Antidiabetic effect of cyclocarya paliurus leaves depends on the contents of antihyperglycemic flavonoids and antihyperlipidemic triterpenoids

Molecules

Volumn 23, Issue 5, 2018, Pages

  Liu, Yang ^a   Cao, Yanni ^a   Fang, Shengzuo ^a   Wang, Tongli ^b   Yin, Zhiqi ^c   Shang, Xulan ^a   Yang, Wanxia ^a   Fu, Xiangxiang ^a  

^a NANJING FORESTRY UNIVERSITY   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cyclocarya paliurus; Diabetes; Extraction solvents; Flavonoids; Geographical locations; Triterpenoids

Indexed keywords

ANTILIPEMIC AGENT; FLAVONOID; GLUCURONIDE; KAEMPFEROL DERIVATIVE; KAEMPFEROL-3-O-GLUCURONIDE; PLANT EXTRACT; QUERCETIN; QUERCETIN 3-O-GLUCURONIDE; STREPTOZOCIN; TRITERPENE;

ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; JUGLANDACEAE; LIPID METABOLISM; METABOLISM; MOUSE; PLANT LEAF;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FLAVONOIDS; GLUCURONIDES; HYPOLIPIDEMIC AGENTS; JUGLANDACEAE; KAEMPFEROLS; LIPID METABOLISM; MICE; MOLECULAR STRUCTURE; PLANT EXTRACTS; PLANT LEAVES; QUERCETIN; STREPTOZOCIN; TRITERPENES;

EID: 85046649095     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules23051042     Document Type: Article

References (41)

1. Jia, W.; Gao, W.; Tang, L. Antidiabetic herbal drugs officially approved in China. Phytother. Res. 2003, 17, 1127–1134. [CrossRef] [PubMed]
2. Ahmad Aufa, Z.; Hassan, F.A.; Ismail, A.; Mohd Yusof, B.N.; Hamid, M. Chemical compositions and antioxidative and antidiabetic properties of underutilized vegetable palm hearts from Plectocomiopsis geminiflora and Eugeissona insignis. J. Agric. Food Chem. 2014, 62, 2077–2084. [CrossRef] [PubMed]
3. Jung, M.; Park, M.; Lee, H.C.; Kang, Y.H.; Kang, E.S.; Kim, S.K. Antidiabetic agents from medicinal plants. Curr. Med. Chem. 2006, 13, 1203–1218. [CrossRef] [PubMed]
4. Dehghan-Kooshkghazi, M.; Mathers, J.C. Starch digestion, large-bowel fermentation and intestinal mucosal cell proliferation in rats treated with the α-glucosidase inhibitor acarbose. Br. J. Nutr. 2004, 91, 357–365. [CrossRef] [PubMed]
5. Umeno, A.; Horie, M.; Murotomi, K.; Nakajima, Y.; Yoshida, Y. Antioxidative and antidiabetic effects of natural polyphenols and isoflavones. Molecules 2016, 21, 708. [CrossRef] [PubMed]
6. Phan, M.A.T.; Wang, J.; Tang, J.; Lee, Y.Z.; Ng, K. Evaluation of α-glucosidase inhibition potential of some flavonoids from Epimedium brevicornum. Food Sci. Technol. 2013, 53, 492–498. [CrossRef]
7. Numonov, S.; Edirs, S.; Bobakulov, K.; Qureshi, M.N.; Bozorov, K.; Sharopov, F.; Aisa, H.A. Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts-Computational and Experimental Investigations. Molecules 2017, 22, 983. [CrossRef] [PubMed]
8. Fang, S.; Wang, J.; Wei, Z.; Zhu, Z. Methods to break seed dormancy in Cyclocarya paliurus (Batal) Iljinskaja. Sci. Hortic. 2006, 110, 305–309. [CrossRef]
9. Liu, Y.; Fang, S.; Yang, W.; Shang, X.; Fu, X. Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus. J. Photoch. Photobio. B. 2018, 179, 66–73. [CrossRef] [PubMed]
10. Xie, J.H.; Dong, C.J.; Nie, S.P.; Li, F.; Wang, Z.J.; Shen, M.Y.; Xie, M.Y. Extraction, chemical composition and antioxidant activity of flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja leaves. Food Chem. 2015, 186, 97–105. [CrossRef] [PubMed]
11. Kurihara, H.; Asami, S.; Shibata, H.; Fukami, H.; Tanaka, T. Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice. Biol. Pharm. Bull. 2003, 26, 383–385. [CrossRef] [PubMed]
12. Xie, J.H.; Shen, M.Y.; Xie, M.Y.; Nie, S.P.; Chen, Y.; Li, C.; Wang, Y.X. Ultrasonic-assisted extraction, antimicrobial and antioxidant activities of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides. Carbohyd. Polym. 2012, 89, 177–184. [CrossRef] [PubMed]
13. Liu, Y.; Qian, C.; Ding, S.; Shang, X.; Yang, W.; Fang, S. Effect of light regime and provenance on leaf characteristics, growth and flavonoid accumulation in Cyclocarya paliurus (Batal) Iljinskaja coppices. Bot. Stud. 2016, 57, 28. [CrossRef] [PubMed]
14. Fang, S.; Yang, W.; Chu, X.; Shang, X.; She, C.; Fu, X. Provenance and temporal variations in selected flavonoids in leaves of Cyclocarya paliurus. Food Chem. 2011, 124, 1382–1386. [CrossRef]
15. Wright, M.; Byrd, J.; Gao, Y.; Stubblefield, J.; Park, H.; Dunlap, N. Isolation and structural clarification of triterpenes from Cyclocarya paliurus: Cyclocaric acid A and B. Planta Med. 2014, 80, PD19. [CrossRef]
16. Kurihara, H.; Fukami, H.; Kusumoto, A.; Toyoda, Y.; Shibata, H.; Matsui, Y.; Tanaka, T. Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice. Biosci. Biotechnol. Biochem. 2013, 67, 877–880. [CrossRef] [PubMed]
17. Li, S.; Li, J.; Guan, X.L.; Li, J.; Deng, S.P.; Li, L.Q.; Yang, R.Y. Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase. Fitoterapia 2011, 82, 1081–1085. [CrossRef] [PubMed]
18. Yang, Z.W.; Ouyang, K.H.; Zhao, J.; Chen, H.; Xiong, L.; Wang, W.J. Structural characterization and hypolipidemic effect of Cyclocarya paliurus polysaccharide in rat. Int. J. Biol. Macromol. 2016, 91, 1073–1080. [CrossRef] [PubMed]
19. Hu, W.B.; Zhao, J.; Chen, H.; Xiong, L.; Wang, W.J. Polysaccharides from Cyclocarya paliurus: Chemical composition and lipid-lowering effect on rats challenged with high-fat diet. J. Funct. Foods 2017, 36, 262–273. [CrossRef]
20. Wang, Q.; Jiang, C.; Fang, S.; Wang, J.; Ji, Y.; Shang, X.; Zhang, J. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. J. Ethnopharmacol. 2013, 150, 1119–1127. [CrossRef] [PubMed]
21. Jiang, C.; Wang, Q.; Wei, Y.; Yao, N.; Wu, Z.; Ma, Y.; Zhang, J. Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice. J. Ethnopharmacol. 2015, 176, 17–26. [CrossRef] [PubMed]
22. Ma, Y.; Jiang, C.; Yao, N.; Li, Y.; Wang, Q.; Fang, S.; Zhang, J. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. J. Ethnopharmacol. 2015, 166, 286–296. [CrossRef] [PubMed]
23. Wu, Z.F.; Meng, F.C.; Cao, L.J.; Jiang, C.H.; Zhao, M.G.; Shang, X.L.; Yin, Z.Q. Triterpenoids from Cyclocarya paliurus and their inhibitory effect on the secretion of apoliprotein B48 in Caco-2 cells. Phytochemistry 2017, 142, 76–84. [CrossRef] [PubMed]
24. Cao, Y.; Fang, S.; Yin, Z.; Fu, X.; Shang, X.; Yang, W.; Yang, H. Chemical Fingerprint and Multicomponent Quantitative Analysis for the Quality Evaluation of Cyclocarya paliurus Leaves by HPLC-Q-TOF-MS. Molecules 2017, 22, 1927. [CrossRef] [PubMed]
25. Yang, L.; Wen, K.S.; Ruan, X.; Zhao, Y.X.; Wei, F.; Wang, Q. Response of Plant Secondary Metabolites to Environmental Factors. Molecules 2018, 23, 762. [CrossRef] [PubMed]
26. Zhang, L.; Hogan, S.; Li, J.; Sun, S.; Canning, C.; Zheng, S.J.; Zhou, K. Grape skin extract inhibits mammalian intestinal α-glucosidase activity and suppresses postprandial glycemic response in streptozocin-treated mice. Food Chem. 2011, 126, 466–471. [CrossRef]
27. Shehata, A.M.; Quintanilla-Fend, L.; Bettio, S.; Singh, C.B.; Ammon, H.P.T. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE). Phytomedicine 2011, 18, 1037–1044. [CrossRef] [PubMed]
28. Zhang, M.; Du, N.; Wang, L.; Wang, X.; Xiao, Y.; Zhang, K.; Wang, P. Conjugated fatty acid-rich oil from Gynostrmma pentaphyllum seed can ameliorate lipid and glucose metabolism in type 2 diabetes mellitus mice. Food Funct. 2017, 8, 3696–3706. [CrossRef] [PubMed]
29. Mensah-Brown, E.P.K.; Al Rabesi, Z.; Shahin, A.; Al Shamsi, M.; Arsenijevic, N.; Hsu, D.K.; Lukic, M.L. Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice. Clin. Immunol. 2009, 130, 83–88. [CrossRef] [PubMed]
30. Fang, X.K.; Gao, J.; Zhu, D.N. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci. 2008, 82, 615–622. [CrossRef] [PubMed]
31. Mukhopadhyay, P.; Prajapati, A.K. Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers-a review. RSC Advances 2015, 5, 97547–97562. [CrossRef]
32. Yao, Y.; Chen, F.; Wang, M.; Wang, J.; Ren, G. Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice. J. Agric. Food Chem. 2008, 56, 8869–8873. [CrossRef] [PubMed]
33. Somova, L.O.; Nadar, A.; Rammanan, P.; Shode, F.O. Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension. Phytomedicine 2003, 10, 115–121. [CrossRef] [PubMed]
34. Ejelonu, O.C.; Elekofehinti, O.O.; Adanlawo, I.G. Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats. Biomed. Phar. 2017, 87, 589–595. [CrossRef] [PubMed]
35. James, D.B.; Elebo, N.; Sanusi, A.M.; Odoemene, L. Some biochemical effect of intraperitoneal administration of Phyllanthus amarus aquoeus extacts on normaglycemic albino rats. Asian J. Med. Sci. 2010, 2, 7–10.
36. Kew, M.C. Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet 2000, 355, 591–592. [CrossRef]
37. Ostfeld, R.; Spinelli, M.; Mookherjee, D.; Holtzman, D.; Shoyeb, A.; Schaefer, M.; Duc, Y. The association of blood urea nitrogen levels and coronary artery disease. Einstein J. Biol. Med. 2016, 25, 3–7. [CrossRef]
38. Cao, J.; Wang, S.; Yao, C.; Xu, Z.; Xu, X. Hypolipidemic effect of porphyran extracted from Pyropia yezoensis in ICR mice with high fatty diet. J. Appl. Phycol. 2016, 28, 1315–1322. [CrossRef]
39. Shi, F.; Li, J.; Yang, L.; Hou, G.; Ye, M. Hypolipidemic effect and protection ability of liver-kidney functions of melanin from Lachnum YM226 in high-fat diet fed mice. Food Funct. 2018, 9, 880–889. [CrossRef] [PubMed]
40. Wu, C.; Wang, X.; Wang, H.; Shen, B.; He, X.; Gu, W.; Wu, Q. Extraction optimization, isolation, preliminary structural characterization and antioxidant activities of the cell wall polysaccharides in the petioles and pedicels of Chinese herbal medicine Qian (Euryale ferox Salisb.). Int. J. Biol. Macromol. 2014, 64, 458–467. [CrossRef] [PubMed]
41. Srinivasan, K.; Viswanad, B.; Asrat, L.; Kaul, C.L.; Ramarao, P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol. Res. 2005, 52, 313–320. [CrossRef] [PubMed]