Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

Nature Communications

Volumn 9, Issue 1, 2018, Pages

  Joas, Simone ^a   Parrish, Erica H ^b,i   Gnanadurai, Clement W ^a,j   Lump, Edina ^a   Stürzel, Christina M ^a   Parrish, Nicholas F ^b,k   Learn, Gerald H ^b   Sauermann, Ulrike ^c   Neumann, Berit ^c   Rensing, Kerstin Mätz ^c   Fuchs, Dietmar ^d   Billingsley, James M ^e   Bosinger, Steven E ^e   Silvestri, Guido ^e   Apetrei, Cristian ^f   Huot, Nicolas ^g,h   Garcia Tellez, Thalia ^g   Müller Trutwin, Michaela ^g   Hotter, Dominik ^a   Sauter, Daniel ^a   Stahl Hennig, Christiane ^c   Hahn, Beatrice H ^b   Kirchhoff, Frank ^a   more..

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c GERMAN PRIMATE CENTER   (Germany)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e EMORY UNIVERSITY   (United States)

^f UNIVERSITY OF PITTSBURGH   (United States)

^g INSTITUT PASTEUR   (France)

^h HENRI MONDOR HOSPITAL   (France)

ⁱ VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF GEORGIA   (United States)

^k VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW STROMAL ANTIGEN 2; CD3 ANTIGEN; HOST FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; NEF PROTEIN; VPU PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRAL PROTEIN; VPU PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

CELL; HOST; IMMUNE RESPONSE; PATHOGENICITY; PRIMATE; PROTEIN; VIRULENCE; VIRUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CHLOROCEBUS AETHIOPS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; GENETIC TRANSCRIPTION; HEK293T CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOREACTIVITY; INFLAMMATION; LENTIVIRUS; NONHUMAN; PATHOGENICITY; PRIMATE; PROTEIN FUNCTION; SIMIAN IMMUNODEFICIENCY VIRUS; SPECIES; T LYMPHOCYTE ACTIVATION; VIREMIA; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; AMINO ACID SEQUENCE; ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HOST RANGE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PRIMATE LENTIVIRUS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; VIRULENCE; VIRUS LOAD;

CERCOPITHECUS AETHIOPS; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMATES; SIMIAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW STROMAL ANTIGEN 2; CD3 COMPLEX; CERCOPITHECUS AETHIOPS; FEMALE; GENE EXPRESSION REGULATION; HIV-1; HOST SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; LENTIVIRUSES, PRIMATE; LYMPHOCYTE ACTIVATION; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; NF-KAPPA B; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SIMIAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION, GENETIC; VIRAL LOAD; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRULENCE; VIRUS REPLICATION;

EID: 85045331504     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-018-03762-3     Document Type: Article

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