Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target

Journal of Cell Science

Volumn 115, Issue 4, 2002, Pages 849-856

  Beningo, Karen A ^a   Wang, Yu Li ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cytoskeleton; GTPase; Lysophosphatidic acid; Mechanical sensing; Phosphotyrosine; Rac1

Indexed keywords

ACTIN; FC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; LYSOPHOSPHATIDIC ACID; POLYACRYLAMIDE; RAC1 PROTEIN; RECEPTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LIGAND BINDING; MACROPHAGE; MOUSE; NONHUMAN; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; RECEPTOR BINDING; REGULATORY MECHANISM; RIGIDITY; TISSUE REPAIR;

NASA DISCIPLINE CELL BIOLOGY; NASA PROGRAM FUNDAMENTAL SPACE BIOLOGY; NON-NASA CENTER;

ACRYLIC RESINS; ANIMALS; CELLS, CULTURED; LYSOPHOSPHOLIPIDS; MACROPHAGES; MICE; MICE, INBRED C3H; MICROFILAMENTS; OPSONIN PROTEINS; PARTICLE SIZE; PHAGOCYTOSIS; RAC1 GTP-BINDING PROTEIN; RECEPTORS, FC; STRESS, MECHANICAL;

ANIMALIA;

EID: 0037084460     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Mechanisms of phagocytosis in macrophages
2. Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
3. Rho, rac and cdc42 regulate actin organization and cell adhesion in macrophages
4. Phosphorylation and activation of myosin by rho-associated kinase (Rho-kinase)
5. Localized biphasic changes in phosphatidylinositol-4,5 bisphosphate at sites of phagocytosis
6. Axonal growth in response to experimentally applied tension
7. Kinetic studies of the polymerization of acrylamide in inverse microemulsion
8. The macrophage capacity for phagocytosis
9. Identification of two distinct mechanisms of phagocytosis controlled by different rho GTPases
10. Membrane recruitment of rac1 triggers phagocytosis
11. Function of rho family proteins in actin dynamics during phagocytosis and engulfment
12. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
13. Requirements for both rac1 and cdc42 in membrane ruffling and phagocytosis in leukocytes
14. Localization of p21 activated kinase one (pak1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils
15. Asbestos-stimulated tumour necrosis factor release from alveolar macrophages depends on fibre length and opsonization
16. Elastic, flexible peptidoglycan and bacterial cell wall properties
17. Tyrosine phosphorylation is required for fc receptor-mediated phagocytosis in mouse macrophages
18. Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages
19. Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages
20. Viscoelastic properties of human articular cartilage
21. Direct observation of the mechanical behaviors of the cytoskeleton in living fibroblasts
22. Interaction of cells with immune complexes: Adherence, release of constituents, and tissue injury
23. Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway
24. Size of IgG-opsonized particles determines macrophage response during internalization
25. Innocous labeling of the subfragment-2 region of skeletal muscle heavy meromyosin with a fluorescent polyacrylamide nanobead and visualization of individual heavy meromyosin molecules
26. Cell movement is guided by the rigidity of the substrate
27. Fc receptor-mediated phagocytosis requires CDC42 and Rac1
28. Phagocytosis and the actin cytoskeleton
29. Involvement of the arp2/3 complex in phagocytosis mediated by FcγR or CR3
30. Bioactive lysophospholipids and their G protein-coupled receptors
31. Rho GTPases control polarity, protrusion, and adhesion during cell movement
32. The additive effects on the spreading of guinea pig macrophages of exogenous ATP and a surface coated with antigen-antibody molecules
33. The small GTP-binding protein rho regulates cortical activities in cultured cells during division
34. Cell locomotion and focal adhesions are regulated by substrate flexibility
35. Macrophage spreading in vitro. I. Inducers of spreading
36. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors
37. Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
38. Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins
39. Cell migration: Regulation of force on extracellular matrix-integrin complexes
40. Phorbol esters stimulate macropinocytosis and solute flow through macrophages
41. Mechanical behavior of bacterial cell walls
42. Self-polarization and directional motility of cytoplasm
43. Microinjection of proteins into somatic cells: Needle microinjection and scrape loading
44. Preparation of a flexible porous polyacrylamide substrate for mechanical studies of cultured cells