-
1
-
-
84978287529
-
c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src
-
Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology 2016; 63: 1987–2003.
-
(2016)
Hepatology
, vol.63
, pp. 1987-2003
-
-
Win, S.1
Than, T.A.2
Min, R.W.3
Aghajan, M.4
Kaplowitz, N.5
-
2
-
-
80053425902
-
C-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
-
Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. C-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem 2011; 286: 35071–35078.
-
(2011)
J Biol Chem
, vol.286
, pp. 35071-35078
-
-
Win, S.1
Than, T.A.2
Han, D.3
Petrovic, L.M.4
Kaplowitz, N.5
-
3
-
-
84867808435
-
Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity
-
Sharma M, Gadang V, Jaeschke A. Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity. Mol Pharmacol 2012; 82: 1001–1007.
-
(2012)
Mol Pharmacol
, vol.82
, pp. 1001-1007
-
-
Sharma, M.1
Gadang, V.2
Jaeschke, A.3
-
4
-
-
53049105071
-
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
-
Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A et al. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology 2008; 135: 1311–1321.
-
(2008)
Gastroenterology
, vol.135
, pp. 1311-1321
-
-
Nakagawa, H.1
Maeda, S.2
Hikiba, Y.3
Ohmae, T.4
Shibata, W.5
Yanai, A.6
-
5
-
-
46649084880
-
Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury
-
Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 2008; 283: 13565–13577.
-
(2008)
J Biol Chem
, vol.283
, pp. 13565-13577
-
-
Hanawa, N.1
Shinohara, M.2
Saberi, B.3
Gaarde, W.A.4
Han, D.5
Kaplowitz, N.6
-
6
-
-
7044226521
-
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
-
Kon K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 2004; 40: 1170–1179.
-
(2004)
Hepatology
, vol.40
, pp. 1170-1179
-
-
Kon, K.1
Kim, J.S.2
Jaeschke, H.3
Lemasters, J.J.4
-
7
-
-
77953701589
-
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
-
Saito C, Lemasters JJ, Jaeschke H. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 2010; 246: 8–17.
-
(2010)
Toxicol Appl Pharmacol
, vol.246
, pp. 8-17
-
-
Saito, C.1
Lemasters, J.J.2
Jaeschke, H.3
-
8
-
-
16844387124
-
Role of JNK activation in apoptosis: A double edged sword
-
Liu J, Lin A. Role of JNK activation in apoptosis: a double edged sword. Cell Res 2005; 15: 36–42.
-
(2005)
Cell Res
, vol.15
, pp. 36-42
-
-
Liu, J.1
Lin, A.2
-
9
-
-
2442429306
-
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins
-
Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y et al. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 2004; 23: 1889–1899.
-
(2004)
EMBO J
, vol.23
, pp. 1889-1899
-
-
Tsuruta, F.1
Sunayama, J.2
Mori, Y.3
Hattori, S.4
Shimizu, S.5
Tsujimoto, Y.6
-
10
-
-
34248597048
-
Role of mitogen-activated protein kinase kinase 4 in cancer
-
Whitmarsh AJ, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 2007; 26: 3172–3184.
-
(2007)
Oncogene
, vol.26
, pp. 3172-3184
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
11
-
-
0034992168
-
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
-
Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001; 15: 1419–1426.
-
(2001)
Genes Dev
, vol.15
, pp. 1419-1426
-
-
Tournier, C.1
Dong, C.2
Turner, T.K.3
Jones, S.N.4
Flavell, R.A.5
Davis, R.J.6
-
12
-
-
84962820648
-
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury
-
Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA et al. Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury. Gastroenterology 2016; 150: 968–981.
-
(2016)
Gastroenterology
, vol.150
, pp. 968-981
-
-
Cubero, F.J.1
Zoubek, M.E.2
Hu, W.3
Peng, J.4
Zhao, G.5
Nevzorova, Y.A.6
-
13
-
-
33745758229
-
c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
-
Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 2006; 131: 165–178.
-
(2006)
Gastroenterology
, vol.131
, pp. 165-178
-
-
Gunawan, B.K.1
Liu, Z.X.2
Han, D.3
Hanawa, N.4
Gaarde, W.A.5
Kaplowitz, N.6
-
14
-
-
53249111250
-
p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure
-
Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M. p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. EMBO Rep 2008; 9: 1048–1054.
-
(2008)
EMBO Rep
, vol.9
, pp. 1048-1054
-
-
Heinrichsdorff, J.1
Luedde, T.2
Perdiguero, E.3
Nebreda, A.R.4
Pasparakis, M.5
-
15
-
-
0031949068
-
Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6
-
Chen W, Koenigs LL, Thompson SJ, Peter RM, Rettie AE, Trager WF et al. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol 1998; 11: 295–301.
-
(1998)
Chem Res Toxicol
, vol.11
, pp. 295-301
-
-
Chen, W.1
Koenigs, L.L.2
Thompson, S.J.3
Peter, R.M.4
Rettie, A.E.5
Trager, W.F.6
-
16
-
-
84876063014
-
Regulation of drug-induced liver injury by signal transduction pathways: Critical role of mitochondria
-
Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ et al. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci 2013; 34: 243–253.
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 243-253
-
-
Han, D.1
Dara, L.2
Win, S.3
Than, T.A.4
Yuan, L.5
Abbasi, S.Q.6
-
17
-
-
72549094548
-
A novel technique for selective NF-kappaB inhibition in Kupffer cells: Contrary effects in fulminant hepatitis and ischaemia-reperfusion
-
Hoffmann F, Sass G, Zillies J, Zahler S, Tiegs G, Hartkorn A et al. A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. Gut 2009; 58: 1670–1678.
-
(2009)
Gut
, vol.58
, pp. 1670-1678
-
-
Hoffmann, F.1
Sass, G.2
Zillies, J.3
Zahler, S.4
Tiegs, G.5
Hartkorn, A.6
-
18
-
-
14844327760
-
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649–661.
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
19
-
-
0037434841
-
Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol-or 2-methoxyestradiol-induced apoptosis
-
Basu A, Haldar S. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol-or 2-methoxyestradiol-induced apoptosis. FEBS Lett 2003; 538: 41–47.
-
(2003)
FEBS Lett
, vol.538
, pp. 41-47
-
-
Basu, A.1
Haldar, S.2
-
20
-
-
67650076845
-
Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
-
Morel C, Carlson SM, White FM, Davis RJ. Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis. Mol Cell Biol 2009; 29: 3845–3852.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3845-3852
-
-
Morel, C.1
Carlson, S.M.2
White, F.M.3
Davis, R.J.4
-
21
-
-
70350048553
-
The liver's dance with death: Two Bcl-2 guardian proteins from the abyss
-
Cazanave SC, Gores GJ. The liver's dance with death: two Bcl-2 guardian proteins from the abyss. Hepatology 2009; 50: 1009–1013.
-
(2009)
Hepatology
, vol.50
, pp. 1009-1013
-
-
Cazanave, S.C.1
Gores, G.J.2
-
22
-
-
71049151926
-
Mcl-1 degradation during hepatocyte lipoapoptosis
-
Masuoka HC, Mott J, Bronk SF, Werneburg NW, Akazawa Y, Kaufmann SH et al. Mcl-1 degradation during hepatocyte lipoapoptosis. J Biol Chem 2009; 284: 30039–30048.
-
(2009)
J Biol Chem
, vol.284
, pp. 30039-30048
-
-
Masuoka, H.C.1
Mott, J.2
Bronk, S.F.3
Werneburg, N.W.4
Akazawa, Y.5
Kaufmann, S.H.6
-
23
-
-
84941600289
-
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury
-
Xie Y, Ramachandran A, Breckenridge DG, Liles JT, Lebofsky M, Farhood A et al. Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury. Toxicol Appl Pharmacol 2015; 286: 1–9.
-
(2015)
Toxicol Appl Pharmacol
, vol.286
, pp. 1-9
-
-
Xie, Y.1
Ramachandran, A.2
Breckenridge, D.G.3
Liles, J.T.4
Lebofsky, M.5
Farhood, A.6
-
24
-
-
84880322948
-
Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity
-
Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW et al. Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. Chem Res Toxicol 2013; 26: 1088–1096.
-
(2013)
Chem Res Toxicol
, vol.26
, pp. 1088-1096
-
-
Patterson, A.D.1
Carlson, B.A.2
Li, F.3
Bonzo, J.A.4
Yoo, M.H.5
Krausz, K.W.6
-
25
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 2002; 16: 1345–1355.
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
-
26
-
-
34547219895
-
Metabolic stress signaling mediated by mixed-lineage kinases
-
Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 2007; 27: 498–508.
-
(2007)
Mol Cell
, vol.27
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
27
-
-
17644373073
-
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
-
Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol 2005; 25: 3670–3681.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3670-3681
-
-
Brancho, D.1
Ventura, J.J.2
Jaeschke, A.3
Doran, B.4
Flavell, R.A.5
Davis, R.J.6
-
28
-
-
33847750361
-
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury
-
Latchoumycandane C, Goh CW, Ong MM, Boelsterli UA. Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. Hepatology 2007; 45: 412–421.
-
(2007)
Hepatology
, vol.45
, pp. 412-421
-
-
Latchoumycandane, C.1
Goh, C.W.2
Ong, M.M.3
Boelsterli, U.A.4
-
29
-
-
34347234591
-
Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure
-
Henderson NC, Pollock KJ, Frew J, Mackinnon AC, Flavell RA, Davis RJ et al. Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure. Gut 2007; 56: 982–990.
-
(2007)
Gut
, vol.56
, pp. 982-990
-
-
Henderson, N.C.1
Pollock, K.J.2
Frew, J.3
Mackinnon, A.C.4
Flavell, R.A.5
Davis, R.J.6
-
30
-
-
47949101861
-
Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury
-
Bourdi M, Korrapati MC, Chakraborty M, Yee SB, Pohl LR. Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. Biochem Biophys Res Commun 2008; 374: 6–10.
-
(2008)
Biochem Biophys Res Commun
, vol.374
, pp. 6-10
-
-
Bourdi, M.1
Korrapati, M.C.2
Chakraborty, M.3
Yee, S.B.4
Pohl, L.R.5
-
31
-
-
84941600289
-
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury
-
Xie Y, Ramachandran A, Breckenridge DG, Liles JT, Lebofsky M, Farhood A et al. Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury. Toxicol Appl Pharmacol 2015; 286: 1–9.
-
(2015)
Toxicol Appl Pharmacol
, vol.286
, pp. 1-9
-
-
Xie, Y.1
Ramachandran, A.2
Breckenridge, D.G.3
Liles, J.T.4
Lebofsky, M.5
Farhood, A.6
-
32
-
-
84870029447
-
Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury
-
Wancket LM, Meng X, Rogers LK, Liu Y. Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. Toxicol Pathol 2012; 40: 1095–1105.
-
(2012)
Toxicol Pathol
, vol.40
, pp. 1095-1105
-
-
Wancket, L.M.1
Meng, X.2
Rogers, L.K.3
Liu, Y.4
-
33
-
-
84891794636
-
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death
-
Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis 2014; 5: e989.
-
(2014)
Cell Death Dis
, vol.5
, pp. 89
-
-
Win, S.1
Than, T.A.2
Fernandez-Checa, J.C.3
Kaplowitz, N.4
-
34
-
-
84929607060
-
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
-
Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol 2015; 62: 1367–1374.
-
(2015)
J Hepatol
, vol.62
, pp. 1367-1374
-
-
Win, S.1
Than, T.A.2
Le, B.H.3
García-Ruiz, C.4
Fernandez-Checa, J.C.5
Kaplowitz, N.6
-
35
-
-
84958646766
-
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
-
Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L et al. Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics. Cancer Cell 2016; 29: 145–158.
-
(2016)
Cancer Cell
, vol.29
, pp. 145-158
-
-
Lalaoui, N.1
Hänggi, K.2
Brumatti, G.3
Chau, D.4
Nguyen, N.Y.5
Vasilikos, L.6
-
36
-
-
0029164598
-
Conditional site-specific recombination in mammalian cells using a ligand dependent chimeric Cre recombinase
-
Metzger D, Clifford J, Chiba H, Chambon P. Conditional site-specific recombination in mammalian cells using a ligand dependent chimeric Cre recombinase. Proc Natl Acad Sci USA 1995; 92: 6991–6995.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 6991-6995
-
-
Metzger, D.1
Clifford, J.2
Chiba, H.3
Chambon, P.4
-
37
-
-
0029767838
-
Ligand-activated site-specific recombination in mice
-
Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci USA 1996; 93: 10887–10890.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10887-10890
-
-
Feil, R.1
Brocard, J.2
Mascrez, B.3
Lemeur, M.4
Metzger, D.5
Chambon, P.6
-
38
-
-
34548851693
-
Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method
-
Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 2006; 1: 3159–3165.
-
(2006)
Nat Protoc
, vol.1
, pp. 3159-3165
-
-
Rahman, I.1
Kode, A.2
Biswas, S.K.3
-
39
-
-
33746073706
-
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis
-
Han D, Hanawa N, Saberi B, Kaplowitz N. Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis. Free Radic Biol Med 2006; 41: 627–639.
-
(2006)
Free Radic Biol Med
, vol.41
, pp. 627-639
-
-
Han, D.1
Hanawa, N.2
Saberi, B.3
Kaplowitz, N.4
|