Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

Journal of Inflammation

Volumn 8, Issue , 2011, Pages

  Saadane, Aicha ^a   Eastman, Jean ^a   Berger, Melvin ^a   Bonfield, Tracey L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PARTHENOLIDE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSMEMBRANE CONDUCTANCE REGULATOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; IL 1BETA GENE; IL 8 GENE; IMMUNE RESPONSE GENE; IMMUNOREGULATION; IN VITRO STUDY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TNF ALPHA GENE; TRANSCRIPTION REGULATION;

EID: 80053929344     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/1476-9255-8-26     Document Type: Article

References (49)

1. Activation of NF-kB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells. DiMango E, Ratner AJ, Bryan R, Tabibi S, Prince A, J Clin Invest 1998 101 2598 605 10.1172/JCI2865 9616231
2. Proinflammatory cytokine responses to P. aeruginosa infection in human airway epithelial cell lines. Kube D, Sontich U, Fletcher D, Davis PB, Am J Physiol Lung Cell Mol Physiol 2001 280 493 502 11159033
3. Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl- channel function. Weber AJ, Soong G, Bryan R, Saba S, Prince A, Am J Physiol Lung Cell Mol Physiol 2001 281 71 8 11404248
4. Characterization of LPS-induced Lung inflammation in cftr-/- mice and the effectg of docosahexaenoic acid. Freedman SD, Weinstein D, Blanco PG, Martinez-Clark P, Urman S, Zaman M, Morrow JD, Alvarez JG, J Appl Physiol 2002 92 2169 2176 11960971 (Pubitemid 34666448)
5. Role of IL-10 deficiency in excessive nuclear factor-kappaB activation and lung inflammation in cystic fibrosis transmembrane conductance regulator knockout mice. Saadane A, Soltys J, Berger M, J Allergy Clin Immunol 2005 115 405 11 10.1016/j.jaci.2004.10.044 15696103 (Pubitemid 40215111)
6. Acute Pseudomonas challenge in cystic fibrosis mice causes prolonged nuclear factor-kappa B activation, cytokine secretion, and persistent lung inflammation. Saadane A, Soltys J, Berger M, J Allergy Clin Immunol 2006 117 1163 9 10.1016/j.jaci.2006.01.052 16675347
7. Inflammatory cytokines in cystic fibrosis lungs. Bonfield TL, Panuska JR, Konstan MW, Hilliard KA, Hilliard JB, Ghnaim H, Berger M, Am J Respir Crit Care Med 1995 152 2111 8 8520783
8. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. Muhlebach MS, Stewart PW, Leigh MW, Noah TL, Am J Respir Crit Care Med 1999 160 186 91 10390398 (Pubitemid 29326086)
9. Endotoxin activity and inflammatory markers in the airways of young patients with cystic fibrosis. Muhlebach MS, Noah TL, Am J Respir Crit Care Med 2002 165 911 5 11934713 (Pubitemid 34774656)
10. Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells. Venkatakrishnan A, Stecenko AA, King G, Blackwell TR, Brigham KL, Christman JW, Blackwell TS, Am J Respir Cell Mol Biol 2000 23 396 403 10970832
11. DeltaF508-CFTR causes constitutive NF-kB activation through an ER-overload response in cystic fibrosis lungs. Knorre A, Wagner M, Schaefer HE, Colledge WH, Pahl HL, Biol Chem 2002 383 271 82 10.1515/BC.2002.029 11934265 (Pubitemid 34229129)
12. Regulation of human airway epithelial cell IL-8 expression by MAP kinases. Li J, Kartha S, Iasovovskaia S, Tan A, Bhart RK, Manaligod JM, Page K, Brasier AR, Hershenson MB, Am J Physiol Lung Cell Mol Physiol 2002 283 390 L399 12114201
13. NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosa. Joseph T, Look D, Ferkol T, Am J Physiol Lung Cell Mol Physiol 2005 288 471 L479 10.1152/ajplung.00066.2004 15516493 (Pubitemid 40229512)
14. Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. Saadane A, Masters S, DiDonato J, Li J, Berger M, Am J Respir Cell Mol Biol 2007 36 728 736 10.1165/rcmb.2006-0323OC 17272824 (Pubitemid 46871428)
15. Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK 1/2, JNK, and NF-kB activation in a cystic fibrosis epithelial cell line. Blau H, Klein K, Shalit I, Halperin D, Fabian I, Am J Physiol Lung Cell Mol Physiol 2007 292 343 L352 17012372
16. Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Holtmann H, Winzen R, Holland P, Eickemeier S, Hoffmann E, Wallach D, Malinin N, L Cooper JA, Resch K, Kracht M, Mol Cell Biol 1999 19 6742 6753 10490613 (Pubitemid 29441858)
17. Multiple control of interleukin-8 gene expression. Hofmann E, Dittrich-Breiholz O, Holtmann H, Kracht M, J Leukoc Biol 2002 72 847 55 12429706 (Pubitemid 35365158)
18. Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O, Biochem Biophys Res Commun 2007 357 402 407 10.1016/j.bbrc.2007.03.141 17420005 (Pubitemid 46603145)
19. Oxidative stress causes IL-8 promoter hyperacetylation in cystic fibrosis airway cell models. Bartling TR, Drumm ML, Am J Respir Cell Mol Biol 2009 40 58 65 18635816
20. DNA methylation status of the IL-8 gene promoter in aggressive periodontitis. Andia DC, de Oliveira NF, casarin RC, Casati MZ, Line SR, de Souza AP, J Periodontol 2010 81 1336 41 10.1902/jop.2010.100082 20450371
21. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Perez A, Issler AC, Cotton CU, Kelley TJ, Verkman AS, Davis PB, Am J Physiol Lung Cell Mol Physiol 2007 292 383 L395 16920886
22. A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40. Zeitlin PL, Lu L, Rhim J, Cutting G, Stetten G, Kieffer KA, Craig R, Guggino WB, Am J Respir Cell Mol Biol 1991 4 313 319 1849726
23. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP, J Immunol 2001 167 366 374 11418672 (Pubitemid 32567801)
24. Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Aihara M, Tsuchimoto D, Takizawa H, Azuma A, Wakebe H, Ohmoto Y, Imagawa K, Kikuchi M, Mukaida N, Matsushima K, 1997 65 3218 3224
25. Molecular mechanism of interleukin-8 gene expression. Mukaida N, Okamoto S, Ishikawa Y, Matsushima K, J Leukoc Biol 1994 56 554 8 7525815 (Pubitemid 24348811)
26. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. Whitmarsh AJ, Davis RJ, J Mol Med 1996 74 589 607 10.1007/s001090050063 8912180 (Pubitemid 26343761)
27. Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR. Winzen R, Gowrishankar G, Bollig F, Redich N, Resch K, Holtmann H, Mol Cell Biol 2004 24 4835 47 10.1128/MCB.24.11.4835-4847.2004 15143177 (Pubitemid 38668049)
28. Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis. Raia V, Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Auricchio S, Cimmino M, Cavaliere M, Nardone M, Cesaro A, Malcolm J, Quaratino S, Londei M, Thorax 2005 60 773 80 10.1136/thx.2005.042564 15994249 (Pubitemid 41297898)
29. Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. Cigana C, Assael BM, Melotti P, Antimicrob Agents Chemother 2006 350 977 982 (Pubitemid 44584188)
30. High susceptibility for cystic fibrosis human airway gland cells to produce IL-8 through the I kappa B kinase alpha pathway in response to extracellular NaCl content. Tabary O, Escotte S, Couetil JP, Hubert D, Dusser D, Puchelle E, Jacquot J, J Immunol 2000 164 3377 3384 10706733 (Pubitemid 30149004)
31. Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma. Newton R, Holden N, BioDrugs 2003 17 113 129 10.2165/00063030-200317020-00004 12641490 (Pubitemid 36433993)
32. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen C, Y Shyu AB, Muller M, Gaestel M, Resch K, Holtmann H, Embo J 1999 18 4969 80 10.1093/emboj/18.18.4969 10487749 (Pubitemid 29443799)
33. NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. Fujioka S, Niu J, Schmidt C, Sclabas GM, Peng B, Uwagawa T, Li Z, Evans DB, Abbruzzese JL, Chiao PJ, Mol Cell Biol 2004 24 7806 7819 10.1128/MCB.24.17.7806-7819.2004 15314185 (Pubitemid 39121503)
34. Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB. Bork PM, Schmitz ML, Kuhnt M, Escher C, Heinrich M, FEBS Lett 1997 402 85 90 10.1016/S0014-5793(96)01502-5 9013864 (Pubitemid 27056030)
35. Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis. Lopez-Franco O, Suzuki Y, Sanjuan G, Hernandez-Vargas P, Yo Y, Kopp J, Egido J, Gomez-Guerrero C, Am J Pathol 2002 161 1497 505 10.1016/S0002-9440(10)64425-2 12368222
36. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta. Hehner SP, Heinrich M, Bork PM, Vogt M, Ratter F, Lehmann V, Schulze-Osthoff K, Droge W, Schmitz ML, J Biol Chem 1998 273 1288 97 10.1074/jbc.273.3.1288 9430659 (Pubitemid 28133643)
37. The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex. Hehner SP, Hofmann TG, Droge W, Schmitz ML, J Immunol 1999 163 5617 23 10553091
38. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Kwok BH, Koh B, Ndubuisi MI, Elofsson M, Crews CM, Chem Biol 2001 8 759 66 10.1016/S1074- 5521(01)00049-7 11514225 (Pubitemid 32752455)
39. Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Sheehan M, Wong HR, Hake PW, Malhotra V, O'Connor M, Zingarelli B, Mol Pharmacol 2002 61 953 63 10.1124/mol.61.5.953 11961112 (Pubitemid 34441759)
40. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato AC, Lang R, J Exp Med 2006 203 15 20 10.1084/jem.20051753 16380512 (Pubitemid 43139639)
41. DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response. Lang R, Hammer M, Mages J, J Immunol 2006 177 7497 504 17114416 (Pubitemid 44846262)
42. The 3'-untranslated region of human interleukin-8 mRNA suppresses IL-8 gene expression. Yu Y, Chadee K, Immunology 2001 102 498 505 10.1046/j.1365-2567.2001.01189.x 11328384 (Pubitemid 32322962)
43. MicroRNAs and their emerging roles in immunology. Pauley KM, Chan EKL, Ann NY Acad Sci 2008 1143 226 239 10.1196/annals.1443.009 19076353
44. MicroRNAs: novel regulators involved in the pathogenesis of Psoriasis? Sonkoly E, Wei T, Janson PC, Saaf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Stahle M, Pivarcsi A, PLos ONE 2007 11 610
45. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H, Arthritis Rheum 2008 58 1284 1292 10.1002/art.23429 18438844 (Pubitemid 351705917)
46. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Hammer M, Mages J, Dietrich H, Schmitz F, Striebel F, Murray PJ, Wagner H, Lang R, Eur J Immunol 2005 35 2991 3001 10.1002/eji.200526192 16184516 (Pubitemid 41555095)
47. Dual-specificity phosphatase 1: a critical regulator of innate immune responses. Abraham SM, Clark AR, Biochem Soc Trans 2006 34 1018 1023 10.1042/BST0341018 17073741 (Pubitemid 46768980)
48. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. Salojin KV, Owusu IB, Millerchip KA, Potter M Platt KA, Oravecz T, J Immunol 2006 176 1899 1907 16424221 (Pubitemid 43134335)
49. Regulation of innate immune response by MAP kinase phosphatase-1. Wang X, Liu Y, Cell Signal 2007 19 1372 1382 10.1016/j.cellsig.2007.03.013 17512700 (Pubitemid 46830880)