The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

BioEssays

Volumn 35, Issue 11, 2013, Pages 945-954

  Ward, Colin W ^a   Menting, John G ^a   Lawrence, Michael C ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Crystal structure; Insulin; Insulin receptor; Insulin like growth factor; Negative cooperativity; Signaling mechanism; Type 1 insulin like growth factor receptor

Indexed keywords

DISULFIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; HOMODIMER; INSULIN RECEPTOR; PIG INSULIN;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CELL INTERACTION; CONFORMATIONAL TRANSITION; CROSS LINKING; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DISULFIDE BOND; ELECTRON MICROSCOPY; ENZYME ACTIVE SITE; HUMAN; INSULIN BINDING; LIGAND BINDING; OBSERVATIONAL STUDY; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE; INSULIN; INSULIN RECEPTOR; INSULIN-LIKE GROWTH FACTOR; NEGATIVE COOPERATIVITY; SIGNALING MECHANISM; TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR;

BINDING SITES; HUMANS; INSULIN; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION;

EID: 84885378451     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201300065     Document Type: Article

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