Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 307, Issue 1, 2014, Pages

  Min, Hae Ki ^a   Sookoian, Silvia ^b   Pirola, Carlos J ^b   Cheng, Jianfeng ^a   Mirshahi, Faridoddin ^a   Sanyal, Arun J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Huh 7 cells; Ile148Met variant; Metabolome; Nonalcoholic fatty liver disease; PNPLA3; Systems biology

Indexed keywords

AMINO ACID; CYSTEINE SULFINIC ACID; DIPEPTIDE; INOSITOL; LACTIC ACID; LIPID; LYSOLIPID; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3; PHOSPHOLIPASE; POLYUNSATURATED FATTY ACID; SMALL INTERFERING RNA; SPHINGOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANAEROBIC METABOLISM; ARTICLE; CODON; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC VARIABILITY; HEPATOMA CELL; HUH7 CELL LINE; HUMAN; HUMAN CELL; LIVER METABOLISM; METABOLOMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; WILD TYPE;

HUH-7 CELLS; ILE148MET VARIANT; METABOLOME; NONALCOHOLIC FATTY LIVER DISEASE; PNPLA3; SYSTEMS BIOLOGY;

BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIPASE; LIVER NEOPLASMS; MEMBRANE PROTEINS; METABOLOMICS; MUTATION; OSMOTIC PRESSURE; RNA INTERFERENCE; SYSTEMS BIOLOGY; TANDEM MASS SPECTROMETRY; TRANSFECTION; TRIGLYCERIDES;

EID: 84903625185     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00335.2013     Document Type: Article

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