Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3416-3419

  Tondi, Donatella ^a,b   Calò, Samuele ^a   Shoichet, Brian K ^b   Costi, Maria Paola ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug design; Enzymology; Lead optimization; Organic synthesis; X ray crystallography

Indexed keywords

4 (2 CARBOXY VINYL)PHENYL BORONIC ACID; 4 CARBOXYPHENYL BORONIC ACID; ANTIBIOTIC AGENT; BETA LACTAMASE AMPC; BIPHENYL 4,4' DIBORONIC ACID; BORONIC ACID DERIVATIVE; CEFALOTIN; NITROPHENYL BORONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DERIVATIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; REACTION OPTIMIZATION; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; BETA-LACTAMASES; BORONIC ACIDS; ENZYME INHIBITORS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 77953289345     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.007     Document Type: Article

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