Characterization of Lhx9, a novel LIM/homeobox gene expressed by the pioneer neurons in the mouse cerebral cortex

Mechanisms of Development

Volumn 81, Issue 1-2, 1999, Pages 193-198

  Bertuzzi, Stefano ^a   Porter, Forbes D ^a   Pitts, Anne ^a   Kumar, Maya ^a   Agulnick, Alan ^a   Wassif, Chris ^a   Westphal, Heiner ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Cajal; Cortex; Eye; Homeobox; Lhx9; LIM; Limb; Pioneer neurons; Preplate; Retzius

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN LHX2; PROTEIN LHX9; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CEREBELLUM CORTEX; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE CONTROL; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; HOMEOBOX; LIMB DEVELOPMENT; MOUSE; NERVE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION;

AGE FACTORS; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BRAIN; CEREBRAL CORTEX; CLONING, MOLECULAR; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 0032933045     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00233-0     Document Type: Article

References (14)

1. Agulnick A.D., Taira M., Breen J.J., Tanaka T., Dawid I.B., Westphal H. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 384:1996;270-272.
2. Arber S., Halder G., Caroni P. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Cell. 79:1994;221-231.
3. Bertuzzi S., Sheng H.Z., Copeland N.G., Gilbert D.J., Jenkins N.A., Taira M., Dawid I.B., Westphal H. Molecular cloning, structure, and chromosomal localization of the mouse LIM/homeobox gene Lhx5. Genomics. 36:1996;234-239.
4. Bourgouin C., Lundgren S.E., Thomas J.B. Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles. Neuron. 9:1992;549-561.
5. Cohen B., McGuffin M.E., Pfeifle C., Segal D., Cohen S.M. Apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev. 6:1992;715-729.
6. Jacobson, M., 1991. Developmental Neurobiology. Plenum Press, New York.
7. Jurata L.W., Kenny D.A., Gill G.N. Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc. Natl. Acad. Sci. USA. 93:1996;11693-11698.
8. Marin-Padilla M. Early prenatal ontogenesis of the cerebral cortex (neocortex) of the cat (Felis domestica). A Golgi study. I. The primordial neocortical organization. Z. Anat. Entwicklungsgesch. 134:1971;117-145.
9. Marin-Padilla M. Cajal-Retzius cells and the development of the neocortex. Trends Neurosci. 21:1998;64-71.
10. Nohno T., Kawakami Y., Wada N., Ishikawa T., Ohuchi H., Noji S. Differential expression of the two closely related LIM-class homeobox genes LH-2A and LH-2B during limb development. Biochem. Biophys. Res. Commun. 238:1997;506-511.
11. Ogawa M., Miyata T., Nakajima K., Yagyu K., Seike M., Ikenaka K., Yamamoto H., Mikoshiba K. The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron. 14:1995;899-912.
12. Porter F.D., Drago J., Xu Y., Cheema S.S., Wassif C., Huang S.P., Lee E., Grinberg A., Massalas J.S., Bodine D., Alt F., Westphal H. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 124:1997;2935-2944.
13. Riddle R.D., Ensini M., Nelson C., Tsuchida T., Jessell T.M., Tabin C. Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell. 83:1995;631-640.
14. Sheng H.Z., Bertuzzi S., Chiang C., Shawlot W., Taira M., Dawid I., Westphal H. Expression of murine Lhx5 suggests a role in specifying the forebrain. Dev. Dyn. 208:1997;266-277.