No effect of single-dose intranasal insulin treatment on verbal memory and sustained attention in patients with schizophrenia

Journal of Clinical Psychopharmacology

Volumn 31, Issue 2, 2011, Pages 231-234

  Fan, Xiaoduo ^a,b   Copeland, Paul M ^a,b   Liu, Emily Y ^c   Chiang, Elaine ^d   Freudenreich, Oliver ^a,b   Goff, Donald C ^a,b   Henderson, David C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Partners Community HealthCare Inc   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

attention; cognition; intranasal insulin; schizophrenia

Indexed keywords

GLUCOSE; INSULIN; ISOPHANE INSULIN; PLACEBO;

ADULT; ARTICLE; ATTENTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RECALL; RESPONSE TIME; SCHIZOPHRENIA; SINGLE DRUG DOSE; TASK PERFORMANCE; VERBAL MEMORY;

ADMINISTRATION, INTRANASAL; ADULT; ATTENTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INSULIN; MALE; MEMORY; MIDDLE AGED; PSYCHOTIC DISORDERS; SCHIZOPHRENIA; TIME FACTORS; TREATMENT OUTCOME; VERBAL LEARNING;

EID: 79952444478     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31820ebd0e     Document Type: Article

References (24)

1. Biessels GJ, Kamal A, Urban IJ, et al. Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment. Brain Res. 1998;800:125-135. (Pubitemid 28361929)
2. Park CR, Seeley RJ, Craft S, et al. Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav. 2000; 68:509-514. (Pubitemid 30129236)
3. Kern W, Peters A, Fruehwald-Schultes B, et al. Improving influence of insulin on cognitive functions in humans. Neuroendocrinology. 2001;74:270-280. (Pubitemid 34701752)
4. Craft S, Asthana S, Newcomer JW, et al. Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose. Arch Gen Psychiatry. 1999;56:1135-1140.
5. Benedict C, Hallschmid M, Hatke A, et al. Intranasal insulin improves memory in humans. Psychoneuroendocrinology. 2004;29:1326-1334. (Pubitemid 39024358)
6. Thorne RG, Pronk GJ, Padmanabhan V, et al. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience. 2004;127:481-496. (Pubitemid 38950662)
7. Born J, Lange T, Kern W, et al. Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci. 2002;5:514-516. (Pubitemid 34568991)
8. Reger MA,Watson GS, Frey WH 2nd, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging. 2006;27:451-458.
9. Reger MA, Watson GS, Green PS, et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology. 2008;70:440-448
10. Grunze HC, Rainnie DG, Hasselmo ME, et al. NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci. 1996; 16:2034-2043. (Pubitemid 26144016)
11. Green MF, Nuechterlein KH, Gold JM, et al. Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry. 2004;56:301-307. (Pubitemid 39164514)
12. Spitzer RL, Williams JB, Gibbon M, et al. The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Arch Gen Psychiatry. 1992;49:624-629.
13. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276. (Pubitemid 18039085)
14. Shapiro AM, Benedict RH, Schretlen D, et al. Construct and concurrent validity of the Hopkins Verbal Learning TestYRevised. Clin Neuropsychol. 1999;13:348-358. (Pubitemid 30040145)
15. Cornblatt BA, Risch NJ, Faris G, et al. The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res. 1988;26:223-238.
16. Balakrishnan S, Mathew J, Antony S, et al. Muscarinic M(1), M(3) receptors function in the brainstem of streptozotocin induced diabetic rats: their role in insulin secretion from the pancreatic islets as a function of age. Eur J Pharmacol. 2009;608:14-22.
17. Zhao WQ, Chen H, Quon MJ, et al. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol. 2004;490:71-81. (Pubitemid 38482161)
18. Sarter M, Hasselmo ME, Bruno JP, et al. Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res Brain Res Rev. 2005;48:98-111. (Pubitemid 40215784)
19. Kozak R, Bruno JP, Sarter M. Augmented prefrontal acetylcholine release during challenged attentional performance. Cereb Cortex. 2006;16:9-17. (Pubitemid 41746726)
20. Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol. 2001;177:125-134. (Pubitemid 32506813)
21. Christie JM, Wenthold RJ, Monaghan DT. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. J Neurochem. 1999;72:1523-1528. (Pubitemid 29140824)
22. Liu L, Brown JC 3rd, Webster WW, et al. Insulin potentiates N-methyl-D-aspartate receptor activity in Xenopus oocytes and rat hippocampus. Neurosci Lett. 1995;192:5-8.
23. Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry. 2001;158:1367-1377. (Pubitemid 32847232)
24. Masiak M, Perzynski J, Bednarski M, et al. Insulin coma therapy in the treatment of early schizophrenia. Mater Med Pol. 1989;21:60-62. (Pubitemid 20094894)