Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide

Journal of the American Chemical Society

Volumn 140, Issue 22, 2018, Pages 6991-6997

  Gao, Shu Shan ^a   Zhang, Tao ^c   Garcia Borràs, Marc ^b   Hung, Yiu Sun ^a   Billingsley, John M ^a   Houk, K N ^b   Hu, Youcai ^c   Tang, Yi ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ENZYMES; KETONES; REACTION INTERMEDIATES; REDOX REACTIONS;

BUILDING BLOCKES; C-C BOND FORMATION; MONOOXYGENASES; OXIDATIVE CLEAVAGES; OXIDATIVE COUPLINGS; REACTION SEQUENCES; REDOX TRANSFORMATIONS; STRUCTURAL COMPLEXITY;

BIOCHEMISTRY;

ACID ANHYDRIDE; AROMATIC COMPOUND; COUMARIN; CYTOCHROME P450; DIHYDROCOUMARIN; DIOXYGENASE; DUCLAUXIN; MONOMER; OXAPHENALENONE; PHENALENONE; POLYKETIDE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; CHROMONE DERIVATIVE; PHENALEN-1-ONE; PHENALENE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CATALYST; CHEMICAL BOND; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; GENE CLUSTER; GENE IDENTIFICATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE COUPLING; TALAROMYCES; TALAROMYCES STIPITATUS; CHEMISTRY; METABOLISM;

CHROMONES; DIOXYGENASES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PHENALENES; POLYKETIDES; TALAROMYCES;

EID: 85046969254     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.8b03705     Document Type: Article

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