AMPKa2 protects against the development of heart failure by enhancing mitophagy via PINK1 phosphorylation

Circulation Research

Volumn 122, Issue 5, 2018, Pages 712-729

  Wang, Bei ^a,b   Nie, Jiali ^a,b   Wu, Lujin ^a,b   Hu, Yangyang ^a   Wen, Zheng ^a,b   Dong, Lingli ^a   Zou, Ming Hui ^c,d   Chen, Chen ^a,b   Wang, Dao Wen ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Autophagy; Constriction; Heart failure; Mice; Mitochondria

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; ALANINE; AMP ACTIVATED PROTEIN KINASE 1; AMP ACTIVATED PROTEIN KINASE 2; ASPARTIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOENZYME; PARKIN; PHENYLEPHRINE; PHOSPHOTRANSFERASE; PTEN INDUCED PUTATIVE KINASE 1; REACTIVE OXYGEN METABOLITE; SEQUESTOSOME 1; SERINE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; AMP-ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE;

ADENO ASSOCIATED VIRUS 9; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC CONSTRICTION; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CARDIAC MUSCLE CELL; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME PHOSPHORYLATION; GENE KNOCKDOWN; GENE MUTATION; GENE OVEREXPRESSION; HEART FAILURE; HEART PROTECTION; HUMAN; HUMAN TISSUE; MALE; MITOPHAGY; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SELECTIVE AUTOPHAGY; VIRUS RECOMBINANT; ANIMAL; CELL CULTURE; GENETICS; HEART MITOCHONDRION; METABOLISM; PHOSPHORYLATION;

ANIMALS; CELLS, CULTURED; HEART FAILURE; HUMANS; ISOENZYMES; MICE; MITOCHONDRIA, HEART; MITOCHONDRIAL DEGRADATION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN KINASES;

EID: 85045707007     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.312317     Document Type: Article

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