Gestational age assessment by methylation and size profiling of maternal plasma DNA: A feasibility study: To the editor

Clinical Chemistry

Volumn 63, Issue 2, 2017, Pages 606-608

  Jiang, Peiyong ^a,b   Tong, Yu K ^b   Sun, Kun ^a,b   Cheng, Suk H ^a,b   Leung, Tak Y ^b   Chan, K C Allen ^a,b   Chiu, Rossa W K ^a,b   Lo, Yuk Ming Dennis ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DNA FRAGMENT;

BLOOD SAMPLING; CHORION VILLUS SAMPLING; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; FEASIBILITY STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; GENE EXPRESSION PROFILING; GESTATIONAL AGE; HETEROZYGOSITY; HUMAN; LETTER; MATERNAL PLASMA; PREGNANT WOMAN; SECOND TRIMESTER PREGNANCY; SINGLE NUCLEOTIDE POLYMORPHISM; THIRD TRIMESTER PREGNANCY; BLOOD; METABOLISM; PARTICLE SIZE;

DNA; DNA METHYLATION; FEASIBILITY STUDIES; GESTATIONAL AGE; HUMANS; PARTICLE SIZE;

EID: 85011629690     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2016.265702     Document Type: Letter

References (5)

1. Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS. Presence of fetal DNA in maternal plasma and serum. Lancet 1997;350: 485-7.
2. Chiu RWK, Chan KCA, Gao Y, Lau VY, Zheng W, Leung TY, et al. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing ofDNAin maternal plasma. Proc Natl Acad Sci U S A 2008;105:20458-63.
3. Lo YMD, Chan KCA, Sun H, Chen EZ, Jiang P, Lun FMF, et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2010;2:61ra91.
4. Lun FMF, Chiu RWK, Sun K, Leung TY, Jiang P, Chan KCA, et al. Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA. Clin Chem 2013;59:1583-94.
5. Jiang P, Sun K, Lun FMF, Guo AM, Wang H, Chan KCA, et al. Methy-pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. PLoS One 2014;9:e100360.