Proteomics analysis of human nonalcoholic fatty liver

Methods in Molecular Biology

Volumn 909, Issue , 2012, Pages 241-258

  Rodriguez Suarez, Eva ^a   Mato, Jose M ^b   Elortza, Felix ^a  

^a CIC BIOGUNE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

DIGE; Liver proteomics; MALDI TOF TOF; NAFLD; Western blot

Indexed keywords

CARBAMOYL PHOSPHATE SYNTHASE; GLUCOSE REGULATED PROTEIN 78;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIFFERENTIAL IN GEL ELECTROPHORESIS; ELECTROPHORESIS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; STEATOSIS; TISSUE HOMOGENATE; WESTERN BLOTTING;

EID: 84934438045     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-959-4_16     Document Type: Article

References (26)

1. Marchesini G, Bugianesi E, Forlani G et al (2003) Nonalcoholic fatty liver, steatohepati-tis, and the metabolic syndrome. Hepatology 37:917-923
2. Reid AE (2001) Nonalcoholic steatohepatitis. Gastroenterology 121:710-723
3. Starley BQ, Calcagno CJ, Harrison SA (2010) Nonalcoholic fatty liver disease and hepatocel-lular carcinoma: a weighty connection. Hepatology 51:1820-1832
4. Clark JM, Diehl AM (2002) Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep 2:210-215
5. Yki-Jarvinen H (2010) Liver fat in the patho-genesis of insulin resistance and type 2 diabetes. Dig Dis 28:203-209
6. Adams LA, Lindor KD (2007) Nonalcoholic fatty liver disease. Ann Epidemiol 17: 863-869
7. Angulo P (2007) Obesity and nonalcoholic fatty liver disease. Nutr Rev 65:S57-S63
8. Charlton M, Viker K, Krishnan A et al (2009) Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. Hepatology 49:1375-1384
9. Rubio A, Guruceaga E, Vazquez-Chantada M et al (2007) Identi fication of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol 46:708-718
10. Imbert-Bismut F, Ratziu V, Pieroni L et al (2001) Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study. Lancet 357:1069-1075
11. Poordad FF (2004) FIBROSpect II: a potential noninvasive test to assess hepatic fibrosis. Expert Rev Mol Diagn 4:593-597
12. Vanderschaeghe D, Laroy W, Sablon E et al (2009) GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics. Mol Cell Proteomics 8:986-994
13. Gorg A, Weiss W, Dunn MJ (2004) Current two-dimensional electrophoresis technology for proteomics. Proteomics 4:3665-3685
14. Ding SJ, Li Y, Shao XX et al (2004) Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. Proteomics 4:982-994
15. Douette P, Navet R, Gerkens P et al (2005) Steatosis-induced proteomic changes in liver mitochondria evidenced by two-dimensional differential in-gel electrophoresis. J Proteome Res 4:2024-2031
16. Gray J, Chattopadhyay D, Beale GS et al (2009) A proteomic strategy to identify novel serum biomarkers for liver cirrhosis and hepatocellu-lar cancer in individuals with fatty liver disease. BMC Cancer 9:271
17. Lee IN, Chen CH, Sheu JC et al (2005) Identi fication of human hepatocellular carcinoma-related biomarkers by two-dimensional difference gel electrophoresis and mass spec-trometry. J Proteome Res 4:2062-2069
18. Santamaria E, Avila MA, Latasa MU et al (2003) Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci USA 100:3065-3070
19. Meneses-Lorente G, Guest PC, Lawrence J et al (2004) A proteomic investigation of drug-induced steatosis in rat liver. Chem Res Toxicol 17:605-612
20. Orimo T, Ojima H, Hiraoka N et al (2008) Proteomic pro filing reveals the prognostic value of adenomatous polyposis coli-end-bind-ing protein 1 in hepatocellular carcinoma. Hepatology 48:1851-1863
21. Santamaria E, Munoz J, Fernandez-Irigoyen J et al (2006) Molecular pro filing of hepatocellular carcinoma in mice with a chronic de ficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. J Proteome Res 5:944-953
22. Rodriguez-Suarez E, Duce AM, Caballeria J et al (2010) Non-alcoholic fatty liver disease proteomics. Proteomics Clin Appl 4:362-371
23. Gharbi S, Gaffney P, Yang A et al (2002) Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system. Mol Cell Proteomics 1:91-98
24. Alban A, David SO, Bjorkesten L et al (2003) A novel experimental design for comparative two-dimensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 3:36-44
25. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
26. Gobom J, Nordhoff E, Mirgorodskaya E et al (1999) Sample puri fication and preparation technique based on nano-scale reversed-phase columns for the sensitive analysis of complex peptide mixtures by matrix-assisted laser des-orption/ionization mass spectrometry. J Mass Spectrom 34:105-116