-
1
-
-
77049183641
-
Subdivision of hexagonal liver lobules into a structural and functional unit; Role in hepatic physiology and pathology
-
Rappaport AM, Borowy ZJ, Lougheed WM, Lotto WN. Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology. Anat Rec 1954; 119: 11-33.
-
(1954)
Anat Rec
, vol.119
, pp. 11-33
-
-
Rappaport, A.M.1
Borowy, Z.J.2
Lougheed, W.M.3
Lotto, W.N.4
-
2
-
-
0033960898
-
Oxygen: Modulator of metabolic zonation and disease of the liver
-
Jungermann K, Kietzmann T. Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology 2000; 31: 255-260.
-
(2000)
Hepatology
, vol.31
, pp. 255-260
-
-
Jungermann, K.1
Kietzmann, T.2
-
3
-
-
0017143908
-
The microcirculatory acinar concept of normal and pathological hepatic structure
-
Rappaport AM. The microcirculatory acinar concept of normal and pathological hepatic structure. Beitr Pathol 1976; 157: 215-243.
-
(1976)
Beitr Pathol
, vol.157
, pp. 215-243
-
-
Rappaport, A.M.1
-
5
-
-
0024226701
-
Metabolic zonation of liver parenchyma
-
Jungermann K. Metabolic zonation of liver parenchyma. Semin Liver Dis 1988; 8: 329-341.
-
(1988)
Semin Liver Dis
, vol.8
, pp. 329-341
-
-
Jungermann, K.1
-
6
-
-
66449086571
-
Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism
-
e2311-2313
-
Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, Tosh D. Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology 2009; 136: 2316-2324 e2311-2313.
-
(2009)
Gastroenterology
, vol.136
, pp. 2316-2324
-
-
Burke, Z.D.1
Reed, K.R.2
Phesse, T.J.3
Sansom, O.J.4
Clarke, A.R.5
Tosh, D.6
-
7
-
-
84873712443
-
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
-
Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 2013; 494: 247-250.
-
(2013)
Nature
, vol.494
, pp. 247-250
-
-
Huch, M.1
Dorrell, C.2
Boj, S.F.3
Van-Es, J.H.4
Li, V.S.5
Van-De-Wetering, M.6
-
8
-
-
84939490816
-
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver
-
Wang B, Zhao L, Fish M, Logan CY, Nusse R. Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature 2015; 524: 180-185.
-
(2015)
Nature
, vol.524
, pp. 180-185
-
-
Wang, B.1
Zhao, L.2
Fish, M.3
Logan, C.Y.4
Nusse, R.5
-
9
-
-
84907487414
-
Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
-
Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 2014; 346: 1248012.
-
(2014)
Science
, vol.346
, pp. 1248012
-
-
Clevers, H.1
Loh, K.M.2
Nusse, R.3
-
10
-
-
84870252814
-
The complex world of WNT receptor signalling
-
Niehrs C. The complex world of WNT receptor signalling. Nat Rev Mol Cell Biol 2012; 13: 767-779.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 767-779
-
-
Niehrs, C.1
-
11
-
-
33744495398
-
Apc tumor suppressor gene is the 'zonation-keeper' of mouse liver
-
Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C et al. Apc tumor suppressor gene is the 'zonation-keeper' of mouse liver. Dev Cell 2006; 10: 759-770.
-
(2006)
Dev Cell
, vol.10
, pp. 759-770
-
-
Benhamouche, S.1
Decaens, T.2
Godard, C.3
Chambrey, R.4
Rickman, D.S.5
Moinard, C.6
-
12
-
-
84856191525
-
Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers
-
White BD, Chien AJ, Dawson DW. Dysregulation of Wnt/beta-catenin signaling in gastrointestinal cancers. Gastroenterology 2012; 142: 219-232.
-
(2012)
Gastroenterology
, vol.142
, pp. 219-232
-
-
White, B.D.1
Chien, A.J.2
Dawson, D.W.3
-
13
-
-
77949481052
-
Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments
-
Bullard JH, Purdom E, Hansen KD, Dudoit S. Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments. BMC Bioinformatics 2010; 11: 94.
-
(2010)
BMC Bioinformatics
, vol.11
, pp. 94
-
-
Bullard, J.H.1
Purdom, E.2
Hansen, K.D.3
Dudoit, S.4
-
14
-
-
0033972791
-
The balance sheet for transcription: An analysis of nuclear RNA metabolism in mammalian cells
-
Jackson DA, Pombo A, Iborra F. The balance sheet for transcription: an analysis of nuclear RNA metabolism in mammalian cells. FASEB J 2000; 14: 242-254.
-
(2000)
FASEB J
, vol.14
, pp. 242-254
-
-
Jackson, D.A.1
Pombo, A.2
Iborra, F.3
-
15
-
-
38749146900
-
TLRdependent cross talk between human Kupffer cells and NK cells
-
Tu Z, Bozorgzadeh A, Pierce RH, Kurtis J, Crispe IN, Orloff MS. TLRdependent cross talk between human Kupffer cells and NK cells. J Exp Med 2008; 205: 233-244.
-
(2008)
J Exp Med
, vol.205
, pp. 233-244
-
-
Tu, Z.1
Bozorgzadeh, A.2
Pierce, R.H.3
Kurtis, J.4
Crispe, I.N.5
Orloff, M.S.6
-
16
-
-
2642582621
-
Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway
-
Maye P, Zheng J, Li L, Wu D. Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem 2004; 279: 24659-24665.
-
(2004)
J Biol Chem
, vol.279
, pp. 24659-24665
-
-
Maye, P.1
Zheng, J.2
Li, L.3
Wu, D.4
-
17
-
-
84947460888
-
The angiocrine factor rspondin3 is a key determinant of liver zonation
-
Rocha AS, Vidal V, Mertz M, Kendall TJ, Charlet A, Okamoto H et al. The angiocrine factor rspondin3 is a key determinant of liver zonation. Cell Rep 2015; 13: 1757-1764.
-
(2015)
Cell Rep
, vol.13
, pp. 1757-1764
-
-
Rocha, A.S.1
Vidal, V.2
Mertz, M.3
Kendall, T.J.4
Charlet, A.5
Okamoto, H.6
-
18
-
-
85018214963
-
Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium
-
Oshida K, Vasani N, Jones C, Moore T, Hester S, Nesnow S et al. Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal 2015; 13: e002.
-
(2015)
Nucl Recept Signal
, vol.13
, pp. e002
-
-
Oshida, K.1
Vasani, N.2
Jones, C.3
Moore, T.4
Hester, S.5
Nesnow, S.6
-
19
-
-
84958034198
-
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1alpha regulates cell proliferation, migration and invasion
-
Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1alpha regulates cell proliferation, migration and invasion. Sci Rep 2016; 6: 21520.
-
(2016)
Sci Rep
, vol.6
, pp. 21520
-
-
Mori, H.1
Yao, Y.2
Learman, B.S.3
Kurozumi, K.4
Ishida, J.5
Ramakrishnan, S.K.6
-
20
-
-
0019809984
-
Modulation of the glucagondependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures
-
Nauck M, Wolfle D, Katz N, Jungermann K. Modulation of the glucagondependent induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by arterial and venous oxygen concentrations in hepatocyte cultures. Eur J Biochem 1981; 119: 657-661.
-
(1981)
Eur J Biochem
, vol.119
, pp. 657-661
-
-
Nauck, M.1
Wolfle, D.2
Katz, N.3
Jungermann, K.4
-
21
-
-
0031971248
-
Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole
-
Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology 1998; 27: 1304-1310.
-
(1998)
Hepatology
, vol.27
, pp. 1304-1310
-
-
Fang, C.1
Lindros, K.O.2
Badger, T.M.3
Ronis, M.J.4
Ingelman-Sundberg, M.5
-
22
-
-
0027533914
-
Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis
-
Sezai S, Sakurabayashi S, Yamamoto Y, Morita T, Hirano M, Oka H. Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis. Liver 1993; 13: 31-35.
-
(1993)
Liver
, vol.13
, pp. 31-35
-
-
Sezai, S.1
Sakurabayashi, S.2
Yamamoto, Y.3
Morita, T.4
Hirano, M.5
Oka, H.6
-
23
-
-
0035868277
-
Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver
-
Kietzmann T, Cornesse Y, Brechtel K, Modaressi S, Jungermann K. Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Biochem J 2001; 354: 531-537.
-
(2001)
Biochem J
, vol.354
, pp. 531-537
-
-
Kietzmann, T.1
Cornesse, Y.2
Brechtel, K.3
Modaressi, S.4
Jungermann, K.5
-
24
-
-
0023805376
-
Physiologic significance and regulation of hepatocellular heterogeneity
-
Traber PG, Chianale J, Gumucio JJ. Physiologic significance and regulation of hepatocellular heterogeneity. Gastroenterology 1988; 95: 1130-1143.
-
(1988)
Gastroenterology
, vol.95
, pp. 1130-1143
-
-
Traber, P.G.1
Chianale, J.2
Gumucio, J.J.3
-
25
-
-
0023801306
-
Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital
-
Wojcik E, Dvorak C, Chianale J, Traber PG, Keren D, Gumucio JJ. Demonstration by in situ hybridization of the zonal modulation of rat liver cytochrome P-450b and P-450e gene expression after phenobarbital. J Clin Invest 1988; 82: 658-666.
-
(1988)
J Clin Invest
, vol.82
, pp. 658-666
-
-
Wojcik, E.1
Dvorak, C.2
Chianale, J.3
Traber, P.G.4
Keren, D.5
Gumucio, J.J.6
-
27
-
-
84939548439
-
Regenerative biology: Maintaining liver mass
-
Zaret KS. Regenerative biology: maintaining liver mass. Nature 2015; 524: 165-166.
-
(2015)
Nature
, vol.524
, pp. 165-166
-
-
Zaret, K.S.1
-
28
-
-
0017656829
-
Cell kinetics in the liver of rats under normal and abnormal dietary conditions. An autoradiographic study by means of [3H]thymidine
-
Blikkendaal-Lieftinck LF, Kooij M, Kramer MF, Den Otter W. Cell kinetics in the liver of rats under normal and abnormal dietary conditions. An autoradiographic study by means of [3H]thymidine. Exp Mol Pathol 1977; 26: 184-192.
-
(1977)
Exp Mol Pathol
, vol.26
, pp. 184-192
-
-
Blikkendaal-Lieftinck, L.F.1
Kooij, M.2
Kramer, M.F.3
Den-Otter, W.4
-
29
-
-
33750536032
-
Differential gene expression in periportal and perivenous mouse hepatocytes
-
Braeuning A, Ittrich C, Kohle C, Hailfinger S, Bonin M, Buchmann A et al. Differential gene expression in periportal and perivenous mouse hepatocytes. FEBS J 2006; 273: 5051-5061.
-
(2006)
FEBS J
, vol.273
, pp. 5051-5061
-
-
Braeuning, A.1
Ittrich, C.2
Kohle, C.3
Hailfinger, S.4
Bonin, M.5
Buchmann, A.6
-
30
-
-
84978229814
-
Retinoid regulation of antiviral innate immunity in hepatocytes
-
Cho NE, Bang BR, Gurung P, Li M, Clemens DL, Underhill TM et al. Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology 2016; 63: 1783-1795.
-
(2016)
Hepatology
, vol.63
, pp. 1783-1795
-
-
Cho, N.E.1
Bang, B.R.2
Gurung, P.3
Li, M.4
Clemens, D.L.5
Underhill, T.M.6
-
31
-
-
84964409148
-
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size
-
Planas-Paz L, Orsini V, Boulter L, Calabrese D, Pikiolek M, Nigsch F et al. The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Nat Cell Biol 2016; 18: 467-479.
-
(2016)
Nat Cell Biol
, vol.18
, pp. 467-479
-
-
Planas-Paz, L.1
Orsini, V.2
Boulter, L.3
Calabrese, D.4
Pikiolek, M.5
Nigsch, F.6
-
32
-
-
84865517676
-
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
-
Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M et al. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature 2012; 488: 665-669.
-
(2012)
Nature
, vol.488
, pp. 665-669
-
-
Koo, B.K.1
Spit, M.2
Jordens, I.3
Low, T.Y.4
Stange, D.E.5
Van-De-Wetering, M.6
-
33
-
-
84901605165
-
T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice
-
Gougelet A, Torre C, Veber P, Sartor C, Bachelot L, Denechaud PD et al. T-cell factor 4 and beta-catenin chromatin occupancies pattern zonal liver metabolism in mice. Hepatology 2014; 59: 2344-2357.
-
(2014)
Hepatology
, vol.59
, pp. 2344-2357
-
-
Gougelet, A.1
Torre, C.2
Veber, P.3
Sartor, C.4
Bachelot, L.5
Denechaud, P.D.6
-
34
-
-
84959017482
-
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
-
Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV et al. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature 2016; 530: 340-343.
-
(2016)
Nature
, vol.530
, pp. 340-343
-
-
Farin, H.F.1
Jordens, I.2
Mosa, M.H.3
Basak, O.4
Korving, J.5
Tauriello, D.V.6
-
35
-
-
84892370818
-
Patterning and growth control by membrane-tethered Wingless
-
Alexandre C, Baena-Lopez A, Vincent JP. Patterning and growth control by membrane-tethered Wingless. Nature 2014; 505: 180-185.
-
(2014)
Nature
, vol.505
, pp. 180-185
-
-
Alexandre, C.1
Baena-Lopez, A.2
Vincent, J.P.3
-
36
-
-
84961054225
-
A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; Autoradiography with thymidine-H3
-
Grisham JW. A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res 1962; 22: 842-849.
-
(1962)
Cancer Res
, vol.22
, pp. 842-849
-
-
Grisham, J.W.1
-
37
-
-
84989945553
-
Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters
-
Platt JL, Salama R, Smythies J, Choudhry H, Davies JO, Hughes JR et al. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. EMBO Rep 2016; 17: 1410-1421.
-
(2016)
EMBO Rep
, vol.17
, pp. 1410-1421
-
-
Platt, J.L.1
Salama, R.2
Smythies, J.3
Choudhry, H.4
Davies, J.O.5
Hughes, J.R.6
-
38
-
-
77955659695
-
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel
-
Panakova D, Werdich AA, Macrae CA. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature 2010; 466: 874-878.
-
(2010)
Nature
, vol.466
, pp. 874-878
-
-
Panakova, D.1
Werdich, A.A.2
Macrae, C.A.3
-
39
-
-
37249042774
-
Lrp6 is required for convergent extension during Xenopus gastrulation
-
Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA et al. Lrp6 is required for convergent extension during Xenopus gastrulation. Development 2007; 134: 4095-4106.
-
(2007)
Development
, vol.134
, pp. 4095-4106
-
-
Tahinci, E.1
Thorne, C.A.2
Franklin, J.L.3
Salic, A.4
Christian, K.M.5
Lee, L.A.6
-
40
-
-
77957584397
-
O2 regulates stem cells through Wnt/beta-catenin signalling
-
Mazumdar J, O'Brien WT, Johnson RS, La Manna JC, Chavez JC, Klein PS et al. O2 regulates stem cells through Wnt/beta-catenin signalling. Nat Cell Biol 2010; 12: 1007-1013.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 1007-1013
-
-
Mazumdar, J.1
O'Brien, W.T.2
Johnson, R.S.3
La-Manna, J.C.4
Chavez, J.C.5
Klein, P.S.6
-
41
-
-
84877157115
-
Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling
-
Zhang Q, Bai X, Chen W, Ma T, Hu Q, Liang C et al. Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1alpha signaling. Carcinogenesis 2013; 34: 962-973.
-
(2013)
Carcinogenesis
, vol.34
, pp. 962-973
-
-
Zhang, Q.1
Bai, X.2
Chen, W.3
Ma, T.4
Hu, Q.5
Liang, C.6
|