Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121: Insights from biochemical studies and crystal structures

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17347-17359

  Fonvielle, Matthieu ^a,d   Le Du, Marie Hélène ^b   Lequin, Olivier ^c   Lecoq, Alain ^a   Jacquet, Mickaël ^a   Thai, Robert ^a   Dubois, Steven ^a   Grach, Guillaume ^a   Gondry, Muriel ^a   Belin, Pascal ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b CEA   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SPECIFICITIES; BIOCHEMICAL STUDIES; CATALYTIC MECHANISMS; CONFORMATIONAL FREEDOM; DIKETOPIPERAZINES; ESSENTIAL PROTEINS; MOLECULAR DETERMINANTS; MYCOBACTERIUM TUBERCULOSIS;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TITRATION; TUBES (COMPONENTS);

SUBSTRATES;

ASPARAGINE; CYCLOPEPTIDE; CYTOCHROME P450; CYTOCHROME P450 121; PHENYLALANINE; PIPERAZINEDIONE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYMATIC ASSAY; ENZYME SPECIFICITY; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY; CYTOCHROME P450; ENZYME SPECIFICITY; ENZYME STRUCTURE; NUCLEAR MAGNETIC RESONANCE; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DIPEPTIDES; ENZYME INHIBITORS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN BINDING; SOLUTIONS; SUBSTRATE SPECIFICITY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84879061483     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.443853     Document Type: Article

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