메뉴 건너뛰기




Volumn 31, Issue 3, 2018, Pages 266-272

Role of bile acids in inflammatory bowel disease

Author keywords

Bile acids; Crohn s disease; Farnesoid X receptor; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

BILE ACID; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 19;

EID: 85046437053     PISSN: 11087471     EISSN: 17927463     Source Type: Journal    
DOI: 10.20524/aog.2018.0239     Document Type: Review
Times cited : (68)

References (54)
  • 2
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: Natural ligands for an orphan nuclear receptor
    • Parks DJ, Blanchard SG, Bledsoe RK, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999;284:1365-1368.
    • (1999) Science , vol.284 , pp. 1365-1368
    • Parks, D.J.1    Blanchard, S.G.2    Bledsoe, R.K.3
  • 3
    • 84927738000 scopus 로고    scopus 로고
    • Bile acid malabsorption in inflammatory bowel disease
    • Vítek L. Bile acid malabsorption in inflammatory bowel disease. Inflamm Bowel Dis 2015;21:476-483.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 476-483
    • Vítek, L.1
  • 4
    • 79952533468 scopus 로고    scopus 로고
    • Bacterial degradation of bile salts
    • Philipp B. Bacterial degradation of bile salts. Appl Microbiol Biotechnol 2011;89:903-915.
    • (2011) Appl Microbiol Biotechnol , vol.89 , pp. 903-915
    • Philipp, B.1
  • 5
    • 0026349793 scopus 로고
    • Serum bile acids in relation to disease activity and intake of dietary fibers in juvenile ulcerative colitis
    • Ejderhamn J, Strandvik B. Serum bile acids in relation to disease activity and intake of dietary fibers in juvenile ulcerative colitis. Digestion 1991;50:162-169.
    • (1991) Digestion , vol.50 , pp. 162-169
    • Ejderhamn, J.1    Strandvik, B.2
  • 6
    • 0025177628 scopus 로고
    • Lipids and total bile acids in the blood of patients with inflammatory bowel diseases
    • Kostić N, Bozanić M, Cvetković R, Adamov A. [Lipids and total bile acids in the blood of patients with inflammatory bowel diseases]. Srp Arh Celok Lek 1990;118:43-46.
    • (1990) Srp Arh Celok Lek , vol.118 , pp. 43-46
    • Kostić, N.1    Bozanić, M.2    Cvetković, R.3    Adamov, A.4
  • 7
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B, Jones SA, Price RR, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000;6:517-526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3
  • 8
    • 84903550751 scopus 로고    scopus 로고
    • Semisynthetic bile acid FXR and TGR5 agonists: Physicochemical properties, pharmacokinetics, and metabolism
    • Roda A, Pellicciari R, Gioiello A, et al. Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism. J Pharmacol Exper Ther 2014;350:56-68.
    • (2014) J Pharmacol Exper Ther , vol.350 , pp. 56-68
    • Roda, A.1    Pellicciari, R.2    Gioiello, A.3
  • 9
    • 85019620517 scopus 로고    scopus 로고
    • Metabolic profile of obeticholic acid and endogenous bile acids in rats with decompensated liver cirrhosis
    • Roda A, Aldini R, Camborata C, et al. Metabolic profile of obeticholic acid and endogenous bile acids in rats with decompensated liver cirrhosis. Clin Transl Sci 2017;10:292-301.
    • (2017) Clin Transl Sci , vol.10 , pp. 292-301
    • Roda, A.1    Aldini, R.2    Camborata, C.3
  • 10
  • 11
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Molec Life Sci 2008;65:2461-2483.
    • (2008) Cell Molec Life Sci , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 12
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang JY. Bile acids: regulation of synthesis. J Lipid Res 2009;50:1955-1966.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 13
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • Russell DW. Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res 2009;50 (Suppl): S120-S125.
    • (2009) J Lipid Res , vol.50 , pp. S120-S125
    • Russell, D.W.1
  • 14
    • 0033591297 scopus 로고    scopus 로고
    • Identification of a nuclear receptor for bile acids
    • Makishima M, Okamoto AY, Repa JJ, et al. Identification of a nuclear receptor for bile acids. Science 1999;284:1362-1365.
    • (1999) Science , vol.284 , pp. 1362-1365
    • Makishima, M.1    Okamoto, A.Y.2    Repa, J.J.3
  • 15
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999,3:543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 16
    • 37349010675 scopus 로고    scopus 로고
    • FXR signaling in metabolic disease
    • Zhang Y, Edwards PA. FXR signaling in metabolic disease. FEBS Lett 2008;582:10-18.
    • (2008) FEBS Lett , vol.582 , pp. 10-18
    • Zhang, Y.1    Edwards, P.A.2
  • 17
    • 84887477319 scopus 로고    scopus 로고
    • Bile acid receptors in non-alcoholic fatty liver disease
    • Li Y, Jadhav K, Zhang Y. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol 2013;86:1517-1524.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1517-1524
    • Li, Y.1    Jadhav, K.2    Zhang, Y.3
  • 18
    • 0037094415 scopus 로고    scopus 로고
    • Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
    • Huber RM, Murphy K, Miao B, et al. Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. Gene 2002;290:35-43.
    • (2002) Gene , vol.290 , pp. 35-43
    • Huber, R.M.1    Murphy, K.2    Miao, B.3
  • 19
    • 0037827787 scopus 로고    scopus 로고
    • Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    • Chen F, Ma L, Dawson PA, et al. Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem 2003;278:19909-19916.
    • (2003) J Biol Chem , vol.278 , pp. 19909-19916
    • Chen, F.1    Ma, L.2    Dawson, P.A.3
  • 20
    • 0033570028 scopus 로고    scopus 로고
    • Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer
    • Grober J, Zaghini I, Fujii H, et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem 1999;274:29749-29754.
    • (1999) J Biol Chem , vol.274 , pp. 29749-29754
    • Grober, J.1    Zaghini, I.2    Fujii, H.3
  • 21
    • 30844445030 scopus 로고    scopus 로고
    • FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine
    • Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res 2006;47:201-214.
    • (2006) J Lipid Res , vol.47 , pp. 201-214
    • Lee, H.1    Zhang, Y.2    Lee, F.Y.3    Nelson, S.F.4    Gonzalez, F.J.5    Edwards, P.A.6
  • 22
    • 0037663483 scopus 로고    scopus 로고
    • Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    • Holt JA, Luo G, Billin AN, et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 2003;17:1581-1591.
    • (2003) Genes Dev , vol.17 , pp. 1581-1591
    • Holt, J.A.1    Luo, G.2    Billin, A.N.3
  • 23
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005;2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3
  • 24
    • 0032822672 scopus 로고    scopus 로고
    • FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
    • Xie MH, Holcomb I, Deuel B, et al. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 1999;11:729-735.
    • (1999) Cytokine , vol.11 , pp. 729-735
    • Xie, M.H.1    Holcomb, I.2    Deuel, B.3
  • 26
    • 84865540426 scopus 로고    scopus 로고
    • Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
    • Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012;56:1034-1043.
    • (2012) Hepatology , vol.56 , pp. 1034-1043
    • Kong, B.1    Wang, L.2    Chiang, J.Y.3    Zhang, Y.4    Klaassen, C.D.5    Guo, G.L.6
  • 27
    • 28544434439 scopus 로고    scopus 로고
    • Fos/AP-1 proteins in bone and the immune system
    • Wagner EF, Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunol Rev 2005;208:126-140.
    • (2005) Immunol Rev , vol.208 , pp. 126-140
    • Wagner, E.F.1    Eferl, R.2
  • 28
    • 84947202257 scopus 로고    scopus 로고
    • Bile acid nuclear receptor FXR and digestive system diseases
    • Ding L, Yang L, Wang Z, Huang W. Bile acid nuclear receptor FXR and digestive system diseases. Acta Pharm Sin B 2015;5:135-144.
    • (2015) Acta Pharm Sin B , vol.5 , pp. 135-144
    • Ding, L.1    Yang, L.2    Wang, Z.3    Huang, W.4
  • 29
    • 79952535597 scopus 로고    scopus 로고
    • Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
    • Gadaleta RM, van Erpecum KJ, Oldenburg B, et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011;60:463-472.
    • (2011) Gut , vol.60 , pp. 463-472
    • Gadaleta, R.M.1    van Erpecum, K.J.2    Oldenburg, B.3
  • 30
    • 79958278121 scopus 로고    scopus 로고
    • Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine
    • Gadaleta RM, Oldenburg B, Willemsen EC, et al. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine. Biochim Biophys Acta 2011;1812:851-858.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 851-858
    • Gadaleta, R.M.1    Oldenburg, B.2    Willemsen, E.C.3
  • 32
    • 80051940457 scopus 로고    scopus 로고
    • Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease
    • Nijmeijer RM, Gadaleta RM, van Mil SW, et al. Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease. PLoS One 2011;6:e23745.
    • (2011) Plos One , vol.6
    • Nijmeijer, R.M.1    Gadaleta, R.M.2    van Mil, S.W.3
  • 33
    • 84928785228 scopus 로고    scopus 로고
    • Bile acid diarrhea: Prevalence, pathogenesis, and therapy
    • Camilleri M. Bile acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver 2015;9:332-339.
    • (2015) Gut Liver , vol.9 , pp. 332-339
    • Camilleri, M.1
  • 34
    • 0019984222 scopus 로고
    • Diagnostic value of serum primary bile acids in detecting bile acid malabsorption
    • Aldini R, Roda A, Festi D, et al. Diagnostic value of serum primary bile acids in detecting bile acid malabsorption. Gut 1982;23:829-834.
    • (1982) Gut , vol.23 , pp. 829-834
    • Aldini, R.1    Roda, A.2    Festi, D.3
  • 35
    • 0015231376 scopus 로고
    • Breath test for altered bile-acid metabolism
    • Fromm H, Hofmann AF. Breath test for altered bile-acid metabolism. Lancet 1971;2:621-625.
    • (1971) Lancet , vol.2 , pp. 621-625
    • Fromm, H.1    Hofmann, A.F.2
  • 36
    • 0025824484 scopus 로고
    • Idiopathic bile acid malabsorption—a review of clinical presentation, diagnosis, and response to treatment
    • Williams AJ, Merrick MV, Eastwood MA. Idiopathic bile acid malabsorption—a review of clinical presentation, diagnosis, and response to treatment. Gut 1991;32:1004-1006.
    • (1991) Gut , vol.32 , pp. 1004-1006
    • Williams, A.J.1    Merrick, M.V.2    Eastwood, M.A.3
  • 37
    • 67650480494 scopus 로고    scopus 로고
    • Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (Or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry
    • Camilleri M, Nadeau A, Tremaine WJ, et al. Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil 2009;21:734-e43.
    • (2009) Neurogastroenterol Motil , vol.21
    • Camilleri, M.1    Nadeau, A.2    Tremaine, W.J.3
  • 38
    • 84924925529 scopus 로고    scopus 로고
    • Effect of increased bile acid synthesis or faecal excretion in irritable bowel syndrome-diarrhea
    • Camilleri M, Busciglio I, Acosta A, et al. Effect of increased bile acid synthesis or faecal excretion in irritable bowel syndrome-diarrhea. Am J Gastroenterol 2014;109:1621-1630.
    • (2014) Am J Gastroenterol , vol.109 , pp. 1621-1630
    • Camilleri, M.1    Busciglio, I.2    Acosta, A.3
  • 40
    • 84883792318 scopus 로고    scopus 로고
    • Application of a novel tool for diagnosing bile acid diarrhoea
    • Covington JA, Westenbrink EW, Ouaret N, et al. Application of a novel tool for diagnosing bile acid diarrhoea. Sensors (Basel) 2013;13:11899-11912.
    • (2013) Sensors (Basel) , vol.13 , pp. 11899-11912
    • Covington, J.A.1    Westenbrink, E.W.2    Ouaret, N.3
  • 42
    • 0015338557 scopus 로고
    • Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride
    • Hofmann AF, Poley JR. Role of bile acid malabsorption in pathogenesis of diarrhea and steatorrhea in patients with ileal resection. I. Response to cholestyramine or replacement of dietary long chain triglyceride by medium chain triglyceride. Gastroenterology 1972;62:918-934.
    • (1972) Gastroenterology , vol.62 , pp. 918-934
    • Hofmann, A.F.1    Poley, J.R.2
  • 43
    • 34548572892 scopus 로고    scopus 로고
    • Bile acid transporters: Structure, function, regulation and pathophysiological implications
    • Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 2007;24:1803-1823.
    • (2007) Pharm Res , vol.24 , pp. 1803-1823
    • Alrefai, W.A.1    Gill, R.K.2
  • 44
    • 70449729508 scopus 로고    scopus 로고
    • Chronic diarrhea caused by idiopathic bile acid malabsorption: An explanation at last
    • Hofmann AF. Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last. Exp Rev Gastroenterol Hepatol 2009;3:461-464.
    • (2009) Exp Rev Gastroenterol Hepatol , vol.3 , pp. 461-464
    • Hofmann, A.F.1
  • 46
    • 79955877884 scopus 로고    scopus 로고
    • Bile acid malabsorption in inflammatory bowel disease: Assessment by serum markers
    • Lenicek M, Duricova D, Komarek V, et al. Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers. Inflamm Bowel Dis 2011;17:1322-1327.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1322-1327
    • Lenicek, M.1    Duricova, D.2    Komarek, V.3
  • 47
    • 13344287538 scopus 로고
    • The role of bile salts in diarrhoea of patients with ulcerative colitis
    • Miettinen TA. The role of bile salts in diarrhoea of patients with ulcerative colitis. Gut 1971;12:632-635.
    • (1971) Gut , vol.12 , pp. 632-635
    • Miettinen, T.A.1
  • 48
    • 0031465555 scopus 로고    scopus 로고
    • Impaired absorption of cholesterol and bile acids in patients with an ileoanal anastomosis
    • Hakala K, Vuoristo M, Luukkonen P, Järvinen HJ, Miettinen TA. Impaired absorption of cholesterol and bile acids in patients with an ileoanal anastomosis. Gut 1997;41:771-777.
    • (1997) Gut , vol.41 , pp. 771-777
    • Hakala, K.1    Vuoristo, M.2    Luukkonen, P.3    Järvinen, H.J.4    Miettinen, T.A.5
  • 49
    • 67651244689 scopus 로고    scopus 로고
    • Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease
    • Gnewuch C, Liebisch G, Langmann T, et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J Gastroenterol 2009;15:3134-3141.
    • (2009) World J Gastroenterol , vol.15 , pp. 3134-3141
    • Gnewuch, C.1    Liebisch, G.2    Langmann, T.3
  • 51
    • 0014254324 scopus 로고
    • Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea
    • Meihoff WE, Kern F Jr. Bile salt malabsorption in regional ileitis, ileal resection and mannitol-induced diarrhea. J Clin Invest 1968;47:261-267.
    • (1968) J Clin Invest , vol.47 , pp. 261-267
    • Meihoff, W.E.1    Kern, F.2
  • 53
    • 84871550471 scopus 로고    scopus 로고
    • Altered enterohepatic circulation of bile acids in Crohn’s disease and their clinical significance: A new perspective
    • Nolan JD, Johnston IM, Walters JR. Altered enterohepatic circulation of bile acids in Crohn’s disease and their clinical significance: a new perspective. Expert Rev Gastroenterol Hepatol 2013;7:49-56.
    • (2013) Expert Rev Gastroenterol Hepatol , vol.7 , pp. 49-56
    • Nolan, J.D.1    Johnston, I.M.2    Walters, J.R.3
  • 54
    • 84874651768 scopus 로고    scopus 로고
    • Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
    • Duboc H, Rajca S, Rainteau D, et al. Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases. Gut 2013;62:531-539.
    • (2013) Gut , vol.62 , pp. 531-539
    • Duboc, H.1    Rajca, S.2    Rainteau, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.