Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 5, 2012, Pages 2713-2718

  Ke, Wei ^a   Bethel, Christopher R ^b   Papp Wallace, Krisztina M ^a,b   Pagadala, Sundar Ram Reddy ^c   Nottingham, Micheal ^c   Fernandez, Daniel ^c   Buynak, John D ^c   Bonomo, Robert A ^a,b   Van Den Akker, Focco ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPHENYL BORONIC ACID; AROMATIC COMPOUND; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA LACTAMASE KPC 2; CARBONYL DERIVATIVE; CLAVULANIC ACID; ENAMINE; HYDROXYL GROUP; PENAM DERIVATIVE; PENAM SULFONE; PSR 3 226; SULBACTAM; SULFONE DERIVATIVE; TAZOBACTAM; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DEACETYLATION; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; BORONIC ACIDS; CARBAPENEMS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HETEROCYCLIC COMPOUNDS, 2-RING; KINETICS; KLEBSIELLA PNEUMONIAE; MODELS, MOLECULAR; SULFONES; THIAZOLIDINES;

EID: 84860120657     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06099-11     Document Type: Article

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