Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a and Csm6

Science

Volumn 360, Issue 6387, 2018, Pages 439-444

  Gootenberg, Jonathan S ^a,b,c,d   Abudayyeh, Omar O ^a,b,c   Kellner, Max J ^a   Joung, Julia ^a,b,c   Collins, James J ^a,c,e   Zhang, Feng ^a,b,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN CAS12A; CRISPR ASSOCIATED PROTEIN CAS13; CRISPR ASSOCIATED PROTEIN CSM6; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; VIRUS RNA; BACTERIAL PROTEIN; DNA; ENDONUCLEASE; RNA;

BIOTECHNOLOGY; ENZYME ACTIVITY; GENE EXPRESSION; MUTATION; NUCLEIC ACID; VIRUS; ZIKA VIRUS DISEASE;

ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DENGUE; DENGUE VIRUS; ENZYME ANALYSIS; GENE MUTATION; HUMAN; LIQUID BIOPSY; NONHUMAN; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SPECIFIC HIGH SENSITIVITY ENZYMATIC REPORTER UNLOCKING; VIRUS DETECTION; ZIKA FEVER; ZIKA VIRUS; CHEMISTRY; ENZYME ASSAY; ISOLATION AND PURIFICATION; SENSITIVITY AND SPECIFICITY;

ZIKA VIRUS;

BACTERIAL PROTEINS; CRISPR-ASSOCIATED PROTEINS; DENGUE VIRUS; DNA; ENDONUCLEASES; ENZYME ASSAYS; HUMANS; RNA; RNA, VIRAL; SENSITIVITY AND SPECIFICITY; ZIKA VIRUS;

EID: 85042220581     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaq0179     Document Type: Article

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