Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages E6382-E6390

  Xu, Zhuojin ^a   Robitaille, Aaron M ^a   Berndt, Jason D ^a   Davidson, Kathryn C ^b   Fischer, Karin A ^a   Mathieu, Julie ^a   Potter, Jennifer C ^a   Ruohola Baker, Hannele ^a   Moon, Randall T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Human embryonic stem cells; Na ve pluripotency; Na ve to primed transition; Self renewal; Wnt catenin signaling

Indexed keywords

BETA CATENIN; KRUPPEL LIKE FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; WNT3A PROTEIN; 7,8 DIHYDRO 2 [4 (TRIFLUOROMETHYL)PHENYL] 5H THIOPYRANO[4,3 D]PYRIMIDIN 4 OL; BENZOTHIAZOLE DERIVATIVE; BIOLOGICAL MARKER; FUSED HETEROCYCLIC RINGS; IWP-2 COMPOUND; SMALL INTERFERING RNA;

ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; KLF4 GENE; NANOG GENE; OCT4 GENE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEOMICS; STELLA GENE; STEM CELL SELF-RENEWAL; WNT SIGNALING PATHWAY; APOPTOSIS; BIOLOGICAL MODEL; CELL CYCLE; CELL DIFFERENTIATION; CELL SELF-RENEWAL; CFU COUNTING; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROCEDURES; WNT SIGNALING;

APOPTOSIS; BENZOTHIAZOLES; BIOMARKERS; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SELF RENEWAL; COLONY-FORMING UNITS ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HETEROCYCLIC COMPOUNDS, 3-RING; HUMAN EMBRYONIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEOMICS; RNA, SMALL INTERFERING; WNT SIGNALING PATHWAY;

EID: 84991687017     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1613849113     Document Type: Article

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