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Volumn 20, Issue 3, 2018, Pages 332-343

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(42)  Zhang, Haiying a   Freitas, Daniela a,b,c   Kim, Han Sang a,d   Fabijanic, Kristina e   Li, Zhong f   Chen, Haiyan a,g   Mark, Milica Tesic h   Molina, Henrik h   Martin, Alberto Benito a   Bojmar, Linda a   Fang, Justin e   Rampersaud, Sham e   Hoshino, Ayuko a   Matei, Irina a   Kenific, Candia M a   Nakajima, Miho a   Mutvei, Anders Peter a   Sansone, Pasquale a   Buehring, Weston a   Wang, Huajuan a   more..


Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; MICROTUBULE PROTEIN; NANOPARTICLE; BIOLOGICAL MARKER; DNA; PROTEIN; RNA;

EID: 85042193942     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/s41556-018-0040-4     Document Type: Article
Times cited : (1167)

References (54)
  • 1
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Thery, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2, 569-579 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 3
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo, G. & Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell. Biol. 200, 373-383 (2013).
    • (2013) J. Cell. Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 4
    • 79551608032 scopus 로고    scopus 로고
    • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    • Balaj, L. et al. Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat. Commun. 2, 180 (2011).
    • (2011) Nat. Commun. , vol.2 , pp. 180
    • Balaj, L.1
  • 5
    • 84878629272 scopus 로고    scopus 로고
    • Proteomics, transcriptomics and lipidomics of exosomes and ectosomes
    • Choi, D. S., Kim, D. K., Kim, Y. K. & Gho, Y. S. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics 13, 1554-1571 (2013).
    • (2013) Proteomics , vol.13 , pp. 1554-1571
    • Choi, D.S.1    Kim, D.K.2    Kim, Y.K.3    Gho, Y.S.4
  • 6
    • 84901842265 scopus 로고    scopus 로고
    • Double-stranded DNA in exosomes: A novel biomarker in cancer detection
    • Thakur, B. K. et al. Double-stranded DNA in exosomes: A novel biomarker in cancer detection. Cell. Res. 24, 766-769 (2014).
    • (2014) Cell. Res. , vol.24 , pp. 766-769
    • Thakur, B.K.1
  • 7
    • 84881139801 scopus 로고    scopus 로고
    • Extracellular vesicles as an emerging mechanism of cell-to-cell communication
    • Tetta, C., Ghigo, E., Silengo, L., Deregibus, M. C. & Camussi, G. Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine 44, 11-19 (2013).
    • (2013) Endocrine , vol.44 , pp. 11-19
    • Tetta, C.1    Ghigo, E.2    Silengo, L.3    Deregibus, M.C.4    Camussi, G.5
  • 8
    • 3843143950 scopus 로고    scopus 로고
    • The use of asymmetrical flow field-flow fractionation in pharmaceutics and biopharmaceutics
    • Fraunhofer, W. & Winter, G. The use of asymmetrical flow field-flow fractionation in pharmaceutics and biopharmaceutics. Eur. J. Pharm. Biopharm. 58, 369-383 (2004).
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 369-383
    • Fraunhofer, W.1    Winter, G.2
  • 9
    • 79958800544 scopus 로고    scopus 로고
    • Asymmetrical flow field-flow fractionation technique for separation and characterization of biopolymers and bioparticles
    • Yohannes, G., Jussila, M., Hartonen, K. & Riekkola, M. L. Asymmetrical flow field-flow fractionation technique for separation and characterization of biopolymers and bioparticles. J. Chromatogr. A 1218, 4104-4116 (2011).
    • (2011) J. Chromatogr. A , vol.1218 , pp. 4104-4116
    • Yohannes, G.1    Jussila, M.2    Hartonen, K.3    Riekkola, M.L.4
  • 10
    • 34249726598 scopus 로고    scopus 로고
    • Miniaturized asymmetrical flow field-flow fractionation: Application to biological vesicles
    • Oh, S. et al. Miniaturized asymmetrical flow field-flow fractionation: Application to biological vesicles. J. Sep. Sci. 30, 1082-1087 (2007).
    • (2007) J. Sep. Sci. , vol.30 , pp. 1082-1087
    • Oh, S.1
  • 11
    • 84941614986 scopus 로고    scopus 로고
    • Size characterization and quantification of exosomes by asymmetrical-flow field-flow fractionation
    • Sitar, S. et al. Size characterization and quantification of exosomes by asymmetrical-flow field-flow fractionation. Anal. Chem. 87, 9225-9233 (2015).
    • (2015) Anal. Chem. , vol.87 , pp. 9225-9233
    • Sitar, S.1
  • 12
    • 84914153712 scopus 로고    scopus 로고
    • A review of exosome separation techniques and characterization of B16-F10 mouse melanoma exosomes with AF4-UVMALS-DLS-TEM
    • Petersen, K. E. et al. A review of exosome separation techniques and characterization of B16-F10 mouse melanoma exosomes with AF4-UVMALS-DLS-TEM. Anal. Bioanal. Chem. 406, 7855-7866 (2014).
    • (2014) Anal. Bioanal. Chem. , vol.406 , pp. 7855-7866
    • Petersen, K.E.1
  • 13
    • 84912063255 scopus 로고    scopus 로고
    • Distribution profiling of circulating microRNAs in serum
    • Ashby, J. et al. Distribution profiling of circulating microRNAs in serum. Anal. Chem. 86, 9343-9349 (2014).
    • (2014) Anal. Chem. , vol.86 , pp. 9343-9349
    • Ashby, J.1
  • 14
    • 84929598148 scopus 로고    scopus 로고
    • Analysis of exosome release as a cellular response to MAPK pathway inhibition
    • Agarwal, K. et al. Analysis of exosome release as a cellular response to MAPK pathway inhibition. Langmuir 31, 5440-5448 (2015).
    • (2015) Langmuir , vol.31 , pp. 5440-5448
    • Agarwal, K.1
  • 15
    • 0037084460 scopus 로고    scopus 로고
    • Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target
    • Beningo, K. A. & Wang, Y. L. Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. J. Cell. Sci. 115, 849-856 (2002).
    • (2002) J. Cell. Sci. , vol.115 , pp. 849-856
    • Beningo, K.A.1    Wang, Y.L.2
  • 16
    • 84952362031 scopus 로고    scopus 로고
    • Soft discoidal polymeric nanoconstructs resist macrophage uptake and enhance vascular targeting in tumors
    • Key, J. et al. Soft discoidal polymeric nanoconstructs resist macrophage uptake and enhance vascular targeting in tumors. ACS Nano 9, 11628-11641 (2015).
    • (2015) ACS Nano , vol.9 , pp. 11628-11641
    • Key, J.1
  • 17
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo, M., Raposo, G. & Thery, C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell. Dev. Biol. 30, 255-289 (2014).
    • (2014) Annu. Rev. Cell. Dev. Biol. , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 18
    • 85025475676 scopus 로고    scopus 로고
    • Current knowledge on exosome biogenesis and release
    • Hessvik, N. P. & Llorente, A. Current knowledge on exosome biogenesis and release. Cell. Mol. Life Sci. 75, 193-208 (2017).
    • (2017) Cell. Mol. Life Sci. , vol.75 , pp. 193-208
    • Hessvik, N.P.1    Llorente, A.2
  • 19
    • 0034646876 scopus 로고    scopus 로고
    • Chaperone selection during glycoprotein translocation into the endoplasmic reticulum
    • Molinari, M. & Helenius, A. Chaperone selection during glycoprotein translocation into the endoplasmic reticulum. Science 288, 331-333 (2000).
    • (2000) Science , vol.288 , pp. 331-333
    • Molinari, M.1    Helenius, A.2
  • 20
    • 11944260919 scopus 로고
    • Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding-mannosidase II
    • Fukuda, M. N., Masri, K. A., Dell, A., Luzzatto, L. & Moremen, K. W. Incomplete synthesis of N-glycans in congenital dyserythropoietic anemia type II caused by a defect in the gene encoding-mannosidase II. Proc. Natl Acad. Sci. USA 87, 7443-7447 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 7443-7447
    • Fukuda, M.N.1    Masri, K.A.2    Dell, A.3    Luzzatto, L.4    Moremen, K.W.5
  • 21
    • 84946233610 scopus 로고    scopus 로고
    • An intrinsic mechanism of secreted protein aging and turnover
    • Yang, W. H. et al. An intrinsic mechanism of secreted protein aging and turnover. Proc. Natl Acad. Sci. USA 112, 13657-13662 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 13657-13662
    • Yang, W.H.1
  • 22
    • 0022005863 scopus 로고
    • Identity of neutral alphaglucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies
    • Martiniuk, F., Ellenbogen, A. & Hirschhorn, R. Identity of neutral alphaglucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies. J. Biol. Chem. 260, 1238-1242 (1985).
    • (1985) J. Biol. Chem. , vol.260 , pp. 1238-1242
    • Martiniuk, F.1    Ellenbogen, A.2    Hirschhorn, R.3
  • 23
    • 84959386845 scopus 로고    scopus 로고
    • Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
    • Kowal, J. et al. Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc. Natl Acad. Sci. USA 113, E968-977 (2016).
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E968-977
    • Kowal, J.1
  • 24
    • 84940449986 scopus 로고    scopus 로고
    • Glycosylation in cancer: Mechanisms and clinical implications
    • Pinho, S. S. & Reis, C. A. Glycosylation in cancer: mechanisms and clinical implications. Nat. Rev. Cancer 15, 540-555 (2015).
    • (2015) Nat. Rev. Cancer , vol.15 , pp. 540-555
    • Pinho, S.S.1    Reis, C.A.2
  • 25
    • 84886312164 scopus 로고    scopus 로고
    • Sialoglycoproteins and N-glycans from secreted exosomes of ovarian carcinoma cells
    • Escrevente, C. et al. Sialoglycoproteins and N-glycans from secreted exosomes of ovarian carcinoma cells. PLoS ONE 8, e78631 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e78631
    • Escrevente, C.1
  • 27
    • 84921914429 scopus 로고    scopus 로고
    • N-linked (N-) glycoproteomics of urinary exosomes
    • Saraswat, M. et al. N-linked (N-) glycoproteomics of urinary exosomes. Mol. Cell. Proteom. 14, 263-276 (2015).
    • (2015) Mol. Cell. Proteom. , vol.14 , pp. 263-276
    • Saraswat, M.1
  • 28
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. 3, 22. 1-22. 29 (2006).
    • (2006) Curr. Protoc. Cell Biol. , vol.3 , pp. 221-2229
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 29
    • 77951749357 scopus 로고    scopus 로고
    • Microfiltration isolation of human urinary exosomes for characterization by MS
    • Merchant, M. L. et al. Microfiltration isolation of human urinary exosomes for characterization by MS. Proteom. Clin. Appl. 4, 84-96 (2010).
    • (2010) Proteom. Clin. Appl. , vol.4 , pp. 84-96
    • Merchant, M.L.1
  • 30
    • 84857011554 scopus 로고    scopus 로고
    • Isolation and characterization of RNA-containing exosomes
    • Lasser, C., Eldh, M. & Lotvall, J. Isolation and characterization of RNA-containing exosomes. J. Vis. Exp. 59, e3037 (2012).
    • (2012) J. Vis. Exp. , vol.59 , pp. e3037
    • Lasser, C.1    Eldh, M.2    Lotvall, J.3
  • 31
    • 75749091133 scopus 로고    scopus 로고
    • Microfluidic isolation and transcriptome analysis of serum microvesicles
    • Chen, C. et al. Microfluidic isolation and transcriptome analysis of serum microvesicles. Lab. Chip 10, 505-511 (2010).
    • (2010) Lab. Chip , vol.10 , pp. 505-511
    • Chen, C.1
  • 32
    • 84902835800 scopus 로고    scopus 로고
    • Extracellular vesicle (EV) array: Microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping
    • Jorgensen, M. et al. Extracellular vesicle (EV) array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping. J. Extracell. Vesicles 2, 20920 (2013).
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20920
    • Jorgensen, M.1
  • 33
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • Tauro, B. J. et al. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 56, 293-304 (2012).
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1
  • 34
    • 85016507155 scopus 로고    scopus 로고
    • Extracellular vesicles, tissue factor, cancer and thrombosis-discussion themes of the ISEV 2014 Educational Day
    • Gardiner, C. et al. Extracellular vesicles, tissue factor, cancer and thrombosis-discussion themes of the ISEV 2014 Educational Day. J. Extracell. Vesicles 4, 26901 (2015).
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 26901
    • Gardiner, C.1
  • 35
    • 84911455823 scopus 로고    scopus 로고
    • Complex N-linked glycans serve as a determinant for exosome/ microvesicle cargo recruitment
    • Liang, Y. et al. Complex N-linked glycans serve as a determinant for exosome/ microvesicle cargo recruitment. J. Biol. Chem. 289, 32526-32537 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 32526-32537
    • Liang, Y.1
  • 36
    • 84938945261 scopus 로고    scopus 로고
    • Galectin-3 binding protein secreted by breast cancer cells inhibits monocyte-derived fibrocyte differentiation
    • White, M. J., Roife, D. & Gomer, R. H. Galectin-3 binding protein secreted by breast cancer cells inhibits monocyte-derived fibrocyte differentiation. J. Immunol. 195, 1858-1867 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 1858-1867
    • White, M.J.1    Roife, D.2    Gomer, R.H.3
  • 37
    • 84912101312 scopus 로고    scopus 로고
    • Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs
    • Laubli, H. et al. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J. Biol. Chem. 289, 33481-33491 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 33481-33491
    • Laubli, H.1
  • 38
    • 0037013248 scopus 로고    scopus 로고
    • Functional studies on recombinant domains of Mac-2-binding protein
    • Hellstern, S. et al. Functional studies on recombinant domains of Mac-2-binding protein. J. Biol. Chem. 277, 15690-15696 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 15690-15696
    • Hellstern, S.1
  • 39
    • 0032536822 scopus 로고    scopus 로고
    • Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin
    • Sasaki, T., Brakebusch, C., Engel, J. & Timpl, R. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. EMBO J. 17, 1606-1613 (1998).
    • (1998) EMBO J. , vol.17 , pp. 1606-1613
    • Sasaki, T.1    Brakebusch, C.2    Engel, J.3    Timpl, R.4
  • 41
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado, H. et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891 (2012).
    • (2012) Nat. Med. , vol.18 , pp. 883-891
    • Peinado, H.1
  • 42
    • 85042619188 scopus 로고    scopus 로고
    • A protocol for asymmetric-flow field-flow fractionation (AF4) of small extracellular vesicles
    • Zhang, H. & Lyden, D. A protocol for asymmetric-flow field-flow fractionation (AF4) of small extracellular vesicles. Protocol Exchange https:// doi. org/10. 1038/protex. 2018. 002 (2018).
    • (2018) Protocol Exchange
    • Zhang, H.1    Lyden, D.2
  • 43
    • 34948851837 scopus 로고    scopus 로고
    • Spring constant calibration of atomic force microscopy cantilevers with a piezosensor transfer standard
    • Langlois, E. D., Shaw, G. A., Kramar, J. A., Pratt, J. R. & Hurley, D. C. Spring constant calibration of atomic force microscopy cantilevers with a piezosensor transfer standard. Rev. Sci. Instrum. 78, 093705 (2007).
    • (2007) Rev. Sci. Instrum. , vol.78 , pp. 093705
    • Langlois, E.D.1    Shaw, G.A.2    Kramar, J.A.3    Pratt, J.R.4    Hurley, D.C.5
  • 44
    • 84930170395 scopus 로고    scopus 로고
    • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
    • Costa-Silva, B. et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17, 816-826 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 816-826
    • Costa-Silva, B.1
  • 45
    • 84947723880 scopus 로고    scopus 로고
    • Tumour exosome integrins determine organotropic metastasis
    • Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329-335 (2015).
    • (2015) Nature , vol.527 , pp. 329-335
    • Hoshino, A.1
  • 46
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad, B. M., Irizarry, R. A., Astrand, M. & Speed, T. P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193 (2003).
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 47
    • 0038724494 scopus 로고    scopus 로고
    • Consensus clustering: A resampling-based method for class discovery and visualization of gene expression microarray data
    • Monti, S., Tamayo, P., Mesirov, J. & Golub, T. Consensus clustering: A resampling-based method for class discovery and visualization of gene expression microarray data. Mach. Learn. 52, 91-118 (2003).
    • (2003) Mach. Learn. , vol.52 , pp. 91-118
    • Monti, S.1    Tamayo, P.2    Mesirov, J.3    Golub, T.4
  • 48
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
    • Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
    • (1999) Science , vol.286 , pp. 531-537
    • Golub, T.R.1
  • 49
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 50
    • 79958135926 scopus 로고    scopus 로고
    • Molecular signatures database (MSigDB) 3. 0
    • Liberzon, A. et al. Molecular signatures database (MSigDB) 3. 0. Bioinformatics 27, 1739-1740 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1739-1740
    • Liberzon, A.1
  • 51
    • 80052813106 scopus 로고    scopus 로고
    • Synthesis and optimization of lectin functionalized nanoprobes for the selective recovery of glycoproteins from human body fluids
    • Ferreira, J. A. et al. Synthesis and optimization of lectin functionalized nanoprobes for the selective recovery of glycoproteins from human body fluids. Anal. Chem. 83, 7035-7043 (2011).
    • (2011) Anal. Chem. , vol.83 , pp. 7035-7043
    • Ferreira, J.A.1
  • 52
    • 84935870683 scopus 로고    scopus 로고
    • Isomer-specific analysis of released N-glycans by LC-ESI MS/MS with porous graphitized carbon
    • Kolarich, D., Windwarder, M., Alagesan, K. & Altmann, F. Isomer-specific analysis of released N-glycans by LC-ESI MS/MS with porous graphitized carbon. Methods Mol. Biol. 1321, 427-435 (2015).
    • (2015) Methods Mol. Biol. , vol.1321 , pp. 427-435
    • Kolarich, D.1    Windwarder, M.2    Alagesan, K.3    Altmann, F.4
  • 53
    • 84862168794 scopus 로고    scopus 로고
    • Structural analysis of N-and O-glycans released from glycoproteins
    • Jensen, P. H., Karlsson, N. G., Kolarich, D. & Packer, N. H. Structural analysis of N-and O-glycans released from glycoproteins. Nat. Protoc. 7, 1299-1310 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 1299-1310
    • Jensen, P.H.1    Karlsson, N.G.2    Kolarich, D.3    Packer, N.H.4
  • 54
    • 45549094069 scopus 로고    scopus 로고
    • GlycoWorkbench: A tool for the computer-assisted annotation of mass spectra of glycans
    • Ceroni, A. et al. GlycoWorkbench: A tool for the computer-assisted annotation of mass spectra of glycans. J. Prote. Res. 7, 1650-1659 (2008).
    • (2008) J. Prote. Res. , vol.7 , pp. 1650-1659
    • Ceroni, A.1


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