Morawska, L., Hitchins, J., Gilbert, D., Contribution from indoor sources to particle number and mass concentrations in residential houses. Atmos. Environ. 38 (2004), 3405–3415.
32. Hess, I.M., Lachireddy, K., Capon, A., A systematic review of the health risks from passive exposure to electronic cigarette vapour. Public Health Res. Pract., 26, 2016.
33. Ingebrethsen, B.J., Alderman, S.L., Ademe, B., Coagulation of mainstream cigarette smoke in the mouth during puffing and inhalation. Aerosol Sci. Technol. 45 (2011), 1422–1428.
34. Ingebrethsen, B.J., Cole, S.K., Alderman, S.L., Electronic cigarette aerosol particle size distribution measurements. Inhal. Toxicol. 24 (2012), 976–984.
35. International Agency for Research on Cancer, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Lyon, France. 2004.
36. International Commission on Radiological Protection, Human respiratory tract model for radiological protection. A report of a Task Group of the International Commission on Radiological Protection. Ann. ICRP 24 (1994), 1–482.
37. Jensen, R.P., Luo, W., Pankow, J.F., Strongin, R.M., Peyton, D.H., Hidden formaldehyde in E-cigarette aerosols. N. Engl. J. Med. 372 (2015), 392–394.
38. Kosmider, L., Sobczak, A., Fik, M., Knysak, J., Zaciera, M., Kurek, J., Goniewicz, M.L., Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob. Res. 16 (2014), 1319–1326.
39. Kruskal, W.H., Wallis, W.A., Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 47 (1952), 583–621.
40. Manigrasso, M., Avino, P., Fast evolution of urban ultrafine particles: implications for deposition doses in the human respiratory system. Atmos. Environ. 51 (2012), 116–123.
41. Manigrasso, M., Buonanno, G., Fuoco, F.C., Stabile, L., Avino, P., Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers. Environ. Pollut. 196 (2015), 257–267.
42. Manigrasso, M., Buonanno, G., Stabile, L., Morawska, L., Avino, P., Particle doses in the pulmonary lobes of electronic and conventional cigarette users. Environ. Pollut. 202 (2015), 24–31.
43. Manigrasso, M., Guerriero, E., Avino, P., Ultrafine particles in residential indoors and doses deposited in the human respiratory system. Atmosphere 6 (2015), 1444–1461.
44. Manigrasso, M., Buonanno, G., Fuoco, F.C., Stabile, L., Avino, P., Electronic cigarettes: age-specific generation-resolved pulmonary doses. Environ. Sci. Pollut. Res. Int. 24 (2017), 13068–13079.
45. Manigrasso, M., Natale, C., Vitali, M., Protano, C., Avino, P., Pedestrians in traffic environments: ultrafine particle respiratory doses. Int. J. Environ. Res. Public Health, 14, 2017.
46. Manigrasso, M., Vernale, C., Avino, P., Traffic aerosol lobar doses deposited in the human respiratory system. Environ. Sci. Pollut. Res. 24 (2017), 13866–13873.
47. McAuley, T.R., Hopke, P.K., Zhao, J., Babaian, S., Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal. Toxicol. 24 (2012), 850–857.
48. Mikheev, V.B., Brinkman, M.C., Granville, C.A., Gordon, S.M., Clark, P.I., Real-time measurement of electronic cigarette aerosol size distribution and metals content analysis. Nicotine Tob. Res. 18 (2016), 1895–1902.
49. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, (eds.) Technical Support Document for Cancer Potency Factors: Methodologies for Derivation, Listing of Available Values, and Adjustments to Allow for Early Life Stage Exposures, 2009 (Sacramento, CA).
50. Protano, C., Manigrasso, M., Avino, P., Sernia, S., Vitali, M., Second-hand smoke exposure generated by new electronic devices (IQOS(R) and e-cigs) and traditional cigarettes: submicron particle behaviour in human respiratory system. Ann. Ig. 28 (2016), 109–112.
51. Protano, C., Manigrasso, M., Avino, P., Vitali, M., Second-hand smoke generated by combustion and electronic smoking devices used in real scenarios: ultrafine particle pollution and age-related dose assessment. Environ. Int. 107 (2017), 190–195.
52. Saffari, A., Daher, N., Ruprecht, A., De Marco, C., Pozzi, P., Boffi, R., Hamad, S.H., Shafer, M.M., Schauer, J.J., Westerdahl, D., Sioutas, C., Particulate metals and organic compounds from electronic and tobacco-containing cigarettes: comparison of emission rates and secondhand exposure. Environ. Sci.: Processes Impacts 16 (2014), 2259–2267.
53. Sahu, S.K., Tiwari, M., Bhangare, R.C., Pandit, G.G., Particle size distribution of mainstream and exhaled cigarette smoke and predictive deposition in human respiratory tract. Aerosol Air Qual. Res. 13 (2013), 324–332.
54. Schober, W., Szendrei, K., Matzen, W., Osiander-Fuchs, H., Heitmann, D., Schettgen, T., Jörres, R.A., Fromme, H., Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int. J. Hyg. Environ. Health 217 (2014), 628–637.
55. Schripp, T., Markewitz, D., Uhde, E., Salthammer, T., Does e-cigarette consumption cause passive vaping?. Indoor Air 23 (2013), 25–31.
56. Schwartz, A.G., Cote, M.L., Epidemiology of lung cancer. Adv. Exp. Med. Biol. 893 (2016), 21–41.
57. Scungio, M., Buonanno, G., Stabile, L., Ficco, G., Lung cancer risk assessment at receptor site of a waste-to-energy plant. Waste Manag. 56 (2016), 207–215.
58. Scungio, M., Vitanza, T., Stabile, L., Buonanno, G., Morawska, L., Characterization of particle emission from laser printers. Sci. Total Environ. 586 (2017), 623–630.
59. Scungio, M., Stabile, L., Buonanno, G., Measurements of electronic cigarette-generated particles for the evaluation of lung cancer risk of active and passive users. J. Aerosol Sci., 115(1), 2018.
60. Sosnowski, T.R., Kramek-Romanowska, K., Predicted deposition of E-cigarette aerosol in the human lungs. J. Aerosol Med. Pulm. Drug Deliv. 29 (2016), 299–309.
61. Stabile, L., Fuoco, F.C., Buonanno, G., Characteristics of particles and black carbon emitted by combustion of incenses, candles and anti-mosquito products. Build. Environ. 56 (2012), 184–191.
62. Stabile, L., Jayaratne, E.R., Buonanno, G., Morawska, L., Charged particles and cluster ions produced during cooking activities. Sci. Total Environ. 497–498 (2014), 516–526.
63. Stabile, L., Frattolillo, A., Dell'Isola, M., Massimo, A., Russi, A., Air permeability of naturally ventilated Italian classrooms. Energy Procedia 78 (2015), 3150–3155.
64. Stabile, L., Dell'Isola, M., Frattolillo, A., Massimo, A., Russi, A., Effect of natural ventilation and manual airing on indoor air quality in naturally ventilated Italian classrooms. Build. Environ. 98 (2016), 180–189.
65. Stabile, L., Buonanno, G., Ficco, G., Scungio, M., Smokers’ lung cancer risk related to the cigarette-generated mainstream particles. J. Aerosol Sci. 107 (2017), 41–54.
66. Stabile, L., Dell'Isola, M., Russi, A., Massimo, A., Buonanno, G., The effect of natural ventilation strategy on indoor air quality in schools. Sci. Total Environ. 595 (2017), 894–902.
67. Stabile, L., Scungio, M., Buonanno, G., Arpino, F., Ficco, G., Airborne particle emission of a commercial 3D printer: the effect of filament material and printing temperature. Indoor Air 27 (2017), 398–408.
68. Sze-To, G.N., Wu, C.L., Chao, C.Y.H., Wan, M.P., Chan, T.C., Exposure and cancer risk toward cooking-generated ultrafine and coarse particles in Hong Kong homes. HVAC&R Res. 18 (2012), 204–216.
69. Talih, S., Balhas, Z., Eissenberg, T., Salman, R., Karaoghlanian, N., El Hellani, A., Baalbaki, R., Saliba, N., Shihadeh, A., Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: measurements and model predictions. Nicotine Tob. Res. 17 (2015), 150–157.
70. U.S. Environmental Protection Agency, Development O.o.R.a., (eds.) Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part B, Development of Risk-based Preliminary Remediation Goals), 1991, United States Environmental Protection Agency, Washington, DC.
71. Yeh, H.-C., Schum, G.M., Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42 (1980), 461–480.
72. Zhao, J., Pyrgiotakis, G., Demokritou, P., Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions. Inhal. Toxicol. 28 (2016), 658–669.