TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency

Development (Cambridge)

Volumn 145, Issue 4, 2018, Pages

  Sierra, Robert A ^a   Hoverter, Nathan P ^a   Ramirez, Ricardo N ^b   Vuong, Linh M ^b   Mortazavi, Ali ^b   Merrill, Bradley J ^c   Waterman, Marian L ^a   Donovan, Peter J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

BMP4; Gastrulation; Human ES cells; Primitive streak; TCF7L1; WNT signaling

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN 4; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN NODAL; TRANSCRIPTION FACTOR 7 LIKE 1; TRANSCRIPTION FACTOR NANOG; WNT3 PROTEIN; BMP4 PROTEIN, HUMAN; TCF7L1 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GAIN OF FUNCTION MUTATION; GASTRULATION; GENE EXPRESSION; GENE ONTOLOGY; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIMITIVE STREAK; PRIORITY JOURNAL; WNT SIGNALING; CELL LINEAGE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROARRAY ANALYSIS; PLURIPOTENT STEM CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION;

BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELL LINEAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION; HUMAN EMBRYONIC STEM CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; PLURIPOTENT STEM CELLS; POLYMERASE CHAIN REACTION; PRIMITIVE STREAK; TRANSCRIPTION FACTOR 7-LIKE 1 PROTEIN; WNT SIGNALING PATHWAY;

EID: 85044695561     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/DEV.161075     Document Type: Article

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