Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols

European Journal of Pharmaceutical Sciences

Volumn 53, Issue 1, 2014, Pages 55-61

  Yuan, Yang ^a   Qiu, Xi ^a   Nikolić, Dejan ^a   Chen, Shao Nong ^a   Huang, Ke ^a   Li, Guannan ^a   Pauli, Guido F ^a   Van Breemen, Richard B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

8 Prenylnaringenin; Cytochrome P450 inhibition; Drug botanical interactions; Hops; Isoxanthohumol

Indexed keywords

4' HYDROXYMEPHENYTOIN; 6 PRENYLNARINGENIN; 8 PRENYLNARINGENIN; AMFEBUTAMONE; AMODIAQUINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DEETHYLAMODIAQUINE; DEXTROMETHORPHAN; ISOXANTHOHUMOL; MEPHENYTOIN; MIDAZOLAM; PARACETAMOL; PHENACETIN; PHENOL DERIVATIVE; RADAFAXINE; TOLBUTAMIDE; UNCLASSIFIED DRUG; XANTHOHUMOL;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOPS; HUMAN; HUMAN CELL; HUMULUS LUPULUS; IC 50; LIVER; MICROSOME; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

8-PRENYLNARINGENIN; CYTOCHROME P450 INHIBITION; DRUG-BOTANICAL INTERACTIONS; HOPS; ISOXANTHOHUMOL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HUMULUS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PHENOLS; PLANT EXTRACTS; TANDEM MASS SPECTROMETRY;

EID: 84891762999     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.12.003     Document Type: Article

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