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Volumn 23, Issue 3, 2018, Pages

Therapeutic perspectives of 8-prenylnaringenin, a potent phytoestrogen from hops

Author keywords

8 prenylnaringenin; Hops; Menopause; Phytoestrogens

Indexed keywords

8-PRENYLNARINGENIN; ANTINEOPLASTIC AGENT; FLAVANONE DERIVATIVE; PHYTOESTROGEN;

EID: 85044272755     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules23030660     Document Type: Review
Times cited : (71)

References (86)
  • 1
    • 40249086705 scopus 로고    scopus 로고
    • Pharmacognostic and pharmacological profile of Humulus lupulus L
    • [CrossRef] [PubMed]
    • Zanoli, P.; Zavatti, M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J. Ethnopharmacol. 2008, 116, 383-396. [CrossRef] [PubMed]
    • (2008) J. Ethnopharmacol. , vol.116 , pp. 383-396
    • Zanoli, P.1    Zavatti, M.2
  • 2
    • 84959508421 scopus 로고    scopus 로고
    • Biologically active compounds from hops and prospects for their use
    • [CrossRef]
    • Karabin, M.; Hudcova, T.; Jelinek, L.; Dostalek, P. Biologically active compounds from hops and prospects for their use. Compr. Rev. Food Sci. Food Saf. 2016, 15, 542-567. [CrossRef]
    • (2016) Compr. Rev. Food Sci. Food Saf. , vol.15 , pp. 542-567
    • Karabin, M.1    Hudcova, T.2    Jelinek, L.3    Dostalek, P.4
  • 3
    • 84905111487 scopus 로고    scopus 로고
    • Phytoestrogens in postmenopause: The state of the art from a chemical, pharmacological and regulatory perspective
    • [CrossRef] [PubMed]
    • Poluzzi, E.; Piccinni, C.; Raschi, E.; Rampa, A.; Recanatini, M.; De Ponti, F. Phytoestrogens in postmenopause: The state of the art from a chemical, pharmacological and regulatory perspective. Curr. Med. Chem. 2014, 21, 417-436. [CrossRef] [PubMed]
    • (2014) Curr. Med. Chem. , vol.21 , pp. 417-436
    • Poluzzi, E.1    Piccinni, C.2    Raschi, E.3    Rampa, A.4    Recanatini, M.5    De Ponti, F.6
  • 4
    • 84891342851 scopus 로고    scopus 로고
    • Biotransformations of prenylated hop flavonoids for drug discovery and production
    • [CrossRef] [PubMed]
    • Bartmanska, A.; Tronina, T.; Poplonski, J.; Huszcza, E. Biotransformations of prenylated hop flavonoids for drug discovery and production. Curr. Drug Metab. 2013, 14, 1083-1097. [CrossRef] [PubMed]
    • (2013) Curr. Drug Metab. , vol.14 , pp. 1083-1097
    • Bartmanska, A.1    Tronina, T.2    Poplonski, J.3    Huszcza, E.4
  • 5
    • 29144475373 scopus 로고    scopus 로고
    • The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties
    • [CrossRef] [PubMed]
    • Chadwick, L.; Pauli, G.; Farnsworth, N. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine 2006, 13, 119-131. [CrossRef] [PubMed]
    • (2006) Phytomedicine , vol.13 , pp. 119-131
    • Chadwick, L.1    Pauli, G.2    Farnsworth, N.3
  • 6
    • 0037238744 scopus 로고    scopus 로고
    • Phytoestrogens: Pharmacological and therapeutic perspectives
    • [CrossRef] [PubMed]
    • Bolego, C.; Poli, A.; Cignarella, A.; Paoletti, R. Phytoestrogens: Pharmacological and therapeutic perspectives. Curr. Drug Targets 2003, 4, 77-87. [CrossRef] [PubMed]
    • (2003) Curr. Drug Targets , vol.4 , pp. 77-87
    • Bolego, C.1    Poli, A.2    Cignarella, A.3    Paoletti, R.4
  • 7
    • 0141829776 scopus 로고    scopus 로고
    • Phytoestrogens: A review of the present state of research
    • [CrossRef] [PubMed]
    • Ososki, A.L.; Kennelly, E.J. Phytoestrogens: A review of the present state of research. Phytother. Res. 2003, 17, 845-869. [CrossRef] [PubMed]
    • (2003) Phytother. Res. , vol.17 , pp. 845-869
    • Ososki, A.L.1    Kennelly, E.J.2
  • 8
    • 84904478125 scopus 로고    scopus 로고
    • Prenylation modulates the bioavailability and bioaccumulation of dietary flavonoids
    • [CrossRef] [PubMed]
    • Terao, J.; Mukai, R. Prenylation modulates the bioavailability and bioaccumulation of dietary flavonoids. Arch. Biochem. Biophys. 2014, 559, 12-16. [CrossRef] [PubMed]
    • (2014) Arch. Biochem. Biophys. , vol.559 , pp. 12-16
    • Terao, J.1    Mukai, R.2
  • 9
    • 85029533738 scopus 로고    scopus 로고
    • Chinese and Indian women's experience with alternative medications for menopause related symptoms: A qualitative analysis
    • [CrossRef] [PubMed]
    • Ohn Mar, S.; Malhi, F.S.; Syed Rahim, S.H.; Soe, M.M. Chinese and Indian women's experience with alternative medications for menopause related symptoms: A qualitative analysis. Chin. J. Integr. Med. 2017, 1-7. [CrossRef] [PubMed]
    • (2017) Chin. J. Integr. Med. , pp. 1-7
    • Ohn Mar, S.1    Malhi, F.S.2    Syed Rahim, S.H.3    Soe, M.M.4
  • 10
    • 0037190065 scopus 로고    scopus 로고
    • Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the women's health initiative observational study
    • [CrossRef] [PubMed]
    • Pradhan, A.D.; Manson, J.E.; Rossouw, J.E.; Siscovick, D.S.; Mouton, C.P.; Rifai, N.; Wallace, R.B.; Jackson, R.D.; Pettinger, M.B.; Ridker, P.M. Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: Prospective analysis from the women's health initiative observational study. JAMA 2002, 288, 980-987. [CrossRef] [PubMed]
    • (2002) JAMA , vol.288 , pp. 980-987
    • Pradhan, A.D.1    Manson, J.E.2    Rossouw, J.E.3    Siscovick, D.S.4    Mouton, C.P.5    Rifai, N.6    Wallace, R.B.7    Jackson, R.D.8    Pettinger, M.B.9    Ridker, P.M.10
  • 12
    • 1542610624 scopus 로고    scopus 로고
    • Estrogen replacement therapy and ovarian cancer
    • [CrossRef] [PubMed]
    • Folsom, A.R.; Anderson, J.P.; Ross, J.A. Estrogen replacement therapy and ovarian cancer. Epidemiology 2004, 15, 100-104. [CrossRef] [PubMed]
    • (2004) Epidemiology , vol.15 , pp. 100-104
    • Folsom, A.R.1    Anderson, J.P.2    Ross, J.A.3
  • 13
    • 33646128011 scopus 로고    scopus 로고
    • A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts
    • [CrossRef] [PubMed]
    • Heyerick, A.; Vervarcke, S.; Depypere, H.; Bracke, M.; De Keukeleire, D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas 2006, 54, 164-175. [CrossRef] [PubMed]
    • (2006) Maturitas , vol.54 , pp. 164-175
    • Heyerick, A.1    Vervarcke, S.2    Depypere, H.3    Bracke, M.4    De Keukeleire, D.5
  • 14
    • 84929223987 scopus 로고    scopus 로고
    • The effect of hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo-controlled trial
    • [CrossRef] [PubMed]
    • Aghamiri, V.; Mirghafourvand, M.; Mohammad-Alizadeh-Charandabi, S.; Nazemiyeh, H. The effect of hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo-controlled trial. Complement. Ther. Clin. Pract. 2016, 23, 130-135. [CrossRef] [PubMed]
    • (2016) Complement. Ther. Clin. Pract. , vol.23 , pp. 130-135
    • Aghamiri, V.1    Mirghafourvand, M.2    Mohammad-Alizadeh-Charandabi, S.3    Nazemiyeh, H.4
  • 15
    • 77950299463 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts
    • [CrossRef] [PubMed]
    • Erkkola, R.; Vervarcke, S.; Vansteelandt, S.; Rompotti, P.; De Keukeleire, D.; Heyerick, A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine 2010, 17, 389-396. [CrossRef] [PubMed]
    • (2010) Phytomedicine , vol.17 , pp. 389-396
    • Erkkola, R.1    Vervarcke, S.2    Vansteelandt, S.3    Rompotti, P.4    De Keukeleire, D.5    Heyerick, A.6
  • 16
    • 84876715047 scopus 로고    scopus 로고
    • Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model
    • [CrossRef] [PubMed]
    • Van Duursen, M.B.; Smeets, E.E.; Rijk, J.C.; Nijmeijer, S.M.; van den Berg, M. Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model. Toxicol. Appl. Pharmacol. 2013, 269, 132-140. [CrossRef] [PubMed]
    • (2013) Toxicol. Appl. Pharmacol. , vol.269 , pp. 132-140
    • Van Duursen, M.B.1    Smeets, E.E.2    Rijk, J.C.3    Nijmeijer, S.M.4    Van Den Berg, M.5
  • 17
    • 84969914908 scopus 로고    scopus 로고
    • Prenylated chalcones and flavonoids for the prevention and treatment of cancer
    • [CrossRef] [PubMed]
    • Venturelli, S.; Burkard, M.; Biendl, M.; Lauer, U.M.; Frank, J.; Busch, C. Prenylated chalcones and flavonoids for the prevention and treatment of cancer. Nutrition 2016, 32, 1171-1178. [CrossRef] [PubMed]
    • (2016) Nutrition , vol.32 , pp. 1171-1178
    • Venturelli, S.1    Burkard, M.2    Biendl, M.3    Lauer, U.M.4    Frank, J.5    Busch, C.6
  • 18
    • 85027832060 scopus 로고    scopus 로고
    • In vitro effect of 8-prenylnaringenin and naringenin on fibroblasts and glioblastoma cells-cellular accumulation and cytotoxicity
    • [CrossRef] [PubMed]
    • Stompor, M.; Uram, L.; Podgorski, R. In vitro effect of 8-prenylnaringenin and naringenin on fibroblasts and glioblastoma cells-cellular accumulation and cytotoxicity. Molecules 2017, 22, 1092. [CrossRef] [PubMed]
    • (2017) Molecules , vol.22 , pp. 1092
    • Stompor, M.1    Uram, L.2    Podgorski, R.3
  • 19
    • 80054754782 scopus 로고    scopus 로고
    • Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-B signaling in HER2-overexpressing breast cancer cells
    • [PubMed]
    • Seo, H.S.; Choi, H.S.; Choi, H.S.; Choi, Y.K.; Um, J.Y.; Choi, I.; Shin, Y.C.; Ko, S.G. Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-B signaling in HER2-overexpressing breast cancer cells. Anticancer Res. 2011, 31, 3301-3313. [PubMed]
    • (2011) Anticancer Res. , vol.31 , pp. 3301-3313
    • Seo, H.S.1    Choi, H.S.2    Choi, H.S.3    Choi, Y.K.4    Um, J.Y.5    Choi, I.6    Shin, Y.C.7    Ko, S.G.8
  • 20
    • 84938964964 scopus 로고    scopus 로고
    • Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines
    • [CrossRef] [PubMed]
    • Busch, C.; Noor, S.; Leischner, C.; Burkard, M.; Lauer, U.M.; Venturelli, S. Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines. Wien. Med. Wochenschr. 2015, 165, 258-261. [CrossRef] [PubMed]
    • (2015) Wien. Med. Wochenschr. , vol.165 , pp. 258-261
    • Busch, C.1    Noor, S.2    Leischner, C.3    Burkard, M.4    Lauer, U.M.5    Venturelli, S.6
  • 21
    • 85028066350 scopus 로고    scopus 로고
    • A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus
    • [CrossRef] [PubMed]
    • Keiler, A.M.; Helle, J.; Bader, M.I.; Ehrhardt, T.; Nestler, K.; Kretzschmar, G.; Bernhardt, R.; Vollmer, G.; Nikolic, D.; Bolton, J.L.; et al. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus. Phytomedicine 2017, 34, 50-58. [CrossRef] [PubMed]
    • (2017) Phytomedicine , vol.34 , pp. 50-58
    • Keiler, A.M.1    Helle, J.2    Bader, M.I.3    Ehrhardt, T.4    Nestler, K.5    Kretzschmar, G.6    Bernhardt, R.7    Vollmer, G.8    Nikolic, D.9    Bolton, J.L.10
  • 23
    • 84955176938 scopus 로고    scopus 로고
    • Biotransformations and biological activities of hop flavonoids
    • [CrossRef] [PubMed]
    • Karabin, M.; Hudcova, T.; Jelinek, L.; Dostalek, P. Biotransformations and biological activities of hop flavonoids. Biotechnol. Adv. 2015, 33, 1063-1090. [CrossRef] [PubMed]
    • (2015) Biotechnol. Adv. , vol.33 , pp. 1063-1090
    • Karabin, M.1    Hudcova, T.2    Jelinek, L.3    Dostalek, P.4
  • 24
    • 84872971273 scopus 로고    scopus 로고
    • Význam chmelových prenylflavonoidu° pro lidské zdraví
    • Karabin, M.; Hudcova, T. Význam chmelových prenylflavonoidu° pro lidské zdraví. Chem. Listy 2012, 106, 1095-1103.
    • (2012) Chem. Listy , vol.106 , pp. 1095-1103
    • Karabin, M.1    Hudcova, T.2
  • 25
    • 84874902779 scopus 로고    scopus 로고
    • Analytical methods for quantitation of prenylated flavonoids from hops
    • [CrossRef] [PubMed]
    • Nikolic, D.; van Breemen, R.B. Analytical methods for quantitation of prenylated flavonoids from hops. Curr. Anal. Chem. 2013, 9, 71-85. [CrossRef] [PubMed]
    • (2013) Curr. Anal. Chem. , vol.9 , pp. 71-85
    • Nikolic, D.1    Van Breemen, R.B.2
  • 26
    • 0033007552 scopus 로고    scopus 로고
    • Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry
    • [CrossRef]
    • Stevens, J.F.; Taylor, A.W.; Deinzer, M.L. Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1999, 832, 97-107. [CrossRef]
    • (1999) J. Chromatogr. A , vol.832 , pp. 97-107
    • Stevens, J.F.1    Taylor, A.W.2    Deinzer, M.L.3
  • 27
    • 84953364587 scopus 로고    scopus 로고
    • Prenylated flavonoids, promising nutraceuticals with impressive biological activities
    • [CrossRef]
    • Yang, X.; Jiang, Y.; Yang, J.; He, J.; Sun, J.; Chen, F.; Zhang, M.; Yang, B. Prenylated flavonoids, promising nutraceuticals with impressive biological activities. Trends Food Sci. Technol. 2015, 44, 93-104. [CrossRef]
    • (2015) Trends Food Sci. Technol. , vol.44 , pp. 93-104
    • Yang, X.1    Jiang, Y.2    Yang, J.3    He, J.4    Sun, J.5    Chen, F.6    Zhang, M.7    Yang, B.8
  • 28
    • 84906291520 scopus 로고    scopus 로고
    • Reproductive and estrogenic effects of 8-prenylnaringenin in hops
    • Preedy, V.R., Ed.; Elsevier: San Diego, CA, USA
    • Milligan, S.R. Reproductive and estrogenic effects of 8-prenylnaringenin in hops. In Beer in Health and Disease Prevention; Preedy, V.R., Ed.; Elsevier: San Diego, CA, USA, 2008; pp. 711-723.
    • (2008) Beer in Health and Disease Prevention , pp. 711-723
    • Milligan, S.R.1
  • 29
    • 77951386504 scopus 로고
    • Estrogens in hops and beer; Preliminary report
    • [PubMed]
    • Koch, W.; Heim, G. Estrogens in hops and beer; preliminary report. Munch. Med. Wochenschr. 1953, 95, 845. [PubMed]
    • (1953) Munch. Med. Wochenschr. , vol.95 , pp. 845
    • Koch, W.1    Heim, G.2
  • 31
    • 84991628424 scopus 로고    scopus 로고
    • The potential health effects of dietary phytoestrogens
    • [CrossRef] [PubMed]
    • Rietjens, I.M.; Louisse, J.; Beekmann, K. The potential health effects of dietary phytoestrogens. Br. J. Pharmacol. 2017, 174, 1263-1280. [CrossRef] [PubMed]
    • (2017) Br. J. Pharmacol. , vol.174 , pp. 1263-1280
    • Rietjens, I.M.1    Louisse, J.2    Beekmann, K.3
  • 32
    • 0037174535 scopus 로고    scopus 로고
    • Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens
    • [CrossRef]
    • Mueller, S.O. Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2002, 777, 155-165. [CrossRef]
    • (2002) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.777 , pp. 155-165
    • Mueller, S.O.1
  • 34
    • 84992088580 scopus 로고    scopus 로고
    • Estrogen receptor ligands: A review (2013-2015)
    • [CrossRef] [PubMed]
    • Farzaneh, S.; Zarghi, A. Estrogen receptor ligands: A review (2013-2015). Sci. Pharm. 2016, 84, 409. [CrossRef] [PubMed]
    • (2016) Sci. Pharm. , vol.84 , pp. 409
    • Farzaneh, S.1    Zarghi, A.2
  • 35
    • 84864754756 scopus 로고    scopus 로고
    • Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)
    • [CrossRef] [PubMed]
    • Simons, R.; Gruppen, H.; Bovee, T.F.; Verbruggen, M.A.; Vincken, J.-P. Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs). Food Funct. 2012, 3, 810-827. [CrossRef] [PubMed]
    • (2012) Food Funct. , vol.3 , pp. 810-827
    • Simons, R.1    Gruppen, H.2    Bovee, T.F.3    Verbruggen, M.A.4    Vincken, J.-P.5
  • 36
    • 3042559902 scopus 로고    scopus 로고
    • Xanthohumol and related prenylflavonoids from hops and beer: To your good health!
    • [CrossRef] [PubMed]
    • Stevens, J.F.; Page, J.E. Xanthohumol and related prenylflavonoids from hops and beer: To your good health! Phytochemistry 2004, 65, 1317-1330. [CrossRef] [PubMed]
    • (2004) Phytochemistry , vol.65 , pp. 1317-1330
    • Stevens, J.F.1    Page, J.E.2
  • 37
    • 85021753127 scopus 로고    scopus 로고
    • ERAAs for menopause treatment: Welcome the 'designer estrogens'
    • [CrossRef] [PubMed]
    • Hirsch, H.D.; Shih, E.; Thacker, H.L. ERAAs for menopause treatment: Welcome the 'designer estrogens'. Clevel. Clin. J. Med. 2017, 84, 463-470. [CrossRef] [PubMed]
    • (2017) Clevel. Clin. J. Med. , vol.84 , pp. 463-470
    • Hirsch, H.D.1    Shih, E.2    Thacker, H.L.3
  • 38
    • 84870032509 scopus 로고    scopus 로고
    • The evolution of selective estrogen receptor modulators in osteoporosis therapy
    • [CrossRef] [PubMed]
    • Hadji, P. The evolution of selective estrogen receptor modulators in osteoporosis therapy. Climacteric 2012, 15, 513-523. [CrossRef] [PubMed]
    • (2012) Climacteric , vol.15 , pp. 513-523
    • Hadji, P.1
  • 39
    • 24144496829 scopus 로고    scopus 로고
    • Phytoestrogens induce differential estrogen receptor alpha-or beta-mediated responses in transfected breast cancer cells
    • [CrossRef]
    • Harris, D.; Besselink, E.; Henning, S.; Go, V.; Heber, D. Phytoestrogens induce differential estrogen receptor alpha-or beta-mediated responses in transfected breast cancer cells. Exp. Biol. Med. 2005, 230, 558-568. [CrossRef]
    • (2005) Exp. Biol. Med. , vol.230 , pp. 558-568
    • Harris, D.1    Besselink, E.2    Henning, S.3    Go, V.4    Heber, D.5
  • 40
    • 33845539126 scopus 로고    scopus 로고
    • Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors and J
    • [CrossRef] [PubMed]
    • Roelens, F.; Heldring, N.; Dhooge, W.; Bengtsson, M.; Comhaire, F.; Gustafsson, J.A.; Treuter, E.; De Keukeleire, D. Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors and J. Med. Chem. 2006, 49, 7357-7365. [CrossRef] [PubMed]
    • (2006) Med. Chem. , vol.49 , pp. 7357-7365
    • Roelens, F.1    Heldring, N.2    Dhooge, W.3    Bengtsson, M.4    Comhaire, F.5    Gustafsson, J.A.6    Treuter, E.7    De Keukeleire, D.8
  • 41
    • 72449155036 scopus 로고    scopus 로고
    • Prenylation has a compound specific effect on the estrogenicity of naringenin and genistein
    • [CrossRef] [PubMed]
    • Kretzschmar, G.; Zierau, O.; Wober, J.; Tischer, S.; Metz, P.; Vollmer, G. Prenylation has a compound specific effect on the estrogenicity of naringenin and genistein. J. Steroid Biochem. Mol. Biol. 2010, 118, 1-6. [CrossRef] [PubMed]
    • (2010) J. Steroid Biochem. Mol. Biol. , vol.118 , pp. 1-6
    • Kretzschmar, G.1    Zierau, O.2    Wober, J.3    Tischer, S.4    Metz, P.5    Vollmer, G.6
  • 42
    • 85044221871 scopus 로고    scopus 로고
    • Prenylation enhances the biological activity of dietary flavonoids by altering their bioavailability
    • [CrossRef] [PubMed]
    • Mukai, R. Prenylation enhances the biological activity of dietary flavonoids by altering their bioavailability. Biosci. Biotechnol. Biochem. 2018, 82, 207-215. [CrossRef] [PubMed]
    • (2018) Biosci. Biotechnol. Biochem. , vol.82 , pp. 207-215
    • Mukai, R.1
  • 43
    • 84922772731 scopus 로고    scopus 로고
    • Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2)
    • [CrossRef] [PubMed]
    • Tan, K.W.; Cooney, J.; Jensen, D.; Li, Y.; Paxton, J.W.; Birch, N.P.; Scheepens, A. Hop-derived prenylflavonoids are substrates and inhibitors of the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Mol. Nutr. Food Res. 2014, 58, 2099-2110. [CrossRef] [PubMed]
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 2099-2110
    • Tan, K.W.1    Cooney, J.2    Jensen, D.3    Li, Y.4    Paxton, J.W.5    Birch, N.P.6    Scheepens, A.7
  • 44
    • 33747067740 scopus 로고    scopus 로고
    • Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women
    • [CrossRef] [PubMed]
    • Rad, M.; Hümpel, M.; Schaefer, O.; Schoemaker, R.; Schleuning, W.D.; Cohen, A.; Burggraaf, J. Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women. Br. J. Clin. Pharmacol. 2006, 62, 288-296. [CrossRef] [PubMed]
    • (2006) Br. J. Clin. Pharmacol. , vol.62 , pp. 288-296
    • Rad, M.1    Hümpel, M.2    Schaefer, O.3    Schoemaker, R.4    Schleuning, W.D.5    Cohen, A.6    Burggraaf, J.7
  • 45
    • 0029098973 scopus 로고
    • Pharmacokinetic and pharmacologic variation between different estrogen products
    • [CrossRef] [PubMed]
    • O'Connell, M.B. Pharmacokinetic and pharmacologic variation between different estrogen products. J. Clin. Pharmacol. 1995, 35, 18S-24S. [CrossRef] [PubMed]
    • (1995) J. Clin. Pharmacol. , vol.35 , pp. 18S-24S
    • O'Connell, M.B.1
  • 46
    • 85044261832 scopus 로고    scopus 로고
    • The oral bioavailability of 8-prenylnaringenin from hops (Humulus lupulus L.) in healthy women and men is significantly higher than that of its positional isomer 6-prenylnaringenin in a randomized crossover trial
    • [CrossRef] [PubMed]
    • Calvo-Castro, L.A.; Burkard, M.; Sus, N.; Scheubeck, G.; Leischner, C.; Lauer, U.M.; Bosy-Westphal, A.; Hund, V.; Busch, C.; Venturelli, S. The oral bioavailability of 8-prenylnaringenin from hops (Humulus lupulus L.) in healthy women and men is significantly higher than that of its positional isomer 6-prenylnaringenin in a randomized crossover trial. Mol. Nutr. Food Res. 2018. [CrossRef] [PubMed]
    • (2018) Mol. Nutr. Food Res.
    • Calvo-Castro, L.A.1    Burkard, M.2    Sus, N.3    Scheubeck, G.4    Leischner, C.5    Lauer, U.M.6    Bosy-Westphal, A.7    Hund, V.8    Busch, C.9    Venturelli, S.10
  • 48
    • 0842347421 scopus 로고    scopus 로고
    • Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes
    • [CrossRef] [PubMed]
    • Nikolic, D.; Li, Y.; Chadwick, L.R.; Grubjesic, S.; Schwab, P.; Metz, P.; Van Breemen, R.B. Metabolism of 8-prenylnaringenin, a potent phytoestrogen from hops (Humulus lupulus), by human liver microsomes. Drug Metab. Dispos. 2004, 32, 272-279. [CrossRef] [PubMed]
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 272-279
    • Nikolic, D.1    Li, Y.2    Chadwick, L.R.3    Grubjesic, S.4    Schwab, P.5    Metz, P.6    Van Breemen, R.B.7
  • 49
    • 55149107267 scopus 로고    scopus 로고
    • Microbial metabolites of 8-prenylnaringenin, an estrogenic prenylflavanone
    • [CrossRef] [PubMed]
    • Kim, H.J.; Kim, S.-H.; Kang, B.Y.; Lee, I.-S. Microbial metabolites of 8-prenylnaringenin, an estrogenic prenylflavanone. Arch. Pharm. Res. 2008, 31, 1241-1246. [CrossRef] [PubMed]
    • (2008) Arch. Pharm. Res. , vol.31 , pp. 1241-1246
    • Kim, H.J.1    Kim, S.-H.2    Kang, B.Y.3    Lee, I.-S.4
  • 50
    • 33745670638 scopus 로고    scopus 로고
    • The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    • [CrossRef] [PubMed]
    • Possemiers, S.; Bolca, S.; Grootaert, C.; Heyerick, A.; Decroos, K.; Dhooge, W.; De Keukeleire, D.; Rabot, S.; Verstraete, W.; Van de Wiele, T. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J. Nutr. 2006, 136, 1862-1867. [CrossRef] [PubMed]
    • (2006) J. Nutr. , vol.136 , pp. 1862-1867
    • Possemiers, S.1    Bolca, S.2    Grootaert, C.3    Heyerick, A.4    Decroos, K.5    Dhooge, W.6    De Keukeleire, D.7    Rabot, S.8    Verstraete, W.9    Van De Wiele, T.10
  • 51
    • 84994894525 scopus 로고    scopus 로고
    • Hops for menopausal vasomotor symptoms: Mechanisms of action
    • [CrossRef] [PubMed]
    • Abdi, F.; Mobedi, H.; Roozbeh, N. Hops for menopausal vasomotor symptoms: Mechanisms of action. J. Menopausal Med. 2016, 22, 62-64. [CrossRef] [PubMed]
    • (2016) J. Menopausal Med. , vol.22 , pp. 62-64
    • Abdi, F.1    Mobedi, H.2    Roozbeh, N.3
  • 53
    • 85020052870 scopus 로고    scopus 로고
    • Review of efficacy of complementary and alternative medicine treatments for menopausal symptoms
    • [CrossRef] [PubMed]
    • Moore, T.R.; Franks, R.B.; Fox, C. Review of efficacy of complementary and alternative medicine treatments for menopausal symptoms. J. Midwifery Womens Health 2017, 62, 286-297. [CrossRef] [PubMed]
    • (2017) J. Midwifery Womens Health , vol.62 , pp. 286-297
    • Moore, T.R.1    Franks, R.B.2    Fox, C.3
  • 54
    • 84957542046 scopus 로고    scopus 로고
    • Hormone therapy for relieving postmenopausal vasomotor symptoms: A systematic review
    • [PubMed]
    • Abdi, F.; Mobedi, H.; Mosaffa, N.; Dolatian, M.; Ramezani Tehrani, F. Hormone therapy for relieving postmenopausal vasomotor symptoms: A systematic review. Arch. Iran. Med. 2016, 19, 141-146. [PubMed]
    • (2016) Arch. Iran. Med. , vol.19 , pp. 141-146
    • Abdi, F.1    Mobedi, H.2    Mosaffa, N.3    Dolatian, M.4    Ramezani Tehrani, F.5
  • 55
    • 85032972475 scopus 로고    scopus 로고
    • An update on hormone therapy in postmenopausal women: Mini-review for the basic scientist
    • [CrossRef] [PubMed]
    • Miller, V.M.; Harman, S.M. An update on hormone therapy in postmenopausal women: Mini-review for the basic scientist. Am. J. Physiol. Heart Circ. Physiol. 2017, 313, H1013-H1021. [CrossRef] [PubMed]
    • (2017) Am. J. Physiol. Heart Circ. Physiol. , vol.313 , pp. H1013-H1021
    • Miller, V.M.1    Harman, S.M.2
  • 56
    • 85014752763 scopus 로고    scopus 로고
    • The evidence base for HRT: What can we believe?
    • [CrossRef] [PubMed]
    • Langer, R.D. The evidence base for HRT: What can we believe? Climacteric 2017, 20, 91-96. [CrossRef] [PubMed]
    • (2017) Climacteric , vol.20 , pp. 91-96
    • Langer, R.D.1
  • 57
    • 84994301732 scopus 로고    scopus 로고
    • Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause
    • [CrossRef] [PubMed]
    • Lobo, R.A.; Pickar, J.H.; Stevenson, J.C.; Mack, W.J.; Hodis, H.N. Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause. Atherosclerosis 2016, 254, 282-290. [CrossRef] [PubMed]
    • (2016) Atherosclerosis , vol.254 , pp. 282-290
    • Lobo, R.A.1    Pickar, J.H.2    Stevenson, J.C.3    Mack, W.J.4    Hodis, H.N.5
  • 58
    • 84940446951 scopus 로고    scopus 로고
    • Complementary and alternative approaches to menopause
    • [CrossRef] [PubMed]
    • Taylor, M. Complementary and alternative approaches to menopause. Endocrinol. Metab. Clin. N. Am. 2015, 44, 619-648. [CrossRef] [PubMed]
    • (2015) Endocrinol. Metab. Clin. N. Am. , vol.44 , pp. 619-648
    • Taylor, M.1
  • 59
    • 85014502559 scopus 로고    scopus 로고
    • Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review
    • [CrossRef] [PubMed]
    • Tonob, D.; Melby, M.K. Broadening our perspectives on complementary and alternative medicine for menopause: A narrative review. Maturitas 2017, 99, 79-85. [CrossRef] [PubMed]
    • (2017) Maturitas , vol.99 , pp. 79-85
    • Tonob, D.1    Melby, M.K.2
  • 60
    • 85027844341 scopus 로고    scopus 로고
    • Menopause in Latin America: Symptoms attitudes treatments and future directions in Costa Rica
    • [CrossRef] [PubMed]
    • Locklear, T.D.; Doyle, B.J.; Perez, A.L.;Wicks, S.M.; Mahady, G.B. Menopause in Latin America: Symptoms, attitudes, treatments and future directions in Costa Rica. Maturitas 2017, 104, 84-89. [CrossRef] [PubMed]
    • (2017) Maturitas , vol.104 , pp. 84-89
    • Locklear, T.D.1    Doyle, B.J.2    Perez, A.L.3    Wicks, S.M.4    Mahady, G.B.5
  • 61
    • 84893701565 scopus 로고    scopus 로고
    • Herbal preparations for the menopause: Beyond isoflavones and black cohosh
    • [CrossRef] [PubMed]
    • Depypere, H.T.; Comhaire, F.H. Herbal preparations for the menopause: Beyond isoflavones and black cohosh. Maturitas 2014, 77, 191-194. [CrossRef] [PubMed]
    • (2014) Maturitas , vol.77 , pp. 191-194
    • Depypere, H.T.1    Comhaire, F.H.2
  • 62
    • 33751531570 scopus 로고    scopus 로고
    • The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes
    • [CrossRef] [PubMed]
    • Bowe, J.; Li, X.F.; Kinsey-Jones, J.; Heyerick, A.; Brain, S.; Milligan, S.; O'Byrne, K. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. J. Endocrinol. 2006, 191, 399-405. [CrossRef] [PubMed]
    • (2006) J. Endocrinol. , vol.191 , pp. 399-405
    • Bowe, J.1    Li, X.F.2    Kinsey-Jones, J.3    Heyerick, A.4    Brain, S.5    Milligan, S.6    O'Byrne, K.7
  • 63
    • 4243181350 scopus 로고    scopus 로고
    • International versions of the menopause rating scale (MRS)
    • [CrossRef] [PubMed]
    • Heinemann, L.A.; Potthoff, P.; Schneider, H.P. International versions of the menopause rating scale (MRS). Health Qual. Life Outcomes 2003, 1, 28. [CrossRef] [PubMed]
    • (2003) Health Qual. Life Outcomes , vol.1 , pp. 28
    • Heinemann, L.A.1    Potthoff, P.2    Schneider, H.P.3
  • 64
    • 84877837248 scopus 로고    scopus 로고
    • Hop extracts and hop substances in treatment of menopausal complaints
    • [CrossRef] [PubMed]
    • Keiler, A.M.; Zierau, O.; Kretzschmar, G. Hop extracts and hop substances in treatment of menopausal complaints. Planta Med. 2013, 79, 576-579. [CrossRef] [PubMed]
    • (2013) Planta Med. , vol.79 , pp. 576-579
    • Keiler, A.M.1    Zierau, O.2    Kretzschmar, G.3
  • 66
    • 27744471449 scopus 로고    scopus 로고
    • Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus
    • [CrossRef] [PubMed]
    • Humpel, M.; Isaksson, P.; Schaefer, O.; Kaufmann, U.; Ciana, P.; Maggi, A.; Schleuning, W.D. Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus. J. Steroid Biochem. Mol. Biol. 2005, 97, 299-305. [CrossRef] [PubMed]
    • (2005) J. Steroid Biochem. Mol. Biol. , vol.97 , pp. 299-305
    • Humpel, M.1    Isaksson, P.2    Schaefer, O.3    Kaufmann, U.4    Ciana, P.5    Maggi, A.6    Schleuning, W.D.7
  • 67
    • 84874616259 scopus 로고    scopus 로고
    • The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro
    • [CrossRef] [PubMed]
    • Ming, L.G.; Lv, X.; Ma, X.N.; Ge, B.F.; Zhen, P.; Song, P.; Zhou, J.; Ma, H.P.; Xian, C.J.; Chen, K.M. The prenyl group contributes to activities of phytoestrogen 8-prenynaringenin in enhancing bone formation and inhibiting bone resorption in vitro. Endocrinology 2013, 154, 1202-1214. [CrossRef] [PubMed]
    • (2013) Endocrinology , vol.154 , pp. 1202-1214
    • Ming, L.G.1    Lv, X.2    Ma, X.N.3    Ge, B.F.4    Zhen, P.5    Song, P.6    Zhou, J.7    Ma, H.P.8    Xian, C.J.9    Chen, K.M.10
  • 68
    • 84939573258 scopus 로고    scopus 로고
    • Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7
    • [CrossRef] [PubMed]
    • Luo, D.; Kang, L.; Ma, Y.; Chen, H.; Kuang, H.; Huang, Q.; He, M.; Peng, W. Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7. Food Sci. Nutr. 2014, 2, 341-350. [CrossRef] [PubMed]
    • (2014) Food Sci. Nutr. , vol.2 , pp. 341-350
    • Luo, D.1    Kang, L.2    Ma, Y.3    Chen, H.4    Kuang, H.5    Huang, Q.6    He, M.7    Peng, W.8
  • 69
    • 84862943050 scopus 로고    scopus 로고
    • Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A)
    • [CrossRef] [PubMed]
    • Hemachandra, L.; Madhubhani, P.; Chandrasena, R.; Esala, P.; Chen, S.-N.; Main, M.; Lankin, D.C.; Scism, R.A.; Dietz, B.M.; Pauli, G.F. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prev. Res. 2012, 5, 73-81. [CrossRef] [PubMed]
    • (2012) Cancer Prev. Res. , vol.5 , pp. 73-81
    • Hemachandra, L.1    Madhubhani, P.2    Chandrasena, R.3    Esala, P.4    Chen, S.-N.5    Main, M.6    Lankin, D.C.7    Scism, R.A.8    Dietz, B.M.9    Pauli, G.F.10
  • 72
    • 0037532873 scopus 로고    scopus 로고
    • Bust enhancing herbal products
    • [PubMed]
    • Fugh-Berman, A. "Bust enhancing" herbal products. Obstet. Gynecol. 2003, 101, 1345-1349. [PubMed]
    • (2003) Obstet. Gynecol. , vol.101 , pp. 1345-1349
    • Fugh-Berman, A.1
  • 73
    • 84864762802 scopus 로고    scopus 로고
    • The phytoestrogen 8-prenylnaringenin inhibits agonist-dependent activation of human platelets
    • [CrossRef] [PubMed]
    • Di Vito, C.; Bertoni, A.; Nalin, M.; Sampietro, S.; Zanfa, M.; Sinigaglia, F. The phytoestrogen 8-prenylnaringenin inhibits agonist-dependent activation of human platelets. Biochim. Biophys. Acta Gen. Subj. 2012, 1820, 1724-1733. [CrossRef] [PubMed]
    • (2012) Biochim. Biophys. Acta Gen. Subj. , vol.1820 , pp. 1724-1733
    • Di Vito, C.1    Bertoni, A.2    Nalin, M.3    Sampietro, S.4    Zanfa, M.5    Sinigaglia, F.6
  • 75
    • 77649180155 scopus 로고    scopus 로고
    • Controversies concerning the use of phytoestrogens in menopause management: Bioavailability and metabolism
    • [CrossRef] [PubMed]
    • De Cremoux, P.; This, P.; Leclercq, G.; Jacquot, Y. Controversies concerning the use of phytoestrogens in menopause management: Bioavailability and metabolism. Maturitas 2010, 65, 334-339. [CrossRef] [PubMed]
    • (2010) Maturitas , vol.65 , pp. 334-339
    • De Cremoux, P.1    This, P.2    Leclercq, G.3    Jacquot, Y.4
  • 76
    • 78650589344 scopus 로고    scopus 로고
    • Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes
    • [CrossRef] [PubMed]
    • Leclercq, G.; De Cremoux, P.; This, P.; Jacquot, Y. Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes. Maturitas 2011, 68, 56-64. [CrossRef] [PubMed]
    • (2011) Maturitas , vol.68 , pp. 56-64
    • Leclercq, G.1    De Cremoux, P.2    This, P.3    Jacquot, Y.4
  • 78
    • 84901977637 scopus 로고    scopus 로고
    • Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland
    • [CrossRef] [PubMed]
    • Helle, J.; Kraker, K.; Bader, M.I.; Keiler, A.M.; Zierau, O.; Vollmer, G.; Welsh, J.; Kretzschmar, G. Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland. Mol. Cell. Endocrinol. 2014, 392, 125-135. [CrossRef] [PubMed]
    • (2014) Mol. Cell. Endocrinol. , vol.392 , pp. 125-135
    • Helle, J.1    Kraker, K.2    Bader, M.I.3    Keiler, A.M.4    Zierau, O.5    Vollmer, G.6    Welsh, J.7    Kretzschmar, G.8
  • 81
    • 84889881769 scopus 로고    scopus 로고
    • Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety
    • [CrossRef] [PubMed]
    • Leclercq, G.; Jacquot, Y. Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer-considerations concerning related efficacy and safety. J. Steroid Biochem. Mol. Biol. 2014, 139, 237-244. [CrossRef] [PubMed]
    • (2014) J. Steroid Biochem. Mol. Biol. , vol.139 , pp. 237-244
    • Leclercq, G.1    Jacquot, Y.2
  • 82
    • 85032615313 scopus 로고    scopus 로고
    • Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health
    • [CrossRef]
    • Van Duursen, M.B. Modulation of estrogen synthesis and metabolism by phytoestrogens in vitro and the implications for women's health. Toxicol. Res. 2017, 6, 772-794. [CrossRef]
    • (2017) Toxicol. Res. , vol.6 , pp. 772-794
    • Van Duursen, M.B.1
  • 83
    • 85029828238 scopus 로고    scopus 로고
    • Botanicals and their bioactive phytochemicals for women's health
    • [CrossRef] [PubMed]
    • Dietz, B.M.; Hajirahimkhan, A.; Dunlap, T.L.; Bolton, J.L. Botanicals and their bioactive phytochemicals for women's health. Pharmacol. Rev. 2016, 68, 1026-1073. [CrossRef] [PubMed]
    • (2016) Pharmacol. Rev. , vol.68 , pp. 1026-1073
    • Dietz, B.M.1    Hajirahimkhan, A.2    Dunlap, T.L.3    Bolton, J.L.4
  • 84
    • 84904512774 scopus 로고    scopus 로고
    • Naringenin (NAR) and 8-prenylnaringenin (8-PN) reduce the developmental competence of porcine oocytes in vitro
    • [CrossRef] [PubMed]
    • Solak, K.A.; Santos, R.R.; van den Berg, M.; Blaauboer, B.J.; Roelen, B.A.; van Duursen, M.B. Naringenin (NAR) and 8-prenylnaringenin (8-PN) reduce the developmental competence of porcine oocytes in vitro. Reprod. Toxicol. 2014, 49, 1-11. [CrossRef] [PubMed]
    • (2014) Reprod. Toxicol. , vol.49 , pp. 1-11
    • Solak, K.A.1    Santos, R.R.2    Van Den Berg, M.3    Blaauboer, B.J.4    Roelen, B.A.5    Van Duursen, M.B.6
  • 85
    • 84891762999 scopus 로고    scopus 로고
    • Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols
    • [CrossRef] [PubMed]
    • Yuan, Y.; Qiu, X.; Nikolic, D.; Chen, S.N.; Huang, K.; Li, G.; Pauli, G.F.; van Breemen, R.B. Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. Eur. J. Pharm. Sci. 2014, 53, 55-61. [CrossRef] [PubMed]
    • (2014) Eur. J. Pharm. Sci. , vol.53 , pp. 55-61
    • Yuan, Y.1    Qiu, X.2    Nikolic, D.3    Chen, S.N.4    Huang, K.5    Li, G.6    Pauli, G.F.7    Van Breemen, R.B.8
  • 86
    • 34547663626 scopus 로고    scopus 로고
    • The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects
    • Lynch, T.; Price, A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am. Fam. Phys. 2007, 76, 391-396.
    • (2007) Am. Fam. Phys. , vol.76 , pp. 391-396
    • Lynch, T.1    Price, A.2


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