Complementary and Alternative Approaches to Menopause

Endocrinology and Metabolism Clinics of North America

Volumn 44, Issue 3, 2015, Pages 619-648

  Taylor, Maida ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Black cohosh; Botanic medicine; Daidzein; Flaxseed; Genistein; Hops; Pine bark; S equol

Indexed keywords

ALPHA TOCOPHEROL; ANGELICA SINENSIS EXTRACT; CALCIUM; CIMICIFUGA RACEMOSA EXTRACT; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; DAIDZEIN; DIOSGENIN; EQUOL; GENISTEIN; GINSENG EXTRACT; HUMULUS LUPULUS EXTRACT; IPRIFLAVONE; ISOFLAVONE DERIVATIVE; LEPIDIUM MEYENII EXTRACT; PHYTOESTROGEN; PLACEBO; POLLEN EXTRACT; PRIMROSE OIL; PROANTHOCYANIDIN; PYCNOGENOL; RED CLOVER EXTRACT; RHUBARB EXTRACT; SOYBEAN EXTRACT; SOYBEAN PROTEIN; PLANT EXTRACT;

ALLERGY; ALTERNATIVE MEDICINE; AMENORRHEA; ARTHRITIS; AUTOIMMUNE DISEASE; CONSTIPATION; CRINUM; DIABETIC NEUROPATHY; DIARRHEA; DIET SUPPLEMENTATION; DIOSCOREA VILLOSA; DRUG DOSE COMPARISON; DYSMENORRHEA; ECZEMA; GASTROINTESTINAL DISEASE; GOOD MANUFACTURING PRACTICE; HERBAL MEDICINE; HORMONAL THERAPY; HOT FLUSH; HUMAN; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY DISEASE; IRRITABLE COLON; LINSEED; MASTALGIA; MENOPAUSAL SYNDROME; NIGHT SWEAT; NONHUMAN; OLIGOMENORRHEA; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PREMENSTRUAL SYNDROME; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; SOY FOOD; STANDARDIZATION; VASOMOTOR DISORDER; YAM; FEMALE; HOT FLASHES; MENOPAUSE; TREATMENT OUTCOME;

CIMICIFUGA DAHURICA; HUMULUS;

COMPLEMENTARY THERAPIES; FEMALE; HOT FLASHES; HUMANS; MENOPAUSE; PLANT EXTRACTS; TREATMENT OUTCOME;

EID: 84940446951     PISSN: 08898529     EISSN: 15584410     Source Type: Journal    
DOI: 10.1016/j.ecl.2015.05.008     Document Type: Review

References (85)

1. Rossouw J.E., Anderson G.L., Prentice R.L., Writing Group for the Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002, 288(3):321-333.
2. Wilson R.A. Feminine Forever 1966, M Evans Co, New York.
3. Bair Y.A., Gold E.B., Greendale G.A., et al. Ethnic differences in use of complementary and alternative medicine at midlife: longitudinal results from SWAN participants. Am J Public Health 2002, 92:1832-1835.
4. Bair Y.A., Gold E.B., Azari R.A., et al. Use of conventional and complementary healthcare during the transition to menopause: longitudinal results from the Study of Women's Health Across the Nation (SWAN). Menopause 2005, 12:31-39.
5. Gold E.B., Bair Y., Zhang G., et al. Cross-sectional analysis of specific complementary and alternative medicine (CAM) use by racial/ethnic group and menopausal status: the Study of Women's Health Across the Nation (SWAN). Menopause 2007, 14:612-623.
6. Bair Y.A., Gold E.B., Zhang G., et al. Use of complementary and alternative medicine during the menopause transition: longitudinal results from the Study of Women's Health Across the Nation. Menopause 2008, 15:32-43.
7. Peng W., Adams J., Sibbritt D.W., et al. Critical review of complementary and alternative medicine use in menopause: focus on prevalence, motivation, decision-making, and communication. Menopause 2014, 21(5):536-548.
8. Geller S.E., Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what doesn't. J Womens Health 2005, 14(7):634-649.
9. Gentry-Maharaj A., Karpinskyj C., Glazer C., et al. Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study. Menopause 2015, 22(4):384-390.
10. Adams N.R. Detection of the effects of phytoestrogens on sheep and cattle. J Anim Sci 1995, 73(5):1509-1515.
11. Kim J., Kang M., Lee J.S., et al. Fermented and nonfermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies. Cancer Sci 2011, 102(1):231-244.
12. Green R., Santoro N. Menopausal symptoms and ethnicity: the Study of Women's Health Across the Nation. Womens Health (London England) 2009, 5(2):127-133.
13. Ishizuka B., Kudo Y., Tango T. Cross-sectional community survey of menopause symptoms among Japanese women. Maturitas 2008, 61(3):260-267.
14. Sievert L.L., Morrison L., Brown D.E., et al. Vasomotor symptoms among Japanese-American and European-American women living in Hilo, Hawaii. Menopause 2007, 14(2):261-269.
15. North American Menopause Society The role of soy isoflavones in menopausal health: report of The North American MenopauseSociety/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause 2011, 18(7):732-753.
16. Bolaños R., Del Castillo A., Francia J. Soy isoflavones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and meta-analysis. Menopause 2010, 17(3):660-666. [review].
17. Lethaby A., Marjoribanks J., Kronenberg F., et al. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 2013, (12). CD001395.
18. Taku K., Melby M.K., Kronenberg F., et al. Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials. Menopause 2012, 19(7):776-790.
19. Chen M.N., Lin C.C., Liu C.F. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric 2015, 18(2):260-269.
20. Suarez F.L., Springfield J., Furne J.K., et al. Gas production in human ingesting a soybean flour derived from beans naturally low in oligosaccharides. Am J Clin Nutr 1999, 69(1):135-139.
21. Setchell K.D.R., Clerici C. Equol: history, chemistry, and formation. The J Nutr 2010, 140(7):1355S-1362S.
22. Newton K.M., Reed S.D., Uchiyama S., et al. A cross-sectional study of equol producer status and self-reported vasomotor symptoms. Menopause 2015, 22(5):489-495.
23. Aso T., Uchiyama S., Matsumura Y., et al. A natural S-(-)equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (larchmt) 2012, 21(1):92-100.
24. Aso T. Equol improves menopausal symptoms in Japanese women. J Nutr 2010, 140(7):1386S-1389S.
25. Utian W.H., Jones M., Setchell K.D. S-equol: a potential nonhormonal agent for menopause-related symptom relief. J Womens Health (Larchmt) 2015, 24(3):200-208.
26. D'Anna R., Cannata M.L., Atteritano M., et al. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study. Menopause 2007, 14(4):648-655.
27. Crisafulli A., Altavilla D., Marini H., et al. Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause 2005, 12(2):186-192.
28. Evans M., Elliott J.G., Sharma P., et al. The effect of synthetic genistein on menopause symptom management in healthy postmenopausal women: a multi-center, randomized, placebo-controlled study. Maturitas 2011, 68(2):189-196.
29. Khaodhiar L., Ricciotti H.A., Li L., et al. Daidzein-rich isoflavone aglycones are potentially effective in reducing hot flashes in menopausal women. Menopause 2008, 15(1):125-132.
30. Orlich M.J., Singh P.N., Sabaté J., et al. Vegetarian dietary patterns and mortality in Adventist Health Study 2. JAMA Intern Med 2013, 173(13):1230-1238.
31. Geller S., Studee L. Soy and red clover for mid-life and aging. Climacteric 2006, 9(4):245-263.
32. Sartippour M.R., Rao J.Y., Apple S., et al. A pilot clinical study of short-term isoflavone supplements in breast cancer patients. Nutr Cancer 2004, 49(1):59-65.
33. Shu X.O., Zheng Y., Cai H., et al. Soy food intake and breast cancer survival. JAMA 2009, 302(22):2437-2443.
34. Fritz H., Seely D., Flower G., et al. Soy, red clover, and isoflavones and breast cancer: a systematic review. PLoS One 2013, 8(11):e81968.
35. Unfer V., Casini M.L., Costabile L., et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004, 82(1):145-148. [quiz: 265].
36. Alexandersen P., Toussaint A., Christiansen C., et al. Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial. JAMA 2001, 285(11):1482-1488.
37. Available at: . Accessed June 15, 2015. http://www.swansonvitamins.com/swanson-premium-ipriflavone-complex-wo-stivone-120-tabs.
38. Kruse S.O., Löhning A., Pauli G.F., et al. Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid. Planta Med 1999, 65(8):763-764.
39. Wuttke W., Jarry H., Becker T., et al. Phytoestrogens: endocrine disrupters or replacement for hormone replacement therapy?. Maturitas 2003, 44(Suppl 1):S9-20. [review].
40. Newton K.M., Reed S.D., LaCroix A.Z., et al. Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial. Ann Intern Med 2006, 145(12):869-879.
41. Pockaj B., Gallagher J.G., Loprinzi C.L., et al. Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol 2006, 24(18):2836-2841.
42. Raus K., Brucker C., Gorkow C., et al. First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055. Menopause 2006, 13(4):678-691.
43. Mahady G.B., Low Dog T., Barrett M.L., et al. United States Pharmacopeia review of the black cohosh case reports of hepatotoxicity. Menopause 2008, 15(4 Pt 1):628-638.
44. Jenny M., Wondrak A., Zvetkova E., et al. Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells. Scientia Pharmaceutica 2011, 79:323-335.
45. Wu W.H., Liu L.Y., Chung C.J., et al. Estrogenic effect of yam ingestion in healthy postmenopausal women. J Am Coll Nutr 2005, 24(4):235-243.
46. Komesaroff P.A., Black C.V., Cable V., et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001, 4(2):144-150.
47. Beinfeld H., Korngold E. Between heaven and earth: a guide to Chinese medicine 1991, Ballantine Books, New York.
48. Circosta C., Pasquale R.D., Palumbo D.R., et al. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res 2006, 20(8):665-669.
49. Hirata J.D., Swiersz L.M., Zell B., et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997, 68(6):981-986.
50. Chenoy R., Hussain S., Tayob Y., et al. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing. BMJ 1994, 308(6927):501-503.
51. Lewis J.E., Nickell L.A., Thompson L.U., et al. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause. Menopause 2006, 13(4):631-642.
52. Colli M.C., Bracht A., Soares A.A., et al. Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms. J Med Food 2012, 15(9):840-845.
53. Pruthi S., Qin R., Terstreip S.A., et al. A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7. Menopause 2012, 19(1):48-53.
54. Baranov A.I. Medicinal uses of ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol 1982, 6(3):339-353.
55. Heyerick A., Vervarcke S., Depypere H., et al. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas 2006, 54(2):164-175.
56. Erkkola R., Vervarcke S., Vansteelandt S., et al. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine 2010, 17(6):389-396.
57. Lee M.S., Shin B.C., Yang E.J., et al. Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas 2011, 70:227-233.
58. Brooks N.A., Wilcox G., Walker K.Z., et al. Beneficial effects of Lepidium meyenii (maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause 2008, 15:1157-1162.
59. Meissner H.O., Mscisz A., Reich-Bilinska H., et al. Hormone-balancing effect of pre-gelatinized organic maca (Lepidium peruvanum chacon): (ii) physiological and symptomatic responses of early-postmenopausal women to standardized doses of maca in double blind, randomized, placebo-controlled, multi-centre clinical study. Int J Biomed Sci 2006, 2:360-374.
60. Meissner H.O., Reich-Bilinska H., Mscisz A., et al. Therapeutic effects of pre-gelatinized organic maca (Lepidium peruvanum chacon) used as a nonhormonal alternative to HRT in perimenopausal women-clinical pilot study. Int J Biomed Sci 2006, 2:143-159.
61. Yang H.M., Liao M.F., Zhu S.Y., et al. A randomised, double-blind, placebo-controlled trial on the effect of Pycnogenol on the climacteric syndrome in peri-menopausal women. Acta Obstet Gynecol Scand 2007, 86(8):978-985.
62. Errichi S., Bottari A., Belcaro G., et al. Supplementation with Pycnogenol improves signs and symptoms of menopausal transition. Panminerva Med 2011, 53(3 Suppl 1):65-70.
63. Kohama T., Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med 2013, 58(1-2):39-46.
64. Hellström A.C., Muntzing J. The pollen extract Femal-a nonestrogenic alternative to hormone therapy in women with menopausal symptoms. Menopause 2012, 19(7):825-829.
65. Winther K., Rein E., Hedman C. Femal, a herbal remedy made from pollen extracts, reduces hot flushes and improves quality of life in menopausal women: a randomized, placebo-controlled, parallel study. Climacteric 2005, 8(2):162-170.
66. Wober J., Möller F., Richter T., et al. Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds. J Steroid Biochem Mol Biol 2007, 107(3-5):191-201.
67. Heger M., Ventskovskiy B.M., Borzenko I., et al. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause 2006, 13(5):744-759.
68. Hasper I., Ventskovskiy B.M., Rettenberger R., et al. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause 2009, 16(1):117-131.
69. Kaszkin-Bettag M., Richardson A., Rettenberger R., et al. Long-term toxicity studies in dogs support the safety of the special extract ERr 731 from the roots of Rheum rhaponticum. Food Chem Toxicol 2008, 46(5):1608-1618.
70. Kupfersztain C., Rotem C., Fagot R., et al. The immediate effect of natural plant extract, Angelica sinensis and Matricaria chamomilla (Climex) for the treatment of hot flushes during menopause. A preliminary report. Clin Exp Obstet Gynecol 2003, 30(4):203-206.
71. Haines C.J., Lam P.M., Chung T.K., et al. A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation (Dang Gui Buxue Tang) on menopausal symptoms in Hong Kong Chinese women. Climacteric 2008, 11(3):244-251.
72. Verhoeven M.O., van der Mooren M.J., van de Weijer P.H., et al. CuraTrial Research Group. Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study. Menopause 2005, 12(4):412-420.
73. Zhong L.L., Tong Y., Tang G.W., et al. A randomized, double-blind, controlled trial of a Chinese herbal formula (Er-Xian decoction) for menopausal symptoms in Hong Kong perimenopausal women. Menopause 2013, 20(7):767-776.
74. Sammartino A., Tommaselli G.A., Gargano V., et al. Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Gynecol Endocrinol 2006, 22(11):646-650.
75. Xia Y., Zhao Y., Ren M., et al. A randomized double-blind placebo-controlled trial of a Chinese herbal medicine preparation (Jiawei Qing'e Fang) for hot flashes and quality of life in perimenopausal women. Menopause 2012, 19(2):234-244.
76. Liu D., Lu Y., Ma H., et al. A pilot observational study to assess the safety and efficacy of Menoprogen for the management of menopausal symptoms in Chinese women. J Altern Complement Med 2009, 15(1):79-85.
77. Garcia J.T., Gonzaga F., Tan D., et al. Use of a multibotanical (Nutrafem) for the relief of menopausal vasomotor symptoms: a double-blind, placebo-controlled study. Menopause 2010, 17(2):303-308.
78. Rotem C., Kaplan B. Phyto-Female Complex for the relief of hot flushes, night sweats and quality of sleep: randomized, controlled, double-blind pilot study. Gynecol Endocrinol 2007, 23(2):117-122.
79. Nedeljkovic M., Tian L., Ji P., et al. Effects of acupuncture and Chinese herbal medicine (Zhi Mu 14) on hot flushes and quality of life in postmenopausal women: results of a four-arm randomized controlled pilot trial. Menopause 2014, 21(1):15-24.
80. Available at: . Accessed June 15, 2015. https://www.consumerlab.com/recall_detail.asp?recallid=10799.
81. Available at: . Accessed June 15, 2015. http://well.blogs.nytimes.com/2015/02/03/new-york-attorney-general-targets-supplements-at-major-retailers/.
82. Available at: . Accessed June 15, 2015. http://well.blogs.nytimes.com/2015/03/09/safety-of-herbal-supplements-pulls-prosecutors-together/.
83. Available at: . Accessed June 15, 2015. http://www.usp.org/usp-verification-services/usp-verified-dietary-supplements/verified-supplements.
84. Available at: . Accessed June 15, 2015. https://www.consumerlab.com/products.asp.
85. Available at: . Accessed June 15, 2015. http://www.fda.gov/AboutFDA/Transparency/Basics/ucm194344.htm.