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Volumn 24, Issue 15, 2018, Pages 1601-1615

Multiomics biomarkers for the prediction of nonalcoholic fatty liver disease severity

Author keywords

Fibrosis; Genetics; Liver biopsy; Metabolomics; MiR122; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; PNPLA3; Proteomics; TM6SF2; Transcriptomics

Indexed keywords

BIOLOGICAL MARKER; CELL FREE DNA; CELL FREE NUCLEIC ACID; CIRCULATING MICRORNA; DNA; PROTEIN; UNCLASSIFIED DRUG;

EID: 85045845276     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v24.i15.1601     Document Type: Review
Times cited : (62)

References (74)
  • 2
    • 85030176004 scopus 로고    scopus 로고
    • The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
    • PMID: 28714183
    • Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology 2018;67: 328-357 [PMID: 28714183 DOI: 10.1002/ hep.29367]
    • (2018) Hepatology , vol.67 , pp. 328-357
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Charlton, M.4    Cusi, K.5    Rinella, M.6    Harrison, S.A.7    Brunt, E.M.8    Sanyal, A.J.9
  • 3
    • 70349773095 scopus 로고    scopus 로고
    • Histopathology of non-alcoholic fatty liver disease
    • PMID: 19818303
    • Brunt EM. Histopathology of non-alcoholic fatty liver disease. Clin Liver Dis 2009;13: 533-544 [PMID: 19818303 DOI: 10.1016/ j.cld.2009.07.008]
    • (2009) Clin Liver Dis , vol.13 , pp. 533-544
    • Brunt, E.M.1
  • 4
    • 77950858243 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease
    • PMID: 20195271
    • Brunt EM. Pathology of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2010;7: 195-203 [PMID: 20195271 DOI: 10.1038/nrgastro.2010.21]
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 195-203
    • Brunt, E.M.1
  • 5
    • 84992468335 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis
    • PMID: 27480050
    • Sookoian S, Pirola CJ. Nonalcoholic fatty liver disease and metabolic syndrome: Shared genetic basis of pathogenesis. Hepatology 2016;64: 1417-1420 [PMID: 27480050 DOI: 10.1002/ hep.28746]
    • (2016) Hepatology , vol.64 , pp. 1417-1420
    • Sookoian, S.1    Pirola, C.J.2
  • 6
    • 85050579211 scopus 로고    scopus 로고
    • Genetic predisposition in nonalcoholic fatty liver disease
    • PMID: 28268262
    • Sookoian S, Pirola CJ. Genetic predisposition in nonalcoholic fatty liver disease. Clin Mol Hepatol 2017;23: 1-12 [PMID: 28268262 DOI: 10.3350/cmh.2016.0109]
    • (2017) Clin Mol Hepatol , vol.23 , pp. 1-12
    • Sookoian, S.1    Pirola, C.J.2
  • 8
    • 69249111667 scopus 로고    scopus 로고
    • A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
    • PMID: 19738004
    • Sookoian S, Castaño GO, Burgueño AL, Gianotti TF, Rosselli MS, Pirola CJ. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res 2009;50: 2111-2116 [PMID: 19738004 DOI: 10.1194/jlr. P900013-JLR200]
    • (2009) J Lipid Res , vol.50 , pp. 2111-2116
    • Sookoian, S.1    Castaño, G.O.2    Burgueño, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5    Pirola, C.J.6
  • 9
    • 79957462315 scopus 로고    scopus 로고
    • Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease
    • PMID: 21381068
    • Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011;53: 1883-1894 [PMID: 21381068 DOI: 10.1002/hep.24283]
    • (2011) Hepatology , vol.53 , pp. 1883-1894
    • Sookoian, S.1    Pirola, C.J.2
  • 11
    • 84955203053 scopus 로고    scopus 로고
    • The dual and opposite role of the TM6SF2- rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis
    • PMID: 26331730
    • Pirola CJ, Sookoian S. The dual and opposite role of the TM6SF2- rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis. Hepatology 2015;62: 1742-1756 [PMID: 26331730 DOI: 10.1002/ hep.28142]
    • (2015) Hepatology , vol.62 , pp. 1742-1756
    • Pirola, C.J.1    Sookoian, S.2
  • 14
    • 84921485234 scopus 로고    scopus 로고
    • Liver enzymes, metabolomics and genomewide association studies: From systems biology to the personalized medicine
    • PMID: 25624707
    • Sookoian S, Pirola CJ. Liver enzymes, metabolomics and genomewide association studies: from systems biology to the personalized medicine. World J Gastroenterol 2015;21: 711-725 [PMID: 25624707 DOI: 10.3748/wjg.v21.i3.711]
    • (2015) World J Gastroenterol , vol.21 , pp. 711-725
    • Sookoian, S.1    Pirola, C.J.2
  • 15
    • 84921528716 scopus 로고    scopus 로고
    • Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
    • PMID: 25302781
    • Sookoian S, Castaño GO, Scian R, Mallardi P, Fernández Gianotti T, Burgueño AL, San Martino J, Pirola CJ. Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity. Hepatology 2015;61: 515-525 [PMID: 25302781 DOI: 10.1002/ hep.27556]
    • (2015) Hepatology , vol.61 , pp. 515-525
    • Sookoian, S.1    Castaño, G.O.2    Scian, R.3    Mallardi, P.4    Fernández Gianotti, T.5    Burgueño, A.L.6    San Martino, J.7    Pirola, C.J.8
  • 17
    • 84900417152 scopus 로고    scopus 로고
    • A 4-polymorphism risk score predicts steatohepatitis in children with nonalcoholic fatty liver disease
    • PMID: 24345846
    • Nobili V, Donati B, Panera N, Vongsakulyanon A, Alisi A, Dallapiccola B, Valenti L. A 4-polymorphism risk score predicts steatohepatitis in children with nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2014;58: 632-636 [PMID: 24345846 DOI: 10.1097/MPG.0000000000000279]
    • (2014) J Pediatr Gastroenterol Nutr , vol.58 , pp. 632-636
    • Nobili, V.1    Donati, B.2    Panera, N.3    Vongsakulyanon, A.4    Alisi, A.5    Dallapiccola, B.6    Valenti, L.7
  • 23
    • 78649568544 scopus 로고    scopus 로고
    • Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter
    • PMID: 20890895
    • Sookoian S, Rosselli MS, Gemma C, Burgueño AL, Fernández Gianotti T, Castaño GO, Pirola CJ. Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter. Hepatology 2010;52: 1992-2000 [PMID: 20890895 DOI: 10.1002/hep.23927]
    • (2010) Hepatology , vol.52 , pp. 1992-2000
    • Sookoian, S.1    Rosselli, M.S.2    Gemma, C.3    Burgueño, A.L.4    Fernández Gianotti, T.5    Castaño, G.O.6    Pirola, C.J.7
  • 26
    • 85031278345 scopus 로고    scopus 로고
    • Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study
    • PMID: 29028809
    • Zhang X, Biagini Myers JM, Yadagiri VK, Ulm A, Chen X, Weirauch MT, Khurana Hershey GK, Ji H. Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study. PLoS One 2017;12: e0186150 [PMID: 29028809 DOI: 10.1371/journal.pone.0186150]
    • (2017) PLoS One , vol.12 , pp. e0186150
    • Zhang, X.1    Biagini Myers, J.M.2    Yadagiri, V.K.3    Ulm, A.4    Chen, X.5    Weirauch, M.T.6    Khurana Hershey, G.K.7    Ji, H.8
  • 28
    • 79952749156 scopus 로고    scopus 로고
    • DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
    • PMID: 21321201
    • Shock LS, Thakkar PV, Peterson EJ, Moran RG, Taylor SM. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A 2011;108: 3630-3635 [PMID: 21321201 DOI: 10.1073/ pnas.1012311108]
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3630-3635
    • Shock, L.S.1    Thakkar, P.V.2    Peterson, E.J.3    Moran, R.G.4    Taylor, S.M.5
  • 29
    • 84881546730 scopus 로고    scopus 로고
    • Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease
    • PMID: 22879518
    • Pirola CJ, Gianotti TF, Burgueño AL, Rey-Funes M, Loidl CF, Mallardi P, Martino JS, Castaño GO, Sookoian S. Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease. Gut 2013;62: 1356-1363 [PMID: 22879518 DOI: 10.1136/gutjnl-2012-302962]
    • (2013) Gut , vol.62 , pp. 1356-1363
    • Pirola, C.J.1    Gianotti, T.F.2    Burgueño, A.L.3    Rey-Funes, M.4    Loidl, C.F.5    Mallardi, P.6    Martino, J.S.7    Castaño, G.O.8    Sookoian, S.9
  • 33
    • 85032744406 scopus 로고    scopus 로고
    • Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: A gap between innovation and implementation
    • PMID: 28503559
    • Sookoian S, Pirola CJ. Cell-free DNA methylation as liquid biopsy for the assessment of fibrosis in patients with nonalcoholic steatohepatitis: a gap between innovation and implementation. Hepatobiliary Surg Nutr 2017;6: 117-121 [PMID: 28503559 DOI: 10.21037/hbsn.2017.01.07]
    • (2017) Hepatobiliary Surg Nutr , vol.6 , pp. 117-121
    • Sookoian, S.1    Pirola, C.J.2
  • 34
    • 84956550206 scopus 로고    scopus 로고
    • Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis
    • PMID: 26565986
    • Becker PP, Rau M, Schmitt J, Malsch C, Hammer C, Bantel H, Müllhaupt B, Geier A. Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis. PLoS One 2015;10: e0142661 [PMID: 26565986 DOI: 10.1371/journal.pone.0142661]
    • (2015) PLoS One , vol.10 , pp. e0142661
    • Becker, P.P.1    Rau, M.2    Schmitt, J.3    Malsch, C.4    Hammer, C.5    Bantel, H.6    Müllhaupt, B.7    Geier, A.8
  • 35
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • PMID: 21886843
    • Cermelli S, Ruggieri A, Marrero JA, Ioannou GN, Beretta L. Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 2011;6: e23937 [PMID: 21886843 DOI: 10.1371/journal.pone.0023937]
    • (2011) PLoS One , vol.6 , pp. e23937
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 37
    • 84907853062 scopus 로고    scopus 로고
    • A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease
    • PMID: 25141008
    • Tan Y, Ge G, Pan T, Wen D, Gan J. A pilot study of serum microRNAs panel as potential biomarkers for diagnosis of nonalcoholic fatty liver disease. PLoS One 2014;9: e105192 [PMID: 25141008 DOI: 10.1371/journal.pone.0105192]
    • (2014) PLoS One , vol.9 , pp. e105192
    • Tan, Y.1    Ge, G.2    Pan, T.3    Wen, D.4    Gan, J.5
  • 39
    • 63949086512 scopus 로고    scopus 로고
    • A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem
    • PMID: 19071103
    • Sookoian S, Castaño G, Burgueño AL, Gianotti TF, Rosselli MS, Pirola CJ. A diagnostic model to differentiate simple steatosis from nonalcoholic steatohepatitis based on the likelihood ratio form of Bayes theorem. Clin Biochem 2009;42: 624-629 [PMID: 19071103 DOI: 10.1016/j.clinbiochem.2008.11.005]
    • (2009) Clin Biochem , vol.42 , pp. 624-629
    • Sookoian, S.1    Castaño, G.2    Burgueño, A.L.3    Gianotti, T.F.4    Rosselli, M.S.5    Pirola, C.J.6
  • 42
    • 85020295837 scopus 로고    scopus 로고
    • A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis
    • PMID: 28589339
    • Okanoue T, Ebise H, Kai T, Mizuno M, Shima T, Ichihara J, Aoki M. A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis. J Gastroenterol 2018;53: 129-139 [PMID: 28589339 DOI: 10.1007/s00535-017-1355-9]
    • (2018) J Gastroenterol , vol.53 , pp. 129-139
    • Okanoue, T.1    Ebise, H.2    Kai, T.3    Mizuno, M.4    Shima, T.5    Ichihara, J.6    Aoki, M.7
  • 43
    • 84872133663 scopus 로고    scopus 로고
    • Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease
    • PMID: 22930399
    • Tanwar S, Trembling PM, Guha IN, Parkes J, Kaye P, Burt AD, Ryder SD, Aithal GP, Day CP, Rosenberg WM. Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. Hepatology 2013;57: 103-111 [PMID: 22930399 DOI: 10.1002/hep.26030]
    • (2013) Hepatology , vol.57 , pp. 103-111
    • Tanwar, S.1    Trembling, P.M.2    Guha, I.N.3    Parkes, J.4    Kaye, P.5    Burt, A.D.6    Ryder, S.D.7    Aithal, G.P.8    Day, C.P.9    Rosenberg, W.M.10
  • 44
    • 84934438045 scopus 로고    scopus 로고
    • Proteomics analysis of human nonalcoholic fatty liver
    • PMID: 22903720
    • Rodriguez-Suarez E, Mato JM, Elortza F. Proteomics analysis of human nonalcoholic fatty liver. Methods Mol Biol 2012;909: 241-258 [PMID: 22903720 DOI: 10.1007/978-1-61779-959-4-16]
    • (2012) Methods Mol Biol , vol.909 , pp. 241-258
    • Rodriguez-Suarez, E.1    Mato, J.M.2    Elortza, F.3
  • 46
    • 72449172087 scopus 로고    scopus 로고
    • Proteomic analysis of serum in patients with non-alcoholic steatohepatitis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    • PMID: 19883279
    • Ulukaya E, Yilmaz Y, Moshkovskii S, Karpova M, Pyatnitskiy M, Atug O, Dolar E. Proteomic analysis of serum in patients with non-alcoholic steatohepatitis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Scand J Gastroenterol 2009;44: 1471-1476 [PMID: 19883279 DOI: 10.3109/003655209 03353379]
    • (2009) Scand J Gastroenterol , vol.44 , pp. 1471-1476
    • Ulukaya, E.1    Yilmaz, Y.2    Moshkovskii, S.3    Karpova, M.4    Pyatnitskiy, M.5    Atug, O.6    Dolar, E.7
  • 51
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • PMID: 22152305
    • Sunny NE, Parks EJ, Browning JD, Burgess SC. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab 2011;14: 804-810 [PMID: 22152305 DOI: 10.1016/j.cmet.2011.11.004]
    • (2011) Cell Metab , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 55
    • 84898015383 scopus 로고    scopus 로고
    • NAFLD. Metabolic make-up of NASH: From fat and sugar to amino acids
    • PMID: 24566880
    • Sookoian S, Pirola CJ. NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids. Nat Rev Gastroenterol Hepatol 2014;11: 205-207 [PMID: 24566880 DOI: 10.1038/nrgastro.2014.25]
    • (2014) Nat Rev Gastroenterol Hepatol , vol.11 , pp. 205-207
    • Sookoian, S.1    Pirola, C.J.2
  • 56
    • 85041241825 scopus 로고    scopus 로고
    • The nonalcoholic steatohepatitis metabotype: Imbalance of circulating amino acids and transamination reactions reflect impaired mitochondrial function
    • PMID: 29205411
    • Sookoian S, Pirola CJ. The nonalcoholic steatohepatitis metabotype: Imbalance of circulating amino acids and transamination reactions reflect impaired mitochondrial function. Hepatology 2018;67: 1177-1178 [PMID: 29205411 DOI: 10.1002/hep.29705]
    • (2018) Hepatology , vol.67 , pp. 1177-1178
    • Sookoian, S.1    Pirola, C.J.2
  • 59
    • 84903625185 scopus 로고    scopus 로고
    • Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
    • PMID: 24763554
    • Min HK, Sookoian S, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ. Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells. Am J Physiol Gastrointest Liver Physiol 2014;307: G66-G76 [PMID: 24763554 DOI: 10.1152/ajpgi.00335.2013]
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , pp. G66-G76
    • Min, H.K.1    Sookoian, S.2    Pirola, C.J.3    Cheng, J.4    Mirshahi, F.5    Sanyal, A.J.6
  • 60
    • 84994853514 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency
    • PMID: 27614103
    • Sookoian S, Puri P, Castaño GO, Scian R, Mirshahi F, Sanyal AJ, Pirola CJ. Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency. Liver Int 2017;37: 611-619 [PMID: 27614103 DOI: 10.1111/liv.13249]
    • (2017) Liver Int , vol.37 , pp. 611-619
    • Sookoian, S.1    Puri, P.2    Castaño, G.O.3    Scian, R.4    Mirshahi, F.5    Sanyal, A.J.6    Pirola, C.J.7
  • 61
    • 85011275765 scopus 로고    scopus 로고
    • Metabox: A Toolbox for Metabolomic Data Analysis, Interpretation and Integrative Exploration
    • [PMID: 28141874]
    • Wanichthanarak K, Fan S, Grapov D, Barupal DK, Fiehn O. Metabox: A Toolbox for Metabolomic Data Analysis, Interpretation and Integrative Exploration. PLoS One 2017;12: e0171046 [PMID: 28141874]
    • (2017) PLoS One , vol.12 , pp. e0171046
    • Wanichthanarak, K.1    Fan, S.2    Grapov, D.3    Barupal, D.K.4    Fiehn, O.5
  • 62
    • 84941365835 scopus 로고    scopus 로고
    • Genomic, Proteomic, and Metabolomic Data Integration Strategies
    • PMID: 26396492
    • Wanichthanarak K, Fahrmann JF, Grapov D. Genomic, Proteomic, and Metabolomic Data Integration Strategies. Biomark Insights 2015;10: 1-6 [PMID: 26396492 DOI: 10.4137/BMI.S29511]
    • (2015) Biomark Insights , vol.10 , pp. 1-6
    • Wanichthanarak, K.1    Fahrmann, J.F.2    Grapov, D.3
  • 64
    • 84874851698 scopus 로고    scopus 로고
    • Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease
    • [PMID: 23516571]
    • Sookoian S, Pirola CJ. Systems biology elucidates common pathogenic mechanisms between nonalcoholic and alcoholic-fatty liver disease. PLoS One 2013;8: e58895 [PMID: 23516571]
    • (2013) PLoS One , vol.8 , pp. e58895
    • Sookoian, S.1    Pirola, C.J.2
  • 65
    • 85020192349 scopus 로고    scopus 로고
    • Analysis of metabolomic data: Tools, current strategies and future challenges for omics data integration
    • [PMID: 27075479]
    • Cambiaghi A, Ferrario M, Masseroli M. Analysis of metabolomic data: tools, current strategies and future challenges for omics data integration. Brief Bioinform 2017;18: 498-510 [PMID: 27075479]
    • (2017) Brief Bioinform , vol.18 , pp. 498-510
    • Cambiaghi, A.1    Ferrario, M.2    Masseroli, M.3
  • 66
    • 84890597306 scopus 로고    scopus 로고
    • Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease
    • PMID: 24211299
    • Dumas ME, Kinross J, Nicholson JK. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology 2014;146: 46-62 [PMID: 24211299 DOI: 10.1053/j.gastro.2013.11.001]
    • (2014) Gastroenterology , vol.146 , pp. 46-62
    • Dumas, M.E.1    Kinross, J.2    Nicholson, J.K.3
  • 67
    • 80053976986 scopus 로고    scopus 로고
    • Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA
    • PMID: 21893519
    • Kamburov A, Cavill R, Ebbels TM, Herwig R, Keun HC. Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA. Bioinformatics 2011;27: 2917-2918 [PMID: 21893519 DOI: 10.1093/bioinformatics/btr499]
    • (2011) Bioinformatics , vol.27 , pp. 2917-2918
    • Kamburov, A.1    Cavill, R.2    Ebbels, T.M.3    Herwig, R.4    Keun, H.C.5
  • 69
    • 84979865433 scopus 로고    scopus 로고
    • MetaboAnalyst 3.0-making metabolomics more meaningful
    • PMID: 25897128
    • Xia J, Sinelnikov IV, Han B, Wishart DS. MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Res 2015;43: W251-W257 [PMID: 25897128 DOI: 10.1093/nar/ gkv380]
    • (2015) Nucleic Acids Res , vol.43 , pp. W251-W257
    • Xia, J.1    Sinelnikov, I.V.2    Han, B.3    Wishart, D.S.4
  • 70
    • 85029425714 scopus 로고    scopus 로고
    • Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis
    • PMID: 27603023
    • Xia J, Wishart DS. Using MetaboAnalyst 3.0 for Comprehensive Metabolomics Data Analysis. Curr Protoc Bioinformatics 2016;55: 14.10.1-14.10.91 [PMID: 27603023 DOI: 10.1002/cpbi.11]
    • (2016) Curr Protoc Bioinformatics , vol.55 , pp. 14101-141091
    • Xia, J.1    Wishart, D.S.2
  • 71
    • 84863502669 scopus 로고    scopus 로고
    • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    • PMID: 22290395
    • Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 2012;56: 118-129 [PMID: 22290395 DOI: 10.1002/hep.25630]
    • (2012) Hepatology , vol.56 , pp. 118-129
    • Tanaka, N.1    Matsubara, T.2    Krausz, K.W.3    Patterson, A.D.4    Gonzalez, F.J.5
  • 72
    • 84936888336 scopus 로고    scopus 로고
    • Is there a role for adaptive immunity in nonalcoholic steatohepatitis?
    • PMID: 26167244
    • Sutti S, Jindal A, Bruzzì S, Locatelli I, Bozzola C, Albano E. Is there a role for adaptive immunity in nonalcoholic steatohepatitis? World J Hepatol 2015;7: 1725-1729 [PMID: 26167244 DOI: 10.4254/wjh.v7.i13.1725]
    • (2015) World J Hepatol , vol.7 , pp. 1725-1729
    • Sutti, S.1    Jindal, A.2    Bruzzì, S.3    Locatelli, I.4    Bozzola, C.5    Albano, E.6
  • 74


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.