Development and characterization of electronic-cigarette exposure generation system (Ecig-EGS) for the physico-chemical and toxicological assessment of electronic cigarette emissions

Inhalation Toxicology

Volumn 28, Issue 14, 2016, Pages 658-669

  Zhao, Jiayuan ^a   Pyrgiotakis, Georgios ^a   Demokritou, Philip ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Electronic cigarette; exposure assessment; exposure platform; particulate matter; smoking; vaping

Indexed keywords

CARBON DIOXIDE; VOLATILE ORGANIC COMPOUND;

AIR; ARTICLE; CLINICAL ASSESSMENT; ECOTOXICOLOGY; ELECTRONIC CIGARETTE; ELECTRONIC CIGARETTE GENERATOR; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MIXING CHAMBER; ENVIRONMENTAL MONITORING; ENVIRONMENTAL PARAMETERS; EXHAUST GAS; GENERATOR; HEALTH HAZARD; IN VITRO STUDY; IN VIVO STUDY; PARTICLE SIZE; PARTICULATE MATTER; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; AIR POLLUTANT; ANALYSIS; DEVICES; EQUIPMENT DESIGN; EXPOSURE; HUMAN; PROCEDURES; REPRODUCIBILITY; TOXICITY; TOXICITY TESTING;

AIR POLLUTANTS; ELECTRONIC NICOTINE DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; INHALATION EXPOSURE; PARTICULATE MATTER; REPRODUCIBILITY OF RESULTS; TOXICITY TESTS;

EID: 84994806220     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958378.2016.1246628     Document Type: Article

References (84)

1. Allen JG, Flanigan SS, Leblanc M, et al. (2016). Flavoring chemicals in E-cigarettes:diacetyl, 2,3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored E-cigarettes. Env Heal Perspect 124:733–9
2. American Society of Heating, Refrigerating and Air-Conditioning Engineers. (2003). ANSI/ASHRAE Standard 62-2001. Ventilation for Acceptable Indoor Air Quality
3. Behar RZ, Davis B, Wang Y, et al. (2014). Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol Vitr 28:198–208
4. Berg CJ, Haardoerfer R, Escoffery C, et al. (2015). Cigarette users' interest in using or switching to electronic nicotine delivery systems for smokeless tobacco for harm reduction, cessation, or novelty:a cross-sectional survey of US adults. Nicotine Tob Res 17:245–55
5. Brobell D, Tröller S, Dziurowitz N, et al. (2013). A thermal precipitator for the deposition of airborne nanoparticles onto living cells - rationale and development. J Aerosol Sci 63:75–86
6. Cameron JM, Howell DN, White JR, et al. (2014). Variable and potentially fatal amounts of nicotine in e-cigarette nicotine solutions. Tob Control 23:77–8
7. Cervellati F, Muresan XM, Sticozzi C, et al. (2014). Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol Vitr 28:999–1005
8. Chang C, Demokritou P, Shafer M, Christiani D., (2013). Physicochemical and toxicological characteristics of welding fume derived particles generated from real time welding processes. Environ Sci Process Impacts 15:214–24
9. Cheah NP, Chong NWL, Tan J, et al. (2014). Electronic nicotine delivery systems:regulatory and safety challenges:Singapore perspective. Tob Control 23:119–25
10. Cohen J, Deloid G, Pyrgiotakis G, Demokritou P., (2013). Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry. Nanotoxicology 7:417–31
11. Cohen JM, DeLoid M, Demokritou P., (2015). A critical review of in vitro dosimetry for engineered nanomaterials. Nanomedicine 10:3015–32
12. Cohen JM, Teeguarden JG, Demokritou P., (2014). An integrated approach for the in vitro dosimetry of engineered nanomaterials. Part Fibre Toxicol 11:20
13. Coleman BN, Johnson SE, Tessman GK, et al. (2016). "It’s not smoke. It's not tar. It's not 4000 chemicals. Case closed":exploring attitudes, beliefs, and perceived social norms of e-cigarette use among adult users. Drug Alcohol Depend 159:80–5
14. Dawkins L, Turner J, Roberts A, Soar K., (2013). ‘Vaping' profiles and preferences:an online survey of electronic cigarette users. Addiction 108:1115–25
15. DeLoid G, Cohen JM, Darrah T, et al. (2014). Estimating the effective density of engineered nanomaterials for in vitro dosimetry. Nat Commun 5:3514
16. DeLoid GM, Cohen JM, Pyrgiotakis G, et al. (2015). Advanced computational modeling for in vitro nanomaterial dosimetry. Part Fibre Toxicol 12:32
17. Demokritou P, Gupta T, Koutrakis P., (2002). A high volume apparatus for the condensational growth of ultrafine particles for inhalation toxicological studies. Aerosol Sci Technol 36:1061–72
18. Demokritou P, Lee SJ, Ferguson ST, Koutrakis P., (2004). A compact multistage (cascade) impactor for the characterization of atmospheric aerosols. J Aerosol Sci 35:281–99
19. Dockrell M, Morrison R, Bauld L, McNeill A., (2013). E-cigarettes:prevalence and attitudes in Great Britain. Nicotine Tob Res 15:1737–44
20. Etter JF, Zäther E, Svensson S., (2013). Analysis of refill liquids for electronic cigarettes. Addiction 108:1671–9
21. Evans P. (2015). E-Cigarette Makers Face Rise of Fakes. E-cigarette global sales hit $7 billion at the end of 2014. The Wall Street Journal. Feb. 20 2015
22. Farsalinos KE, Romagna G, Tsiapras D, et al. (2013). Evaluation of electronic cigarette use (Vaping) topography and estimation of liquid consumption:implications for research protocol standards definition and for public health authorities' regulation. Int J Environ Res Public Health 10:2500–14
23. Farsalinos K, Romagna G, Tsiapras D, et al. (2014). Characteristics, perceived side effects and benefits of electronic cigarette use:a worldwide survey of more than 19,000 consumers. Int J Environ Res Public Health 11:4356–73
24. Feng Y, Kleinstreuer C, Rostami A., (2015). Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit. J Aerosol Sci 80:58–74
25. Fuoco F, Buonanno G, Stabile L, Vigo P., (2014). Influential parameters on particle concentration and size distribution in the mainstream of e-cigarettes. Environ Pollut 184:523–9
26. Ganong WF., (2010). Review of medical physiology. 23rd ed. New York:The McGraw- Hill Companies, Inc
27. Geiss O, Bianchi I, Barahona F, Barrero-Moreno J., (2014). Characterisation of mainstream and passive vapours emitted by selected electronic cigarettes. Int J Hyg Environ Health 218:169–80
28. Giovenco DP, Lewis MJ, Delnevo CD., (2014). Factors associated with e-cigarette use:a national population survey of current and former smokers. Am J Prev Med 47:476–80
29. Goniewicz ML, Knysak J, Gawron M, et al. (2014). Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 23:133–9
30. Goniewicz ML, Kuma T, Gawron M, et al. (2012). Nicotine levels in electronic cigarettes. Nicotine Tob Res 15:158–66
31. Gowadia N, Oldham MJ, Dunn-Rankin D., (2009). Particle size distribution of nicotine in mainstream smoke from 2R4F, Marlboro Medium, and Quest1 cigarettes under different puffing regimens. Inhal Toxicol 21:435–46
32. Gupta T, Demokritou P, Koutrakis P., (2004a). Development and performance evaluation of a high-volume ultrafine particle concentrator for inhalation toxicological studies. Inhal Toxicol 16:851–62
33. Gupta T, Demokritou P, Koutrakis P., (2004b). Effects of physicochemical properties of ultrafine particles on the performance of an ultrafine particle concentrator. Aerosol Sci Technol 38:37–45
34. Hecht SS, Carmella SG, Kotandeniya D, et al. (2015). Evaluation of toxicant and carcinogen metabolites in the urine of E-cigarette users versus cigarette smokers. Nicotine Tob Res. 6:704–9
35. Herrington JS, Myers C., (2015). Electronic cigarette solutions and resultant aerosol profiles. J Chromatogr A 1418:192–9
36. Hinds W., (1999). Aerosol technology–properties, behavior, and measurement of airborne particles. 2nd ed. New York:John Wiley
37. Ingebrethsen BJ, Cole SK, Alderman SL., (2012). Electronic cigarette aerosol particle size distribution measurements. Inhal Toxicol 24:976–84
38. Invernizzi G, Ruprecht A, De Marco C, et al. (2007). Residual tobacco smoke:measurement of its washout time in the lung and of its contribution to environmental tobacco smoke. Tob Control 16:29–33
39. ISO. (2012). ISO 3308:routine analytical cigarette-smoking machine–definitions and standard conditions. Geneva, Switzerland:International Organization for Standardization (ISO)
40. Jensen P, Luo W, Pankow J, et al. (2015). Hidden formaldehyde in e-cigarette aerosols. N Engl J Med 372:389–92
41. Kanji GK., (2006). 100 Statistical tests. 3rd ed. London:Sage Publications
42. Kim AE, Arnold KY, Makarenko O., (2014). E-cigarette advertising expenditures in the U.S., 2011-2012. Am J Prev Med 46:409–12
43. Kim K-H, Kabir E, Kabir S., (2015). A review on the human health impact of airborne particulate matter. Environ Int 74:136–43
44. King B, Patel R, Nguyen K, Dube SR., (2015). Trends in awareness and use of electronic cigarettes among US adults, 2010–2013. Nicotine Tob Res 17:219–27
45. Kosmider L, Sobczak A, Fik M, et al. (2014). Carbonyl compounds in electronic cigarette vapors:effects of nicotine solvent and battery output voltage. Tob Res 16:1319–26
46. Laugesen M., (2008). Safety report on the Ruyan® e-cigarette cartridge and inhaled aerosol. Christchurch, New Zealand:Health New Zealand Ltd. p 1–23
47. Laugesen M, Thornley S, Mcrobbie H, Bullen C., (2008). How safe is an E-cigarette? The results of an independent chemical and microbiological analysis. SRNT Conference Portland Oregon. March 2008, poster. p 1–14
48. Lauterstein DE, Tijerina PB, Corbett K, et al. (2016). Frontal cortex transcriptome analysis of mice exposed to electronic cigarettes during early life stages. Int J Environ Res Public Health 13:1–14
49. Lee YH, Gawron M, Goniewicz ML., (2015). Changes in puffing behavior among smokers who switched from tobacco to electronic cigarettes. Addict Behav 48:1–4
50. Lerner C, Sundar I, Watson R, et al. (2015). Environmental health hazards of e-cigarettes and their components:oxidants and copper in e-cigarette aerosols chad. Env Pollut 198:100–7
51. Lerner CA, Sundar IK, Yao H, et al. (2015). Vapors produced by electronic cigarettes and E-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10:1–26
52. Lim HB, Kim SH., (2014). Inhalation of e-cigarette cartridge solution aggravates allergen-induced airway inflammation and hyper-responsiveness in mice. Toxicol Res 30:13–18
53. Londahl J, Pagels J, Swietlicki E, et al. (2006). A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans. J Aerosol Sci 37:1152–63
54. Lu X, Miousse IR, Pirela SV, et al. (2016). In vivo epigenetic effects induced by engineered nanomaterials:a case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology 10:629–39
55. Marco E, Grimalt JO., (2015). A rapid method for the chromatographic analysis of volatile organic compounds in exhaled breath of tobacco cigarette and electronic cigarette smokers. J Chromatogr A 1410:51–9
56. Marini S, Buonanno G, Stabile L, Ficco G., (2014). Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide. Toxicol Appl Pharmacol 278:9–15
57. McAuley TR, Hopke PK, Zhao J, Babaian S., (2012). Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol 24:850–7
58. Pal AK, Bello D, Cohen J, Demokritou P., (2015). Implications of in-vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials. Nanotoxicology 9:871–85
59. Pal AK, Watson CY, Pirela SV, et al. (2015). Linking exposures of particles released from nano-enabled products to toxicology:an integrated methodology for particle sampling, extraction, dispersion, and dosing. Toxicol Sci 146:321–33
60. Pellegrino RM, Tinghino B, Mangiaracina G, et al. (2012). Electronic cigarettes:an evaluation of exposure to chemicals and fine particulate matter (PM). Ann Ig 24:279–88
61. Pirela S, Molina R, Watson C, et al. (2013). Effects of copy center particles on the lungs:a toxicological characterization using a Balb/c mouse model. Inhal Toxicol 25:498–508
62. Pirela SV, Lu X, Miousse I, et al. (2016). Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model:a case study of toxicological implications from nanomaterials released during consumer use. NanoImpact 1:1–8
63. Pirela SV, Pyrgiotakis G, Bello D, et al. (2014). Development and characterization of an exposure platform suitable for physico-chemical, morphological and toxicological characterization of printer-emitted particles (PEPs). Inhal Toxicol 26:400–8
64. Pisinger C, Døssing M., (2014). A systematic review of health effects of electronic cigarettes. Prev Med (Baltim) 69:248–60
65. Repace J., (2005). Controlling tobacco smoke pollution. ASHRAE IAQ Applications. Vol, 6, No. 3, Summer 2005
66. Robinson RJ, Oldham MJ, Clinkenbeard RE, Rai P., (2006). Experimental and numerical smoke carcinogen deposition in a multi-generation human replica tracheobronchial model. Ann Biomed Eng 34:373–83
67. Rowell TR, Tarran R., (2015). Will chronic e-cigarette use cause lung disease? Am J Physiol Lung Cell Mol Physiol 309:L1398–409
68. Rubenstein DA, Hom S, Ghebrehiwet B, Yin W., (2015). Tobacco and e-cigarette products initiate Kupffer cell inflammatory responses. Mol Immunol 67:652–60
69. Salturk Z, Çakir Ç, Sünnetçi G, et al. (2015). Effects of electronic nicotine delivery system on larynx:experimental study. J Voice 29:560–3
70. Schober W, Szendrei K, Matzen W, et al. (2014). Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J Hyg Environ Health 217:628–37
71. Schripp T, Markewitz D, Uhde E, Salthammer T., (2013). Does e-cigarette consumption cause passive vaping? Indoor Air 23:25–31
72. Sisler JD, Pirela SV, Friend S, et al. (2015). Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model. Nanotoxicology 9:769–79
73. Strak M, Janssen NAH, Godri KJ, et al. (2012). Respiratory health effects of airborne particulate matter:The role of particle size, composition, and oxidative potential-the RAPTES project. Environ Health Perspect 120:1183–9
74. Tayyarah R, Long GA., (2014). Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air. Regul Toxicol Pharmacol 70:704–10
75. Trehy ML, Ye W, Hadwiger ME, et al. (2011). Analysis of electronic cigarette cartridges, refill solutions, and smoke for nicotine and nicotine related impurities. J Liq Chromatogr Relat Technol 34:1442–58
76. Wang M, SaiYin H, LokTung L, Lam T., (2015). Addictive behaviors electronic cigarette use and its association with smoking in Hong Kong Chinese adolescents. Addict Behav 50:124–7
77. Watson C, Ge J, Cohen J, et al. (2014). High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using cometchip technology. ACS Nano 8:2118–33
78. Westenberger BJ., (2009). Evaluation of e-cigarettes. Washington, DC:U.S. Food and Drug Administration
79. White J, Li J, Newcombe R, Walton D., (2015). Tripling use of electronic cigarettes among New Zealand adolescents between 2012 and 2014. J Adolesc Health 56:522–8
80. Williams M, Villarreal A, Bozhilov K, et al. (2013). Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One 8:e57987
81. World Health Organization. (2014). Electronic nicotine delivery systems. Conference of the Parties to the WHO Framework Convention on Tobacco Control, Sixth session Moscow, Russian Federation
82. Yingst JM, Veldheer S, Hrabovsky S, et al. (2015). Factors associated with electronic cigarette users' device preferences and transition from first generation to advanced generation devices. Nicotine Tob Res 17:1242–6
83. Zhang Y, Sumner W, Chen D-R., (2013). In vitro particle size distributions in electronic and conventional cigarette aerosols suggest comparable deposition patterns. Nicotine Tob Res 15:501–8
84. Zhu S-H, Sun JY, Bonnevie E, et al. (2014). Four hundred and sixty brands of e-cigarettes and counting:implications for product regulation. Tob Control 23:iii3–9