Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase

Chemistry and Biology

Volumn 8, Issue 6, 2001, Pages 593-610

  Tondi, Donatella ^a,b   Powers, Rachel A ^a   Caselli, Emilia ^a,b   Negri, María Cristina ^c   Blázquez, Jesús ^c   Costi, Maria Paola ^b   Shoichet, Brian K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Antibiotic resistance; Boronic acids; Structure based drug design; Transition state analog; X ray crystallography

Indexed keywords

ANTIBIOTIC RESISTANCE; BETA LACTAM ANTIBIOTIC; BETA LACTAM; BETA LACTAMASE INHIBITOR; BETA LACTAMASE; CRYSTAL STRUCTURE; ENZYME INHIBITION; GENETIC CONSERVATION; SOLUBILITY;

BACTERIAL PROTEINS; BETA-LACTAMASES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR STRUCTURE;

NEGIBACTERIA; POSIBACTERIA;

EID: 0034974174     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00034-5     Document Type: Article

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