6,7,4′-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice

European Journal of Pharmacology

Volumn 826, Issue , 2018, Pages 140-147

  Ko, Yong Hyun ^a   Kim, Sun Yeou ^b   Lee, Seok Yong ^a   Jang, Choon Gon ^a  

^a Sungkyunkwan University   (South Korea)

^b Gachon University   (South Korea)

Author keywords

6,7,4 Trihydroxyisoflavone; Alzheimer's disease; Brain derived neurotrophic factor; cAMP response element binding; Cognition

Indexed keywords

4',6,7 TRIHYDROXYISOFLAVONE; ACETYLCHOLINESTERASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DAIDZEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; 6,7,4'-TRIHYDROXYISOFLAVONE; CHOLINERGIC RECEPTOR STIMULATING AGENT; CREB1 PROTEIN, MOUSE; ISOFLAVONE DERIVATIVE; MALONALDEHYDE; SCOPOLAMINE BROMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; LEARNING; LEARNING DISORDER; MALE; MEMORY; MEMORY DISORDER; MOUSE; NONHUMAN; PASSIVE AVOIDANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION LEVEL; SCOPOLAMINE-INDUCED COGNITIVE DEFECT; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; UPREGULATION; WESTERN BLOTTING; Y-MAZE TEST; ANIMAL; AVOIDANCE BEHAVIOR; CHEMICALLY INDUCED; COGNITIVE DEFECT; DISEASE MODEL; HUMAN; MAZE TEST; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ACETYLCHOLINESTERASE; ANIMALS; AVOIDANCE LEARNING; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLINERGIC AGENTS; COGNITION; COGNITIVE DYSFUNCTION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; ISOFLAVONES; MALE; MALONDIALDEHYDE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED ICR; PHOSPHORYLATION; SCOPOLAMINE HYDROBROMIDE; SIGNAL TRANSDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 85043391292     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2018.02.048     Document Type: Article

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