Chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus

Psychopharmacology

Volumn 230, Issue 2, 2013, Pages 245-260

  Shi, Zhe ^a   Chen, Lingling ^b   Li, Sidi ^a   Chen, Shanguang ^c   Sun, Xiuping ^d   Sun, Lihua ^e   Li, Yinghui ^c   Zeng, Jianguo ^b   He, Yiran ^b   Liu, Xinmin ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

^c CHINA ASTRONAUT RESEARCH AND TRAINING CENTER   (China)

^d INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^e INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

BDNF; Cerebral cortex; Cognitive dysfunction; CREB; Dorsal hippocampus; Rat; Reward directed instrumental learning; Scopolamine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; PHOSPHOPROTEIN; SCOPOLAMINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CHRONIC DRUG ADMINISTRATION; COGNITIVE DEFECT; CONTROLLED STUDY; DORSAL HIPPOCAMPUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REWARD DIRECTED INSTRUMENTAL LEARNING; SIGNAL TRANSDUCTION; TASK PERFORMANCE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; COGNITION DISORDERS; CONDITIONING, OPERANT; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; MALE; MEMORY; MUSCARINIC ANTAGONISTS; PHOSPHORYLATION; RATS; RATS, WISTAR; REWARD; SCOPOLAMINE HYDROBROMIDE; SIGNAL TRANSDUCTION;

EID: 84891820863     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3149-y     Document Type: Article

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