Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice

Pharmacology Biochemistry and Behavior

Volumn 135, Issue , 2015, Pages 182-191

  Ghumatkar, Priya J ^a   Patil, Sachin P ^a   Jain, Pankaj D ^a   Tambe, Rufi M ^a   Sathaye, Sadhana ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Alzheimer's disease; Brain derived neurotrophic factor; Phloretin; Scopolamine

Indexed keywords

ACETYLCHOLINESTERASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CATALASE; DONEPEZIL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; MALONALDEHYDE; PHLORETIN; SCOPOLAMINE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; INDAN DERIVATIVE; MUSCARINIC AGENT; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; PIPERIDINE DERIVATIVE; SCOPOLAMINE BROMIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN HOMOGENATE; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; MORRIS WATER MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEPLETION; SCOPOLAMINE-INDUCED AMNESIA; SPATIAL MEMORY; TREATMENT DURATION; ALZHEIMER DISEASE; AMNESIA; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; MAZE TEST; METABOLISM; MOTOR ACTIVITY; PSYCHOLOGY;

MALUS X DOMESTICA; MUS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMNESIA; ANIMALS; ANTIOXIDANTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION DISORDERS; GLIAL FIBRILLARY ACIDIC PROTEIN; INDANS; MALE; MAZE LEARNING; MICE; MOTOR ACTIVITY; MUSCARINIC AGONISTS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; PHLORETIN; PIPERIDINES; SCOPOLAMINE HYDROBROMIDE;

EID: 84935919935     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.06.005     Document Type: Article

References (48)

1. K.S. Bhullar, and H.P. Rupasinghe Polyphenols: multipotent therapeutic agents in neurodegenerative diseases Oxid. Med. Cell. Longev. 2013 2013 891748
2. G.M. Bores, F.P. Huger, W. Petko, A.E. Mutlib, F. Camacho, D.K. Rush, D.E. Selk, V. Wolf, R.W. Kosley Jr., L. Davis, and H.M. Vargas Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine J. Pharmacol. Exp. Ther. 277 2 1996 728 738 (May)
3. N.J. Broadbent, L.R. Squire, and R.E. Clark Spatial memory, recognition memory, and the hippocampus Proc. Natl. Acad. Sci. U. S. A. 101 2004 14515 14520
4. R. Brookmeyer, E. Johnson, K. Ziegler-Graham, and H.M. Arrighi Forecasting the global burden of Alzheimer's disease Alzheimers Dement. 3 3 2007 186 189 (Jul)
5. W.T. Chang, W.C. Huang, and C.J. Liou Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages Food Chem. 134 2 2012 972 979 (Sep 15)
6. Z. Chen, A.J. Xu, R. Li, and E.Q. Wei Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147 Acta Pharmacol. Sin. 23 4 2002 355 360 (Apr)
7. M. da Penha Berzaghi, J. Cooper, E. Castrén, F. Zafra, M. Sofroniew, H. Thoenen, and D. Lindholm Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus J. Neurosci. 13 9 1993 3818 3826 (Sep)
8. C.A. Duva, S.B. Floresco, G.R. Wunderlich, T.L. Lao, J.P. Pinel, and A.G. Phillips Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats Behav. Neurosci. 111 1997 1184 1196
9. G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Feather-Stone A new and rapidcolorimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88 95
10. T. Fukuda, J. Takahashi, and J. Tanaka Tyrosine hydroxylase-immunoreactive neurons are decreased in number in the cerebral cortex of Parkinson's disease Neuropathology 19 1999 10 13
11. N. Gacar, O. Mutlu, T. Utkan, I. KomsuogluCelikyurt, S.S. Gocmez, and G. Ulak Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats Pharmacol. Biochem. Behav. 99 3 2011 316 323 (Sep)
12. G.J. Gage, D.R. Kipke, and W. Shain Whole animal perfusion fixation for rodents J. Vis. Exp. 65 2012 1 9
13. V.V. Giridharan, R.A. Thandavarayan, S. Sato, K.M. Ko, and T. Konishi Prevention of scopolamine-induced memory deficits by schisandrin B, anantioxidant lignan from Schisandra chinensis in mice Free Radic. Res. 45 2011 950 958
14. P. Goverdhan, A. Sravanthi, and T. Mamatha Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress Int. J. Alzheimers Dis. 2012 2012 974013
15. F.E. Harrison, A.H. Hosseini, S.M. Dawes, S. Weaver, and J.M. May Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze Behav. Brain Res. 205 2009 550 558
16. Y.J. Jang, J. Kim, J. Shim, C.Y. Kim, J.H. Jang, K.W. Lee, and H.J. Lee Decaffeinated coffee prevents scopolamine-induced memory impairment in rats Behav. Brain Res. 245 2013 113 119 (May 15)
17. M. Kawahara, and Y. Kuroda Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol Cell. Mol. Neurobiol. 21 1 2001 1 13 (Feb)
18. P. Komulainen, M. Pedersen, T. Hänninen, H. Bruunsgaard, T.A. Lakka, M. Kivipelto, M. Hassinen, T.H. Rauramaa, B.K. Pedersen, and R. Rauramaa BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study Neurobiol. Learn. Mem. 90 4 2008 596 603 (Nov)
19. A. Konar, N. Shah, R. Singh, N. Saxena, S.C. Kaul, R. Wadhwa, and M.K. Thakur Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells PLoS One 6 11 2011 e27265
20. H. Kumar, B.W. Kim, S.Y. Song, J.S. Kim, I.S. Kim, Y.S. Kwon, S. Koppula, and D.K. Choi Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms Biosci. Biotechnol. Biochem. 76 8 2012 1518 1522
21. P. Kurosinski, and J. Gotz Glial cells under physiologic and pathologic conditions Arch. Neurol. 59 10 2002 1524 1528 (Oct)
22. S.H. Kwon, H.C. Kim, S.Y. Lee, and C.G. Jang Loganin improves learning and memory impairments induced by scopolamine in mice Eur. J. Pharmacol. 619 1-3 2009 44 49 (Oct 1)
23. M.G. Lacey, P. Calabresi, and R.A. North Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors J. Pharmacol. Exp. Ther. 253 1 1990 395 400 (Apr)
24. X. Li Improved pyrogallol autoxidation method: a reliable and cheap superoxide-scavenging assay suitable for all antioxidants J. Agric. Food Chem. 60 2012 6418 6424
25. R.M. LoPachin, T. Gavin, B.C. Geohagen, L. Zhang, D. Casper, R. Lekhraj, and D.S. Barber β-Dicarbonyl enolates: a new class of neuroprotectants J. Neurochem. 116 1 2011 132 143 (Jan)
26. A. Mathur, A. Shandarin, S.R. LaViolette, J. Parker, and J.S. Yeomans Locomotion and stereotypy induced by scopolamine: contributions of muscarinic receptors near the pedunculopontine tegmental nucleus Brain Res. 775 1-2 1997 144 155 (Nov 14)
27. S. Matsuda, M. Umeda, H. Uchida, H. Kato, and T. Araki Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats J. Neural Transm. 116 2009 395 404
28. M.P. Mattson, W.A. Pedersen, W. Duan, C. Culmsee, and S. Camandola Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases Ann. N. Y. Acad. Sci. 893 1999 154 175
29. R.G. Morris Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-d-aspartate receptor antagonist AP5 J. Neurosci. 9 9 1989 3040 3057 (Sep)
30. R.G. Morris, E. Anderson, G.S. Lynch, and M. Baudry Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5 Nature 319 6056 1986 774 776 (Feb 27-Mar 5)
31. A. Nandi, and I.B. Chatterjee Assay of superoxide dismutase activity in animal tissues J. Biosci. 13 1988 305 315
32. A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda, E.K. Balraj, P.K. Jones, H. Ghanbari, T. Wataya, S. Shimohama, S. Chiba, C.S. Atwood, R.B. Petersen, and M.A. Smith Oxidative damage is the earliest event in Alzheimer disease J. Neuropathol. Exp. Neurol. 60 8 2001 759 767 (Aug)
33. H. Ohkawa, O. Nobuko, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
34. C. Oresajo, T. Stephens, and P.D. Hino Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photo damage in human skin J. Cosmet. Dermatol. 7 2008 290 297
35. K.V. Otari, O.G. Bichewar, R.V. Shete, and C.D. Upasani Effect of hydroalcoholic extract of Vitex negundo Linn. leaves on learning and memory in normal and cognitive deficit mice Asian Pac. J. Trop. Biomed. 2012 S104 S111
36. C.A. Reilly, and S.D. Aust Measurement of lipid peroxidation Curr. Protoc. Toxicol. 2 4 1999 1 13
37. B.M. Rezk, G.R. Haenen, W.J. van der Vijgh, and A. Bast The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids Biochem. Biophys. Res. Commun. 295 1 2002 9 13 (Jul 5)
38. M. Sakuma, N. Hayakawa, H. Kato, and T. Araki Time dependent changes of striatal interneurons after focal cerebral ischemia J. Neural Transm. 115 2008 413 422
39. G. Silvestrelli, A. Lanari, L. Parnetti, D. Tomassoni, and F. Amenta Treatment of Alzheimer's disease: from pharmacology to a better understanding of disease pathophysiology Mech. Ageing Dev. 127 2 2006 148 157 (Feb)
40. M. Singh, M. Kaur, H. Kukreja, R. Chugh, O. Silakari, and D. Singh Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection Eur. J. Med. Chem. 70 2013 165 188 (Dec)
41. A.K. Sinha Colorimetric assay of catalase Anal. Biochem. 47 1972 389 394
42. M.A. Smith Alzheimer disease Int. Rev. Neurobiol. 42 1998 1 54
43. I.K. Smith, T.L. Vierheller, and C.A. Thorne Assay of glutathione reductase in crude tissue homogenates using 5,5′-dithiobis(2-nitrobenzoic acid) Anal. Biochem. 175 1988 408 413
44. R.H. Swerdlow Brain aging, Alzheimer's disease, and mitochondria Biochim. Biophys. Acta 1812 12 2011 1630 1639 (Dec)
45. H.P. Vasantha Rupasinghe, and A. Yasmin Inhibition of oxidation of aqueous emulsions of omega-3 fatty acids and fish oil by phloretin and phloridzin Molecules 15 2010 251 257
46. M. Verri, O. Pastoris, M. Dossena, R. Aquilani, F. Guerriero, G. Cuzzoni, L. Venturini, G. Ricevuti, and A.I. Bongiorno Mitochondrial alterations, oxidative stress and neuroinflammation in Alzheimer's disease Int. J. Immunopathol. Pharmacol. 25 2 2012 345 353 (Apr-Jun)
47. X. Wang, W. Wang, L. Li, G. Perry, H.G. Lee, and X. Zhu Oxidative stress and mitochondrial dysfunction in Alzheimer's disease Biochim. Biophys. Acta 1842 8 2014 1240 1247
48. Q. Zhu, N.Q. Zhang, C.F. Lau, J. Chao, Z. Sun, R.C. Chang, F. Chen, and M. Wang In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple Food Chem. 135 3 2012 1762 1768 (Dec 1)