hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation

Cancer Biology and Therapy

Volumn 8, Issue 7, 2009, Pages

  Gao, Fangming ^a   Ponte, Jose F ^a,b   Levy, Mary ^a   Papageorgis, Panagiotis ^a   Cook, Nathaniel M ^a   Ozturk, Sait ^a   Lambert, Arthur W ^a   Thiagalingam, Arunthathi ^a,c   Abdolmaleky, Hamid M ^a   Sullivan, Beth A ^a,d   Thiagalingam, Sam ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TolerRx Inc   (United States)

^c Biomeasure Inc   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aneuploidy; Cancer; Cancer therapy; Early apoptosis; Genomic instability; hBub1; hMad2; p53; Phosphorylation; Spindle assembly checkpoint

Indexed keywords

BUB1 RELATED PROTEIN; LENTIVIRUS VECTOR; LUCIFERASE; NOCODAZOLE; PROTEIN BAX; PROTEIN P53; PUMA PROTEIN; SHORT HAIRPIN RNA; BUB1 SPINDLE CHECKPOINT PROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN;

ANEUPLOIDY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL STRAIN HCT116; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ASSAY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MITOSIS; MITOSIS SPINDLE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; HCT116 CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85046913922     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.7.7929     Document Type: Article

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