Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro

Cell Stem Cell

Volumn 22, Issue 5, 2018, Pages 684-697.e9

  Sarkar, Anindita ^a   Mei, Arianna ^a   Paquola, Apua C M ^a,b   Stern, Shani ^a   Bardy, Cedric ^a,c   Klug, Jason R ^a   Kim, Stacy ^a   Neshat, Neda ^a   Kim, Hyung Joon ^a,d   Ku, Manching ^a,g   Shokhirev, Maxim N ^a   Adamowicz, David H ^a,e   Marchetto, Maria C ^a   Jappelli, Roberto ^a   Erwin, Jennifer A ^a,b   Padmanabhan, Krishnan ^a,f   Shtrahman, Matthew ^a,e   Jin, Xin ^a   Gage, Fred H ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FLINDERS UNIVERSITY   (Australia)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^g UNIVERSITY OF FREIBURG   (Germany)

Author keywords

CA3; DG; disease in a dish; hippocampus; neuronal diversity; pyramidal neurons; rabies tracing; schizophrenia; single cell sequencing; synaptic connectivity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; SECRETAGOGIN; TRANSCRIPTOME; VESICULAR GLUTAMATE TRANSPORTER 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE GYRUS; EVOKED RESPONSE; FEMALE; FUNCTIONAL CONNECTIVITY; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MALE; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE CELL NETWORK; NEURAL STEM CELL; NONHUMAN; PERSECUTORY DELUSION; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RABIES VIRUS; RESTLESSNESS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SYNAPSE; YOUNG ADULT; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; HIPPOCAMPUS; METABOLISM; MIDDLE AGED; NERVE CELL; NONOBESE DIABETIC MOUSE; PATHOLOGY; SCID MOUSE;

ADULT; ANIMALS; CELL DIFFERENTIATION; DENTATE GYRUS; FEMALE; HIPPOCAMPUS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; MIDDLE AGED; NEURONS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 85046167409     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2018.04.009     Document Type: Article

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