-
2
-
-
84893401365
-
Airway epithelial regulation of pulmonary immune homeostasis and inflammation
-
Hallstrand, T. S., Hackett, T. L., Altemeier, W. A., Matute-Bello, G., Hansbro, P. M., and Knight, D. A. (2014) Airway epithelial regulation of pulmonary immune homeostasis and inflammation. Clin. Immunol. 151, 1-15
-
(2014)
Clin. Immunol.
, vol.151
, pp. 1-15
-
-
Hallstrand, T.S.1
Hackett, T.L.2
Altemeier, W.A.3
Matute-Bello, G.4
Hansbro, P.M.5
Knight, D.A.6
-
3
-
-
0036194724
-
Mucus clearance as a primary innate defense mechanism for mammalian airways
-
Knowles, M. R., and Boucher, R. C. (2002) Mucus clearance as a primary innate defense mechanism for mammalian airways. J. Clin. Invest. 109, 571-577
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 571-577
-
-
Knowles, M.R.1
Boucher, R.C.2
-
4
-
-
78649735324
-
Airway mucus function and dysfunction
-
Fahy, J. V., and Dickey, B. F. (2010) Airway mucus function and dysfunction. N. Engl. J. Med. 363, 2233-2247
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 2233-2247
-
-
Fahy, J.V.1
Dickey, B.F.2
-
5
-
-
78349273579
-
Cystic fibrosis transmembrane conductance regulator is involved in airway epithelial wound repair
-
Schiller, K. R., Maniak, P. J., and O'Grady, S. M. (2010) Cystic fibrosis transmembrane conductance regulator is involved in airway epithelial wound repair. Am. J. Physiol. Cell Physiol. 299, C912-C921
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
, pp. C912-C921
-
-
Schiller, K.R.1
Maniak, P.J.2
O'Grady, S.M.3
-
6
-
-
84859620802
-
Cystic fibrosis: A mucosal immunodeficiency syndrome
-
Cohen, T. S., and Prince, A. (2012) Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat. Med. 18, 509-519
-
(2012)
Nat. Med.
, vol.18
, pp. 509-519
-
-
Cohen, T.S.1
Prince, A.2
-
7
-
-
4944235029
-
Newborn screening for cystic fibrosis: Evaluation of benefits and risks and recommendations for state newborn screening programs
-
Grosse, S. D., Boyle, C. A., Botkin, J. R., Comeau, A. M., Kharrazi, M., Rosenfeld, M., and Wilfond, B. S. (2004) Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs. National Center on Birth Defects and Developmental Disabilities. C. D. C. M. M. W. R. 53, 1-36
-
(2004)
National Center on Birth Defects and Developmental Disabilities. C. D. C. M. M. W. R.
, vol.53
, pp. 1-36
-
-
Grosse, S.D.1
Boyle, C.A.2
Botkin, J.R.3
Comeau, A.M.4
Kharrazi, M.5
Rosenfeld, M.6
Wilfond, B.S.7
-
8
-
-
0028914085
-
Early pulmonary inflammation in infants with cystic fibrosis
-
Khan, T. Z., Wagener, J. S., Bost, T., Martinez, J., Accurso, F. J., and Riches, D. W. (1995) Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151, 1075-1082
-
(1995)
Am. J. Respir. Crit. Care Med.
, vol.151
, pp. 1075-1082
-
-
Khan, T.Z.1
Wagener, J.S.2
Bost, T.3
Martinez, J.4
Accurso, F.J.5
Riches, D.W.6
-
9
-
-
0028015883
-
Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation
-
Konstan, M. W., Hilliard, K. A., Norvell, T. M., and Berger, M. (1994) Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am. J. Respir. Crit. Care Med. 150, 448-454
-
(1994)
Am. J. Respir. Crit. Care Med.
, vol.150
, pp. 448-454
-
-
Konstan, M.W.1
Hilliard, K.A.2
Norvell, T.M.3
Berger, M.4
-
10
-
-
0034764166
-
Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis
-
Rosenfeld, M., Gibson, R. L., McNamara, S., Emerson, J., Burns, J. L., Castile, R., Hiatt, P., McCoy, K., Wilson, C. B., Inglis, A., Smith, A., Martin, T. R., and Ramsey, B. W. (2001) Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis. Pediatr. Pulmonol. 32, 356-366
-
(2001)
Pediatr. Pulmonol.
, vol.32
, pp. 356-366
-
-
Rosenfeld, M.1
Gibson, R.L.2
McNamara, S.3
Emerson, J.4
Burns, J.L.5
Castile, R.6
Hiatt, P.7
McCoy, K.8
Wilson, C.B.9
Inglis, A.10
Smith, A.11
Martin, T.R.12
Ramsey, B.W.13
-
11
-
-
29544436136
-
Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis
-
Hartl, D., Griese, M., Kappler, M., Zissel, G., Reinhardt, D., Rebhan, C., Schendel, D. J., and Krauss-Etschmann, S. (2006) Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J. Allergy Clin. Immunol. 117, 204-211
-
(2006)
J. Allergy Clin. Immunol.
, vol.117
, pp. 204-211
-
-
Hartl, D.1
Griese, M.2
Kappler, M.3
Zissel, G.4
Reinhardt, D.5
Rebhan, C.6
Schendel, D.J.7
Krauss-Etschmann, S.8
-
12
-
-
80051553123
-
The Th17 pathway in cystic fibrosis lung disease
-
Tan, H. L., Regamey, N., Brown, S., Bush, A., Lloyd, C. M., and Davies, J. C. (2011) The Th17 pathway in cystic fibrosis lung disease. Am. J. Respir. Crit. Care Med. 184, 252-258
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.184
, pp. 252-258
-
-
Tan, H.L.1
Regamey, N.2
Brown, S.3
Bush, A.4
Lloyd, C.M.5
Davies, J.C.6
-
13
-
-
84875159113
-
A Th17-and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection
-
Tiringer, K., Treis, A., Fucik, P., Gona, M., Gruber, S., Renner, S., Dehlink, E., Nachbaur, E., Horak, F., Jaksch, P., Döring, G., Crameri, R., Jung, A., Rochat, M. K., Hörmann, M., et al. (2013) A Th17-and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am. J. Respir. Crit. Care Med. 187, 621-629
-
(2013)
Am. J. Respir. Crit. Care Med.
, vol.187
, pp. 621-629
-
-
Tiringer, K.1
Treis, A.2
Fucik, P.3
Gona, M.4
Gruber, S.5
Renner, S.6
Dehlink, E.7
Nachbaur, E.8
Horak, F.9
Jaksch, P.10
Döring, G.11
Crameri, R.12
Jung, A.13
Rochat, M.K.14
Hörmann, M.15
-
14
-
-
0036344597
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
-
Kuperman, D. A., Huang, X., Koth, L. L., Chang, G. H., Dolganov, G. M., Zhu, Z., Elias, J. A., Sheppard, D., and Erle, D. J. (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8, 885-889
-
(2002)
Nat. Med.
, vol.8
, pp. 885-889
-
-
Kuperman, D.A.1
Huang, X.2
Koth, L.L.3
Chang, G.H.4
Dolganov, G.M.5
Zhu, Z.6
Elias, J.A.7
Sheppard, D.8
Erle, D.J.9
-
15
-
-
0037458605
-
Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-and interleukin-8 release in human bronchial epithelial cells
-
Prause, O., Laan, M., Lötvall, J., and Lindén, A. (2003) Pharmacological modulation of interleukin-17-induced GCP-2-, GRO-and interleukin-8 release in human bronchial epithelial cells. Eur. J. Pharmacol. 462, 193-198
-
(2003)
Eur. J. Pharmacol.
, vol.462
, pp. 193-198
-
-
Prause, O.1
Laan, M.2
Lötvall, J.3
Lindén, A.4
-
16
-
-
0031871137
-
Subepithelial fibrosis and degradation of the bronchial extracellular matrix in cystic fibrosis
-
Durieu, I., Peyrol, S., Gindre, D., Bellon, G., Durand, D. V., and Pacheco, Y. (1998) Subepithelial fibrosis and degradation of the bronchial extracellular matrix in cystic fibrosis. Am. J. Respir. Crit. Care Med. 158, 580-588
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.158
, pp. 580-588
-
-
Durieu, I.1
Peyrol, S.2
Gindre, D.3
Bellon, G.4
Durand, D.V.5
Pacheco, Y.6
-
17
-
-
0037090744
-
Clinical findings and lung pathology in children with cystic fibrosis
-
Hamutcu, R., Rowland, J. M., Horn, M. V., Kaminsky, C., MacLaughlin, E. F., Starnes, V. A., and Woo, M. S. (2002) Clinical findings and lung pathology in children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 165, 1172-1175
-
(2002)
Am. J. Respir. Crit. Care Med.
, vol.165
, pp. 1172-1175
-
-
Hamutcu, R.1
Rowland, J.M.2
Horn, M.V.3
Kaminsky, C.4
MacLaughlin, E.F.5
Starnes, V.A.6
Woo, M.S.7
-
18
-
-
36048972322
-
Airway remodelling in children with cystic fibrosis
-
Hilliard, T. N., Regamey, N., Shute, J. K., Nicholson, A. G., Alton, E. W., Bush, A., and Davies, J. C. (2007) Airway remodelling in children with cystic fibrosis. Thorax 62, 1074-1080
-
(2007)
Thorax
, vol.62
, pp. 1074-1080
-
-
Hilliard, T.N.1
Regamey, N.2
Shute, J.K.3
Nicholson, A.G.4
Alton, E.W.5
Bush, A.6
Davies, J.C.7
-
19
-
-
79959287741
-
Airway remodelling and its relationship to inflammation in cystic fibrosis
-
Regamey, N., Jeffery, P. K., Alton, E. W., Bush, A., and Davies, J. C. (2011) Airway remodelling and its relationship to inflammation in cystic fibrosis. Thorax 66, 624-629
-
(2011)
Thorax
, vol.66
, pp. 624-629
-
-
Regamey, N.1
Jeffery, P.K.2
Alton, E.W.3
Bush, A.4
Davies, J.C.5
-
20
-
-
43349158916
-
New concepts in the pathobiology of chronic obstructive pulmonary disease
-
Kim, V., Rogers, T. J., and Criner, G. J. (2008) New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 5, 478-485
-
(2008)
Proc. Am. Thorac. Soc.
, vol.5
, pp. 478-485
-
-
Kim, V.1
Rogers, T.J.2
Criner, G.J.3
-
21
-
-
79959369140
-
The sentinel role of the airway epithelium in asthma pathogenesis
-
Holgate, S. T. (2011) The sentinel role of the airway epithelium in asthma pathogenesis. Immunol. Rev. 242, 205-219
-
(2011)
Immunol. Rev.
, vol.242
, pp. 205-219
-
-
Holgate, S.T.1
-
22
-
-
0035827691
-
The epitheliumspecific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades
-
Tugores, A., Le, J., Sorokina, I., Snijders, A. J., Duyao, M., Reddy, P. S., Carlee, L., Ronshaugen, M., Mushegian, A., Watanaskul, T., Chu, S., Buckler, A., Emtage, S., and McCormick, M. K. (2001) The epitheliumspecific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. J. Biol. Chem. 276, 20397-20406
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20397-20406
-
-
Tugores, A.1
Le, J.2
Sorokina, I.3
Snijders, A.J.4
Duyao, M.5
Reddy, P.S.6
Carlee, L.7
Ronshaugen, M.8
Mushegian, A.9
Watanaskul, T.10
Chu, S.11
Buckler, A.12
Emtage, S.13
McCormick, M.K.14
-
23
-
-
0036891561
-
Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung
-
Silverman, E. S., Baron, R. M., Palmer, L. J., Le, L., Hallock, A., Subramaniam, V., Riese, R. J., McKenna, M. D., Gu, X., Libermann, T. A., Tugores, A., Haley, K. J., Shore, S., Drazen, J. M., and Weiss, S. T. (2002) Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. Am. J. Respir. Cell Mol. Biol. 27, 697-704
-
(2002)
Am. J. Respir. Cell Mol. Biol.
, vol.27
, pp. 697-704
-
-
Silverman, E.S.1
Baron, R.M.2
Palmer, L.J.3
Le, L.4
Hallock, A.5
Subramaniam, V.6
Riese, R.J.7
McKenna, M.D.8
Gu, X.9
Libermann, T.A.10
Tugores, A.11
Haley, K.J.12
Shore, S.13
Drazen, J.M.14
Weiss, S.T.15
-
24
-
-
0034723354
-
ESE-3, a novel member of an epithelium-specific Ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1
-
Kas, K., Finger, E., Grall, F., Gu, X., Akbarali, Y., Boltax, J., Weiss, A., Oettgen, P., Kapeller, R., and Libermann, T. A. (2000) ESE-3, a novel member of an epithelium-specific Ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. J. Biol. Chem. 275, 2986-2998
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2986-2998
-
-
Kas, K.1
Finger, E.2
Grall, F.3
Gu, X.4
Akbarali, Y.5
Boltax, J.6
Weiss, A.7
Oettgen, P.8
Kapeller, R.9
Libermann, T.A.10
-
25
-
-
44849138714
-
Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: Potential roles in airway inflammation
-
Wu, J., Duan, R., Cao, H., Field, D., Newnham, C. M., Koehler, D. R., Zamel, N., Pritchard, M. A., Hertzog, P., Post, M., Tanswell, A. K., and Hu, J. (2008) Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation. Cell Res. 18, 649-663
-
(2008)
Cell Res.
, vol.18
, pp. 649-663
-
-
Wu, J.1
Duan, R.2
Cao, H.3
Field, D.4
Newnham, C.M.5
Koehler, D.R.6
Zamel, N.7
Pritchard, M.A.8
Hertzog, P.9
Post, M.10
Tanswell, A.K.11
Hu, J.12
-
26
-
-
84861903355
-
ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features
-
Albino, D., Longoni, N., Curti, L., Mello-Grand, M., Pinton, S., Civenni, G., Thalmann, G., D'Ambrosio, G., Sarti, M., Sessa, F., Chiorino, G., Catapano, C. V., and Carbone, G. M. (2012) ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 72, 2889-2900
-
(2012)
Cancer Res.
, vol.72
, pp. 2889-2900
-
-
Albino, D.1
Longoni, N.2
Curti, L.3
Mello-Grand, M.4
Pinton, S.5
Civenni, G.6
Thalmann, G.7
D'Ambrosio, G.8
Sarti, M.9
Sessa, F.10
Chiorino, G.11
Catapano, C.V.12
Carbone, G.M.13
-
27
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J. P., and Sleeman, J. P. (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
28
-
-
33748375828
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
-
Kim, K. K., Kugler, M. C., Wolters, P. J., Robillard, L., Galvez, M. G., Brumwell, A. N., Sheppard, D., and Chapman, H. A. (2006) Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl. Acad. Sci. U. S. A. 103, 13180-13185
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 13180-13185
-
-
Kim, K.K.1
Kugler, M.C.2
Wolters, P.J.3
Robillard, L.4
Galvez, M.G.5
Brumwell, A.N.6
Sheppard, D.7
Chapman, H.A.8
-
29
-
-
79957588506
-
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13. 2
-
Wright, F. A., Strug, L. J., Doshi, V. K., Commander, C. W., Blackman, S. M., Sun, L., Berthiaume, Y., Cutler, D., Cojocaru, A., Collaco, J. M., Corey, M., Dorfman, R., Goddard, K., Green, D., Kent, J. W., Jr., et al. (2011) Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13. 2. Nat. Genet. 43, 539-546
-
(2011)
Nat. Genet.
, vol.43
, pp. 539-546
-
-
Wright, F.A.1
Strug, L.J.2
Doshi, V.K.3
Commander, C.W.4
Blackman, S.M.5
Sun, L.6
Berthiaume, Y.7
Cutler, D.8
Cojocaru, A.9
Collaco, J.M.10
Corey, M.11
Dorfman, R.12
Goddard, K.13
Green, D.14
Kent, J.W.15
-
30
-
-
84942880568
-
Genomewide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
-
Corvol, H., Blackman, S. M., Boëlle, P. Y., Gallins, P. J., Pace, R. G., Stonebraker, J. R., Accurso, F. J., Clement, A., Collaco, J. M., Dang, H., Dang, A. T., Franca, A., Gong, J., Guillot, L., Keenan, K., et al. (2015) Genomewide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. Nat. Commun. 6, 8382
-
(2015)
Nat. Commun.
, vol.6
, pp. 8382
-
-
Corvol, H.1
Blackman, S.M.2
Boëlle, P.Y.3
Gallins, P.J.4
Pace, R.G.5
Stonebraker, J.R.6
Accurso, F.J.7
Clement, A.8
Collaco, J.M.9
Dang, H.10
Dang, A.T.11
Franca, A.12
Gong, J.13
Guillot, L.14
Keenan, K.15
-
31
-
-
84927621581
-
Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells
-
Fossum, S. L., Mutolo, M. J., Yang, R., Dang, H., O'Neal, W. K., Knowles, M. R., Leir, S. H., and Harris, A. (2014) Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells. Nucleic Acids Res. 42, 13588-13598
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 13588-13598
-
-
Fossum, S.L.1
Mutolo, M.J.2
Yang, R.3
Dang, H.4
O'Neal, W.K.5
Knowles, M.R.6
Leir, S.H.7
Harris, A.8
-
33
-
-
33747836850
-
CEAS: Cis-regulatory element annotation system
-
Ji, X., Li, W., Song, J., Wei, L., and Liu, X. S. (2006) CEAS: cis-regulatory element annotation system. Nucleic Acids Res. 34, W551-554
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. W551-554
-
-
Ji, X.1
Li, W.2
Song, J.3
Wei, L.4
Liu, X.S.5
-
34
-
-
33847334699
-
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
-
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., Wang, W., Weng, Z., Green, R. D., Crawford, G. E., and Ren, B. (2007) Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39, 311-318
-
(2007)
Nat. Genet.
, vol.39
, pp. 311-318
-
-
Heintzman, N.D.1
Stuart, R.K.2
Hon, G.3
Fu, Y.4
Ching, C.W.5
Hawkins, R.D.6
Barrera, L.O.7
Van Calcar, S.8
Qu, C.9
Ching, K.A.10
Wang, W.11
Weng, Z.12
Green, R.D.13
Crawford, G.E.14
Ren, B.15
-
35
-
-
78650304236
-
Charting histone modifications and the functional organization of mammalian genomes
-
Zhou, V. W., Goren, A., and Bernstein, B. E. (2011) Charting histone modifications and the functional organization of mammalian genomes. Nat. Rev. Genet. 12, 7-18
-
(2011)
Nat. Rev. Genet.
, vol.12
, pp. 7-18
-
-
Zhou, V.W.1
Goren, A.2
Bernstein, B.E.3
-
36
-
-
84859885816
-
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
-
Trapnell, C., Roberts, A., Goff, L., Pertea, G., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., and Pachter, L. (2012) Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7, 562-578
-
(2012)
Nat. Protoc.
, vol.7
, pp. 562-578
-
-
Trapnell, C.1
Roberts, A.2
Goff, L.3
Pertea, G.4
Kim, D.5
Kelley, D.R.6
Pimentel, H.7
Salzberg, S.L.8
Rinn, J.L.9
Pachter, L.10
-
37
-
-
84888374584
-
Target analysis by integration of transcriptome and ChIP-seq data with BETA
-
Wang, S., Sun, H., Ma, J., Zang, C., Wang, C., Wang, J., Tang, Q., Meyer, C. A., Zhang, Y., and Liu, X. S. (2013) Target analysis by integration of transcriptome and ChIP-seq data with BETA. Nat. Protoc. 8, 2502-2515
-
(2013)
Nat. Protoc.
, vol.8
, pp. 2502-2515
-
-
Wang, S.1
Sun, H.2
Ma, J.3
Zang, C.4
Wang, C.5
Wang, J.6
Tang, Q.7
Meyer, C.A.8
Zhang, Y.9
Liu, X.S.10
-
38
-
-
34147151188
-
SPDEF regulates goblet cell hyperplasia in the airway epithelium
-
Park, K. S., Korfhagen, T. R., Bruno, M. D., Kitzmiller, J. A., Wan, H., Wert, S. E., Khurana Hershey, G. K., Chen, G., and Whitsett, J. A. (2007) SPDEF regulates goblet cell hyperplasia in the airway epithelium. J. Clin. Invest. 117, 978-988
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 978-988
-
-
Park, K.S.1
Korfhagen, T.R.2
Bruno, M.D.3
Kitzmiller, J.A.4
Wan, H.5
Wert, S.E.6
Khurana Hershey, G.K.7
Chen, G.8
Whitsett, J.A.9
-
39
-
-
70349664159
-
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
-
Chen, G., Korfhagen, T. R., Xu, Y., Kitzmiller, J., Wert, S. E., Maeda, Y., Gregorieff, A., Clevers, H., and Whitsett, J. A. (2009) SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J. Clin. Invest. 119, 2914-2924
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2914-2924
-
-
Chen, G.1
Korfhagen, T.R.2
Xu, Y.3
Kitzmiller, J.4
Wert, S.E.5
Maeda, Y.6
Gregorieff, A.7
Clevers, H.8
Whitsett, J.A.9
-
40
-
-
44849090900
-
Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharidemediated responses in airway epithelial cells
-
Pace, E., Ferraro, M., Siena, L., Melis, M., Montalbano, A. M., Johnson, M., Bonsignore, M. R., Bonsignore, G., and Gjomarkaj, M. (2008) Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharidemediated responses in airway epithelial cells. Immunology 124, 401-411
-
(2008)
Immunology
, vol.124
, pp. 401-411
-
-
Pace, E.1
Ferraro, M.2
Siena, L.3
Melis, M.4
Montalbano, A.M.5
Johnson, M.6
Bonsignore, M.R.7
Bonsignore, G.8
Gjomarkaj, M.9
-
41
-
-
84900563188
-
Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased 1-integrin signaling and delayed wound repair
-
Itokazu, Y., Pagano, R. E., Schroeder, A. S., O'Grady, S. M., Limper, A. H., and Marks, D. L. (2014) Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased 1-integrin signaling and delayed wound repair. Am. J. Physiol. Cell Physiol. 306, C819-830
-
(2014)
Am. J. Physiol. Cell Physiol.
, vol.306
, pp. C819-830
-
-
Itokazu, Y.1
Pagano, R.E.2
Schroeder, A.S.3
O'Grady, S.M.4
Limper, A.H.5
Marks, D.L.6
-
42
-
-
34248346723
-
Heritability of lung disease severity in cystic fibrosis
-
Vanscoy, L. L., Blackman, S. M., Collaco, J. M., Bowers, A., Lai, T., Naughton, K., Algire, M., McWilliams, R., Beck, S., Hoover-Fong, J., Hamosh, A., Cutler, D., and Cutting, G. R. (2007) Heritability of lung disease severity in cystic fibrosis. Am. J. Respir. Crit. Care Med. 175, 1036-1043
-
(2007)
Am. J. Respir. Crit. Care Med.
, vol.175
, pp. 1036-1043
-
-
Vanscoy, L.L.1
Blackman, S.M.2
Collaco, J.M.3
Bowers, A.4
Lai, T.5
Naughton, K.6
Algire, M.7
McWilliams, R.8
Beck, S.9
Hoover-Fong, J.10
Hamosh, A.11
Cutler, D.12
Cutting, G.R.13
-
43
-
-
0027517995
-
Correlation between genotype and phenotype in patients with cystic fibrosis
-
Cystic Fibrosis Genotype-Phenotype Consortium
-
Cystic Fibrosis Genotype-Phenotype Consortium (1993) Correlation between genotype and phenotype in patients with cystic fibrosis. N. Engl. J. Med. 329, 1308-1313
-
(1993)
N. Engl. J. Med.
, vol.329
, pp. 1308-1313
-
-
-
44
-
-
84889032488
-
The Ets transcription factor EHF as a regulator of cornea epithelial cell identity
-
Stephens, D. N., Klein, R. H., Salmans, M. L., Gordon, W., Ho, H., and Andersen, B. (2013) The Ets transcription factor EHF as a regulator of cornea epithelial cell identity. J. Biol. Chem. 288, 34304-34324
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 34304-34324
-
-
Stephens, D.N.1
Klein, R.H.2
Salmans, M.L.3
Gordon, W.4
Ho, H.5
Andersen, B.6
-
45
-
-
79960002978
-
A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis
-
Taniue, K., Oda, T., Hayashi, T., Okuno, M., and Akiyama, T. (2011) A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO Rep. 12, 682-689
-
(2011)
EMBO Rep.
, vol.12
, pp. 682-689
-
-
Taniue, K.1
Oda, T.2
Hayashi, T.3
Okuno, M.4
Akiyama, T.5
-
46
-
-
77956285565
-
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3. 1 in prostate cancer
-
Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C. V., and Carbone, G. M. (2010) ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3. 1 in prostate cancer. PLoS ONE 5, e10547
-
(2010)
PLoS ONE
, vol.5
, pp. e10547
-
-
Kunderfranco, P.1
Mello-Grand, M.2
Cangemi, R.3
Pellini, S.4
Mensah, A.5
Albertini, V.6
Malek, A.7
Chiorino, G.8
Catapano, C.V.9
Carbone, G.M.10
-
47
-
-
0036891937
-
Role and regulation of activator protein-1 in toxicant-induced responses of the lung
-
Reddy, S. P., and Mossman, B. T. (2002) Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am. J. Physiol. Lung Cell Mol. Physiol. 283, L1161-L1178
-
(2002)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.283
, pp. L1161-L1178
-
-
Reddy, S.P.1
Mossman, B.T.2
-
48
-
-
33744736979
-
Oxidants and signaling by mitogen-activated protein kinases in lung epithelium
-
Mossman, B. T., Lounsbury, K. M., and Reddy, S. P. (2006) Oxidants and signaling by mitogen-activated protein kinases in lung epithelium. Am. J. Respir. Cell Mol. Biol. 34, 666-669
-
(2006)
Am. J. Respir. Cell Mol. Biol.
, vol.34
, pp. 666-669
-
-
Mossman, B.T.1
Lounsbury, K.M.2
Reddy, S.P.3
-
49
-
-
34247557545
-
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways
-
Verhaeghe, C., Remouchamps, C., Hennuy, B., Vanderplasschen, A., Chariot, A., Tabruyn, S. P., Oury, C., and Bours, V. (2007) Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. Biochem. Pharmacol. 73, 1982-1994
-
(2007)
Biochem. Pharmacol.
, vol.73
, pp. 1982-1994
-
-
Verhaeghe, C.1
Remouchamps, C.2
Hennuy, B.3
Vanderplasschen, A.4
Chariot, A.5
Tabruyn, S.P.6
Oury, C.7
Bours, V.8
-
50
-
-
84892748994
-
Lung development: Orchestrating the generation and regeneration of a complex organ
-
Herriges, M., and Morrisey, E. E. (2014) Lung development: orchestrating the generation and regeneration of a complex organ. Development 141, 502-513
-
(2014)
Development
, vol.141
, pp. 502-513
-
-
Herriges, M.1
Morrisey, E.E.2
-
51
-
-
1342283994
-
Foxa2 regulates alveolarization and goblet cell hyperplasia
-
Wan, H., Kaestner, K. H., Ang, S. L., Ikegami, M., Finkelman, F. D., Stahlman, M. T., Fulkerson, P. C., Rothenberg, M. E., and Whitsett, J. A. (2004) Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131, 953-964
-
(2004)
Development
, vol.131
, pp. 953-964
-
-
Wan, H.1
Kaestner, K.H.2
Ang, S.L.3
Ikegami, M.4
Finkelman, F.D.5
Stahlman, M.T.6
Fulkerson, P.C.7
Rothenberg, M.E.8
Whitsett, J.A.9
-
52
-
-
17144407948
-
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
-
Wan, H., Dingle, S., Xu, Y., Besnard, V., Kaestner, K. H., Ang, S. L., Wert, S., Stahlman, M. T., and Whitsett, J. A. (2005) Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J. Biol. Chem. 280, 13809-13816
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13809-13816
-
-
Wan, H.1
Dingle, S.2
Xu, Y.3
Besnard, V.4
Kaestner, K.H.5
Ang, S.L.6
Wert, S.7
Stahlman, M.T.8
Whitsett, J.A.9
-
53
-
-
0033770431
-
Stage-dependent responses of the developing lung to retinoic acid signaling
-
Mollard, R., Ghyselinck, N. B., Wendling, O., Chambon, P., and Mark, M. (2000) Stage-dependent responses of the developing lung to retinoic acid signaling. Int. J. Dev. Biol. 44, 457-462
-
(2000)
Int. J. Dev. Biol.
, vol.44
, pp. 457-462
-
-
Mollard, R.1
Ghyselinck, N.B.2
Wendling, O.3
Chambon, P.4
Mark, M.5
-
54
-
-
0036337973
-
GATA6 regulates differentiation of the distal lung epithelium
-
Yang, H., Lu, M. M., Zhang, L., Whitsett, J. A., and Morrisey, E. E. (2002) GATA6 regulates differentiation of the distal lung epithelium. Development 129, 2233-2246
-
(2002)
Development
, vol.129
, pp. 2233-2246
-
-
Yang, H.1
Lu, M.M.2
Zhang, L.3
Whitsett, J.A.4
Morrisey, E.E.5
-
55
-
-
33846544536
-
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo
-
Zhang, Y., Rath, N., Hannenhalli, S., Wang, Z., Cappola, T., Kimura, S., Atochina-Vasserman, E., Lu, M. M., Beers, M. F., and Morrisey, E. E. (2007) GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development 134, 189-198
-
(2007)
Development
, vol.134
, pp. 189-198
-
-
Zhang, Y.1
Rath, N.2
Hannenhalli, S.3
Wang, Z.4
Cappola, T.5
Kimura, S.6
Atochina-Vasserman, E.7
Lu, M.M.8
Beers, M.F.9
Morrisey, E.E.10
-
56
-
-
46249127489
-
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
-
Zhang, Y., Goss, A. M., Cohen, E. D., Kadzik, R., Lepore, J. J., Muthukumaraswamy, K., Yang, J., DeMayo, F. J., Whitsett, J. A., Parmacek, M. S., and Morrisey, E. E. (2008) A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat. Genet. 40, 862-870
-
(2008)
Nat. Genet.
, vol.40
, pp. 862-870
-
-
Zhang, Y.1
Goss, A.M.2
Cohen, E.D.3
Kadzik, R.4
Lepore, J.J.5
Muthukumaraswamy, K.6
Yang, J.7
DeMayo, F.J.8
Whitsett, J.A.9
Parmacek, M.S.10
Morrisey, E.E.11
-
57
-
-
33746617492
-
Hop functions downstream of Nkx2. 1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression
-
Yin, Z., Gonzales, L., Kolla, V., Rath, N., Zhang, Y., Lu, M. M., Kimura, S., Ballard, P. L., Beers, M. F., Epstein, J. A., and Morrisey, E. E. (2006) Hop functions downstream of Nkx2. 1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L191-L199
-
(2006)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.291
, pp. L191-L199
-
-
Yin, Z.1
Gonzales, L.2
Kolla, V.3
Rath, N.4
Zhang, Y.5
Lu, M.M.6
Kimura, S.7
Ballard, P.L.8
Beers, M.F.9
Epstein, J.A.10
Morrisey, E.E.11
-
58
-
-
50649096444
-
Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
-
Wan, H., Luo, F., Wert, S. E., Zhang, L., Xu, Y., Ikegami, M., Maeda, Y., Bell, S. M., and Whitsett, J. A. (2008) Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135, 2563-2572
-
(2008)
Development
, vol.135
, pp. 2563-2572
-
-
Wan, H.1
Luo, F.2
Wert, S.E.3
Zhang, L.4
Xu, Y.5
Ikegami, M.6
Maeda, Y.7
Bell, S.M.8
Whitsett, J.A.9
-
59
-
-
84867340544
-
SAMpointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia
-
Korfhagen, T. R., Kitzmiller, J., Chen, G., Sridharan, A., Haitchi, H.-M., Hegde, R. S., Divanovic, S., Karp, C. L., and Whitsett, J. A. (2012) SAMpointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia. Proc. Natl. Acad. Sci. U. S. A. 109, 16630-16635
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 16630-16635
-
-
Korfhagen, T.R.1
Kitzmiller, J.2
Chen, G.3
Sridharan, A.4
Haitchi, H.-M.5
Hegde, R.S.6
Divanovic, S.7
Karp, C.L.8
Whitsett, J.A.9
-
60
-
-
84928997878
-
Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation
-
Rajavelu, P., Chen, G., Xu, Y., Kitzmiller, J. A., Korfhagen, T. R., and Whitsett, J. A. (2015) Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation. J. Clin. Invest. 125, 2021-2031
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 2021-2031
-
-
Rajavelu, P.1
Chen, G.2
Xu, Y.3
Kitzmiller, J.A.4
Korfhagen, T.R.5
Whitsett, J.A.6
-
61
-
-
84940884841
-
Airway gland structure and function
-
Widdicombe, J. H., and Wine, J. J. (2015) Airway gland structure and function. Physiol. Rev. 95, 1241-1319
-
(2015)
Physiol. Rev.
, vol.95
, pp. 1241-1319
-
-
Widdicombe, J.H.1
Wine, J.J.2
-
62
-
-
0028240276
-
Protease-antiprotease imbalance in the lungs of children with cystic fibrosis
-
Birrer, P., McElvaney, N. G., Rüdeberg, A., Sommer, C. W., Liechti-Gallati, S., Kraemer, R., Hubbard, R., and Crystal, R. G. (1994) Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am. J. Respir. Crit. Care Med. 150, 207-213
-
(1994)
Am. J. Respir. Crit. Care Med.
, vol.150
, pp. 207-213
-
-
Birrer, P.1
McElvaney, N.G.2
Rüdeberg, A.3
Sommer, C.W.4
Liechti-Gallati, S.5
Kraemer, R.6
Hubbard, R.7
Crystal, R.G.8
-
63
-
-
43049135102
-
Proteases and cystic fibrosis
-
Voynow, J. A., Fischer, B. M., and Zheng, S. (2008) Proteases and cystic fibrosis. Int. J. Biochem. Cell Biol. 40, 1238-1245
-
(2008)
Int. J. Biochem. Cell Biol.
, vol.40
, pp. 1238-1245
-
-
Voynow, J.A.1
Fischer, B.M.2
Zheng, S.3
-
64
-
-
16644381108
-
Well differentiated human airway epithelial cell cultures
-
Fulcher, M. L., Gabriel, S., Burns, K. A., Yankaskas, J. R., and Randell, S. H. (2005) Well differentiated human airway epithelial cell cultures. Methods Mol. Med. 107, 183-206
-
(2005)
Methods Mol. Med.
, vol.107
, pp. 183-206
-
-
Fulcher, M.L.1
Gabriel, S.2
Burns, K.A.3
Yankaskas, J.R.4
Randell, S.H.5
-
65
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., and Glass, C. K. (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589
-
(2010)
Mol. Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
Benner, C.2
Spann, N.3
Bertolino, E.4
Lin, Y.C.5
Laslo, P.6
Cheng, J.X.7
Murre, C.8
Singh, H.9
Glass, C.K.10
-
66
-
-
84899132703
-
Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells
-
Kerschner, J. L., Gosalia, N., Leir, S. H., and Harris, A. (2014) Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells. Epigenetics 9, 557-565
-
(2014)
Epigenetics
, vol.9
, pp. 557-565
-
-
Kerschner, J.L.1
Gosalia, N.2
Leir, S.H.3
Harris, A.4
|