Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 14, 2011, Pages 5807-5812

  Karalay, Özlem ^a   Doberauer, Kathrin ^b   Vadodaria, Krishna C ^a   Knobloch, Marlen ^a   Berti, Lucia ^b   Miquelajauregui, Amaya ^c,d   Schwark, Manuela ^c,d   Jagasia, Ravi ^b,e   Taketo, Makoto M ^f   Tarabykin, Victor ^c,d   Lie, D Chichung ^b   Jessberger, Sebastian ^a  

^a ETH ZURICH   (Switzerland)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROSPERO RELATED HOMEOBOX 1; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; CELL LINEAGE; CELL SURVIVAL; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GENETIC REGULATION; GRANULE CELL; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

MAMMALIA; PROSPERO;

EID: 79955025124     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013456108     Document Type: Article

References (41)

1. Gage F (2000) Mammalian neural stem cells. Science 287:1433-1438. (Pubitemid 30127128)
2. Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:645-660. (Pubitemid 351253687)
3. Clelland CD, et al. (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325:210-213.
4. Suh H, Deng W, Gage FH (2009) Signaling in adult neurogenesis. Ann Rev Cell Dev Biol 25:253-275.
5. Alvarez-Buylla A, Lim DA (2004) For the long run: Maintaining germinal niches in the adult brain. Neuron 41:683-686. (Pubitemid 38326831)
6. Lai K, Kaspar BK, Gage FH, Schaffer DV (2003) Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 6:21-27. (Pubitemid 36026328)
7. Lie DC, et al. (2005) Wnt signalling regulates adult hippocampal neurogenesis. Nature 437:1370-1375.
8. Song H, Stevens CF, Gage FH (2002) Astroglia induce neurogenesis from adult neural stem cells. Nature 417:39-44. (Pubitemid 34498810)
9. Pleasure SJ, Collins AE, Lowenstein DH (2000) Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development. J Neurosci 20: 6095-6105. (Pubitemid 30658403)
10. Liu M, et al. (2000) Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci USA 97:865-870. (Pubitemid 30070401)
11. Gao Z, et al. (2009) Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci 12:1090-1092.
12. Kuwabara T, et al. (2009) Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci 12:1097-1105.
13. Boutin C, et al. (2010) NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis. Proc Natl Acad Sci USA 107:1201-1206.
14. Roybon L, Deierborg T, Brundin P, Li JY (2009) Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci 29:232-243.
15. Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004) Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447-452. (Pubitemid 38951037)
16. Lavado A, Oliver G (2007) Prox1 expression patterns in the developing and adult murine brain. Dev Dyn 236:518-524. (Pubitemid 46233295)
17. Lavado A, Lagutin OV, Chow LML, Baker SJ, Oliver G (2010) Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol 8:e1000460.
18. Misra K, Gui H, Matise MP (2008) Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord. Dev Dyn 237:393-402. (Pubitemid 351312111)
19. Wigle JT, Chowdhury K, Gruss P, Oliver G (1999) Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet 21:318-322. (Pubitemid 29124943)
20. Wigle JT, Oliver G (1999) Prox1 function is required for the development of the murine lymphatic system. Cell 98:769-778. (Pubitemid 29446894)
21. Petrova TV, et al. (2008) Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell 13:407-419. (Pubitemid 351609440)
22. Sottile V, Li M, Scotting PJ (2006) Stem cell marker expression in the Bergmann glia population of the adult mouse brain. Brain Res 1099:8-17. (Pubitemid 44080085)
23. Cheng LC, Pastrana E, Tavazoie M, Doetsch F (2009) miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 12:399-408.
24. Suh HK, et al. (2007) In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell 1:515-528.
25. Steiner B, et al. (2006) Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Glia 54:805-814. (Pubitemid 44671986)
26. Couillard-Despres S, et al. (2005) Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci 21:1-14. (Pubitemid 40193870)
27. Maretto S, et al. (2003) Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 100:3299-3304. (Pubitemid 36356577)
28. Harada N, et al. (1999) Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18:5931-5942. (Pubitemid 29515670)
29. Gorski JA, et al. (2002) Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22:6309-6314. (Pubitemid 35386383)
30. Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH (2003) Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130:391-399. (Pubitemid 36175935)
31. Brandt MD, et al. (2003) Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Mol Cell Neurosci 24:603-613. (Pubitemid 37506005)
32. Jessberger S, et al. (2009) Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. . Learning Memory 16: 147-154.
33. Shi Y, et al. (2004) Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 427:78-83. (Pubitemid 38094825)
34. Favaro R, et al. (2009) Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12:1248-1256.
35. Shin JW, et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: A role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17:576-584. (Pubitemid 43191094)
36. Mishima K, et al. (2007) Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell 18:1421-1429. (Pubitemid 46626636)
37. Jessberger S, et al. (2008) Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol 6:e272.
38. Jessberger S, Toni N, Clemenson GD, Jr, Ray J, Gage FH (2008) Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci 11:888-893.
39. Ray J, Gage FH (2006) Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci 31:560-573. (Pubitemid 43358027)
40. Jessberger S, Kempermann G (2003) Adult-born hippocampal neurons mature into activity-dependent responsiveness. Eur J Neurosci 18:2707-2712. (Pubitemid 37542123)
41. Wilkinson DG, ed (1998) In Situ Hybridization: A Practical Approach. (Oxford Univ Press, New York), 2nd Ed.