Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR

Archives of Toxicology

Volumn 84, Issue 10, 2010, Pages 787-798

  Elcombe, Clifford R ^a   Elcombe, Barbara M ^a   Foster, John R ^b   Farrar, David G ^c   Jung, Reinhard ^d   Chang, Shu Ching ^e   Kennedy, Gerald L ^f   Butenhoff, John L ^e  

^a CXR Biosciences Ltd   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c Ineos Manufacturing Scotland Limited   (United Kingdom)

^d CLARIANT PRODUKTE DEUTSCHLAND GMBH   (Germany)

^e 3M   (United States)

^f DUPONT COMPANY   (United States)

Author keywords

Ammonium perfluorooctanoate; CAR; Hepatomegaly; PFOA; PPAR ; PXR

Indexed keywords

BROXURIDINE; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; CYTOCHROME P450 4A1; GLYCOGEN; PERFLUOROOCTANOIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIRINIXIC ACID; PREGNANE X RECEPTOR; CELL RECEPTOR; CYTOCHROME P450; DNA; FLUOROCARBON; OCTANOIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; POLLUTANT; STEROID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LABELING; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID OXIDATION; GLYCOGEN LIVER LEVEL; HEPATOMEGALY; HYPOLIPEMIA; LIVER CARCINOGENESIS; LIVER HYPERPLASIA; LIVER HYPERTROPHY; LONG TERM EXPOSURE; MALE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; HYPERTROPHY; LIVER; LIVER CELL; METABOLISM; ORGAN SIZE; PATHOLOGY; POLLUTANT; TOXICITY;

ANIMALS; APOPTOSIS; BODY WEIGHT; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; DNA; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; HEPATOCYTES; HEPATOMEGALY; HYPERTROPHY; LIVER; MALE; OCTANOIC ACIDS; ORGAN SIZE; PEROXISOMES; PPAR ALPHA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; CAPRYLATES;

MUS; RATTUS; RODENTIA;

EID: 77957803158     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0572-2     Document Type: Article

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