Managing bile acid diarrhoea

Therapeutic Advances in Gastroenterology

Volumn 3, Issue 6, 2010, Pages 349-357

  Walters, Julian R F ^a   Pattni, Sanjeev S ^b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

Bile acids; Colesevelam; Colestipol; Colestyramine; Crohn's disease; Fibroblast growth factor 19; Functional diarrhoea; Irritable bowel syndrome; Malabsorption; SeHCAT

Indexed keywords

7 ALPHA OH 4 CHOLESTEN 3 ONE; APICAL SODIUM DEPENDENT BILE TRANSPORTER; BILE ACID; BILE ACID SEQUESTRANT; BINDING PROTEIN; BUDESONIDE; CARRIER PROTEIN; COLESEVELAM; COLESTIPOL; COLESTYRAMINE; FIBROBLAST GROWTH FACTOR 19; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ILEAL BILE ACID BINDING PROTEIN; STEROL; TAUROSELCHOLIC ACID SE 75; UNCLASSIFIED DRUG;

ARTICLE; BILE ACID DIARRHEA; BILE ACID MALABSORPTION; BREATH ANALYSIS; DIARRHEA; DISEASE ASSOCIATION; FECES ANALYSIS; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LYMPHOCYTIC COLITIS; MALABSORPTION; PREVALENCE; PRIORITY JOURNAL;

EID: 77958052334     PISSN: 1756283X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1756283X10377126     Document Type: Review

References (55)

1. Andreyev, J. ( 2007) Gastrointestinal symptoms after pelvic radiotherapy: a new understanding to improve management of symptomatic patients. Lancet Oncol 8: 1007-1017.
2. Bajor, A., Kilander, A., Fae, A., Galman, C., Jonsson, O., Ohman, L. et al. (2006 a) Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption. Eur J Gastroenterol Hepatol 18: 397-403.
3. Bajor, A., Kilander, A., Galman, C., Rudling, M. and Ung, K.A. ( 2006b) Budesonide treatment is associated with increased bile acid absorption in collagenous colitis. Ailment Pharmacol Ther 24: 1643-1649.
4. Bajor, A., Ung, K.A., Ohman, L., Simren, M., Thomas, E.A., Bornstein, J.C. et al. (2009) Indirect evidence for increased mechanosensitivity of jejunal secretomotor neurones in patients with idiopathic bile acid malabsorption. Acta Physiol (Oxf) 197: 128-137.
5. Balesaria, S., Pell, R.J., Abbott, L.J., Tasleem, A., Chavele, K.M., Barley, N.F. et al. (2008) Exploring possible mechanisms for primary bile acid malabsorption: evidence for different regulation of ileal bile acid transporter transcripts in chronic diarrhoea. Eur J Gastroenterol Hepatol 20: 413-422.
6. Boyd, G.S., Merrick, M.V., Monks, R. and Thomas, I.L. ( 1981) Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation. J Nucl Med 22: 720-725.
7. Brydon, W.G., Nyhlin, H., Eastwood, M.A. and Merrick, M.V. ( 1996) Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Eur J Gastroenterol Hepatol 8: 117-123.
8. Camilleri, M., Nadeau, A., Tremaine, W.J., Lamsam, J., Burton, D., Odunsi, S. et al. (2009) Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry. Neurogastroenterol Motil 21: 734-743.
9. Danielsson, A., Nyhlin, H., Persson, H., Stendahl, U., Stenling, R. and Suhr, O. ( 1991) Chronic diarrhoea after radiotherapy for gynaecological cancer: occurrence and aetiology. Gut 32: 1180-1187.
10. Davidson, M.H., Dillon, M.A., Gordon, B., Jones, P., Samuels, J., Weiss, S. et al. (1999) Colesevelam hydrochloride (cholestagel): a new, potent bile acid sequestrant associated with a low incidence of gastrointestinal side effects. Arch Intern Med 159: 1893-1900.
11. Eusufzai, S. ( 1993) Bile acid malabsorption in patients with chronic diarrhoea. Scand J Gastroenterol 28: 865-868.
12. Fernandez-Banares, F., Esteve, M., Salas, A., Forne, T.M., Espinos, J.C., Martin-Comin, J. et al. (2001) Bile acid malabsorption in microscopic colitis and in previously unexplained functional chronic diarrhea. Dig Dis Sci 46: 2231-2238.
13. Ford, G.A., Preece, J.D., Davies, I.H. and Wilkinson, S.P. ( 1992) Use of the SeHCAT test in the investigation of diarrhoea. Postgrad Med J 68: 272-276.
14. Fromm, H. and Malavolti, M. ( 1986) Bile acid-induced diarrhoea. Clin Gastroenterol 15: 567-582.
15. Hiatt, J.G., Shamsie, S.G. and Schectman, G. ( 1999) Discontinuation rates of cholesterol-lowering medications: implications for primary care. Am J Manag Care 5: 437-444.
16. Hofmann, A.F. ( 1967) The syndrome of ileal disease and the broken enterohepatic circulation: cholerheic enteropathy. Gastroenterology 52: 752-757.
17. Hofmann, A.F. (2009 a) Bile acids: trying to understand their chemistry and biology with the hope of helping patients. Hepatology 49: 1403-1418.
18. Hofmann, A.F. ( 2009b) Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last. Expert Rev Gastroenterol Hepatol 3: 461-464.
19. Hofmann, A.F. and Poley, J.R. ( 1969) Cholestyramine treatment of diarrhea associated with ileal resection. N Engl J Med 281: 397-402.
20. Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C.L., McDonald, J.G. et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2: 217-225.
21. Inagaki, T., Moschetta, A., Lee, Y.K., Peng, L., Zhao, G., Downes, M. et al. (2006) Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 103: 3920-3925.
22. Jacobsen, O., Hojgaard, L., Hylander, M.E., Wielandt, T.O., Thale, M., Jarnum, S. et al. (1985) Effect of enterocoated cholestyramine on bowel habit after ileal resection: a double blind crossover study. Br Med J (Clin Res Ed) 290: 1315-1318.
23. Jung, D., Fantin, A.C., Scheurer, U., Fried, M. and Kullak-Ublick, G.A. ( 2004) Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut 53: 78-84.
24. Jung, D., Inagaki, T., Gerard, R.D., Dawson, P.A., Kliewer, S.A., Mangelsdorf, D.J. et al. (2007) FXR agonists and FGF 15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res 48: 2693-2700.
25. Khalid, U., Lalji, A., Stafferton, R. and Andreyev, J. (2010) Bile acid malabsorption: a forgotten diagnosis? Clin Medicine 10: 124-126.
26. Lundasen, T., Galman, C., Angelin, B. and Rudling, M. ( 2006) Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 260: 530-536.
27. Merrick, M.V., Eastwood, M.A. and Ford, M.J. ( 1985) Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurement of SeHCAT retention. Br Med J (Clin Res Ed) 290: 665-668.
28. Montagnani, M., Abrahamsson, A., Galman, C., Eggertsen, G., Marschall, H.U., Ravaioli, E. et al. (2006) Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption. World J Gastroenterol 12: 7710-7714.
29. Montagnani, M., Love, M.W., Rössel, P., Dawson, P.A. and Qvist, P. ( 2001) Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. Scand J Gastroenterol 36: 1077-1080.
30. Muller, M., Willen, R. and Stotzer, P.O. ( 2004) Colonoscopy and SeHCAT for investigation of chronic diarrhea. Digestion 69: 211-218.
31. Niaz, S.K., Sandrasegaran, K., Renny, F.H. and Jones, B.J.M. ( 1997) Postinfective diarrhoea and bile acid malabsorption. J Roy Coll Phys Lond 31: 53-56.
32. Odunsi-Shiyanbade, S.T., Camilleri, M., McKinzie, S., Burton, D., Carlson, P., Busciglio, I.A. et al. (2010) Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. Clin Gastroenterol Hepatol 8: 159-165.
33. Oelkers, P., Kirby, L.C., Heubi, J.E. and Dawson, P.A. ( 1997) Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest 99: 1880-1887.
34. Pattni, S.S. and Walters, J.R.F. (2009) Recent advances in the understanding of bile acid malabsorption. Br Med Bull 92: 79-93.
35. Puleston, J., Morgan, H. and Andreyev, J. ( 2005) New treatment for bile salt malabsorption. Gut 54: 441-442.
36. Roberts, S.H., James, O. and Jarvis, E.H. ( 1977) Bacterial overgrowth syndrome without “blind loop”: A cause for malnutrition in the elderly. Lancet 2: 1193-1195.
37. Rössel, P., Jensen, H.S., Qvist, P. and Arveschoug, A. ( 1999) Prognosis of adult-onset idiopathic bile acid malabsorption. Scand J Gastroenterol 34: 587-590.
38. Sadik, R., Abrahamsson, H., Ung, K.-A. and Stotzer, P.-O. ( 2004) Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption. Am J Gastroenterol 99: 711-718.
39. Sauter, G.H., Munzing, W., von Ritter, C. and Paumgartner, G. ( 1999) Bile acid malabsorption as a cause of chronic diarrhea: diagnostic value of 7alpha-hydroxy-4-cholesten-3-one in serum. Dig Dis Sci 44: 14-19.
40. Sciarretta, G., Fagioli, G., Furno, A., Vicini, G., Cecchetti, L., Grigolo, B. et al. (1987) 75SeHCAT test in the detection of bile acid malabsorption in functional diarrhoea and its correlation with small bowel transit. Gut 28: 970-975.
41. Sinha, L., Liston, R., Testa, H.J. and Moriarty, K.J. ( 1998) Idiopathic bile acid malabsorption: qualitative and quantitative clinical features and response to cholestyramine. Ailment Pharmacol Ther 12: 839-844.
42. Smith, M.J., Cherian, P., Raju, G.S., Dawson, B.F., Mahon, S. and Bardhan, K.D. ( 2000) Bile acid malabsorption in persistent diarrhoea. J R Coll Physicians Lond 34: 448-451.
43. Spiller, R.C. and Thompson, W.G. ( 2010) Bowel disorders. Am J Gastroenterol 105: 775-785.
44. Thaysen, E.H. and Pedersen, L. ( 1973) Diarrhoea associated with idiopathic bile acid malabsorption Fact or fantasy?. Dan Med Bull 20: 174-177.
45. Thaysen, E.H. and Pedersen, L. ( 1976) Idiopathic bile acid catharsis. Gut 17: 965-970.
46. Ung, K.A., Gillberg, R., Kilander, A. and Abrahamsson, H. ( 2000a) Role of bile acids and bile acid binding agents in patients with collagenous colitis. Gut 46: 170-175.
47. Ung, K.A., Kilander, A.F., Lindgren, A. and Abrahamsson, H. ( 2000b) Impact of bile acid malabsorption on steatorrhoea and symptoms in patients with chronic diarrhoea. Eur J Gastroenterol Hepatol 12: 541-547.
48. van Tilburg, A.J., de Rooij, F.W., van den Berg, J.W. and van Blankenstein, M. ( 1991) Primary bile acid diarrhoea without an ileal carrier defect: quantification of active bile acid transport across the ileal brush border membrane. Gut 32: 500-503.
49. van Tilburg, A.J., de Rooij, F.W., van den Berg, J.W. and van Blankenstein, M. ( 1992) Primary bile acid malabsorption: a pathophysiologic and clinical entity? Scand J Gastroenterol Suppl 194: 66-70.
50. Walters, J.R.F., Tasleem, A.M., Omer, O.S., Brydon, W.G., Dew, T. and Le Roux, C.W. ( 2009) A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. Clin Gastro Hepatol 7: 1189-1194.
51. Wedlake, L., A'Hern, R., Thomas, K., Walters, J.R.F. and Andreyev, H.J.N. ( 2009a) Systematic review: the prevalence of idiopathic bile acid malabsorption (I-BAM) as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome (IBS). Aliment Pharmacol Ther 30: 707-717.
52. Wedlake, L., Thomas, K., Lalji, A., Anagnostopoulos, C. and Andreyev, J. ( 2009b) A 4-year experience with colesevelam hydrochloride: a new treatment for bile acid malabsorption? Gut 58: A117.
53. Westergaard, H. ( 2007) Bile Acid malabsorption. Curr Treat Options Gastroenterol 10: 28-33.
54. Wildt, S., Rasmussen, S.N., Madsen, J.L. and Rumessen, J.J. ( 2003) Bile acid malabsorption in patients with chronic diarrhoea: clinical value of SeHCAT test. Scand J Gastroenterol 38: 826-830.
55. Williams, A.J.K., Merrick, M.V. and Eastwood, M.A. ( 1991) Idiopathic bile acid malabsorption-a review of clinical presentation, diagnosis, and response to treatment. Gut 32: 1004-1006.