Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis

Nature

Volumn 556, Issue 7699, 2018, Pages 122-125

  Scapin, Giovanna ^a   Dandey, Venkata P ^b   Zhang, Zhening ^b   Prosise, Winifred ^a   Hruza, Alan ^a   Kelly, Theresa ^a   Mayhood, Todd ^a   Strickland, Corey ^a   Potter, Clinton S ^b   Carragher, Bridget ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; FIBRONECTIN TYPE III; INSULIN RECEPTOR; PROTEIN TYROSINE KINASE; RECOMBINANT HUMAN INSULIN; UNCLASSIFIED DRUG; APOPROTEIN; INSULIN;

BIOCHEMICAL COMPOSITION; BRAIN; CANCER; DIABETES; ENZYME; ENZYME ACTIVITY; GLUCOSE; HOMEOSTASIS; PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; COMPETITIVE BINDING ASSAY; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; GLYCOSYLATION; HUMAN; INCUBATION TIME; INSULIN BINDING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; CHEMISTRY; METABOLISM; MOLECULAR MODEL; PROTEIN MULTIMERIZATION; SINGLE MOLECULE IMAGING; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

APOPROTEINS; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SINGLE MOLECULE IMAGING;

EID: 85045130403     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature26153     Document Type: Article

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