메뉴 건너뛰기




Volumn 20, Issue 7, 2018, Pages 1563-1577

Safety of intranasal human insulin: A review

Author keywords

database research; insulin resistance; obesity therapy

Indexed keywords

HUMAN INSULIN; ANTIDIABETIC AGENT; RECOMBINANT PROTEIN;

EID: 85044845956     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13279     Document Type: Review
Times cited : (76)

References (78)
  • 1
    • 84873198464 scopus 로고    scopus 로고
    • CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age
    • Vogt MC, Brüning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age. Trends Endocrinol Metab. 2013;24(2):76-84.
    • (2013) Trends Endocrinol Metab , vol.24 , Issue.2 , pp. 76-84
    • Vogt, M.C.1    Brüning, J.C.2
  • 2
    • 84903173931 scopus 로고    scopus 로고
    • Insulin action in brain regulates systemic metabolism and brain function
    • Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 2014;63(7):2232-2243.
    • (2014) Diabetes , vol.63 , Issue.7 , pp. 2232-2243
    • Kleinridders, A.1    Ferris, H.A.2    Cai, W.3    Kahn, C.R.4
  • 3
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289(5487):2122-2125.
    • (2000) Science , vol.289 , Issue.5487 , pp. 2122-2125
    • Brüning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 4
    • 84947614766 scopus 로고    scopus 로고
    • Impaired insulin action in the human brain: causes and metabolic consequences
    • Heni M, Kullmann S, Preissl H, Fritsche A, Häring H-U. Impaired insulin action in the human brain: causes and metabolic consequences. Nat Rev Endocrinol. 2015;11(12):701-711.
    • (2015) Nat Rev Endocrinol , vol.11 , Issue.12 , pp. 701-711
    • Heni, M.1    Kullmann, S.2    Preissl, H.3    Fritsche, A.4    Häring, H.-U.5
  • 5
    • 84983786153 scopus 로고    scopus 로고
    • Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
    • Kullmann S, Heni M, Hallschmid M, Fritsche A, Preissl H, Häring H-U. Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans. Physiol Rev. 2016;96(4):1169-1209.
    • (2016) Physiol Rev , vol.96 , Issue.4 , pp. 1169-1209
    • Kullmann, S.1    Heni, M.2    Hallschmid, M.3    Fritsche, A.4    Preissl, H.5    Häring, H.-U.6
  • 6
    • 84938304156 scopus 로고    scopus 로고
    • Intranasal neuropeptide administration to target the human brain in health and disease
    • Spetter M, Hallschmid M. Intranasal neuropeptide administration to target the human brain in health and disease. Mol Pharm. 2015;12(8):2767-2780.
    • (2015) Mol Pharm , vol.12 , Issue.8 , pp. 2767-2780
    • Spetter, M.1    Hallschmid, M.2
  • 8
    • 84938691342 scopus 로고    scopus 로고
    • Central nervous system delivery of intranasal insulin: mechanisms of uptake and effects on cognition
    • Salameh TS, Bullock KM, Hujoel IA, et al. Central nervous system delivery of intranasal insulin: mechanisms of uptake and effects on cognition. J Alzheimers Dis. 2015;47(3):715-728.
    • (2015) J Alzheimers Dis , vol.47 , Issue.3 , pp. 715-728
    • Salameh, T.S.1    Bullock, K.M.2    Hujoel, I.A.3
  • 9
    • 0033014163 scopus 로고    scopus 로고
    • Central nervous system effects of intranasally administered insulin during euglycemia in men
    • Kern W, Born J, Schreiber H, Fehm HL. Central nervous system effects of intranasally administered insulin during euglycemia in men. Diabetes. 1999;48(3):557-563.
    • (1999) Diabetes , vol.48 , Issue.3 , pp. 557-563
    • Kern, W.1    Born, J.2    Schreiber, H.3    Fehm, H.L.4
  • 10
    • 85045904012 scopus 로고    scopus 로고
    • Dose dependent effects of intranasal insulin on resting-state brain activity
    • Kullmann S, Veit R, Peter A, et al. Dose dependent effects of intranasal insulin on resting-state brain activity. J Clin Endocrinol Metab. 2018;103(1):253-262.
    • (2018) J Clin Endocrinol Metab , vol.103 , Issue.1 , pp. 253-262
    • Kullmann, S.1    Veit, R.2    Peter, A.3
  • 12
    • 36248965689 scopus 로고    scopus 로고
    • Current challenges in non-invasive insulin delivery systems: a comparative review
    • Khafagy E-S, Morishita M, Onuki Y, Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev. 2007;59(15):1521-1546.
    • (2007) Adv Drug Deliv Rev , vol.59 , Issue.15 , pp. 1521-1546
    • Khafagy, E.-S.1    Morishita, M.2    Onuki, Y.3    Takayama, K.4
  • 13
    • 4644230843 scopus 로고    scopus 로고
    • Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    • Harrison LC, Honeyman MC, Steele CE, et al. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care. 2004;27(10):2348-2355.
    • (2004) Diabetes Care , vol.27 , Issue.10 , pp. 2348-2355
    • Harrison, L.C.1    Honeyman, M.C.2    Steele, C.E.3
  • 14
    • 77953248296 scopus 로고    scopus 로고
    • Follow-up study with acoustic rhinometry in children using nasal insulin
    • Haavisto LE, Vahlberg TJ, Sipilä JIA. Follow-up study with acoustic rhinometry in children using nasal insulin. Rhinology. 2010;48(1):95-99.
    • (2010) Rhinology , vol.48 , Issue.1 , pp. 95-99
    • Haavisto, L.E.1    Vahlberg, T.J.2    Sipilä, J.I.A.3
  • 15
    • 55749104546 scopus 로고    scopus 로고
    • Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
    • Näntö-Salonen K, Kupila A, Simell S, et al. Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial. Lancet Lond Engl. 2008;372(9651):1746-1755.
    • (2008) Lancet Lond Engl , vol.372 , Issue.9651 , pp. 1746-1755
    • Näntö-Salonen, K.1    Kupila, A.2    Simell, S.3
  • 16
    • 80051967777 scopus 로고    scopus 로고
    • Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes
    • Ryhänen SJ, Härkönen T, Siljander H, et al. Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetes Care. 2011;34(6):1383-1388.
    • (2011) Diabetes Care , vol.34 , Issue.6 , pp. 1383-1388
    • Ryhänen, S.J.1    Härkönen, T.2    Siljander, H.3
  • 17
    • 65949087001 scopus 로고    scopus 로고
    • Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial
    • Schmidt H, Kern W, Giese R, Hallschmid M, Enders A. Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial. J Med Genet. 2009;46(4):217-222.
    • (2009) J Med Genet , vol.46 , Issue.4 , pp. 217-222
    • Schmidt, H.1    Kern, W.2    Giese, R.3    Hallschmid, M.4    Enders, A.5
  • 18
    • 84984846872 scopus 로고    scopus 로고
    • Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial
    • Zwanenburg RJ, Bocca G, Ruiter SAJ, et al. Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial. Eur J Hum Genet. 2016;24(12):1696-1701.
    • (2016) Eur J Hum Genet , vol.24 , Issue.12 , pp. 1696-1701
    • Zwanenburg, R.J.1    Bocca, G.2    Ruiter, S.A.J.3
  • 19
    • 31844434789 scopus 로고    scopus 로고
    • Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
    • Reger MA, Watson GS, Frey WH, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27(3):451-458.
    • (2006) Neurobiol Aging , vol.27 , Issue.3 , pp. 451-458
    • Reger, M.A.1    Watson, G.S.2    Frey, W.H.3
  • 20
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • Reger MA, Watson GS, Green PS, et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology. 2008;70(6):440-448.
    • (2008) Neurology , vol.70 , Issue.6 , pp. 440-448
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3
  • 21
    • 80053468477 scopus 로고    scopus 로고
    • Randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease
    • Stein MS, Scherer SC, Ladd KS, Harrison LCA. Randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer's disease. J Alzheimers Dis. 2011;26(3):477-484.
    • (2011) J Alzheimers Dis , vol.26 , Issue.3 , pp. 477-484
    • Stein, M.S.1    Scherer, S.C.2    Ladd, K.S.3    Harrison, L.C.A.4
  • 22
    • 47849123972 scopus 로고    scopus 로고
    • Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    • Reger MA, Watson GS, Green PS, et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J Alzheimers Dis. 2008;13(3):323-331.
    • (2008) J Alzheimers Dis , vol.13 , Issue.3 , pp. 323-331
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3
  • 23
    • 84878864610 scopus 로고    scopus 로고
    • Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    • Claxton A, Baker LD, Wilkinson CW, et al. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. J Alzheimers Dis. 2013;35(4):789-497.
    • (2013) J Alzheimers Dis , vol.35 , Issue.4 , pp. 497-789
    • Claxton, A.1    Baker, L.D.2    Wilkinson, C.W.3
  • 24
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial
    • Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial. Arch Neurol. 2012;69(1):29-38.
    • (2012) Arch Neurol , vol.69 , Issue.1 , pp. 29-38
    • Craft, S.1    Baker, L.D.2    Montine, T.J.3
  • 25
    • 85018745780 scopus 로고    scopus 로고
    • Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial
    • Craft S, Claxton A, Baker LD, et al. Effects of regular and long-acting insulin on cognition and Alzheimer's disease biomarkers: a pilot clinical trial. J Alzheimers Dis. 2017;57(4):1325-1334.
    • (2017) J Alzheimers Dis , vol.57 , Issue.4 , pp. 1325-1334
    • Craft, S.1    Claxton, A.2    Baker, L.D.3
  • 26
    • 85014046183 scopus 로고    scopus 로고
    • Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial
    • Hamidovic A, Khafaja M, Brandon V, et al. Reduction of smoking urges with intranasal insulin: a randomized, crossover, placebo-controlled clinical trial. Mol Psychiatry. 2017;22(10):1413-1421.
    • (2017) Mol Psychiatry , vol.22 , Issue.10 , pp. 1413-1421
    • Hamidovic, A.1    Khafaja, M.2    Brandon, V.3
  • 27
    • 84953716695 scopus 로고    scopus 로고
    • Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: a pilot study
    • Schöpf V, Kollndorfer K, Pollak M, Mueller CA, Freiherr J. Intranasal insulin influences the olfactory performance of patients with smell loss, dependent on the body mass index: a pilot study. Rhinology. 2015;53(4):371-378.
    • (2015) Rhinology , vol.53 , Issue.4 , pp. 371-378
    • Schöpf, V.1    Kollndorfer, K.2    Pollak, M.3    Mueller, C.A.4    Freiherr, J.5
  • 28
    • 79952444478 scopus 로고    scopus 로고
    • No effect of single-dose intranasal insulin treatment on verbal memory and sustained attention in patients with schizophrenia
    • Fan X, Copeland PM, Liu EY, et al. No effect of single-dose intranasal insulin treatment on verbal memory and sustained attention in patients with schizophrenia. J Clin Psychopharmacol. 2011;31(2):231-234.
    • (2011) J Clin Psychopharmacol , vol.31 , Issue.2 , pp. 231-234
    • Fan, X.1    Copeland, P.M.2    Liu, E.Y.3
  • 29
    • 84874941052 scopus 로고    scopus 로고
    • No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia
    • Fan X, Liu E, Freudenreich O, et al. No effect of adjunctive, repeated-dose intranasal insulin treatment on psychopathology and cognition in patients with schizophrenia. J Clin Psychopharmacol. 2013;33(2):226-230.
    • (2013) J Clin Psychopharmacol , vol.33 , Issue.2 , pp. 226-230
    • Fan, X.1    Liu, E.2    Freudenreich, O.3
  • 30
    • 84875946274 scopus 로고    scopus 로고
    • No effect of adjunctive, repeated dose intranasal insulin treatment on body metabolism in patients with schizophrenia
    • Li J, Li X, Liu E, et al. No effect of adjunctive, repeated dose intranasal insulin treatment on body metabolism in patients with schizophrenia. Schizophr Res. 2013;146(1–3):40-45.
    • (2013) Schizophr Res , vol.146 , Issue.1–3 , pp. 40-45
    • Li, J.1    Li, X.2    Liu, E.3
  • 31
    • 84868088277 scopus 로고    scopus 로고
    • A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder
    • McIntyre RS, Soczynska JK, Woldeyohannes HO, et al. A randomized, double-blind, controlled trial evaluating the effect of intranasal insulin on neurocognitive function in euthymic patients with bipolar disorder. Bipolar Disord. 2012;14(7):697-706.
    • (2012) Bipolar Disord , vol.14 , Issue.7 , pp. 697-706
    • McIntyre, R.S.1    Soczynska, J.K.2    Woldeyohannes, H.O.3
  • 32
    • 85007049075 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, crossover trial evaluating the effect of intranasal insulin on cognition and mood in individuals with treatment-resistant major depressive disorder
    • Cha DS, Best MW, Bowie CR, et al. A randomized, double-blind, placebo-controlled, crossover trial evaluating the effect of intranasal insulin on cognition and mood in individuals with treatment-resistant major depressive disorder. J Affect Disord. 2017;210:57-65.
    • (2017) J Affect Disord , vol.210 , pp. 57-65
    • Cha, D.S.1    Best, M.W.2    Bowie, C.R.3
  • 33
    • 84977083882 scopus 로고    scopus 로고
    • Insulin in the nervous system and the mind: functions in metabolism, memory, and mood
    • Lee S-H, Zabolotny JM, Huang H, Lee H, Kim Y-B. Insulin in the nervous system and the mind: functions in metabolism, memory, and mood. Mol Metab. 2016;5(8):589-601.
    • (2016) Mol Metab , vol.5 , Issue.8 , pp. 589-601
    • Lee, S.-H.1    Zabolotny, J.M.2    Huang, H.3    Lee, H.4    Kim, Y.-B.5
  • 34
    • 84880555817 scopus 로고    scopus 로고
    • Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence
    • Freiherr J, Hallschmid M, Frey WH, et al. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS Drugs. 2013;27(7):505-514.
    • (2013) CNS Drugs , vol.27 , Issue.7 , pp. 505-514
    • Freiherr, J.1    Hallschmid, M.2    Frey, W.H.3
  • 35
    • 42049089751 scopus 로고    scopus 로고
    • Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin
    • Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab. 2008;93(4):1339-1344.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.4 , pp. 1339-1344
    • Benedict, C.1    Kern, W.2    Schultes, B.3    Born, J.4    Hallschmid, M.5
  • 36
    • 56249148830 scopus 로고    scopus 로고
    • Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress
    • Bohringer A, Schwabe L, Richter S, Schachinger H. Intranasal insulin attenuates the hypothalamic-pituitary-adrenal axis response to psychosocial stress. Psychoneuroendocrinology. 2008;33(10):1394-1400.
    • (2008) Psychoneuroendocrinology , vol.33 , Issue.10 , pp. 1394-1400
    • Bohringer, A.1    Schwabe, L.2    Richter, S.3    Schachinger, H.4
  • 37
    • 76149103529 scopus 로고    scopus 로고
    • Insulin modulates food-related activity in the central nervous system
    • Guthoff M, Grichisch Y, Canova C, et al. Insulin modulates food-related activity in the central nervous system. J Clin Endocrinol Metab. 2010;95(2):748-755.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.2 , pp. 748-755
    • Guthoff, M.1    Grichisch, Y.2    Canova, C.3
  • 38
    • 78650054323 scopus 로고    scopus 로고
    • Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory
    • Krug R, Benedict C, Born J, Hallschmid M. Comparable sensitivity of postmenopausal and young women to the effects of intranasal insulin on food intake and working memory. J Clin Endocrinol Metab. 2010;95(12):E468-E472.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.12 , pp. E468-E472
    • Krug, R.1    Benedict, C.2    Born, J.3    Hallschmid, M.4
  • 40
    • 78751485383 scopus 로고    scopus 로고
    • Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men
    • Benedict C, Brede S, Schiöth HB, et al. Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes. 2011;60(1):114-118.
    • (2011) Diabetes , vol.60 , Issue.1 , pp. 114-118
    • Benedict, C.1    Brede, S.2    Schiöth, H.B.3
  • 41
    • 79955935863 scopus 로고    scopus 로고
    • The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects
    • Guthoff M, Stingl KT, Tschritter O, et al. The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects. PL oS One. 2011;6(5):e19482.
    • (2011) PL oS One , vol.6 , Issue.5
    • Guthoff, M.1    Stingl, K.T.2    Tschritter, O.3
  • 42
    • 80052554457 scopus 로고    scopus 로고
    • Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial
    • Stockhorst U, de Fries D, Steingrueber H-J, Scherbaum WA. Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial. Diabetologia. 2011;54(6):1502-1506.
    • (2011) Diabetologia , vol.54 , Issue.6 , pp. 1502-1506
    • Stockhorst, U.1    de Fries, D.2    Steingrueber, H.-J.3    Scherbaum, W.A.4
  • 43
    • 84855915021 scopus 로고    scopus 로고
    • Differential effects of intranasal insulin and caffeine on cerebral blood flow
    • Grichisch Y, Çavuşoğlu M, Preissl H, et al. Differential effects of intranasal insulin and caffeine on cerebral blood flow. Hum Brain Mapp. 2012;33(2):280-287.
    • (2012) Hum Brain Mapp , vol.33 , Issue.2 , pp. 280-287
    • Grichisch, Y.1    Çavuşoğlu, M.2    Preissl, H.3
  • 44
    • 84859526987 scopus 로고    scopus 로고
    • Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women
    • Hallschmid M, Higgs S, Thienel M, Ott V, Lehnert H. Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. Diabetes. 2012;61(4):782-789.
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 782-789
    • Hallschmid, M.1    Higgs, S.2    Thienel, M.3    Ott, V.4    Lehnert, H.5
  • 45
    • 84865434170 scopus 로고    scopus 로고
    • Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions
    • Heni M, Kullmann S, Ketterer C, et al. Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions. Diabetologia. 2012;55(6):1773-1782.
    • (2012) Diabetologia , vol.55 , Issue.6 , pp. 1773-1782
    • Heni, M.1    Kullmann, S.2    Ketterer, C.3
  • 46
    • 84895819571 scopus 로고    scopus 로고
    • Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action
    • Ketterer C, Heni M, Stingl K, et al. Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action. Obes Silver Spring Md. 2014;22(3):925-931.
    • (2014) Obes Silver Spring Md , vol.22 , Issue.3 , pp. 925-931
    • Ketterer, C.1    Heni, M.2    Stingl, K.3
  • 47
    • 84865522894 scopus 로고    scopus 로고
    • Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans
    • Jauch-Chara K, Friedrich A, Rezmer M, et al. Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans. Diabetes. 2012;61(9):2261-2268.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2261-2268
    • Jauch-Chara, K.1    Friedrich, A.2    Rezmer, M.3
  • 48
    • 84885191812 scopus 로고    scopus 로고
    • Intranasal insulin reduces olfactory sensitivity in normosmic humans
    • Brünner YF, Benedict C, Freiherr J. Intranasal insulin reduces olfactory sensitivity in normosmic humans. J Clin Endocrinol Metab. 2013;98(10):E1626-E1630.
    • (2013) J Clin Endocrinol Metab , vol.98 , Issue.10 , pp. E1626-E1630
    • Brünner, Y.F.1    Benedict, C.2    Freiherr, J.3
  • 49
    • 84876283390 scopus 로고    scopus 로고
    • Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women
    • Kullmann S, Frank S, Heni M, et al. Intranasal insulin modulates intrinsic reward and prefrontal circuitry of the human brain in lean women. Neuroendocrinology. 2013;97(2):176-182.
    • (2013) Neuroendocrinology , vol.97 , Issue.2 , pp. 176-182
    • Kullmann, S.1    Frank, S.2    Heni, M.3
  • 50
    • 84911916822 scopus 로고    scopus 로고
    • Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
    • Heni M, Wagner R, Kullmann S, et al. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes. 2014;63(12):4083-4088.
    • (2014) Diabetes , vol.63 , Issue.12 , pp. 4083-4088
    • Heni, M.1    Wagner, R.2    Kullmann, S.3
  • 51
    • 84893726788 scopus 로고    scopus 로고
    • Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans
    • Iwen KA, Scherer T, Heni M, et al. Intranasal insulin suppresses systemic but not subcutaneous lipolysis in healthy humans. J Clin Endocrinol Metab. 2014;99(2):E246-E251.
    • (2014) J Clin Endocrinol Metab , vol.99 , Issue.2 , pp. E246-E251
    • Iwen, K.A.1    Scherer, T.2    Heni, M.3
  • 52
    • 84896692580 scopus 로고    scopus 로고
    • Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes
    • Novak V, Milberg W, Hao Y, et al. Enhancement of vasoreactivity and cognition by intranasal insulin in type 2 diabetes. Diabetes Care. 2014;37(3):751-759.
    • (2014) Diabetes Care , vol.37 , Issue.3 , pp. 751-759
    • Novak, V.1    Milberg, W.2    Hao, Y.3
  • 53
    • 84962114196 scopus 로고    scopus 로고
    • Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes
    • Zhang H, Hao Y, Manor B, et al. Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes. 2015;64(3):1025-1034.
    • (2015) Diabetes , vol.64 , Issue.3 , pp. 1025-1034
    • Zhang, H.1    Hao, Y.2    Manor, B.3
  • 54
    • 84908404763 scopus 로고    scopus 로고
    • Cortisol, but not intranasal insulin, affects the central processing of visual food cues
    • Ferreira de Sá DS, Schulz A, Streit FE, et al. Cortisol, but not intranasal insulin, affects the central processing of visual food cues. Psychoneuroendocrinology. 2014;50:311-320.
    • (2014) Psychoneuroendocrinology , vol.50 , pp. 311-320
    • Ferreira de Sá, D.S.1    Schulz, A.2    Streit, F.E.3
  • 55
    • 84898048515 scopus 로고    scopus 로고
    • Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation
    • Schilling TM, Ferreira de Sá DS, Westerhausen R, et al. Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation. Hum Brain Mapp. 2014;35(5):1944-1956.
    • (2014) Hum Brain Mapp , vol.35 , Issue.5 , pp. 1944-1956
    • Schilling, T.M.1    Ferreira de Sá, D.S.2    Westerhausen, R.3
  • 56
    • 84920627307 scopus 로고    scopus 로고
    • Central insulin administration improves odor-cued reactivation of spatial memory in young men
    • Brünner YF, Kofoet A, Benedict C, Freiherr J. Central insulin administration improves odor-cued reactivation of spatial memory in young men. J Clin Endocrinol Metab. 2015;100(1):212-219.
    • (2015) J Clin Endocrinol Metab , vol.100 , Issue.1 , pp. 212-219
    • Brünner, Y.F.1    Kofoet, A.2    Benedict, C.3    Freiherr, J.4
  • 57
    • 84931289812 scopus 로고    scopus 로고
    • Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans
    • Gancheva S, Koliaki C, Bierwagen A, et al. Effects of intranasal insulin on hepatic fat accumulation and energy metabolism in humans. Diabetes. 2015;64(6):1966-1975.
    • (2015) Diabetes , vol.64 , Issue.6 , pp. 1966-1975
    • Gancheva, S.1    Koliaki, C.2    Bierwagen, A.3
  • 58
    • 85019091008 scopus 로고    scopus 로고
    • Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
    • Kullmann S, Heni M, Veit R, et al. Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger. Sci Rep. 2017;7(1):1627.
    • (2017) Sci Rep , vol.7 , Issue.1 , pp. 1627
    • Kullmann, S.1    Heni, M.2    Veit, R.3
  • 59
    • 85016401321 scopus 로고    scopus 로고
    • Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans
    • Kullmann S, Fritsche A, Wagner R, et al. Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans. Physiol Behav. 2017;176:134-138.
    • (2017) Physiol Behav , vol.176 , pp. 134-138
    • Kullmann, S.1    Fritsche, A.2    Wagner, R.3
  • 60
    • 84938302676 scopus 로고    scopus 로고
    • Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults
    • Kullmann S, Heni M, Veit R, et al. Selective insulin resistance in homeostatic and cognitive control brain areas in overweight and obese adults. Diabetes Care. 2015;38(6):1044-1050.
    • (2015) Diabetes Care , vol.38 , Issue.6 , pp. 1044-1050
    • Kullmann, S.1    Heni, M.2    Veit, R.3
  • 61
    • 84963704904 scopus 로고    scopus 로고
    • Central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation
    • Feld GB, Wilhem I, Benedict C, et al. Central nervous insulin signaling in sleep-associated memory formation and neuroendocrine regulation. Neuropsychopharmacology. 2016;41(6):1540-1550.
    • (2016) Neuropsychopharmacology , vol.41 , Issue.6 , pp. 1540-1550
    • Feld, G.B.1    Wilhem, I.2    Benedict, C.3
  • 62
    • 84991094843 scopus 로고    scopus 로고
    • Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application
    • (Pt B), -
    • Brünner YF, Rodriguez-Raecke R, Mutic S, Benedict C, Freiherr J. Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application. Neurobiol Learn Mem. 2016;134(Pt B):256-263.
    • (2016) Neurobiol Learn Mem. , vol.134 , pp. 256-263
    • Brünner, Y.F.1    Rodriguez-Raecke, R.2    Mutic, S.3    Benedict, C.4    Freiherr, J.5
  • 63
    • 85019154856 scopus 로고    scopus 로고
    • Hypothalamic and striatal insulin action suppresses endogenous glucose production and may stimulate glucose uptake during hyperinsulinemia in lean but not in overweight men
    • Heni M, Wagner R, Kullmann S, et al. Hypothalamic and striatal insulin action suppresses endogenous glucose production and may stimulate glucose uptake during hyperinsulinemia in lean but not in overweight men. Diabetes. 2017;66(7):1797-1806.
    • (2017) Diabetes , vol.66 , Issue.7 , pp. 1797-1806
    • Heni, M.1    Wagner, R.2    Kullmann, S.3
  • 65
    • 85014415337 scopus 로고    scopus 로고
    • Central nervous insulin administration before nocturnal sleep decreases breakfast intake in healthy young and elderly subjects
    • Santiago JCP, Hallschmid M. Central nervous insulin administration before nocturnal sleep decreases breakfast intake in healthy young and elderly subjects. Front Neurosci. 2017;11:54.
    • (2017) Front Neurosci , vol.11 , pp. 54
    • Santiago, J.C.P.1    Hallschmid, M.2
  • 66
    • 85016642155 scopus 로고    scopus 로고
    • Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults
    • Akintola AA, van Opstal AM, Westendorp RG, Postmus I, van der Grond J, van Heemst D. Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults. Aging. 2017;9(3):790-802.
    • (2017) Aging , vol.9 , Issue.3 , pp. 790-802
    • Akintola, A.A.1    van Opstal, A.M.2    Westendorp, R.G.3    Postmus, I.4    van der Grond, J.5    van Heemst, D.6
  • 67
    • 85017390597 scopus 로고    scopus 로고
    • Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans
    • Thienel M, Wilhelm I, Benedict C, Born J, Hallschmid M. Intranasal insulin decreases circulating cortisol concentrations during early sleep in elderly humans. Neurobiol Aging. 2017;54:170-174.
    • (2017) Neurobiol Aging , vol.54 , pp. 170-174
    • Thienel, M.1    Wilhelm, I.2    Benedict, C.3    Born, J.4    Hallschmid, M.5
  • 68
    • 85031778341 scopus 로고    scopus 로고
    • Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion
    • 13327
    • Opstal AMV, Akintola AA, Elst MV, et al. Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion. Sci Rep. 2017;7(1):13327.
    • (2017) Sci Rep , vol.7 , Issue.1
    • Opstal, A.M.V.1    Akintola, A.A.2    Elst, M.V.3
  • 69
    • 0141725404 scopus 로고    scopus 로고
    • Intranasally administered insulin intended for prevention of type 1 diabetes–a safety study in healthy adults
    • Kupila A, Sipilä J, Keskinen P, et al. Intranasally administered insulin intended for prevention of type 1 diabetes–a safety study in healthy adults. Diabetes Metab Res Rev. 2003;19(5):415-420.
    • (2003) Diabetes Metab Res Rev , vol.19 , Issue.5 , pp. 415-420
    • Kupila, A.1    Sipilä, J.2    Keskinen, P.3
  • 70
  • 72
    • 24344505341 scopus 로고    scopus 로고
    • Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings
    • Benedict C, Dodt C, Hallschmid M, et al. Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings. Metabolism. 2005;54(10):1356-1361.
    • (2005) Metabolism , vol.54 , Issue.10 , pp. 1356-1361
    • Benedict, C.1    Dodt, C.2    Hallschmid, M.3
  • 73
    • 33845695894 scopus 로고    scopus 로고
    • Intranasal insulin improves memory in humans: superiority of insulin aspart
    • Benedict C, Hallschmid M, Schmitz K, et al. Intranasal insulin improves memory in humans: superiority of insulin aspart. Neuropsychopharmacology. 2007;32(1):239-243.
    • (2007) Neuropsychopharmacology , vol.32 , Issue.1 , pp. 239-243
    • Benedict, C.1    Hallschmid, M.2    Schmitz, K.3
  • 74
    • 39449093463 scopus 로고    scopus 로고
    • Obese men respond to cognitive but not to catabolic brain insulin signaling
    • Hallschmid M, Benedict C, Schultes B, Born J, Kern W. Obese men respond to cognitive but not to catabolic brain insulin signaling. Int J Obes (Lond). 2008;32(2):275-282.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.2 , pp. 275-282
    • Hallschmid, M.1    Benedict, C.2    Schultes, B.3    Born, J.4    Kern, W.5
  • 75
    • 79953220761 scopus 로고    scopus 로고
    • Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
    • Fourlanos S, Perry C, Gellert SA, et al. Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes. 2011;60(4):1237-1245.
    • (2011) Diabetes , vol.60 , Issue.4 , pp. 1237-1245
    • Fourlanos, S.1    Perry, C.2    Gellert, S.A.3
  • 76
    • 85017305293 scopus 로고    scopus 로고
    • Chronic intranasal insulin does not affect hepatic lipids but lowers circulating BCAAs in healthy male subjects
    • Scherer T, Wolf P, Smajis S, et al. Chronic intranasal insulin does not affect hepatic lipids but lowers circulating BCAAs in healthy male subjects. J Clin Endocrinol Metab. 2017;102(4):1325-1332.
    • (2017) J Clin Endocrinol Metab , vol.102 , Issue.4 , pp. 1325-1332
    • Scherer, T.1    Wolf, P.2    Smajis, S.3
  • 77
    • 84946558738 scopus 로고    scopus 로고
    • Position on zinc delivery to olfactory nerves in intranasal insulin phase I-III clinical trials
    • Hamidovic A. Position on zinc delivery to olfactory nerves in intranasal insulin phase I-III clinical trials. Contemp Clin Trials. 2015;45(Pt B):277-280.
    • (2015) Contemp Clin Trials , vol.45 , pp. 277-280
    • Hamidovic, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.