Altered hippocampal-parahippocampal function during stimulus encoding:A potential indicator of genetic liability for schizophrenia

JAMA Psychiatry

Volumn 71, Issue 3, 2014, Pages 236-247

  Rasetti, Roberta ^a   Mattay, Venkata S ^b   White, Michael G ^b   Sambataro, Fabio ^a   Podell, Jamie E ^a   Zoltick, Brad ^a   Chen, Qiang ^b   Berman, Karen F ^a   Callicott, Joseph H ^a   Weinberger, Daniel R ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ADULT; ALTERED HIPPOCAMPAL PARAHIPPOCAMPAL FUNCTION; ANALYSIS OF COVARIANCE; ARTICLE; BOLD SIGNAL; BRAIN DYSFUNCTION; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DECLARATIVE MEMORY; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC RISK; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PARAHIPPOCAMPUS; SCHIZOPHRENIA; STATISTICAL MODEL; STIMULUS; VISUAL MEMORY; WIDE RANGE ACHIEVEMENT TEST;

ADULT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; NEUROIMAGING; PARAHIPPOCAMPAL GYRUS; PARIETAL LOBE; SCHIZOPHRENIA; SIBLINGS;

EID: 84896693647     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2013.3911     Document Type: Article

References (47)

1. FioravantiM, Carlone O, Vitale B, CintiME, Clare L. Ameta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia. Neuropsychol Rev. 2005;15(2):73-95.
2. Aleman A, Hijman R, de Haan EH, Kahn RS. Memory impairment in schizophrenia: ametaanalysis. AmJ Psychiatry. 1999;156(9):1358-1366.
3. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12(3):426-445.
4. Dickinson D, RamseyME, Gold JM. Overlooking the obvious: ameta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Arch Gen Psychiatry. 2007;64(5):532-542.
5. Snitz BE, Macdonald AWIII, Carter CS. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: ameta-analytic review of putative endophenotypes. Schizophr Bull. 2006;32(1):179-194.
6. Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC, Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: ameta-analysis. Schizophr Res. 2004;71(2-3):285-295.
7. Schacter DL,Wagner AD. Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus. 1999;9(1):7-24.
8. Ranganath C, RitcheyM. Two cortical systems for memory-guided behaviour. Nat Rev Neurosci. 2012;13(10):713-726.
9. Dickerson BC, Eichenbaum H. The episodic memory system: neurocircuitry and disorders. Neuropsychopharmacology. 2010;35(1):86-104.
10. Reichenberg A, Harvey PD. Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychol Bull. 2007;133(5):833-858.
11. PelletierM, Achim AM, Montoya A, Lal S, Lepage M. Cognitive and clinical moderators of recognition memory in schizophrenia: ameta-analysis. Schizophr Res. 2005;74(2-3):233-252.
12. Egeland J, Sundet K, Rund BR, et al. Sensitivity and specificity of memory dysfunction in schizophrenia: a comparisonwith major depression. J Clin Exp Neuropsychol. 2003;25(1):79-93.
13. Gold JM, Poet MS,Wilk CM, Buchanan RW. The family pictures test as a measure of impaired feature binding in schizophrenia. J Clin Exp Neuropsychol. 2004;26(4):511-520.
14. GrillonML, Krebs MO, Gourevitch R, Giersch A, Huron C. Episodic memory and impairment of an early encoding process in schizophrenia. Neuropsychology. 2010;24(1):101-108
15. Kopald BE, Mirra KM, Egan MF,Weinberger DR, Goldberg TE. Magnitude of impact of executive functioning and IQ on episodic memory in schizophrenia. Biol Psychiatry. 2012;71(6):545-551.
16. Weinberger DR. Cell biology of the hippocampal formation in schizophrenia. Biol Psychiatry. 1999;45(4):395-402.
17. Harrison PJ,Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10(1):40-68; image 5.
18. Lipska BK. Using animal models to test a neurodevelopmental hypothesis of schizophrenia. J Psychiatry Neurosci. 2004;29(4):282-286.
19. Tseng KY, Chambers RA, Lipska BK. The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res. 2009;204(2):295-305.
20. Lipska BK,Weinberger DR. To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology. 2000;23(3):223-239.
21. Bertolino A, Nawroz S, Mattay VS, et al. Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. AmJ Psychiatry. 1996;153(12):1554- 1563.
22. Achim AM, Lepage M. Episodic memory-related activation in schizophrenia: meta analysis. Br J Psychiatry. 2005;187:500-509.
23. Ragland JD, Laird AR, Ranganath C, Blumenfeld RS, Gonzales SM, Glahn DC. Prefrontal activation deficits during episodic memory in schizophrenia. Am J Psychiatry. 2009;166(8):863-874.
24. Thermenos HW, Seidman LJ, Poldrack RA, et al. Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI. Biol Psychiatry. 2007;61(4):564-574.
25. Di Giorgio A, Gelao B, Caforio G, et al. Evidence that hippocampal parahippocampal dysfunction is related to genetic risk for schizophrenia. Psychol Med. 2013;43(8):1661-1671.
26. Skelley SL, Goldberg TE, Egan MF,Weinberger DR, Gold JM. Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophrenia. Schizophr Res. 2008;105(1-3):78-85.
27. Goldberg TE, Torrey EF, Gold JM, Ragland JD, Bigelow LB,Weinberger DR. Learning and memory in monozygotic twins discordant for schizophrenia. Psychol Med. 1993;23(1):71-85.
28. Rasetti R, Sambataro F, Chen Q, Callicott JH, Mattay VS,Weinberger DR. Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and associationwith ZNF804A. Arch Gen Psychiatry. 2011;68(12):1207-1217.
29. Genderson MR, Dickinson D, Diaz-Asper CM, Egan MF,Weinberger DR, Goldberg TE. Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls. Schizophr Res. 2007;94(1-3):231-239.
30. Lang PJBM, Cuthbert BN. International Affective Picture System (IAPS): Technical Manual and Affective Ratings. Gainesville, FL: NIMH Center for the Study of Emotion and Attention, University of Florida; 1997.
31. Gescheider GA. Psychophysics: The Fundamentals. 3rd ed. Mahwah, NJ: Lawrence Erlbaum Associates Inc; 1997.
32. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15(4):870-878.
33. Callicott JH, Egan MF, Mattay VS, et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry. 2003;160(4):709-719.
34. Sambataro FMV, Mattay VS, Thurin K, et al. Altered cerebral response during cognitive control: a potential indicator of genetic liability for schizophrenia. Neuropsychopharmacology. 2013;38(5):846-853.
35. Hariri AR, Mattay VS, Tessitore A, Fera F, Weinberger DR. Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry. 2003;53(6):494-501.
36. Sambataro F, Murty VP, Lemaitre HS, et al. BDNF modulates normal human hippocampal ageing [corrected]. Mol Psychiatry. 2010;15(2):116-118.
37. Callicott JH, Egan MF, Bertolino A, et al. Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biol Psychiatry. 1998;44(10):941-950.
38. Capizzano AA, Toscano JL, Ho BC.Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands. Schizophr Res. 2011;131(1-3):4-10.
39. Barnett JH, Sahakian BJ,Werners U, et al. Visuospatial learning and executive function are independently impaired in first-episode psychosis. Psychol Med. 2005;35(7):1031-1041.
40. Cabeza R. Role of parietal regions in episodic memory retrieval: the dual attentional processes hypothesis. Neuropsychologia. 2008;46(7):1813-1827.
41. Kim H. Neural activity that predicts subsequent memory and forgetting: ameta analysis of 74 fMRI studies. Neuroimage. 2011;54(3):2446-2461.
42. Mattay VS, Callicott JH, Bertolino A, et al. Abnormal functional lateralization of the sensorimotor cortex in patients with schizophrenia. Neuroreport. 1997;8(13):2977-2984.
43. AltamuraM, Fazio L, De SalviaM, et al. Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia. Psychiatry Res. 2012;203(1):54-60.
44. Honea RA,Meyer-Lindenberg A, Hobbs KB, et al. Is gray matter volume an intermediate phenotype for schizophrenia? a voxel-based morphometry study of patients with schizophrenia and their healthy siblings. Biol Psychiatry. 2008;63(5):465-474.
45. Goldman AL, Pezawas L, Mattay VS, et al. Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study. Biol Psychiatry. 2008;63(5):475-483.
46. Goldman AL, Pezawas L, Mattay VS, et al. Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry. 2009;66(5):467-477.
47. Owens SF, Picchioni MM, Ettinger U, et al. Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia. Brain. 2012;135(pt 7):2231-2244.