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Volumn 17, Issue 4, 2018, Pages 444-453

Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells

Author keywords

Airway epithelium; DNase seq; Molecular signature; Open chromatin; Primary human bronchial cells; Primary human tracheal cells; RNA seq; Transcriptional networks

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DEOXYRIBONUCLEASE I; INTERFERON REGULATORY FACTOR 1; KRUPPEL LIKE FACTOR 4; PROTEIN C JUN; PROTEIN FOS; SPACER DNA; STAT1 PROTEIN; STAT2 PROTEIN; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR ELK 4; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR YY1;

EID: 85042083834     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2018.01.009     Document Type: Article
Times cited : (7)

References (32)
  • 1
    • 0025134125 scopus 로고
    • Beta-adrenergic receptors on human tracheal epithelial cells in primary culture
    • Davis, P.B., Silski, C.L., Kercsmar, C.M., Infeld, M., Beta-adrenergic receptors on human tracheal epithelial cells in primary culture. Am J Phys 258:1 Pt 1 (1990), C71–6.
    • (1990) Am J Phys , vol.258 , Issue.1 , pp. C71-6
    • Davis, P.B.1    Silski, C.L.2    Kercsmar, C.M.3    Infeld, M.4
  • 3
    • 84866067664 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
    • Wong, A.P., Bear, C.E., Chin, S., Pasceri, P., Thompson, T.O., Huan, L.J., et al. Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 30:9 (2012), 876–882.
    • (2012) Nat Biotechnol , vol.30 , Issue.9 , pp. 876-882
    • Wong, A.P.1    Bear, C.E.2    Chin, S.3    Pasceri, P.4    Thompson, T.O.5    Huan, L.J.6
  • 4
    • 84899644608 scopus 로고    scopus 로고
    • Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells
    • Firth, A.L., Dargitz, C.T., Qualls, S.J., Menon, T., Wright, R., Singer, O., et al. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A 111:17 (2014), E1723–30.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.17 , pp. E1723-30
    • Firth, A.L.1    Dargitz, C.T.2    Qualls, S.J.3    Menon, T.4    Wright, R.5    Singer, O.6
  • 5
    • 84980343841 scopus 로고    scopus 로고
    • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells
    • Gao, X., Bali, A.S., Randell, S.H., Hogan, B.L., GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. J Cell Biol 211:3 (2015), 669–682.
    • (2015) J Cell Biol , vol.211 , Issue.3 , pp. 669-682
    • Gao, X.1    Bali, A.S.2    Randell, S.H.3    Hogan, B.L.4
  • 6
    • 84942292394 scopus 로고    scopus 로고
    • Unjamming and cell shape in the asthmatic airway epithelium
    • Park, J.A., Kim, J.H., Bi, D., Mitchel, J.A., Qazvini, N.T., Tantisira, K., et al. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater 14:10 (2015), 1040–1048.
    • (2015) Nat Mater , vol.14 , Issue.10 , pp. 1040-1048
    • Park, J.A.1    Kim, J.H.2    Bi, D.3    Mitchel, J.A.4    Qazvini, N.T.5    Tantisira, K.6
  • 7
    • 80051569065 scopus 로고    scopus 로고
    • Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease
    • Polosukhin, V.V., Cates, J.M., Lawson, W.E., Zaynagetdinov, R., Milstone, A.P., Massion, P.P., et al. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 184:3 (2011), 317–327.
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.3 , pp. 317-327
    • Polosukhin, V.V.1    Cates, J.M.2    Lawson, W.E.3    Zaynagetdinov, R.4    Milstone, A.P.5    Massion, P.P.6
  • 8
  • 9
    • 84899823633 scopus 로고    scopus 로고
    • A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function
    • [1-8]
    • Bischof, J.M., Gillen, A.E., Song, L., Gosalia, N., London, D., Furey, T.S., et al. A genome-wide analysis of open chromatin in human epididymis epithelial cells reveals candidate regulatory elements for genes coordinating epididymal function. Biol Reprod, 89(4), 2013, 104 [1-8].
    • (2013) Biol Reprod , vol.89 , Issue.4 , pp. 104
    • Bischof, J.M.1    Gillen, A.E.2    Song, L.3    Gosalia, N.4    London, D.5    Furey, T.S.6
  • 10
    • 84859856764 scopus 로고    scopus 로고
    • A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function
    • Bischof, J.M., Ott, C.J., Leir, S.H., Gosalia, N., Song, L., London, D., et al. A genome-wide analysis of open chromatin in human tracheal epithelial cells reveals novel candidate regulatory elements for lung function. Thorax 67:5 (2012), 385–391.
    • (2012) Thorax , vol.67 , Issue.5 , pp. 385-391
    • Bischof, J.M.1    Ott, C.J.2    Leir, S.H.3    Gosalia, N.4    Song, L.5    London, D.6
  • 11
    • 38649099445 scopus 로고    scopus 로고
    • High-resolution mapping and characterization of open chromatin across the genome
    • Boyle, A.P., Davis, S., Shulha, H.P., Meltzer, P., Margulies, E.H., Weng, Z., et al. High-resolution mapping and characterization of open chromatin across the genome. Cell 132:2 (2008), 311–322.
    • (2008) Cell , vol.132 , Issue.2 , pp. 311-322
    • Boyle, A.P.1    Davis, S.2    Shulha, H.P.3    Meltzer, P.4    Margulies, E.H.5    Weng, Z.6
  • 12
    • 80053539409 scopus 로고    scopus 로고
    • Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity
    • Song, L., Zhang, Z., Grasfeder, L.L., Boyle, A.P., Giresi, P.G., Lee, B.K., et al. Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity. Genome Res 21:10 (2011), 1757–1767.
    • (2011) Genome Res , vol.21 , Issue.10 , pp. 1757-1767
    • Song, L.1    Zhang, Z.2    Grasfeder, L.L.3    Boyle, A.P.4    Giresi, P.G.5    Lee, B.K.6
  • 13
    • 84899653339 scopus 로고    scopus 로고
    • Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells
    • Aksoy, I., Giudice, V., Delahaye, E., Wianny, F., Aubry, M., Mure, M., et al. Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Nat Commun, 5, 2014, 3719.
    • (2014) Nat Commun , vol.5 , pp. 3719
    • Aksoy, I.1    Giudice, V.2    Delahaye, E.3    Wianny, F.4    Aubry, M.5    Mure, M.6
  • 15
    • 84893840620 scopus 로고    scopus 로고
    • Kruppel-like factors in cancer progression: three fingers on the steering wheel
    • Limame, R., Op de Beeck, K., Lardon, F., De Wever, O., Pauwels, P., Kruppel-like factors in cancer progression: three fingers on the steering wheel. Oncotarget 5:1 (2014), 29–48.
    • (2014) Oncotarget , vol.5 , Issue.1 , pp. 29-48
    • Limame, R.1    Op de Beeck, K.2    Lardon, F.3    De Wever, O.4    Pauwels, P.5
  • 16
    • 0035061538 scopus 로고    scopus 로고
    • IRF family of transcription factors as regulators of host defense
    • Taniguchi, T., Ogasawara, K., Takaoka, A., Tanaka, N., IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19 (2001), 623–655.
    • (2001) Annu Rev Immunol , vol.19 , pp. 623-655
    • Taniguchi, T.1    Ogasawara, K.2    Takaoka, A.3    Tanaka, N.4
  • 17
    • 42649114059 scopus 로고    scopus 로고
    • The IRF family transcription factors in immunity and oncogenesis
    • Tamura, T., Yanai, H., Savitsky, D., Taniguchi, T., The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol 26 (2008), 535–584.
    • (2008) Annu Rev Immunol , vol.26 , pp. 535-584
    • Tamura, T.1    Yanai, H.2    Savitsky, D.3    Taniguchi, T.4
  • 18
    • 84880675359 scopus 로고    scopus 로고
    • Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer
    • Zhang, Z., Leir, S.H., Harris, A., Immune mediators regulate CFTR expression through a bifunctional airway-selective enhancer. Mol Cell Biol 33:15 (2013), 2843–2853.
    • (2013) Mol Cell Biol , vol.33 , Issue.15 , pp. 2843-2853
    • Zhang, Z.1    Leir, S.H.2    Harris, A.3
  • 19
    • 84927621581 scopus 로고    scopus 로고
    • Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells
    • Fossum, S.L., Mutolo, M.J., Yang, R., Dang, H., O'Neal, W.K., Knowles, M.R., et al. Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells. Nucleic Acids Res 42:22 (2014), 13588–13598.
    • (2014) Nucleic Acids Res , vol.42 , Issue.22 , pp. 13588-13598
    • Fossum, S.L.1    Mutolo, M.J.2    Yang, R.3    Dang, H.4    O'Neal, W.K.5    Knowles, M.R.6
  • 20
    • 17244367891 scopus 로고    scopus 로고
    • An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head
    • Mace, K.A., Pearson, J.C., McGinnis, W., An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science 308:5720 (2005), 381–385.
    • (2005) Science , vol.308 , Issue.5720 , pp. 381-385
    • Mace, K.A.1    Pearson, J.C.2    McGinnis, W.3
  • 21
    • 20244389223 scopus 로고    scopus 로고
    • A homolog of Drosophila grainy head is essential for epidermal integrity in mice
    • Ting, S.B., Caddy, J., Hislop, N., Wilanowski, T., Auden, A., Zhao, L.L., et al. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science 308:5720 (2005), 411–413.
    • (2005) Science , vol.308 , Issue.5720 , pp. 411-413
    • Ting, S.B.1    Caddy, J.2    Hislop, N.3    Wilanowski, T.4    Auden, A.5    Zhao, L.L.6
  • 22
    • 40949147805 scopus 로고    scopus 로고
    • Perturbed desmosomal cadherin expression in grainy head-like 1-null mice
    • Wilanowski, T., Caddy, J., Ting, S.B., Hislop, N.R., Cerruti, L., Auden, A., et al. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J 27:6 (2008), 886–897.
    • (2008) EMBO J , vol.27 , Issue.6 , pp. 886-897
    • Wilanowski, T.1    Caddy, J.2    Ting, S.B.3    Hislop, N.R.4    Cerruti, L.5    Auden, A.6
  • 23
    • 78650802901 scopus 로고    scopus 로고
    • The unique and cooperative roles of the grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity
    • Boglev, Y., Wilanowski, T., Caddy, J., Parekh, V., Auden, A., Darido, C., et al. The unique and cooperative roles of the grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Dev Biol 349:2 (2011), 512–522.
    • (2011) Dev Biol , vol.349 , Issue.2 , pp. 512-522
    • Boglev, Y.1    Wilanowski, T.2    Caddy, J.3    Parekh, V.4    Auden, A.5    Darido, C.6
  • 24
  • 27
    • 34248596190 scopus 로고    scopus 로고
    • Elf5 is an epithelium-specific, fibroblast growth factor–sensitive transcription factor in the embryonic lung
    • Metzger, D.E., Xu, Y., Shannon, J.M., Elf5 is an epithelium-specific, fibroblast growth factor–sensitive transcription factor in the embryonic lung. Dev Dyn 236 (2007), 1175–1192.
    • (2007) Dev Dyn , vol.236 , pp. 1175-1192
    • Metzger, D.E.1    Xu, Y.2    Shannon, J.M.3
  • 28
    • 36548999223 scopus 로고    scopus 로고
    • Ets-1 is a negative regulator of Th17 differentiation
    • Moisan, J., Grenningloh, R., Bettelli, E., Oukka, M., Ho, I.-C., Ets-1 is a negative regulator of Th17 differentiation. J Exp Med 204 (2007), 2825–2835.
    • (2007) J Exp Med , vol.204 , pp. 2825-2835
    • Moisan, J.1    Grenningloh, R.2    Bettelli, E.3    Oukka, M.4    Ho, I.-C.5
  • 29
    • 80053366591 scopus 로고    scopus 로고
    • Elf3 plays a role in regulating bronchiolar epithelial repair kinetics following Clara cell-specific injury
    • Oliver, J.R., Kushwah, R., Wu, J., Pan, J., Cutz, E., Yeger, H., et al. Elf3 plays a role in regulating bronchiolar epithelial repair kinetics following Clara cell-specific injury. Lab Investig 91:10 (2011), 1514–1529.
    • (2011) Lab Investig , vol.91 , Issue.10 , pp. 1514-1529
    • Oliver, J.R.1    Kushwah, R.2    Wu, J.3    Pan, J.4    Cutz, E.5    Yeger, H.6
  • 30
    • 80053929344 scopus 로고    scopus 로고
    • Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells
    • Saadane, A., Eastman, J., Berger, M., Bonfield, T.L., Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells. J Inflamm (Lond), 8, 2011, 26.
    • (2011) J Inflamm (Lond) , vol.8 , pp. 26
    • Saadane, A.1    Eastman, J.2    Berger, M.3    Bonfield, T.L.4
  • 31
    • 84942880568 scopus 로고    scopus 로고
    • Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
    • Corvol, H., Blackman, S.M., Boelle, P.Y., Gallins, P.J., Pace, R.G., Stonebraker, J.R., et al. Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. Nat Commun, 6, 2015, 8382.
    • (2015) Nat Commun , vol.6 , pp. 8382
    • Corvol, H.1    Blackman, S.M.2    Boelle, P.Y.3    Gallins, P.J.4    Pace, R.G.5    Stonebraker, J.R.6
  • 32
    • 85021666943 scopus 로고    scopus 로고
    • Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease
    • Fossum, S.L., Mutolo, M.J., Tugores, A., Ghosh, S., Randell, S.H., Jones, L.C., et al. Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease. J Biol Chem 292:26 (2017), 10938–10949.
    • (2017) J Biol Chem , vol.292 , Issue.26 , pp. 10938-10949
    • Fossum, S.L.1    Mutolo, M.J.2    Tugores, A.3    Ghosh, S.4    Randell, S.H.5    Jones, L.C.6


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