Tithonia diversifolia saponin-blood lipid interaction and its influence on immune system of normal wistar rats

Biomedicine and Pharmacotherapy

Volumn 87, Issue , 2017, Pages 589-595

  Ejelonu, Oluwamodupe Cecilia ^a,b   Elekofehinti, Olusola Olalekan ^a   Adanlawo, Isaac Gbadura ^b  

^a ADEKUNLE AJASIN UNIVERSITY   (Nigeria)

^b UNIVERSITY OF ADO EKITI   (Nigeria)

Author keywords

Heart; Hematology; Kidney; Lipid profile; Liver; Tithonia diversifolia

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SAPONIN; TRIACYLGLYCEROL; UREA; ANTIOXIDANT; CHOLESTEROL; PLANT EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ASTERACEAE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG INTERACTION; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEART FUNCTION; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; KIDNEY FUNCTION; LIPID BLOOD LEVEL; LIVER FUNCTION; LYMPHOCYTE COUNT; MALE; MEDICINAL PLANT; NONHUMAN; PERENNIAL PLANT; PLANT LEAF; PRIORITY JOURNAL; RAT; SHRUB; TITHONIA DIVERSIFOLIA; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; HEART; IMMUNE SYSTEM; KIDNEY; LIVER; METABOLISM; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ASTERACEAE; CHOLESTEROL; CREATININE; HEART; IMMUNE SYSTEM; KIDNEY; LIPIDS; LIVER; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SAPONINS; TRIGLYCERIDES; UREA;

EID: 85008867867     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.01.017     Document Type: Article

References (29)

1. [1] Nohara, J., Fujiwara, Y., Zhou, J.R., Urata, J., Ikeda, T., Murakami, K., El-Aasr, M., Ono, M., Saponins, esculeosides B-1 and B-2, in tomato juice and sapogenol, esculeogenin B. Chem. Pharm. Bull. 63 (2015), 848–850.
2. [2] Ogundare, A.O., Antimicrobial effect of Tithonia diversifolia and Jatropha gossypifolia leaf extracts. Trends Appl. Sci. Res. 2 (2007), 145–150.
3. [3] Patel, D.K., Kumar, R., Laloo, D., hemalatha, S., Evaluation of phytochemical and antioxidant activities of the different fractions of Hybanthus enneaspermus (Linn.) F. Muell. (Violaceae). Asian Pac. J. Trop. Med. 1 (2011), 391–396.
4. [4] Patel, D.K., Kumar, R., Laloo, D., Hemalatha, S., Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asian Pac. J. Trop. Biomed. 2 (2012), 411–420.
5. [5] John-Dewole, O.O., Oni, S.O., Phytochemical and antimicrobial studies of extracts from the leaves of Tithonia Diversifolia for pharmaceutical importance. J. Pharm. Biol. Sci. 6 (2013), 21–25.
6. [6] Lifongo, L.L., Simoben, C.V., Ntie-Kang, F., A bioactivity versus ethnobotanical survey of medicinal plants from Nigeria, West Africa. Nat. Prod. Bioprospect. 4 (2014), 1–19.
7. [7] Di Giacomo, C., Vanella, L., Sorrenti, V., Santangelo, R., Barbagallo, I., Calabrese, G., Effects of Tithonia diversifolia (Hemsl.) A. gray extract on adipocyte differentiation of human mesenchymal stem cells. PLoS One, 10, 2015, e0122320, 10.1371/journal.pone.0122320.
8. [8] Passoni, F.D., Oliveira, R.B., Chagas-Paula, D.A., Gobbo-Neto, L., Da Costa, F.B., Repeated-dose toxicological studies of Tithonia diversifolia (Hemsl.) A. gray and identification of the toxic compounds. J. Ethnopharmacol. 147 (2013), 389–394, 10.1016/j.jep.2013.03.024.
9. [9] Lee, M., Liao, M., Tsai, Y., Chiu, K., Wen, H., Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract. Agric. Food Chem. 59 (2011), 2347–2355.
10. [10] Vinarova, L., Vinarov, Z., Atanasov, V., Pantcheva, I., cholakova, S., Denkov, N., Stoyanov, S., Lowering of cholesterol bioaccessibility and serum concentrations by saponins: in vitro and in vivo studies. Food Funct. 6 (2015), 501–512.
11. [11] Elekofehinti, O.O., Saponins: antidiabetic principles from medicinal plants-a review. Pathophysiology 22 (2015), 95–103, 10.1016/j.pathophys.2015.02.001.
12. [12] Elekofehinti, O.O., Kamdem, J.P., Kade, I.J., Adanlawo, I.G., Rocha, J.B.T., Saponins from Solanum anguivi lam. fruit exhibits in vitro and in vivo antioxidant activities in alloxan-induced oxidative stress. Asian J. Pharm. Clin. Res. 6 (2013), 249–254.
13. [13] Akanji, M.A., Nlumanze, S.E., Alkaline phosphatase activities following repeated suramin administration in some rat tissue in relation to their functions. Pharmacol. Toxicol. 61 (1987), 182–183.
14. [14] Hostettmann, K., Marston, A., Chemistry and Pharmacology of Natural Products: Saponins. 1995, Cambridge University Press, Cambridge, 233–283.
15. [15] Francis, G., Kerem, Z., Makker, H.P.S., Becker, K., The biological action of saponins in animal systems: a review. Br. J. Nutr. 88 (2002), 587–605.
16. [16] Keller, A.C., Ma, J., Kavalier, A., He, K., Brillantes, A.B., Kennelly, E.J., Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 19 (2011), 32–37, 10.1016/j.phymed.2011.06.019.
17. [17] Song, Y.B., An, Y.R., Kim, S.J., Park, S.J., Jung, H.W., Kyung, W., Hwang, J.S., Kim, S.Y., Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet. J. Sci. Food Agric. 92 (2011), 388–396.
18. [18] Elekofehinti, O.O., Adanlawo, I.G., Fakoya, A., The effect of saponin from Solanum anguivi Lam. fruit on serum lipid and oxidative stress in hepatocyte of diabetic rats. Rev. Bras. Plant. Med. 14 (2012), S15–S16.
19. [19] Gowda, S., Desai, P.B., Kulkami, S.S., Hull, V.V., Math, A.A.K., Vernekar, S.N., Markers of renal function tests. N. Am. J. Med. Sci. 2 (2010), 170–173.
20. [20] Han, C., Hui, Q., Wang, W., Hypoglycaemic activity of saponin fraction extracted from Momordica charantia in PEG/salt aqueous two-phase systems. Nat. Prod. Res. 22 (2008), 1112–1119, 10.1080/14786410802079675.
21. [21] Alli-Smith, Y.R., Adanlawo, I.G., Protective effect of saponin extract from the root of Garcinia kola (Bitter kola) against paracetamol-induced hepatotoxicity in albino rats. Int. J. Biol. Biomol. Agric. Food Bioctechnol. Eng. 9 (2015), 130–134.
22. [22] Abdelhalim, M.A.K., Moussa, S.A.A., The biochemical changes in rats' blood serum levels exposed to different gamma radiation doses. Afr. J. Pharm. Pharmacol. 7 (2013), 785–792.
23. [23] Thamer, C., Tschritter, O., Haap, M., Shirkavand, F., Machann, J., Fritsche, A., Schick, F., Haring, H., Stumvoll, M., Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids. Horm. Metab. Res. 37 (2005), 246–251.
24. [24] Vijaya, B., Jayalakshmi, N.R., Manjunath, K., Enumeration of biosurfactant producing microorganisms from oil contaminated soil in and around Bangalore (India). Int. J. Curr. Sci. 5 (2013), 86–94.
25. [25] Sabir, A., Adnan, M., Naser, A., Wabel, A.l., Karim, S., Ali, M., Pharmacological evaluation of crude saponin fraction from fenugreek seed extract on ethylene glycol induced nephrolithiasis in rats. J. Harmon. Res. Pharm. 4 (2015), 11–20.
26. [26] Oakenfull, D.G., Topping, D.L., Illman, R.J., Fenwick, D.E., Nutr. Rep. Int. 29 (1984), 1039–1046.
27. [27] Sidhu, G.S., Oakenfull, D.G., Br. J. Nutr. 55 (1986), 643–649.
28. [28] Rajput, Z.I., Hu, S.H., Xiao, C.W., Arijo, A.G., Adjuvant effects of saponins on animal immune responses. J. Zhejiang Univ. Sci. B 3 (2007), 153–161.
29. [29] Dhama, K., Saminathan, M., Jacob, S.S., Singh, M., Karthik, K., Amarpal, F., Tiwari, R., Sunkara, L.T., Malik, Y.S., Singh, R.K., Effect of immunomodulation and immunomodulatory agents on health with some bioactive principles, modes of action and potent biomedical applications. Int. J. Pharmacol. 11 (2015), 253–290.