Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract

Inhalation Toxicology

Volumn 26, Issue 14, 2014, Pages 829-842

  Asgharian, B ^a   Price, O T ^a   Oldham, M ^b   Chen, Lung Chi ^c   Saunders, E L ^c   Gordon, T ^c   Mikheev, V B ^d   Minard, K R ^e   Teeguarden, J G ^e  

^a APPLIED RESEARCH ASSOCIATES   (United States)

^b Virginia Commonwealth University   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BATTELLE MEMORIAL INSTITUTE   (United States)

^e PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Lung deposition, nanosized particles, particle retention, rats and mice

Indexed keywords

FULLERENE DERIVATIVE; IRON OXIDE NANOPARTICLE; METAL NANOPARTICLE; SILVER NANOPARTICLE; UNCLASSIFIED DRUG; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B6C3F1 MOUSE; BAGG ALBINO MOUSE; CLEARANCE; CONTROLLED STUDY; EXPOSURE; FEMALE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; INHALATION; LUNG DEPOSIT; LUNG MINUTE VOLUME; LUNG PARENCHYMA; MATHEMATICAL MODEL; MOUSE; NANOTOXICOLOGY; NONHUMAN; PARTICLE SIZE; RAT; RESPIRATORY SYSTEM; RISK ASSESSMENT; SPECIES COMPARISON; UPPER RESPIRATORY TRACT; ANIMAL; ANIMAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; INBRED MOUSE STRAIN; INHALATIONAL DRUG ADMINISTRATION; LUNG; SPECIES DIFFERENCE; TRACHEA;

MUS; RATTUS;

ADMINISTRATION, INHALATION; ANIMALS; COMPUTER SIMULATION; FEMALE; HUMANS; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; MODELS, ANIMAL; NANOPARTICLES; PARTICLE SIZE; RATS; SPECIES SPECIFICITY; TRACHEA;

EID: 84915781294     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2014.935535     Document Type: Article

References (60)

1. Andersen ME, Krewski D. (2009). Toxicity testing in the 21st century: bringing the vision to life. Toxicol Sci 107:324-30.
2. Anjilvel S, Asgharian B. (1995). A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28:41-50.
3. Asgharian B, Anjilvel S. (1998). A multiple-path model of fiber deposition in the rat lung. Toxicol Sci 44:80-6.
4. Asgharian B, Hofman W, Bergmann R. (2001a). Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol 34: 332-9.
5. Asgharian B, Hofmann W, Miller FJ. (2001b). Mucociliary clearance of insoluble particles from the tracheobronchial airways of the human lung. J Aerosol Sci 32:817-32.
6. Asgharian B, Kelly JT, Tewksbury EW. (2003). Respiratory deposition and inhalability of monodisperse aerosols in Long-Evans rats. Toxicol Sci 71:104-11.
7. Asgharian B, Price OT, McClellan G, et al. (2012). Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. Inhal Toxicol 24:869-99.
8. Asgharian B, Price O, Oberdorster G. (2006a). A modeling study of the effect of gravity on airflow distribution and particle deposition in the lung. Inhal Toxicol 18:473-81.
9. Asgharian B, Price OT. (2007). Deposition of ultrafine (nano) particles in the human lung. Inhal Toxicol 19:1045-54.
10. Asgharian B, Price OT, Hofmann W. (2006b). Prediction of particle deposition in the human lung using realistic models of lung ventilation. J Aerosol Sci 37:1209-21.
11. Asgharian B, Yu CP. (1989). Deposition of fibers in the rat lung. J Aerosol Sci 20:355-66.
12. Beckett WS, Chalupa DF, Pauly-Brown A, et al. (2005). Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Am J Respir Crit Care Med 171:1129-35.
13. Benson JM, Carpenter RL, Hahn FF, et al. (1987). Comparative inhalation toxicity of nickel subsulfide to F344/N rats and B6C3F1 mice exposed for 12 days. Fundam Appl Toxicol 9:251-65.
14. Benson JM, Chang I-Y, Cheng YS, et al. (1995). Species differences in the fate of nickel compounds in the respiratory tract. Final report to NiPERA. Submitted by Inhalatin Toxicology Research Institute (ITRI), Lovelace Biomedical and Environmental Research Institute. Albuquerque, NM.
15. Brown JS, Wilson WE, Grant LD. (2005). Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal Toxicol 17: 355-85.
16. Cheng YS, Hansen GK, Su YF, et al. (1990). Deposition of ultrafine aerosols in rat nasal molds. Toxicol Appl Pharmacol 106:222-33.
17. Delorme MP, Moss OR. (2002). Pulmonary function assessment by whole-body plethysmography in restrained versus unrestrained mice. J Pharmacol Toxicol Methods 47:1-10.
18. Dill JA, Lee KM, Mellinger KH, et al. (2004). Lung deposition and clearance of inhaled vanadium pentoxide in chronically exposed F344 rats and B6C3F1 mice. Toxicol Sci 77:6-18.
19. Dunnick JK, Elwell MR, Benson JM, et al. (1989). Lung toxicity after 13-week inhalation exposure to nickel oxide, nickel subsulfide, or nickel sulfate hexahydrate in F344/N rats and B6C3F1 mice. Fundam Appl Toxicol 12:584-94.
20. Flandre TD, Leroy PL, Desmecht DJ. (2003). Effect of somatic growth, strain, and sex on double-chamber plethysmographic respiratory function values in healthy mice. J Appl Physiol 94:1129-36.
21. Garcia GJ, Tewksbury EW, Wong BA, Kimbell JS. (2009). Interindividual variability in nasal filtration as a function of nasal cavity geometry. J Aerosol Med Pulm Drug Deliv 22:139-55.
22. Gillespie PA, Kang GS, Elder A, et al. (2010). Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and longterm studies in mice. Nanotoxicology 4:106-19.
23. Guyton AC. (1947). Measurement of the respiratory volumes of laboratory animals. Am J Physiol 150:70-7.
24. Hinderliter PM, Minard KR, Orr G, et al. (2010). ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies. Part Fibre Toxicol 7:36.
25. Hsieh TH, Yu CP, Oberdorster G. (1999). Deposition and clearance models of Ni compounds in the mouse lung and comparisons with the rat models. Aerosol Sci Technol 31:358-72.
26. ICRP. (1994). Human respiratory tract model for radiological protection: a report of a task group of the International Commission on Radiological Protection. Oxford, UK: Elsevier Sciences, Ltd.
27. Jarabek AM, Asgharian B, Miller FJ. (2005). Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP). Inhal Toxicol 17:317-34.
28. Kimbell JS, Godo MN, Gross EA, et al. (1997). Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol Appl Pharmacol 145:388-98.
29. Kimbell JS, Subramaniam RP. (2001). Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhal Toxicol 13:325-34.
30. Kimbell JS, Subramaniam RP, Gross EA, et al. (2001). Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol Sci 64:100-10.
31. Koblinger L, Hoffmann W. (1993). Aerosol deposition calculations for a stochastic lung model. Aerosol in Medicine Congress; 1993 March 30-April 3; Garmisch-Partenkirchen, Germany.
32. Koblinger L, Hofmann W. (1995). Aerosol inhalation in the rat lung. 2. Theoretical predictions of particle deposition patterns. J Aerosol Med-Deposit Clear Effects Lung 8:21-32.
33. Korsak Z, Majcherek W, Rydzynski K. (1998). Toxic effects of acute inhalation exposure to 1-methylnaphthalene and 2-methylnaphthalene in experimental animals. Int J Occup Med Environ Health 11:335-42.
34. Kuehl PJ, Anderson TL, Candelaria G, et al. (2012). Regional particle size dependent deposition of inhaled aerosols in rats and mice. Inhal Toxicol 24:27-35.
35. Madl P, Hofmann W, Oldham MJ, Asgharian B. (2010). Stochastic morphometric model of the BALB/c mouse lung. Anat Rec (Hoboken) 293:1766-75.
36. Mall MA. (2008). Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulmonary Drug Deliv 21:13-24.
37. Menache MG, Miller FJ, Raabe OG. (1995). Particle inhalability curves for humans and small laboratory-animals. Ann Occupat Hyg 39: 317-28.
38. Mendez LB, Gookin G, Phalen RF. (2010). Inhaled aerosol particle dosimetry in mice: a review. Inhal Toxicol 22:15-20.
39. Minard KR, Littke MH, Wang W, et al. (2013). Magnetic particle detection (MPD) for in-vitro dosimetry. Biosens Bioelectron 43: 88-93.
40. National Council on Radiological Protection and Measurements (NCRP) (1997). Deposition, retention and dosimetry of inhaled radioactive substances. NCRP Report 125. Bethesda, MD.
41. National Toxicology Program. (2009a). Toxicity Evaluation of Nanomaterial (Fullerene-C60 50 nm) in B6C3F1 Mice. Chemical Effects in Biological Systems Database, National Toxicology Program, National Institutes of Environmental Health Sciences.
42. National Toxicology Program. (2009b). Toxicity Evaluation of Nanomaterial (Fullerene-C60 50 nm) in B6C3F1 Mice. Chemical Effects in Biological Systems Database. Research Triangle Park, NC: U.S. Department of Health and Human services, Public Health Service, National Institute of Health.
43. Oberdorster G, Finkelstein J. (1995). Subchronic inhalation studies with insoluble nickel compounds: a species comparison. Rochester, NY: Final report to NiPERA. Submitted by Department of Environmental Medicine.
44. Oberdorster G, Oberdorster E, Oberdorster J. (2005). Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-39.
45. Oldham MJ, Phalen RF, Budiman T. (2009). Comparison of predicted and experimentally measured aerosol deposition efficiency in BALB/ C mice in a new nose-only exposure system. Aerosol Sci Technol 43: 970-7.
46. Oldham MJ, Phalen RF, Schum GM, Daniels DS. (1994). Predicted nasal and tracheobronchial particle deposition efficiencies for the mouse. Inhal Partic Vii:135-41.
47. Oldham MJ, Robinson RJ. (2007). Predicted tracheobronchial and pulmonary deposition in a murine asthma model. Anatom Record-Adv Integr Anatomy Evol Biol 290:1309-14.
48. Phalen RF. (1991). An airway model for the laboratory mouse. Final report submitted to NiPERA. Irvine, CA: University of California, Irvine.
49. Price OT, Asgharian B, Miller FJ, et al. (2002). Multiple path particle dosimetry model (MPPD v1.0): a model for human and rat airway particle dosimetry. Bilthoven, the Netherlands: National Institute for Public Health and the Environment (RIVM).
50. Raabe OG, Yeh H-C, Newton GJ, et al. (1977). Deposition of inhaled monodisperse aerosols in small rodents. In: Walton WH, Mcgovern B (eds.) Inhaled particles IV, Part I: proceedings of an International Symposium. Edinburgh, Scotland: Pergamon Press, Ltd., 3-21.
51. Raabe OGM, Al-Bayati A, Teague SV, Rasolt A. (1988). Regional deposition of inhaled monodisperse aerosols in small rodents. Ann Occup Hyg 32:53-63.
52. Reinhard C, Eder G, Fuchs H, et al. (2002). Inbred strain variation in lung function. Mammalian Genome 13:429-37.
53. Robinson RJ, Snyder P, Oldham MJ. (2008). Comparison of analytical and numerical particle deposition using commercial CFD packages: impaction and sedimentation. Inhal Toxicol 20:485-97.
54. Schroeter JD, Kimbell JS, Andersen ME, Dorman DC. (2006). Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol Sci 94:359-67.
55. Tankersley CG, Fitzgerald RS, Kleeberger SR. (1994). Differential control of ventilation among inbred strains of mice. Am J Physiol-Regulat Integra Compar Physiol 267:R1371-7.
56. Teeguarden J, Mikeev VB, Minard KR, et al. (submitted). Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes. Particle Fiber Toxicol.
57. Teeguarden JG, Hinderliter PM, Orr G, et al. (2007). Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300-12.
58. Yeh HC, Schum GM, Duggan MT. (1979). Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat Rec 195: 483-92.
59. Yu CP. (1978). Exact analysis of aerosol deposition during steady breathing. Powder Technol 21:55-62.
60. Zhang L, Yu CP. (1993). Empirical equations for nasal deposition of inhaled particles in small laboratory-animals and humans. Aerosol Sci Technol 19:51-6.