Chaperone selection during glycoprotein translocation into the endoplasmic reticulum

Science

Volumn 288, Issue 5464, 2000, Pages 331-333

  Molinari, Maurizio ^a   Helenius, Ari ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CALRETICULIN; CHAPERONE; GLYCAN; INFLUENZA VIRUS HEMAGGLUTININ; VIRUS GLYCOPROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SEMLIKI FOREST ALPHAVIRUS;

ANIMALS; BINDING SITES; CALCIUM-BINDING PROTEINS; CALNEXIN; CALRETICULIN; CARRIER PROTEINS; CHO CELLS; CRICETINAE; DITHIOTHREITOL; ENDOPLASMIC RETICULUM; GLYCOPROTEINS; GLYCOSYLATION; HEAT-SHOCK PROTEINS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; MOLECULAR CHAPERONES; MOLECULAR WEIGHT; MUTATION; OXIDATION-REDUCTION; POLYSACCHARIDES; PRECIPITATION; PROTEIN CONFORMATION; PROTEIN FOLDING; RIBONUCLEOPROTEINS; SEMLIKI FOREST VIRUS; VIRAL PROTEINS;

ALPHAVIRUS; ANIMALIA; INFLUENZA VIRUS; SEMLIKI FOREST VIRUS;

EID: 0034646876     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5464.331     Document Type: Article

References (24)

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14. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
15. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
16. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
17. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
18. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
19. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
20. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
21. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
22. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
23. 2-terminus have been shown to fold independently of BiP; examples follow: influenza HA [first glycan at position 8, I. Braakman et al., J. Cell Biol. 114, 401 (1991)], SFV p62 (13, this work), factor V [23, D. D. Pittman et al., J. Biol. Chem. 269, 17329 (1994)], prepro-α-factor [22, K. Su et al., J. Biol. Chem. 268, 14301 (1993)], Sindbis virus (SIN) PE2 [11 (4)], rotavirus NS28 [8, A. Xu et al., J. Virol. 72, 9865 (1998)], CD-mannose 6-P receptor [31, J.-X. Zhang et al., Biochem. J. 295, 841 (1993)]. BiP requirement for folding has been shown for proteins with glycans late in the sequence. As examples VSV glycoprotein [178 (1)], von Willebrandt factor [93, A. J. Dorner et al., J. Cell Biol. 105, 2665 (1987)], SFV E1 (141, this work), SIN E1 [139 (4)], HIV gp 160 [88, P. L. Earl et al., J. Virol. 65, 2047 (1991)], amyloid precursor protein [542, Y. Yang et al., J. Biol. Chem. 273, 25552 (1998)], Ig heavy chain [99-160, I. G. Haas and M. Wabl, Nature 306, 387 (1983)], and simian virus HA [110, D. T. Ng et al., J. Cell Biol. 109, 3273 (1989)].
24. The authors thank M. Silacci for technical assistance; L. Ellgaard, C. Galli, and L. Pelkmans for helpful comments on the manuscript. The work was supported by ETHZ and by a Roche Foundation grant to M.M. and A.H.