Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Stem Cell Reports

Volumn 10, Issue 3, 2018, Pages 712-724

  Loomans, Cindy J M ^a,b   Williams Giuliani, Nerys ^a,b   Balak, Jeetindra ^b   Ringnalda, Femke ^a   van Gurp, Léon ^a   Huch, Meritxell ^a,c   Boj, Sylvia F ^a   Sato, Toshiro ^d   Kester, Lennart ^a   de Sousa Lopes, Susana M Chuva ^b   Roost, Matthias S ^b   Bonner Weir, Susan ^e   Engelse, Marten A ^b   Rabelink, Ton J ^b   Heimberg, Harry ^f   Vries, Robert G J ^a   van Oudenaarden, Alexander ^a   Carlotti, Françoise ^b   Clevers, Hans ^a   de Koning, Eelco J P ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d KEIO UNIVERSITY   (Japan)

^e JOSLIN DIABETES CENTER   (United States)

^f VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

ALDH; beta cells; diabetes; endocrine differentiation; fetal; human; insulin; organoid; pancreas; progenitor

Indexed keywords

CADHERIN; RAS PROTEIN; INSULIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; EMBRYOID BODY; EPIGENETICS; GLYCOLYSIS; METABOLISM; MOUSE; MOUSE EMBRYONIC STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; ADULT; ANIMAL; CELL PROLIFERATION; HUMAN; ORGANOID; PANCREAS ISLET BETA CELL; PATHOLOGY; PHYSIOLOGY; STEM CELL;

ADULT; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; ORGANOIDS; STEM CELLS;

EID: 85043513280     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2018.02.005     Document Type: Article

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